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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Iranian Journal of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Insulin,Pregnancy,diabetes,Gestational diabetes,fasting
- چکیده:
- چکیده انگلیسی: Background: Ramadan fasting for pregnant women with diabetes remains controversial and underreported. The objective of this study was to determine the glycemic control in pregnant diabetic women on insulin who fasted during Ramadan.
Methods: This was a retrospective study carried out over a period of three years including pregnant diabetic women, who were on short-acting, intermediate-acting, or a combination of them, and opted to carry out Ramadan fasting. Glycemic control was assessed before, middle and after Ramadan fasting.
Results: Thirty seven women opted to fast with 24 (64.9%) of them had type 2 diabetes mellitus and 83.8% of them required combined insulin (short- acting, intermediate-acting) therapy. The age of the participants was 32.13±4.68 years, and the age of their pregnancies was 25.60±7.12 weeks when the study was performed. The median number of days fasted was 25 days, and most of the women were able to fast for more than 15 days. There was no difference between glycemic control of type 2 diabetes mellitus and gestational diabetes mellitus women prior to fasting. In the middle of Ramadan, serum fructosamine decreased in both groups. How-ever, only serum HbA1c reduced in gestational diabetes mellitus after Ramadan.
Conclusion: the findings indicate that pregnant diabetic women on insulin were able to fast during Ramadan and that their glycemic control was improved during fasting period. They may also suggest that instead of absolute ban on fasting for pregnant diabetic women more practical approach and close consultation with health care providers might be more helpful.- انتشار مقاله: 08-02-1393
- نویسندگان: Nor Azlin Mohamed Ismail,Hadijat Olaide Raji,Norashikin Abd Wahab,Norlaila Mustafa,Nor Azmi Kamaruddin,Muhammad Abdul Jamil
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Liver cancer,anti-proliferative,Clinicanthus nutans,triterpenes
- چکیده:
- چکیده انگلیسی: Problem statement: Clinicanthus nutans has been used by Malaysian since long time ago. It is used to treat many
diseases including cancer. Many studies carried out on its crude extract but no clear report on the specific secondary
metabolites responsible for its nature in treating selected diseases. Objective: This study aims to confirm the practice
carried out by many people on the usage of Clinicanthus nutans in treating cancer. Methods: C. nutans leaves were
extracted by methanol. Thin layer chromatography was used to identify the suitable solvent for fractions separation.
The fractions were then separated at larger volume using gravity column chromatography. Each fraction was tested on
its anti-proliferative activity on Hep-G2 liver cancer cells by MTT assay. The phytochemical screening was carried out
to identify the bioactive compound based on qualitative analysis. Results: The fraction 2 (F2) of C. nutans showed the
lowest IC50 value of 1.73 μg/ml against Hep-G2 cancer cells, and it is identified as triterpenes. Conclusion: The fraction
F2 identified as triterpenes isolated from C. nutans has potential as an anti-proliferative agent against liver cancer.- انتشار مقاله: 02-05-1397
- نویسندگان: Khairun Najwa Zakaria,Azura Amid,Zubaidah Zakaria,Parveen Jamal,Azli Ismail
- مشاهده