در هنگام جستجو کلمه در قسمت عنوان میتوانید کلمات مورد جستجو را با کاراکتر (-) جدا کنید.
کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: loop electrosurgical excision procedure,Mefenamic acid,pain control,Preinvasive cervical cancer
- چکیده:
- چکیده انگلیسی: Objective: To investigate the effectiveness of pre-procedural oral mefenamic acid compared with placebo in women undergoing Loop Electrosurgical Excision Procedure (LEEP) with intracervical lidocaine injection. Study designs: A prospective double-blinded randomized control trial. Materials, Setting, Methods: Women undergoing LEEP for any indications were asked to participate in the study. The participants were randomly allocated into two groups. In group 1 (oral mefenamic acid), the participants were offered oral mefenamic acid (500 mg) for 30 minutes before procedures. In group 2 (placebo), the patients were given oral placebo (identical tablet) for 30 minutes before operation. All participants received immediate 10 mL of 2% lidocaine with 1:100,000 of epinephrine intracervical injection before undergoing the LEEP. All participants were excised in one piece of LEEP. No top-hat excision in this study. The patients graded their pain on a 10-cm visual analog scale (VAS) at different points during the procedure, including speculum insertion, at starting excision, and 30 minutes post excision. Primary outcomes revealed the difference of VAS during all steps of LEEP by generalized estimating equations procedure. Results: Sixty participants (30 in mefenamic group and 30 in placebo group) participated in this study. The study did not find differences of VAS during all steps of LEEP and analgesic drug requirement at 30 minutes after LEEP procedure. All patients reported no immediate complications and no intervention-related adverse events were observed. Conclusion: Using pre-procedural oral mefenamic acid before LEEP procedure was not associated with pain reduction during all steps of excision.
- انتشار مقاله: 02-07-1399
- نویسندگان: Poochit Dabpookhiew,Amornrat Temtanakitpaisan,Chumnan Kietpeerakool,Bandit Chumworathayi,Apiwat Aue-Aungkul,Fa-Ngam Chareonpol,Nampet Jampathong
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: attitude,Knowledge,human papillomavirus,nationwide,social media site
- چکیده:
- چکیده انگلیسی: Objectives: This study was performed first to assess Thai women’s knowledge and attitude toward Human papillomavirus (HPV) infection and vaccination and second to find out factors associated with knowledge in this regard. Methods: The survey announcement was advertised via Facebook from 17 May 2019 to 14 June 2019 to recruit women aged 18-26 years living in Thailand. A score below 5 out of total score of 10 on the survey was considered as a poor level of knowledge. Multivariate analysis was applied to identify factors associated with HPV infection and vaccination knowledge. Results: A total of 1,175 participants were recruited. The participants’ median age was 22 years. Approximately, 46% of the participants had poor level of knowledge regarding HPV infection and vaccination. Factors associated with poor knowledge included low educational level (adjusted OR, 1.35; 95% CI 1.04-1.77), low family income (adjusted OR, 2.14; 95% CI 1.65-2.78), being Christian (adjusted OR, 4.04; 95% CI 1.22-13.40), being engaged in sexual intercourse (adjusted OR, 0.75; 95%CI 0.58-0.97), and being unvaccinated against HPV infection (adjusted OR, 5.74; 95% CI 3.07-10.74). Conclusion: Nearly half of the Thai women who participated in the survey had poor level of knowledge regarding HPV infection and vaccination, indicating a need for more effective health education intervention. Factors associated with knowledge included socioeconomic status and sexual behavior.
- انتشار مقاله: 14-11-1398
- نویسندگان: Naratassapol Likitdee,Chumnan Kietpeerakool,Bandit Chumworathayi,Amornrat Temtanakitpaisan,Apiwat Aue-aungkul,Wilasinee Nhokaew,Nampet Jampathong
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Vaccines,human papillomavirus,Quality assessment,websites
- چکیده:
- چکیده انگلیسی: Objectives: To assess the quality of websites that provide information about human papillomavirus (HPV) vaccination using the criteria laid out by the World Health Organization Global Advisory Committee on Vaccine Safety. Methods: This study assessed the quality of 154 Thai-language websites accessible in November 2018 via the three most popular search engines. Differences in scores were reported as mean difference (MD) and 95% confidence interval (CI). Results: With regard to credibility, all of the websites examined indicated their mission but, in most cases (91.6%), lacked transparency with regard to sponsorship. In terms of content, almost all of the websites (97.4%) met our writing/editing and content accuracy standards but did not provide complete information regarding the benefits of vaccination or adverse events associated with it. None of the websites contained information regarding their editorial/review process. All of the websites were accessible and were designed to be adaptable to mobile device screens. News and personal websites had lower credit scores than those of academic institutions (MD -0.63, 95% CI -1.05 to -0.20; MD -0.71, 95% CI -1.16 to -0.25, respectively). Conclusion: Most of the websites met standards in terms of writing/editing and content accuracy. However, fundamental information regarding the benefits and adverse events associated with HPV vaccination were infrequently reported, the editorial process and transparency issues were rarely addressed.
