در هنگام جستجو کلمه در قسمت عنوان میتوانید کلمات مورد جستجو را با کاراکتر (-) جدا کنید.
کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pathology
- نوع مقاله: Journal Article
- کلمات کلیدی: Quality Control,Sperm Count,Andrology,Semen analysis,Medical Laboratory
- چکیده:
- چکیده انگلیسی: Background and Objective: Infertility refers to the failure in achieving pregnancy of a couple after one year of regular sexual intercourse without using a protection method. The purpose of this research work was to evaluate the current status of the test and quality control performance in semen analysis in selected laboratories.
Material and Methods: The semen analysis was performed in the Laboratory of Andrology in terms of macroscopic examination which include volume, color, viscosity, pH and acidity, and in terms of microscopy: the rate of sperm movement, the exact number of sperms per ml of semen, the percentage of sperm viability and movement, the presence of germ cells and white blood cells. Several questions for each part of the test were selected and answered by the director of the laboratories or andrology section supervisor.
Results: There was a wide range in the performance of selected medical laboratories in Tehran regarding the standards of semen analysis according to the World Health Organization (WHO) Laboratory Manual for the examination and processing of human semen, fifth edition in 2010. They followed the instructions related to the sample collection in about 70% of the evaluated parameters, initial macroscopic examination in about 87% of the selected subjects, and the microscopic evaluation of sperm in about 65% of the test parameters.
Conclusion: some laboratories do not follow the instructions of the WHO in performing semen analysis, and most of them do not follow the suggested methods in all parts of the test.- انتشار مقاله: 18-07-1397
- نویسندگان: Mahsa Ahadi,Fereshte Aliakbari,Saeedeh Latifi,Seyed Jalil Hosseini,Atossa Gharib,Abolfazl Movafagh,Zahra Abdolalian,Arash Dehghan,Arsham Moradi,Behrang Kazeminejad,Azadeh Rakhshan,Elena Jamali,Farzad Allameh,Afshin Moradi
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pathology
- نوع مقاله: Journal Article
- کلمات کلیدی: age,Grade,Central nervous system,Location,Oligodendrogliomas
- چکیده:
- چکیده انگلیسی: Background and Objectives: Gliomas are the most prevalent subgroup of primary brain tumors with a relatively high mortality. However, oligodendrogliomas have a better prognosis compared to other subtypes due to their sensitivity to chemotherapy. Considering the low incidence and the resulting lack of information about oligodendrogliomas, particularly in Iran, this study aimed at assessing their basic characteristics.
Methods:In this descriptive retrospective study, patients with definite diagnosis of oligodendroglioma were identified by reviewing the archives of pathology reports at the department of pathology of Shohada-e Tajrish Hospital during years 2008 to 2014. Age, gender, location, and the grade of the tumor were extracted and entered to the SPSS statistical software for analysis.
Results: A total of 182 patients, including 115 males (63.2%) and 67 females (36.8%), were included with a mean age of 38.5±13.36 years. Frontal lobe was involved in 53 patients (29.1%), parietal lobe in 31 (17.0%), temporal lobe in 22 (12.1%), frontoparietal area in 15 (8.2%), parieto-occipital area in 11 (6.0%), temporoparietal and frontotemporal areas each in 9 subjects (4.9%), occipital lobe in 5 (2.7%), and the brainstem in 4 (2.2%). Furthermore, 108 cases (59.3%) had grade-2 and the remaining74 patients (40.7%) had grade-3 anaplastic oligodendrogliomas. The mean age of subjects with brainstem oligodendrogliomas was significantly lower than the other patients (p=0.025).
