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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Women’s Health Bulletin
- نوع مقاله: Journal Article
- کلمات کلیدی: Obesity,Experiences,self,Psychological and Social Problems
- چکیده:
- چکیده انگلیسی: Background: Obesity is an identity that is the result of the overweight person’s experience and perception of this problem. Objectives: The purpose of this study is to evaluate various aspects of the lived experience and changes in the self for 29 sleeve surgery patients from two hospitals in southern Iran. Patients and Methods: After in-depth, open-ended interviews with 29 sleeve candidate patients (24 females and 5 males), their statements were analyzed through a thematic method. Results: Findings revealed that obesity is a continually negative experience with four characteristics for participants: losses, limitations, psychological pressures, and social pressures. These experiences can lead to profound changes in the self and cause the patient to develop self-hatred, submissiveness, and passivity. Conclusions: Obesity involves a diversity of negative experiences; more consideration should be given to overweight people, especially overweight women. Accordingly, social policymakers should help by desensitizing this problem in society through media, universities, and schools. Also, fostering a positive attitude in these individuals is important and would require paying attention to their individual, psychological, and social needs through teamwork.
- انتشار مقاله: 11-10-1348
- نویسندگان: Ahmad Kalateh Sadati,Farnaz Rahnavard,Najmeh Ebrahimzadeh,Azam Rezaei
- مشاهده
- جایگاه : پژوهشی
- مجله: Journal of Kerman University of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: cancer,Liver,diabetes,Hyperlipidemia,Thyroid,Chelidonium majus
- چکیده:
- چکیده انگلیسی: Background: Using herbs for the treatment of diseases has a long history. Chelidonium majus from the family of Papaveraceae is one of the best-known and most widely used herbs used in traditional medicine. The aim of this study was to review its active components, as well as its therapeutic and toxic effects on body tissues.
Methods: This short overview was done by searching for relevant contents in many databases including: Magiran, Iran medex, IranDoc, SID, Medlib, Web of Science, Scopus, PubMed, Science Direct and Google Scholar. All articles that met the inclusion criteria were studied and evaluated.
Results: The various compounds available in the plant such as: alkaloids, flavonoids, and opioid derivatives, as well as its ability to produce nitric oxide(NO) and tumor necrosis factor(TNF) and its multiple capabilities in affecting the activities of various body tissues in hepatic, renal, neurological, reproductive and hormonal systems have made it a leading plant in the listofmedicinalherbs.The levels of the active compounds in the plants are influenced by location, altitude, ambient temperature and harvest time, a fact which partly justifies the controversial reports on the effects of this extract on body tissues.
Conclusion: Because of the multiplicity and diversity of its active ingredients, Chelidonium majus has the potential to be used for the diagnosis, treatment and control of hard to treat diseases (HTDS). However, it is recommended to do more research on its mechanism and its possible adverse effects.- انتشار مقاله: 12-12-1395
- نویسندگان: Saeed Changizi-Ashtiyani,Ali Zarei,Azam Rezaei,Majid Ramezani,Alireza Tavakol
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: GLUT4,SNAP23 Protein,Syntaxin-4 Protein,Vesicle-associated membrane Protein 2,Resveratro
- چکیده:
- چکیده انگلیسی: Background: Glucose uptake by muscles and fat cells is carried out by the GLUT4 system. Isoforms of the SNAP23, syntaxin-4 and VAMP-2 play an important role in regulating GLUT-4 trafficking and fusion in adipocytes. The changes of SNARE proteins levels and thus impaired GLUT-4 displacement can be one of the etiological causes of type 2 diabetes.Due to changes in the expression of these proteins in diabetes, the aim of this study was to investigate the effect of the natural compound resveratrol with anti-diabetic properties on impaired expression of SNARE proteins in type 2 diabetes.Methods: Forty male Wistar rats were used in this study. Type 2 diabetes was induced by administering a single dose of streptozotocin and nicotinamide. The expression of SNAP-23, syntaxin-4 and VAMP-2 proteins were assessed using real-time qRT-PCR. Also, some biochemical parameters were examined, including fasting blood glucose, insulin levels and insulin resistance.Results: The results of this study showed that, resveratrol supplementation increased blood insulin level, reduced the fasting blood glucose, and improved the insulin resistance. In addition, resveratrol supplementation increased the expression of SNAP-23, syntaxin-4 and VAMP-2 proteins that involved in GLUT-4 transport in adipose tissue of diabetic rats.Conclusion: Final results showed that SNARE proteins expression is significantly reduced in diabetic rats and treatment with resveratrol supplementation is associated with the increased expression of these proteins.
