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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: International Journal of Travel Medicine and Global Health
- نوع مقاله: Journal Article
- کلمات کلیدی: Diagnosis,Epidemiology,vaccine,Norovirus
- چکیده:
- چکیده انگلیسی: Noroviruses (NoVs), an important pathogenic agent of foodborne illness, lead to acute and chronic gastroenteritis in humans of all ages and to travelers’ diarrhea. Many genotypes exist in nature; GII.4 is widely known as the most predominant. Outbreaks mostly occur in semi-closed settings. Although the disease is self-limited to person, many cases have resulted in death, which has raised more concerns. However, a lack of microbial culture techniques limits research and thus knowledge about these viruses. To date, there are no specific antiviral drugs that fight NoVs. Rehydration is the ideal approach at present for severe cases. The only way to prevent infection is to improve personal hygiene. So many variants and ambiguous evolution mechanisms make research for a vaccine much more difficult. In recent years, several vaccine candidates entered pre-clinical development. This review concentrates on summarizing the aspects of NoV structure, culture, genetic evolution, and the vaccine.
- انتشار مقاله: 17-08-1395
- نویسندگان: Cheng Xu,Jianguang Fu,Yefei Zhu
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Prostate cancer,Meta-Analysis,Polymorphism,IL-18
- چکیده:
- چکیده انگلیسی: Background: Accumulating evidence shows that cytokines play an important role in the proliferation of prostate
cancer. This research is trying to determine that IL-18 -607 C/A polymorphism confers susceptibility to prostate cancer.
Methods: Meta-analysis was used to collect data. The relevant studies were identified through a comprehensive search
from PubMed, Excerpta Medica Database (EMBASE), Web of Science, and Chinese Biomedical Literature Database
(CBM) to obtain related studies published up to December 6, 2017. The association between interleukin (IL)-18 -607 C/A
polymorphism and prostate cancer risk was assessed by odds ratios (ORs) together with their 95% confidence intervals
(CIs). Results: Nine case-control studies from 6 articles were eventually identified. In the overall population, there is a
significant association between IL-18 -607 C/A polymorphism and prostate cancer risk in recessive (CC versus CA/AA:
OR = 0.20, 95% CI = 0.15-0.27, P = 0.000) or dominant (CC/CA versus AA:OR = 0.42, 95% CI = 0.30–0.57, P = 0.000)
models. In the sub-group analysis according to ethnicity, for Asians, IL-18 -607 C/A polymorphism was significantly
associated with prostate cancer in allele contrast (C versus. A: OR=0.82, 95%CI=0.70-0.97, P=0.019), homozygote
(CC versus. AA: OR=0.68, 95%CI=0.50-0.92, P=0.013), recessive (CC versus. CA/AA: OR=0.19, 95%CI=0.13-0.27,
P=0.000), and dominant (CC/CA versus. AA: OR=0.37, 95%CI=0.28-0.48, P=0.000) models, for Caucasians, IL-18
-607 C/A polymorphism was significantly associated with prostate cancer risk in allele contrast (C versus. A: OR=1.27,
95%CI=1.02-1.58, P=0.033), homozygote (CC versus. AA: OR=1.86, 95%CI=1.19-2.91, P=0.007) and recessive (CC
versus. CA/AA: OR=0.25, 95%CI=0.19-0.33, P=0.000) models. Conclusion: This meta-analysis has shown that IL-18
-607 C/A polymorphism contributes to a decreased risk of prostate cancer risk in the Asian population but an increased
risk in the Caucasian population.- انتشار مقاله: 24-04-1397
- نویسندگان: Gao Yuanyuan,Yu Xue,Li Yachao,Feng Xiao,Chen Xu
- مشاهده