Conclusion: Oligodendrogliomas commonly effects the frontal lobe, followed by the parietal and temporal lobes. The mean age of subjects with brainstem lesions was significantly lower than other patients. Age, gender or location of the tumor did not independently predict a higher grade lesion.- انتشار مقاله: 06-06-1395
- نویسندگان: Mahsa Ahadi,Afshin Moradi,Azadeh Rakhshan,Alireza Arefian,Mitra Rafizadeh,Hanieh Zham
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pathology
- نوع مقاله: Journal Article
- کلمات کلیدی: Iran,Lymph node,Cytology,Neck,fine needle aspiration
- چکیده:
- چکیده انگلیسی: Background and Objective: Fine needle aspiration cytology (FNAC) is a well-established method of diagnosis in palpable masses of various sites. This study was conducted to evaluate the usefulness of FNAC as a diagnostic tool in the management of patients with cervical lymphadenopathy. Patients and Methods: Totally 178 patients admitted to Loghman-Hakim Hospital , Tehran, Iran, with cervical masses, were included in this study. They had undergone FNA and subsequently excisional biopsy of the same neck mass in which a lymphoid tissue lesion had been established. Results: Reactive lymphadenitis, metastatic neoplasm, Hodgkin’s lymphoma, and non-Hodgkin’s lymphoma constituted 59.6%, 17.9%, 14.6% and 7.8% of total cases, respectively. In 27 cases (15.2%), the FNA findings were nondiagnostic. Diagnostic accuracy of FNAC was about 88%. Sensitivity, specificity, positive and negative predictive values were 75.8%, 96.6%, 94% and 85.1%, respectively. Conclusion: FNAC has a high accuracy in the diagnosis of malignancies of cervical lymph nodes, but due to the existance of false negative cases, the benign results should be further evaluated if high clinical suspicion of malignancy exists.
- انتشار مقاله: 06-07-1393
- نویسندگان: Mohammad Rakhshan,Azadeh Rakhshan
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pathology
- نوع مقاله: Journal Article
- کلمات کلیدی: Aspergillosis,Gastrointestinal tract
- چکیده:
- چکیده انگلیسی: Gastrointestinal aspergillosis most often occurs in the setting of disseminated infection from a primary pulmonary site and primary gastrointestinal aspergillosis is an unusual presentation. We report a 7 year old female child with aplastic anemia, who was under treatment but experienced periods of neutropenia. She had no evidence of respiratory aspergillosis before the onset of abdominal symptoms including severe abdominal pain and rectorrhagia.The patient died of septic shock two weeks after emergency surgery for rectal bleeding. Although a rare condition, primary gastrointestinal aspergillosis should be considered in differential diagnosis of gastrointestinal symptoms in neutropenic patients.
- انتشار مقاله: 07-07-1393
- نویسندگان: Atoosa Gharib,Azadeh Rakhshan,Farzaneh Jadali
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Diagnosis,skin disease,Child,Pyoderma,Immunologic deficiency syndrome
- چکیده:
- چکیده انگلیسی: Pyoderma vegetans (PV) is a rare inflammatory disorder characterized by vegetating pustules and plaques affecting the skin and mucosal membranes. It is believed that this entity is mostly associated with inflammatory bowel disease (IBD), chronic malnutrition, human immunodeficiency virus (HIV), malignancies, and other immunocompromised states. Pyoderma vegetans occurs more commonly in young and middle-aged adults. There is no sex predilection for this entity. The lesions could heal spontaneously, but usually recur and become chronic.Our patient was an 11-year-old girl suspected to have primary combined immunodeficiency complicated by chronic recurrent vegetating pustular lesions on the face and postauricular area since one year of age. The histological features of the lesions were consistent with pyoderma vegetans. This is the first case of PV beginning from early infancy in the setting of primary immunodeficiency and in an unusual location.
- انتشار مقاله: 17-03-1394
- نویسندگان: Mahboubeh Mansouri,Azadeh Rakhshan,Mohammad Shahidi-Dadras,Abdollah Karimi,Samin Alavi
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Dermatology
- نوع مقاله: Journal Article
- کلمات کلیدی: Hair loss,Alopecia areata,androgenetic alopecia
- چکیده:
- چکیده انگلیسی: Background: Androgenic hair loss (AGA) and alopecia areata (AA) are common conditions which sometimes are histologically difficult to differentiate. This study was conducted to detect differentiating features of these two disorders with IHC analysis of T-cell subsets in the inflammatory infiltrates of alopecia areata and androgenetic alopecia.
Methods: This cross-sectional study was conducted at Shohadae-Tajrish Hospital in 2018. Twenty-eight cases of alopecia areata and 32 androgenic hair loss cases were evaluated. H&E and IHC staining for CD3, CD4, and CD8+ T-lymphocytes were performed. Lymphocytic densities were graded in a quintet grading system. The inflammation density in various areas of skin tissue was evaluated. Statistical analysis was performed using SPSS version 21.
Results: Peribulbar lymphocytic infiltration was seen in 88.5% of AA patients and 12.5% of AGA patients (P = 0.000). Presence of melanin, pigmented casts, and lymphocytes in follicular stela
were in favor of AA diagnosis. CD3, CD4, and CD8+ T-cells in follicular stela, peri-bulbar, and subcutaneous regions were higher and denser in AA patients, while CD3 and CD4+ T-cells around
sebaceous ducts were in favor of AGA diagnosis.