- انتشار مقاله: 22-01-1393
- نویسندگان: Azam Rezaei Farimani,Massoud Saidijam,Mohammad Taghi Goodarzi,Reza Yadegar Azari,Soheila Asadi,Sadegh Zarei,Nooshin Shabab
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Basic Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Resveratrol,Visfatin,Insulin sensitivity,Grape,Vaspin
- چکیده:
- چکیده انگلیسی: Objective(s): Visfatin and vaspin are secreted by adipose tissue and play key roles in glucose homeostasis and subsequently are potential targets for diabetes treatment. Resveratrol (RVS) corrects insulin secretion and improves insulin sensitivity. We investigated the RVS effects on serum antioxidants, insulin and glucose levels, also visfatin and vaspin genes expression in adipose tissue of streptozotocin-nicotinamide (STZ-NA) induced type 2 diabetic rats.
Materials and Methods: Diabetes was induced in Wistar rats (n=32) using STZ (60 mg/kg body weight) and NA (120 mg/kg body weight); rats were divided into 4 groups (n=8). Eight untreated normal rats were used as control group; four diabetic rat groups (2–5) were treated with 0, 1, 5 and 10 mg /kg body weight of RVS, respectively for 30 days. After treatment blood and adipose tissue were prepared from all animals. Serum glucose, insulin, HOMA index, total antioxidant capacity (TAC), and malondialdehyde (MDA) were measured. Visfatin and vaspin genes expression in adipose tissue were evaluated using real-time PCR.
Results: RVS reduced blood glucose significantly and increased insulin level, resulting in insulin sensitivity improvement. Furthermore RVS increased weight and TAC, while reducing serum MDA in the diabetic groups. Visfatin gene expression increased in the diabetic group, and RVS treatment reduced it. Vaspin gene expression was reduced in RVS receiving diabetic groups.
Conclusion: The results indicated that RVS has potential hypoglycemic effect, probably by increasing insulin level and changing gene expression of visfatin and vaspin. Moreover RVS showed antioxidant effects through reduction in peroxidiation products and augmented antioxidant capacity.- انتشار مقاله: 09-04-1394
- نویسندگان: Soheila Asadi,Mohammad Taghi Goodarzi,Massoud Saidijam,Jamshid Karimi,Reza Yadgar Azari,Azam Rezaei Farimani,Iraj Salehi
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Biotechnology
- نوع مقاله: Journal Article
- کلمات کلیدی: SNPs,TNF-α,Milk production traits,SCS,3′-flanking region
- چکیده:
- چکیده انگلیسی: Background: Tumor necrosis factor- a (TNF-α) is a cytokine that was identified as a factor with a wide range of proinflammatory activities. The expression of bovine TNF-α in mammary tissue during pregnancy seems to have a role in development of the corresponding glands.
Objective: Single nucleotide polymorphisms (SNPs) were defined in 3′-flanking region of bovine TNF-α in cattle. Moreover, its association with performance traits in Holstein dairy cattle was evaluated.
Materials and Methods: The 3′-flanking region of TNF-α was screened by single strand conformation polymorphism (SSCP) and DNA sequencing in Holstein cattle breed. SAS statistical software was used to analyze the relationship between different genotypes of amplified fragment with milk production traits (daily milk yield, fat and protein percentage) and somatic cell score (SCS).
Results: A total of 6 distinct SSCP patterns were observed. It was further revealed to be 3 novel SNPs. Statistical analysis revealed that different haplotypes of amplified fragment in the TNF-α 3′-region had a significant effect on average daily milk production (p < 0.05), but no such correlation was established with fat percentage, protein percentage and SCS.
