در هنگام جستجو کلمه در قسمت عنوان میتوانید کلمات مورد جستجو را با کاراکتر (-) جدا کنید.
کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Iranian Journal of Medical Physics
- نوع مقاله: Journal Article
- کلمات کلیدی: modeling,Radiation Therapy,Complications,Acute Esophagitis,Concurrent Chemotherapy
- چکیده:
- چکیده انگلیسی: Introduction: The current study aimed to compare the performance of radiobiological models in predicting acute esophagitis (AE) complications after three-dimensional conformal radiation therapy (3D-CRT).
Material and Methods: Out of a total of 100 patients, 50 patients with concurrent chemotherapy and 50 patients without such therapy were treated with different total doses and a daily dose range of 1.8-2.4 Gy on the basis of 5 days a week for 3 months. Predictions of AE were based on Lyman–Kutcher–Burman (LKB) and equivalent uniform dose (EUD)-based radiobiological models. Consequently, 3 months of follow-upwere performed to monitor the complication incidence among the studied patients. Receiver operating characteristic (ROC) and univariable logistic regression analyses were carried out to determine the effect of mean dose, volume percentage, and weight loss percentage on the probability of AE grade ³ 2.
Results: The EUD-basedmodel showed a better concordance with the clinical data for all patients (area under the curve [AUC]=0.919) and the concurrent chemoradiotherapy (CCRT) group (AUC=0.986). For the radiation therapy group, the LKB model had a better performance than the EUD-based model (AUC=0.921). Grade ³ 2 esophagitis occurred 37.94±4.0 and 68.39±7.1 days after the initiation of radiation therapy in the chemoradiation and radiation therapy groups, respectively.
Conclusion: The EUD-basedmodel showed a higher agreement with the follow-up data. The incidence time of grade ³ 2 AE in the CCRT was approximately two times shorter than that in the non-CCRT group.- انتشار مقاله: 30-02-1398
- نویسندگان: Mostafa Alizade-harakiyan,Amir Ghasemi Jangjoo,Behnam Nasiri,Tohid Jafari-Koshki,Murat Okutan,Asghar Mesbahi
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Medical Physics
- نوع مقاله: Journal Article
- کلمات کلیدی: cancer,Intensity modulated Radiotherapy,Nasopharyngeal,Radiobiology
- چکیده:
- چکیده انگلیسی: Introduction: Radiobiological modeling of radiotherapy plans are used for treatment plan comparisons. The current study aimed to compare the three-dimensional conformal radiation therapy (3DCRT) and intensity-modulated radiation therapy (IMRT) plans for nasopharyngeal cancer using radiobiological modeling.
Materials and Methods: This study was conducted on 10 patients with nasopharyngeal carcinoma, who were planned for 3DCRT and IMRT treatments by using the TiGRT treatment planning system. The planning target volume (PTV) doses of 70 and 72 Gy were administered for the 3DCRT and IMRT plans, respectively. The BIOLPLAN software and the Niemierko’s equivalent uniform dose (EUD) model were utilized for the estimation of tumor control probability (TCP) and normal tissue complication probability (NTCP). The NTCPs of the spinal cord, brain stem, parotid glands, middle ears, temporomandibular joints (TMJ), mandible, and thyroid were calculated by using two radiobiological models.
Results: According to the results, the mean TCPs for 3DCRT and IMRT plans were 89.92%±8.92 and 94.9%±3.86, respectively, showing no statistically significant difference (P=0.08). The NTCPs of the parotid glands, thyroid gland, spinal cord, TMJ, and mandible were considerably lower in the IMRT plans, compared to those in the 3DCRT plans. On the other hand, the calculated NTCPs for the middle ears and brain stem increased for the IMRT plans, which were not statistically significant. On average, the NTCPs of the critical organs were lower based on the EUD model than the Lyman-Kutcher-Burman model.
Conclusion: From the radiobiological point of view, the IMRT plans were significantly advantageous over the 3DCRT plans with some small variations in each patient. On average, the two radiobiological models generated different NTCPs depending on the studied organs. Consequently, more studies are needed for the optimization of radiobiological models for the prediction of the treatment outcomes in radiation therapy.- انتشار مقاله: 21-12-1395
- نویسندگان: Asghar Mesbahi,Naser Rasuli,Behnam Nasiri,Mohammad Mohammadzadeh
- مشاهده