Conclusion: Peribulbar lymphocytic infiltration is among the most important differentiating features of AA and AGA. Infiltration of T-cells in various regions of skin tissue has high diagnostic
value. Histologic and immunohistochemical evaluation of skin tissues according to these factors can differentiate these two entities with high precision.
- انتشار مقاله: 13-08-1398
- نویسندگان: Azadeh Rakhshan,Afshin Moradi,Hedieh Peiroolia
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Dermatology
- نوع مقاله: Journal Article
- کلمات کلیدی: Polymerase Chain Reaction,Human papilloma virus,adnexal tumors
- چکیده:
- چکیده انگلیسی: Background: Some studies have reported a correlation between adnexal tumors and human papilloma virus (HPV) infection. We performed this study to determine the incidence of HPV infection in adnexal tumor samples to further clarify any potential link between HPV and the pathogenesis of adnexal tumors.
Methods: A total of 65 formalin-fixed, paraffin-embedded, tissue samples with a histopathologically confirmed diagnosis of adnexal tumors, obtained between 2006 and 2011, were retrieved and evaluated by polymerase chain reaction (PCR) for the presence of different types of HPV.
Results: The samples included 29 sebaceous gland tumors, 18 sweet gland tumors, and 18 follicular epithelium tumors. The HPV DNA was only detected in four out of 18 sweet gland tumors (22.2%), i.e. in 6.2% of all evaluated tumors. HPV-6 and HPV-54 were detected in one and three samples, respectively.
Conclusion: Considering the low rate of HPV in adnexal tumors, the probability of an association between HPV and adnexal tumor seems slim.- انتشار مقاله: 03-10-1398
- نویسندگان: Mohammad Rahmati-Roodsari,Maryam Ranjbar,Azadeh Rakhshan
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Colorectal polyps,adenomatous polyps,Serrated polyps,non-neoplastic polyps
- چکیده:
- چکیده انگلیسی: Aim: This study was designed to report epidemiologic findings of polyps in Iranian patients, and predict histology of polyp regarding to demographic and colonoscopic findings. Background: Classification of colorectal polyps had been revised in the past two decades and there is a need for polyp categorization in the Iranian Health System. Patients and methods: In this retrospective study, the medical records of patients with colonoscopic diagnosis of polyp in pathology departments of SBMU affiliated teaching hospitals were reviewed. Patient’s slides evaluated and demographics findings were assessed. The anatomical location, macroscopic appearance including size and histological assessment of all polyps were recorded. Results: From total number of 1106 polyps (detected in 862 patients), adenomatous polyps (638 [57.7%]) were the most prevalent findings, followed by colon mucosal tag (184[16.6%]), hyperplastic and serrated polyps (122[11%]), inflammatory polyps (110[9.9%]), hamartomatous (21[1.9%]), and malignant lesions (13[1.2%]). Multivariate logistic regression showed age (each one year increasing age; odds ratio [OR] = 1.026, 95%confidence interval [CI] = 1.016–1.036, p < 0.0001), location of polyp (right colon; OR = 1.905, 95%CI = 1.366–2.656, p < 0.0001), and polyp size of 5-10 mm (OR = 1.662, 95%CI = 1.214–2.276, p = 0.002), and polyp size of >10 mm (OR = 2.778, 95%CI = 1.750–4.411, p< 0.0001) were independently associated with neoplastic polyps. Also, polyp size of >10 mm (OR= 2.613, 95%CI= 1.083-6.307, p=0.033), tubulovillous pattern of polyp (OR= 3.508, 95%CI= 1.666-7.387, p=0.001) and villous pattern of polyp (OR= 10.444, 95%CI= 4.211-25.905, p
- انتشار مقاله: 23-08-1397
- نویسندگان: Mahsa Ahadi,Behrang Kazemi Nejad,Zeinab Kishani Farahani,Tahmineh Mollasharifi,Elena Jamali,Hamid Mohaghegh Shalmani,Arash Dehgan,Maliheh Saberi Afsharian,Amir Sadeghi,Abolfazl Movafagh,Roxana Boran,Azadeh Rakhshan,Arsham Moradi,Mohammad Hassan Heidari,Afshin Moradi
- مشاهده