- انتشار مقاله: 20-05-1398
- نویسندگان: Naratassapol Likitdee,Nampet Jampathong,Chumnan Kietpeerakool
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Survival,Prognostic Value,Ovarian Cancer,PD-L1 expression,Immunotherapy
- چکیده:
- چکیده انگلیسی: Objective: To examine the expression of programmed death ligand 1 (PD-L1) in type I and type II epithelial
ovarian cancers (EOC) and its associations with outcomes. Methods: Records of 132 women with EOC were reviewed.
Immunostaining of PD-L1 was performed with formalin-fixed, paraffin-embedded specimens. Expression of PD-L1 was
classified into four categories (0; 1+; 2+; 3+) according to intensity of expression. Expression of PD-L1 ≥2+ was deemed
to be high. Results: Of the 132 women, 75 (56.8%) and 57 (43.2%) women had type I and type II tumors, respectively.
Approximately 70% of cases exhibited high PD-L1 expression. There was no significant difference in the rate of high
PD-L1 expression between the two EOC types (65.3% versus 59.6%). In type I tumors, high PD-L1 expression was
associated with more advanced stages (51.0% versus 34.6%), greater recurrence (46.9% versus 26.9%), and shorter
median progression-free survival (27 months versus 62 months) than low expression. In type II tumors, there were no
apparent differences between high and low expression of PD-L1 in terms of the percentage of advanced-stage tumors
(82.6% versus 79.4%), recurrence (56.5% versus 58.8%), and median progression-free survival (21 months versus
24 months). Conclusion: high PD-L1 expression is associated with worse oncological outcomes in type I EOC. This
finding emphasizes the merit of further studies to confirm this promising result and to determine the potential role of
PD-L1 blockade therapy in type I EOC.- انتشار مقاله: 14-07-1397
- نویسندگان: Wilasinee Nhokaew,Pilaiwan Kleebkaow,Nipon Chaisuriya,Chumnan Kietpeerakool
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Overall Survival,Risk Factor,Recurrence-free survival,Endometrial cancer,adenomyosis
- چکیده:
- چکیده انگلیسی: Objective: To determine the effects of uterine adenomyosis on endometrial cancerrecurrence rates. Methods: This
retrospective cohort study reviewed all consecutive patients diagnosed with endometrial cancerwho underwent total
hysterectomy-based surgical staging at Srinagarind Hospital between January, 2010 and January, 2016. The patientswere
divided into two groups:a uterine adenomyosisgroup and a non-adenomyosis group. Patient demographics, type of
surgery, histopathology, stage of endometrial cancer, adjuvant treatment, and survival outcomes were compared.
Results: A total 350 patients were enrolled, with 132 (37.71%) in the adenomyosis group and 218 (62.29%) in the nonadenomyosis group. Deep myometrial invasion and lymphovascular space invasion (LVSI) were more commonly found
among patients who had no adenomyosis compared to those with adenomyosis(52.8% vs 39.4%, P=0.02 and 53.2%
vs. 38.6%, P=0.01). There were no significant differences in terms of five-year recurrence-free survival (HR=1.47;
95%CI 0.88-2.44) and five-year overall survival (HR=0.81; 95%CI 0.43-1.53) between the two comparison groups.
Conclusion: Coexisting uterine adenomyosis in endometrial cancer wasassociated withdeep myometrial invasion and
LVSI but did not have significant impact on survival.- انتشار مقاله: 18-07-1397
- نویسندگان: Sarana Boonlak,Apiwat Aue-Aungkul,Chumnan Kietpeerakool,Pilaiwan Kleebkaow,Bandit Chumworathayi,Sanguanchoke Luanratanakorn,Amornrat Temtanakitpaisan
- مشاهده