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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Iranian Journal of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی:
- چکیده:
- چکیده انگلیسی: Background: One of the most important post-operation problems encountered with Hepaticojejunostomy (Kasai operation) in patients with biliary atresia is cholangitis. The aim of this study was to evaluate the efficiency of anti-reflux valve in decreasing the incidence of cholangitis after hepaticojejunostomy. Methods: Ten dogs were randomly divided into two groups of equal size. In group A Roux-en-Y cholecystojejunostomy was performer and in group B antireflux valve was also added. Three months later, liver biopsy was taken to evaluate histopatholic changes. Results: The incidence of cholangitis was significantly reduced in dogs in which anti-reflux valve procedure was performed. Conclusions: Anti-reflux valve procedure effectively decreased post-Roux-en-Y cholecystojejunostomy cholangitis in dogs. Therefore it is plausible and might be beneficial for patients being treated for biliary atresia.Iran J Med Sci 2006; 31(2): 91-93. Keywords ● Cholangitis ● Kasai operation ● antireflux valve ● Roux-en-Y cholecystojejunostomy
- انتشار مقاله: 09-06-1394
- نویسندگان: H.R. Foroutan,U. Dasmeh,B. Geramizadeh,H.R. Kamalipour,N. Tanideh
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی:
- چکیده:
- چکیده انگلیسی: Polyoma virus nephropathy occurs in 3% to 4% of renal transplant recipients, causing graft loss in 50% of cases. The objective of the present study was to explore the effects of age, sex, post-transplantation period and plasma creatinine levels on the polyoma virus infection in kidney transplanted patients. Urine samples were collected from 362 patients, centrifuged and microscopic slides prepared using Papaniclaou staining method. The slides then examined and decoy cells were identified in 96 (27%) patients. The prevalence of the infection increased with increased post-transplantation period and the age of the patients. Moreover, patients with positive decoy cells had more abnormal plasma creatinine levels than those with negative for such cells. In conclusion identification of decoy cells might be of value for the diagnosis of nephropathy, especially if the presence of such cells is accompanied with the elevated plasma levels of creatinine.Iran J Med Sci 2006; 31(2): 109-111. Keywords ● Polyoma virus ● renal transplant ● urine cytology
- انتشار مقاله: 09-06-1394
- نویسندگان: B. Geramizadeh,J. Roozbeh,A. Malek-Hosseini,H. Salahi
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی:
- چکیده:
- چکیده انگلیسی: Background: Gastrointestinal stromal tumors (GISTs) constitute the majority of gastrointestinal mesenchymal tumors. They usually express a proto-oncogen protein called CD117 detected by immunohistochemistry. This study investigated the differentiation of GISTs as well as the risk of aggressive behaviors in GISTs from surgically-treated patients in university affiliated hospitals. Methods: The clinicopathologic, histomorphologic and immunohistochemical features of 36 GISTs of patients referring to two large general hospitals in the last 13 years were examined. Results: The GISTs occurred in 36 patients (41.6% male and 58.4% female) aging 15 to 89 years. 50% of the cases were in the stomach, 30% in the small intestine and the remainder in the colon and mesenter. The diameters of tumors were 0.7 to 30 cm and mostly (60.6%) more than 5. 85% of tumor cells were spindle, 14% epithelioid, and the remainders were mixed. 36.1% of tumors showed mitotic counts > 5/50 HPF and 11.1% less than 5/50HPF. 33.3% of the tumors showed necrosis. 8 tumors had malignant behavior during 13-yrs follow up. Immunoreactivity for c-kit, SMA, chromogranin, synaptophysin, desmin and S100 were 83.3%, 69.4%, 44.4%, 41.6%, 50% and 0%, respectively. The decreasing rank order of differentiation forms were neural, smooth muscle, dual and null. Most of our tumors were in high risk group and most of the high risks were intestinal with neurogenic differentiation. Conclusion: Immunostaining including c-kit is necessary to study the differentiation of gastrointestinal stromal tumors.Iran J Med Sci 2006; 31(1): 14-17. Keywords ● Gastrointestinal stromal ● tumor ● histology ● immunohistochemistry ● c-kit
- انتشار مقاله: 19-03-1394
- نویسندگان: B. Geramizadeh,A. Nosrati
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی:
- چکیده:
- چکیده انگلیسی: Despite increasing detection rates of various forms of extrapulmonary tuberculosis (TB), thyroid involvement with tubercle bacilli is rarely encountered and its imaging features have been reported in less than a handful of cases. Herein, we present the clinical, pathologic and imaging (ultrasound and CT scan) features of TB involvement of the thyroid gland in a 65-year-old woman who presented with a painful and rapidly enlarging thyroid mass. While reviewing fine needle aspiration results, the diagnosis of TB should be borne in mind, especially in the presence of imaging findings of a peripherally enhancing thyroid mass or thickening of the adjacent musculature and skin, the so-called dermal sign.
