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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Journal of Oral Health and Oral Epidemiology
- نوع مقاله: Journal Article
- کلمات کلیدی: ginger,Radiation,Xerostomia
- چکیده:
- چکیده انگلیسی: BACKGROUND AND AIM: Our aim was to assess the clinical efficacy of ginger capsule (Zintoma herbal capsule) in the relief of symptoms in patients with post-radiotherapy xerostomia.METHODS: This study was a randomized double-blind, parallel clinical trial of ginger usage in patients with post-radiotherapy xerostomia. Sixty-one subjects were selected from patients with xerostomia of Imam Khomeini Cancer Institute, Tehran, Iran. Subject-based dry mouth scores derived from 100 mm visual analogue scales (VAS) were recorded at baseline. Patients also completed a questionnaire on the first visit regarding the symptoms of xerostomia. The patients received ginger capsule (30 persons) or placebo (31 persons) three times daily over a 2-weeks period. At the end of day 14, dry mouth scores derived from VAS were recorded again and patients responded to the additional variables regarding dry mouth symptoms and quality of life issues. P < 0.05 was considered significant. Data were analyzed using SPSS.RESULTS: The mean treatment effect on day 14 was 33.7 ± 20.9 mm in the ginger group and 23.6 ± 17.3 mm in the placebo group. The analysis indicated marginally significant improvement of xerostomia with ginger prescription (P = 0.057). At the end of intervention there was no significant difference between the two groups regarding improvement of quality of life or dry mouth symptoms.CONCLUSION: It seems that ginger could be helpful in the treatment of xerostomia. Since ginger is considered a safe herbal medicine with only few and insignificant adverse/side effects further studies in larger group of patients are recommended to provide the effect of ginger on different complaints of xerostomia.
- انتشار مقاله: 21-04-1395
- نویسندگان: Goli Chamani,Mohammad Reza Zarei,Mitra Mehrabani,Nozar Nakhaee,Bita Kalaghchi,Mahdi Aghili,Arezoo Alaee
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Breast cancer,Survival,hypofractionated radiotherapy,late skin toxicity
- چکیده:
- چکیده انگلیسی:
Bckground: Adjuvant radiation therapy is commonly administered following breast-conserving surgery for breast cancer patients. Hypofractionated radiotherapy can significantly reduce the waiting time for radiotherapy, working load on machines, patient visits to radiotherapy departments and medical costs. Material/Methods: Fifty-two patients with operable breast cancer (pT1-3pN0M0) who underwent breast conservation surgery in Tehran Cancer Institute during January 2011 to January 2012, were randomly assigned to undergo radiotherapy in two arms (hypofractionated radiotherapy arm with 30 patients, dose 42.5 Gy in 16 fractions; and conventional radiotherapy arm with 22 patients, dose 50 Gy in 25 fractions). W compared these two groups in terms of overall survival, locoregional control, late skin complications and cosmetic results. Results: At a median follow-up of 52.4 months (range: 0–64 months), the follow-up rate was 82.6%. Overall, after 60 months, there was no detectable significant differences between groups regarding cosmetic results (p = 0.857), locoregional control or survival. Conclusions: The results confirm that hypofractionated radiotherapy with a subsequent boost is as effective as conventional radiotherapy, is well-tolerated and can be used as an alternative treatment method following breast conservation surgery.- انتشار مقاله: 24-05-1395
- نویسندگان: Farnaz Amouzegar Hashemi,Mohammadreza Barzegartahamtan,Rezaali Mohammadpour,Ahmadreza Sebzari,Bita Kalaghchi,Peiman Haddad
- مشاهده