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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Research Journal of Pharmacognosy
- نوع مقاله: Journal Article
- کلمات کلیدی: Antioxidants,Malondialdehyde,Injury,Pistacia,Vascular endothelial growth factor
- چکیده:
- چکیده انگلیسی: Background and objectives: Severe burn damage and its consequences are life threatening which can complicate patients’ health. Burn damage increases reactive oxygen species (ROS) generation which leads to severe damage to tissues and is implicated in burn shock. Some medicinal and traditional plants are considered as safe, natural and inexpensive sources for treatment of different of diseases. Pistacia atlantica has shown anti-inflammatory and anti-oxidant properties and has also been used traditionally as an ointment for wound healing in some parts of Iran. In this study, the beneficial effect of P. atlantica resin oil on rats’ burn wound healing and its potential effects on vascular endothelial growth factor (VEGF), hydroxyproline and antioxidants in wound area was examined. Methods: Thirty male rats (200±10 g) were randomly and divided into three groups (n=10) as follow: Group 1: burn injury, Group 2: burn injury receiving 300 μL/kg/day P. atlantica resin oil topically, Group 3: burn injury receiving 300 mg/kg/day sulfadiazine cream topically. At the end of the study (day 14) the area of wounds were measured and then skins with burn damage were dissected and anti-oxidative parameters, VEGF and hydroxyproline were evaluated. Results: We found that Pistacia Atlantica oil significantly increased antioxidant defense, VEGF and hydroxyproline and reduced malondialdehyde (MDA) levels. Pistacia atlantica remarkably reduced wound size compared to burn the control group and showed more beneficial effects compared to sulfadiazine as the positive control. Conclusion: Pistacia atlantica resin oil could be considered as a new therapeutic agent for treatment of injuries such as burn damages.
- انتشار مقاله: 17-01-1397
- نویسندگان: Beydolah Shahouzehi*,Gholamreza Sepehri,Sakine Sadeghiyan,Yaser Masoumi-Ardakani
- مشاهده
- جایگاه : پژوهشی
- مجله: Journal of Kerman University of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Pyruvate Dehydrogenase Kinase 4 Endurance Training Metabolic Flexibility Estrogen,Related Receptor
- چکیده:
- چکیده انگلیسی: Background:Metabolic flexibility is the capacity of a system to adjust fuel (primarily glucose and fatty acids) oxidation based on nutrient availability. Pyruvate Dehydrogenase Kinase 4 (PDK4) is one of the main enzymes that play a critical role in metabolic flexibility. In current study, we examined PDK4 inhibition along with exercise training (ET) on the gene expression of Estrogen related-receptor alpha (ERRα), medium-chain acyl-CoA dehydrogenase (MCAD), carnitine palmitoyl transferase-1b (CPT-1b), peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α), PDK4 and citrate synthase (CS) in skeletal muscle. Method:Sixty-four male Wistar rats (8 week-old) were randomly divided into 8 groups (n=8); 1- untreated control, 2- STZ-induced diabetic, 3- PDK4 inhibition, 4- endurance training (ET), 5- diabetic + PDK4 inhibition, 6- diabetic + ET, 7- PDK4 inhibition + ET, and 8- diabetic +ET + PDK4 inhibition. ERRα, MCAD, CPT-1b, PGC-1α, PDK4 and CS genes expressions were measured by Real-Time PCR and quantified by 2-ΔΔCt method. Results:ERRα, MCAD, CPT-1b, PGC-1α, PDK4, and CS expressions were significantly higher in non-diabetic+ Endurance Training group compared to the control group. The expressions of CPT-1b, MCAD and CS genes were significantly lower in the non-diabetic+ endurance training/PDK4 inhibition compared to the non-diabetic+ endurance training group, and the expressions of ERRα, CPT-1b and MCAD were significantly lower in the diabetic + PDK4 inhibition group compared to the diabetic group. Conclusion:In sum, PDK4 inhibition has negative effects on lipid metabolism in healthy rats, but in animals with diabetes, PDK4 inhibition can be used for improving lipid metabolism (over-expression of CS and PGC-1α).
- انتشار مقاله: 03-12-1398
- نویسندگان: Hamid Marefati,Yaser Masoumi-Ardakani,Saeed Shakerian,Soheil Aminizadeh,Beydolah Shahouzehi
- مشاهده