- انتشار مقاله: 11-07-1394
- نویسندگان: H.R. Abbasi,B. Geramizadeh,A. Sadeqholvaad,S. Sefidbakht,S. Bolandparvaz
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی:
- چکیده:
- چکیده انگلیسی: Background: Leptin and its receptors have been found in the human gastric mucosa. Its secretion by gastric mucosa has generated interest in its probable role in the gastrointestinal tract and pathophysiology of diseases. Objective: To determine any possible correlation between serum leptin level and pathological findings in patients with duodenal ulcer (DU). Methods: In a cross-sectional study, 22 patients diagnosed as DU were randomly selected and compared with 22 healthy controls. From each participant a fasting blood sample for measurement of serum leptin level and anti-H pylori antibody IgG was taken. Two antral biopsies for evaluating the intensity of gastritis and H. pylori infection were also taken from patients with DU. Results: Compared to the control group, serum leptin level was significantly (p<0.05) higher in patients with DU. Leptin level also significantly (p<0.05) correlated with the presence of gastritis and H. pylori infection. Conclusion: An increase in serum leptin in patients with DU may be a defense mechanism. There is a possibility that leptin accelerates ulcer healing.
- انتشار مقاله: 12-07-1394
- نویسندگان: K. B. Lankarani,M. Moghadami,M. Masoumpoor,B. Geramizadeh,H. Yarmohammadi,G.R. Omrani
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی:
- چکیده:
- چکیده انگلیسی: Background: Previous studies have shown increases in endothelin (ET) concentration of plasma and renal tissues in acute renal failure (ARF). ET has a potent vasoconstrictor effect, through binding with its ETA receptors, and may play some roles in renal hemodynamic dysfunction in ARF.Objective: To examine the beneficial effect of a selective ETA-receptor antagonist on renal dysfunction and tissue damage occurring during the early phase of ischemia/reperfusion-induced ARF.Methods: Pentobarbital anesthetized rats were prepared for the measurement of blood pressure and renal function. A 0.5 hr clearance period was taken as control period, followed by 1 hr, and then a 4 hr experimental clearance period was taken. In ischemia/reperfusion (I/R) group, 30 min after the end of the control clearance period, renal ischemia was induced by bilateral renal artery clamping for 30 min. In drug-treated (I/R+D) group, a selective ETA-receptor antagonist (UK-350,926) was infused iv at 50 mg/kg/min for 30 min before and 2 hr following occlusion of renal arteries. There was also a sham-operated group.Results: In I/R group, renal ischemia lowered creatinine clearance (CCr) by 76% (p<0.001), but elevated urine flow rate (V0) by 2.9-fold (p<0.01) and absolute Na+excretion (UNaV0) by 3.2-fold (p<0.05) during the 4 hr reperfusion period as compared to their own control values. In I/R+D group, V0 and UNaV0 did not change significantly during the 4 hr experimental period, but the amount of decrease in CCr was equal to that of I/R group. Histological examination showed a mild degree of tissue damage in the cortex of I/R group but not in I/R+D and sham groups.Conclusion: Administration of the ETA-receptor antagonist does not prevent the fall of glomerular filtration, but it does ameliorate the damage of renal tissue and tubular reabsorption of Na+ and water during 4 hrs of reperfusion following the ischemic challenge.
- انتشار مقاله: 12-07-1394
- نویسندگان: S.M. Shid Moosavi,B. Barmaki,B. Geramizadeh,H. Fallahzadeh,E. J. Johns
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی:
- چکیده:
- چکیده انگلیسی: A 19-year-old girl referred to our clinic complaining of a painless lump on the left side of her tongue. The patient had no history of dysphagia, lingual paresthesia or bleeding. Physical examination revealed the presence of multiple enlarged lymph nodes on the left side of her neck. Histopathology of lingual mass and lymph nodes showed pleomorphic adenoma. To our knowledge, this is the first case of pleomorphic adenoma of the tongue with metastasis to the cervical nodes.
- انتشار مقاله: 09-08-1394
- نویسندگان: B. Khademi,B. Geramizadeh,B. Gandomi,S. Ghanbarian
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی:
- چکیده:
- چکیده انگلیسی: Background: Rectal bleeding is a relatively uncommon, but potentially important problem in early infancy. The common causes of fresh rectal bleeding in this age group are: bleeding diathesis (vit. K deficiency), infectious colitis, cow’s milk protein allergy and anal fissure. Nodular lymphoid hyperplasia (NLH) is another cause of prolonged fresh rectal bleeding in early infancy. Objective: To evaluate the clinical presentation and outcome of infants with fresh rectal bleeding and final diagnosis of NLH. Methods: During a period of 3 years, from Sept. 1999 to Sept. 2002, 34 consecutive infants with prolonged fresh rectal bleeding were diagnosed as NLH and followed in our center. Results: There were 18 boys and 16 girls. The mean age of onset of rectal bleeding was 1.82 months and the mean age of diagnosis 4.25 months. None of the cases had any signs or symptoms of underlying systemic diseases. All cases showed resolution of bleeding and dramatic response to exclusion of cow’s milk and its by-products from mothers’ diet or replacement of babies' formula with hypoallergenic substitutes. By the age of one year all cases tolerated regular, unrestricted diets without recurrence of bleeding. Conclusion: NLH is an important cause of prolonged fresh rectal bleeding in early infancy. The disease is limited to rectosigmoid area in otherwise healthy infants without underlying disease. Excluding cow’s milk from mother's diet or changing of the infants' formula to hypoallergenic types is the best way of treatment. The long term prognosis of infants with NLH is excellent.
- انتشار مقاله: 10-08-1394
- نویسندگان: M. Haghighat,B. Geramizadeh
- مشاهده