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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Iranian Journal of Veterinary Medicine
- نوع مقاله: Journal Article
- کلمات کلیدی: Tramadol,Liver,Kidney,Dog
- چکیده: ترامادول یک مخدر فعال مرکزی و سنتتیک است که بهترین اثر گذاری را بدون ایجاد آرام بخشی مفرط و عوارض جانبی قابل توجه در سگها داراست. هدف: در این مطالعه تغییرات بیوشیمیایی و هماتولوژیکی متعاقب تجویز کوتاه مدت ترامادول در سگهای سالم تعیین شد. روش کار: برای این منظور 18 قلاده سگ نر دو رگه که سنی بین 22-14 ماه داشتند در 3 گروه مساوی مورد استفاده قرار گرفتند. در گروه اول و دوم به ترتیب mg/kg2و 5 ترامادول به صورت داخل عضلانی و در گروه کنترل، آب مقطر روزی یک بار به مدت 3 روز متوالی تجویز شـد. شمـارش کلـی سلـولهـای خـونـی و ارزیـابـی بیـوشیمیـایـی جهـت انـدازهگیـری سـطـوح آسپـارتـات آمینو ترانسفرازAST()، آلانین آمینوترانسفرازALT()، لاکتات دهیدروژناز (LDH)، کراتینین و نیتروژن اوره خون((BUN، قبل از تجویز( روز صفر)، روز 6 و روز 13 پس از درمان انجام گرفت. نتایج: نتایج نشان داد که تزریق کوتاه مدت ترامادول با دوزهای متفاوت تأثیر معنیداری بر فاکتورهای هماتولوژیک، کبدی و کلیوی در سگها ندارد. نتیجه گیرینهایی: این مطالعه پیشنهاد میکند که ترامادول میتواند به عنوان به یک داروی تخفیف دهنده مناسب درد در کنترل درد حاد متعاقب جراحیهای معمول در سگ استفاده شود.
- چکیده انگلیسی: Tramadol is a synthetic, centrally acting opioid analgesic that has the best analgesic efficacy without excessive sedation and significant side effects in the postoperative pain relief in dogs. OBJECTIVES: In this study, hematological and biochemical changes due to short usage of tramadol were assessed in clinically healthy dogs. METHODS: For this purpose, eighteen male mongrel dogs aged 14 to 22 months were used in three equal groups. In the first and second groups respectively (2 and 5 mg/kg) intramuscular tramadol and in control group distillate water was given once a day for five consecutive days. Complete cell blood count (CBC) and biochemical evaluation were done to measure aspartate amino-transferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), creatinin (Cr), and blood urea nitrogen (BUN) levels, before the intervention (day 0) and on days 6 and 13, post-treatment. RESULTS: Thirteen days post treatment, Red blood cell (RBC) and white blood cell (WBC) count and ALT, AST, ALP, Cr, BUN and packed cell volume (PCV) level was measured as 6.75±0.03, 3.86±0.13, 40.00±7.98, 43.67±8.62, 57.00±17.03, 0.90±0.27, 25.00±5.48 and 40.13±2.88 respect-ively which showed that short-term injection of even high doses of tramadol creates no significant change on hematological, liver, and kidney parameters in dogs. CONCLUSIONS: The present study suggests that tramadol could be a safe postoperative analgesic for control of acute pain in dogs referred for routine surgical procedures.
- انتشار مقاله: 14-08-1392
- نویسندگان: Baharak Akhtardanesh,Hamid Sharifi,Rokhsana Rasooli,Maryam Aghazamani
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Veterinary Surgery
- نوع مقاله: Journal Article
- کلمات کلیدی: Dog,hypospadias,Unilateral and Bilateral testicular agenesis
- چکیده:
- چکیده انگلیسی: Case Description- Hypospadias and testicular agenesis were described in this clinical report in two German shepherd puppies presented with a history of lethargy, anorexia, dysuria, urinary incontinence, severe urine scald dermatitis and pyoderma in the abdominal area.
Clinical Findings- Clinical examinations revealed incomplete development of the external genitalia including penile and preputial hypoplasia with lack of preputial sheath at the penis tip. Moreover, both testes were not found on clinical examination and ultrasonography of one case while another dog had unilateral testicular agenesis.
Treatment and Outcome- One of the puppies died before any other diagnostic and therapeutic interventions. Resection of penile and preputial remnants combined with prescrotal urethrostomy was done on the other puppy.
