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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: response,Vitamin D pathway polymorphisms,pegylated-interferon,HBeAg-negative,Hepatitis B virus infection
- چکیده:
- چکیده انگلیسی: Background: Vitamin D deficiency is related to poor clinical outcomes in patients with chronic hepatitis B virus
(HBV) infection. Methods: We aimed to investigate the association between the genetic variants in the vitamin D
metabolic pathway and the response to pegylated interferon (Peg-IFN) therapy in patients with HBeAg-negative
chronic HBV infection. One hundred seven patients treated with Peg-IFN for 48 weeks were selected from 13 specialty
hospitals. Eight genotypes of vitamin D cascade genes, including CYP27B1 (rs10877012), DHCR7 (rs12785878),
CYP2R1 (rs2060793, rs12794714) and GC (rs4588, rs7041, rs222020, rs2282679), were found. Results: Eighty-two
patients (83.7%) were infected with HBV genotype C. Eight patients had compensated liver cirrhosis (8.7%). At 24
weeks after treatment discontinuation, 41 patients (42.3%) achieved sustained treatment response, 53 (55.2%) obtained
HBV DNA<2,000 IU/ml, 6 (5.6%) gained HBsAg seroclearance, 2 (1.9%) had HBsAg seroconversion and 69 (64.5%)
exhibited alanine aminotransferase (ALT) normalization. Multivariate analysis revealed that baseline HBsAg level (OR
=0.06, 95% CI: 0.08-0.49, p=0.008) and the GC rs222020 TT genotype (OR=17.72, 95% CI: 1.07-294.38, p=0.04)
independently predicted sustained HBsAg seroclearance. In addition, this genotype was a predictor for normalization of
ALT (OR=4.61, 95%CI: 1.59-13.40, p=0.005) after therapy. The HBsAg levels at baseline and during and post-treatment
tended to be reduced with the GC rs222020 TT compared with the non-TT genotypes. The other studied polymorphisms
were not associated with treatment response. Conclusions: The GC rs222020 TT genotype, which is a variant in the
vitamin D-binding protein gene, could identify HBeAg-negative patients who have a high probability to achieve HBsAg
clearance and ALT normalization after treatment with Peg-IFN.- انتشار مقاله: 09-10-1397
- نویسندگان: Kessarin Thanapirom,Sirinporn Suksawatamnuay,Wattana Sukeepaisarnjaroen,Sombat Treeprasertsuk,Tawesak Tanwandee,Phunchai Charatcharoenwitthaya,Satawat Thongsawat,Apinya Leerapun,Teerha Piratvisuth,Rattana Boonsirichan,Chalermrat Bunchorntavakul,Chaowalit Pattanasirigool,Bubpha Pornthisarn,Supot Tuntipanichteerakul,Ekawee Sripariwuth,Woramon Jeamsripong,Theeranan Sanpajit,Yong Poovorawan,Piyawat Komolmit
- مشاهده