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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Survival,Pediatric cancer,treatment abandonment,treatment refusal
- چکیده:
- چکیده انگلیسی: Introduction: Refusal and abandonment of treatment is often considered as an important reason for poor survival of
pediatric cancer patients in developing and underdeveloped countries. In this study we analyze the factors responsible
for treatment abandonment and refusal in a Regional Cancer Centre (RCC) in North East India. Material and Methods:
All histopathologically or cytologically confirmed cases of childhood cancer from below 15 years of age registered from
1st April, 2010 to 31st March, 2017 were included in this study. Parents or caregivers were interviewed thoroughly and
a questionnaire was filled up for analysis of demographic and socio-economic factors. Modified Kuppuswamy scale
was used to measure socioeconomic status. Results: Of 592 patients 161 (27.1%) abandoned therapy and 23 (3.9%)
refused treatment. Factors associated with abandonment of treatment included: lower risk if residing in urban areas
(Odds ratio [OR] = 0.8333, 95% CI 0.565-1.228; P=0.36) and higher risk with maternal education less than secondary
school (OR = 1.357; 95%CI: 0.553-3.326; P=0.505). Low socioeconomic status and age >5yrs were also associated
with abandonment of treatment. In a binary logistic regression analysis, male sex [Odds Ratio (OR) = 0.701; 95% CI
0.48-1.01; P=0.062] have lowest risk of abandoning treatment with trend to statistical significance. Conclusion: There
is a need for proper definition of the problem of childhood cancer patients so that appropriate policy can be introduced
to improve survival by improving treatment compliance.- انتشار مقاله: 30-06-1397
- نویسندگان: Munlima Hazarika,Rakesh Mishra,Bhargab Jyoti Saikia,Chidananda Bhuyan,C W Nyuthe,Anupam Sarma,Gaurav Kumar,Cliffton Sutnaga,Manoj Kalita,Partha Roy
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Gastric cancer,immunohistochemistry,gastroesophageal adenocarcinoma,human epidermal factor receptor,Overexpression
- چکیده:
- چکیده انگلیسی: Objective: Human epidermal growth factor receptor 2 (erbb2/HER2) overexpression, has now been implicated
in advanced gastric and gastroesophageal junction cancers. The study was conducted to determine the rate of HER2
positivity in patients with locally advanced or metastatic gastric and gastroesophageal adenocarcinoma in North-East
India and to assess the impact of various demographic and clinical parameters on HER2 positivity. Methods: A total of
68 patients of age >18 years of gastric and gastroesophageal adenocarcinoma diagnosed on histopathological examination
from September 2016 to February 2018 at Dr B Borooah Cancer Institute, Assam were enrolled for the observational
(epidemiological) study. All patients were subjected to the HER2 immunohistochemistry test using a FDA-approved,
standardized test kit. HER2 expression was correlated with various demographic and clinicopathological parameters.
Results: The overall rate of HER2 positivity in the population studied was 56% (n=38). The rate was non-significantly
higher in male, older age group (>60 years) and Hindu population. Similarly, HER2 positivity rate was higher in patients
with well differentiated histology and was more common in patients with stage II and III diseases, but neither of the
associations is statistically significant. HER2 positivity rate was significantly higher in proximal and in GEJ tumours
(56% versus 44%, P=0.002). Conclusion: HER2 overexpression was evident in 56% of the North-East Indian patients
with locally advanced and metastatic gastric and gastroesophageal adenocarcinoma. The overexpression correlated
significantly with primary tumour site. Routine testing of gastric and gastroesophageal tumours for HER2 expression
is recommended to provide a therapeutic advantage in Indian patients.- انتشار مقاله: 30-06-1397
- نویسندگان: Partha S Roy,Tomar Nyodu,Munlima Hazarika,B J Saikia,C Bhuyan,Amit Inamdar,C W Nyuthe,B Borthakur,J D Sharma
- مشاهده