Clinical Relevance- One of the considerable issues in dog breeding is abnormalities of the external genitalia. Hypospadias and testicular agenesis are rare reproductive disorders which have probably congenital origin. The importance of elimination of affected dogs from reproductive programs should be emphasized by veterinary practitioners.- انتشار مقاله: 24-06-1394
- نویسندگان: Mahdieh Rezaei,Shahrzad Azizi,Baharak Akhtardanesh,Omid Azari,Hadi Hassibi,Talieh Taheri Bojd
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Veterinary Surgery
- نوع مقاله: Journal Article
- کلمات کلیدی: Diclofenac,Cornea,Eye drop,Subconjunctival
- چکیده:
- چکیده انگلیسی: Objective- To compare the effects of topical eye-drop and subconjunctival administration of diclofenac on improvement of experimental corneal alkali wound in rabbits eyes.
Design- Experimental study.
Animal- fifteen rabbits.
Procedures- Alkali wounds were inflicted on the central corneas of 15 rabbits which were divided into three groups, A, B and C. A round 9 mm diameter paper filter that had been soaked in normal NAOH was positioned on all the rabbits’ right central cornea, to cause corneal wound. Group A and B were treated with Diclofenac eye-drop and subconjunctival injection of Diclofenac, respectively. And group C was indicated as a control group. After 21 days, all the right eyes were sent to laboratory for pathological analysis.
Result- Comparison between groups showed that groups A, and B, had significantly lower (P<0.05) discharge days than the control group. Duration of blepharospasm in groups A and B were significantly shorter than the control group (P<0.05). Corneal vascularization revealed significant differences between groups. Pair wise comparison determined that group B had a significantly lower degree of corneal vascularization than the control group. Stromal inflammation was most prominent in group A and control group. Statistical analysis showed significantly less inflammation in group B than the control group (P<0.05)
Conclusion and Clinical Relevance- Corneal ulcer is one of the most important and common disease of the anterior segment of the eye. Many drugs have been used to prevent and treat corneal ulcer complication. According to our results, topical usage of Diclofenac is easier and more practical than subconjunctival injection.- انتشار مقاله: 26-11-1393
- نویسندگان: Noushin Esmaeeli,Mehdi Saberi,Baharak Akhtardanesh
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Veterinary Surgery
- نوع مقاله: Journal Article
- کلمات کلیدی:
- چکیده:
- چکیده انگلیسی: Case Description- A seven-year-old male donkey was admitted with a history of left scrotal swelling with ulcerating wound since 2 years. Clinical Findings- The left scrotum was painful. There was ulcerating and hypergranulating wound discharging bloody discharge. The wall of the scrotum was found thick and infiltratedwith soft slimy non-capsulated and lobulated fibrous tissue masses. The left testis was found small and atrophied. Pathological studies showed the focal areas of myxomatus degeneration with spindle shaped and stillate connective tissue cells. The epitheluim of seminiferous tubules of left testis appeared denuded with loss of spermatocytes. In addition, some tubules appeared collapsed and have wave like hyaline thickened. Treatment and outcome- Surgical castration was done. Daily excerise and systemic antibiotics were recommended. The animal showed recovery within 15 days without recurrent. Clinical Relevence- Peritesticular fibromyxoma should be considered in the diagnosis and treatment of scrotal swelling in the equines. Surgical castration was succeful in the treatment without recurrency.
- انتشار مقاله: 14-05-1386
- نویسندگان: Baharak Akhtardanesh,Omid Azari,Darioush Vosough
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Veterinary Surgery
- نوع مقاله: Journal Article
- کلمات کلیدی:
- چکیده:
- چکیده انگلیسی: Case Description- A 3-year-old male mix breed dog was referred to the veterinary hospital for evaluation of extensive subcutaneous emphysema. The emphysema was Initially confined to the thoracic region and then progressed symmetrically over the abdominal regions, even face and extremities. The animal had normal appetite and physical examination. Crackling sensation was detected on palpation of the swollen areas and emphysema causing closure of palpebral fissures but no respiratory distress and external wounds were noted. Endoscopy was carried out but no mucosal rupture was seen on the pharyngeal area, trachea, and esophagus. Thoracic radiographs showed diffuse subcutaneous emphysema, pneumomediastinum and left fifth and sixth rib's fracture, but there was no evidence of pneumothorax. Treatment and Outcome-Strict cage rest was recommended. Alternate daily radiographs revealed that subcutaneous emphysema was completely resolved spontaneously after ten days. Clinical Relevance-Generalized subcutaneous emphysema occurs when air leaks strongly viatracheobranchial tears or cervical and intrathoracic lesions. This phenomenon is a rare condition in dogs and routinely become complicated because sever accumulation of all' cause side effects such as pleural rapture, pneumothorax and dyspnea in affected animals. Surprisingly no complication was seen after tracheobronchial lesion in this case and the dog heals spontaneously.
- انتشار مقاله: 14-05-1386
- نویسندگان: Baharak Akhtardanesh,Omid Azari,Darioush Vosough
- مشاهده