Conclusion: The association identified in the 3′-flanking region of TNF-α may have potential to serve as candidate genetic marker for genomic selection in dairy cattle.- انتشار مقاله: 15-01-1394
- نویسندگان: Mustafa Muhaghegh-Dolatabady,Azam Rahimi Rezaei
- مشاهده
- جایگاه : پژوهشی
- مجله: Avicenna Journal of Phytomedicine
- نوع مقاله: Journal Article
- کلمات کلیدی: Rat,Thioacetamide,Phenolic compounds,Artemisia,Hepato-protective
- چکیده:
- چکیده انگلیسی: Objective: Liver is an important organ that is exposed to many oxidant and carcinogenic agents, thus antioxidant compounds are beneficial for liver health. Artemisia contains flavonoid compounds and anti-diabetic, antioxidant, and anti-inflammatory properties. Due to possessing terpene and sesquiterpene compounds, this plant has antioxidant properties. This study was done to investigate the effects of Artemisia plant extract on thioacetamide-induced hepatotoxicity in Wistar rats.
Materials and Methods: For induction of hepatotoxicity, 50 mg/kg thioacetamide was injected intraperitoneally (i.p).After extraction and purification, the hydroalcoholicextract was injected i.p. at 100, 200, and 300 mg/kg doses for 21 days together with thioacetamide at 50 mg/kg dose in the last 3 days. After blood sampling and separation of serum, alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), albumin, and total protein concentrations were measured.
Results: Significant decreases in aminotransferase and alkaline phosphatase activities and significant increases in the concentration of albumin and total protein in groups treated with the extract compared with thioacetamide-treated group were observed (p<0.05).
Conclusion: The results indicate that protective effects of Artemisia extract against the thioacetamide-induced hepatotoxicity may be due to its ability to block the bioactivation of thioacetamide, primarily by inhibiting the activity of Cyp450 and free radicals. Artemisia possesses quercetin. Studies have demonstrated that quercetin inhibits lipid peroxidation and as an antioxidant can inhibit lipid peroxidation.- انتشار مقاله: 23-11-1391
- نویسندگان: Azam Rezaei,Shahnaz ShekarForoush,Saeed Changizi Ashtiyani,Hydar Aqababa,Ali Zarei,Maryam Azizi,Hasan Yarmahmodi
- مشاهده
- جایگاه : پژوهشی
- مجله: Avicenna Journal of Phytomedicine
- نوع مقاله: Journal Article
- کلمات کلیدی: Rat,Atorvastatin,Berberis vulgaris,Alanine transaminase,Alkaline phosphatase,Aspartate transaminase,Liver Enzyme
- چکیده:
- چکیده انگلیسی: Objectives: Hyperlipidemia can cause a variety of diseases such as atherosclerosis, diabetes, and fatty liver which is followed by increased liver enzymes. Since Berberis vulgaris (B. vulgaris) root possesses antioxidant properties, the present study was conducted to investigate the effect ofits extract on the activity of liver enzymes in rats. Materials and Methods: In this experimental study, sixty Wistar rats were selected and allocated to six groups of ten each. The control group received a normal diet and the sham group received a fatty diet while the other groups including experimental groups received a fatty diet and the alcoholic extract of B. vulgaris at minimum (75 mg/kg), moderate (150 mg/kg), and maximum (300 mg/kg) doses by intraperitoneal injection (i.p.) or oral atorvastatin (10 mg /kg) with a fatty diet. At the end of this 21-day period, blood samples were drawn and the levels of the intended factors were measured. Data were analyzed using SPSS software version 11.5. Results: The comparison of the obtained results showed that the levels of alanine transaminase (ALT) and alkaline phosphatase (ALP) enzymes in the sham group that only received fatty food increased (p≤0.05), whereas in the treatment groups receiving B. vulgaris extract as well as in the group receiving Atorvastatin, these enzymes significantly decreased; however, no significant changes were observed in aspartate transaminase (AST) levels. Conclusion: Noticing the antioxidant properties of B. vulgaris root extract and its effects on reducing the activity of liver enzymes, the extract of this plant can be a good choice for improving the function of liver.
- انتشار مقاله: 19-01-1391
- نویسندگان: Soheila Taheri,Ali Zarei,Saeed Changizi Ashtiyani,Azam Rezaei,Saeed Zaheiri
- مشاهده