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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Screening,Gastric cancer,Systematic review,Simulation Model
- چکیده:
- چکیده انگلیسی: Background: Together with such high-quality approaches as randomized controlled trials and large-scale cohort
studies, simulation models are often employed to evaluate the effect of cancer screening methods and decide on
their appropriateness. This study aimed to evaluate all effects of gastric cancer screening that have been assessed
using simulation models, including cost-effectiveness, mortality reduction, and early-stage detection. Methods: We
performed a systematic review using PubMed and Web of Science. We evaluated the effect of screening related to
cost, such as incremental cost-effectiveness and incremental cost-effectiveness ratios; we also separately assessed
effects other than cost, such as quality-adjusted life-years, number of deaths prevented, life-years saved, relative risk
of mortality from gastric cancer, life expectancy, and incidence reduction. The methods targeted for evaluation were
Helicobacter pylori testing or endoscopy. Results: We identified 19 studies dealing with simulation models in gastric
cancer screenings: 14 examined H. pylori screening and 7 focused on endoscopy. Among those studies, two assessed
both H. pylori and endoscopy screening. Most of the studies adopted a Markov model, and all the studies evaluated
cost-effectiveness. Of the 14 H. pylori screening studies, 13 demonstrated cost-effectiveness and 11 also showed good
results other than cost-effectiveness, such as extension of life-years and increase in early-stage detection. In three of the
five endoscopy studies, the target population was patients; all five studies obtained good results for cost-effectiveness
and four observed good results other than for cost-effectiveness. Conclusions: In this study, we showed that the H.
pylori screening test was cost-effective in terms of simulation model investigations. However, the H. pylori screening
test should not ordinarily be recommended since there is insufficient evidence that it reduces gastric cancer mortality.
In Japan, simulation modeling should be employed to plan for cancer control, and the appropriate use of simulation
models should be examined for future use.- انتشار مقاله: 22-06-1396
- نویسندگان: Ayako Matsuda,Kumiko Saika,Rina Tanaka,Yuri Ito,Keisuke Fukui,Ken-Ichi Kamo
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Quality of Life,cancer,palliative care,Self monitoring
- چکیده:
- چکیده انگلیسی: Background: Previous studies suggest the use of patient-reported outcome measures in routine clinical practice has
important benefits for patients with cancer, particularly as feedback regarding patients’ quality of life (QOL) improves
doctor-patient communication and clinical decision making. This study aimed to examine the effect of using the Care
Notebook as a routine self-monitoring QOL intervention in clinical practice for patients with cancer receiving palliative
care. The results are expected to clarify the practical use of the Care Notebook in this population. Methods: This
prospective randomized study is being undertaken at Toshima Hospital, Japan. Participating patients who are randomly
assigned to the intervention group will be asked to complete the shortened Care Notebook booklet for patients with
cancer in palliative care once each day. A control group will receive usual care. The primary outcome is global health
status/QOL (Global QOL), as assessed by the European Organization for Research and Treatment of Cancer Quality of
Life Questionnaire Core 15 Palliative. Data will be collected at baseline (after allocation), and at 1 week and 3 weeks
in both the control and intervention groups. The effects of the intervention will be evaluated with a mixed random
effects model. The required sample size is 200 patients. We obtained approval from Toshima Hospital (No 26-11) and
the Tokyo Medical and Dental University Ethics Committee (No 1756). The findings will be disseminated through
publications in peer-reviewed journals and attendance at domestic and international conferences. The trial was registered
with the UMIN clinical trials registry (Trial registration number: UMIN000025322). Conclusions: This study will
provide evidence on whether medical staff can use the Care Notebook as a routine self-monitoring QOL intervention in
clinical practice for patients with cancer receiving palliative care. We expect that a routine Care Notebook intervention
for patients with cancer will be recommended in healthcare facilities.- انتشار مقاله: 06-05-1396
- نویسندگان: Ayako Matsuda,Yosuke Yamada,Noriko Ishizuka,Eisuke Matsushima,Kunihiko Kobayashi,Takayoshi Ohkubo,Kazue Yamaoka
- مشاهده