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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Iranian Journal of Basic Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Spinal cord injury,BBB,Chondroitinase ABC,Contusion,hADSCs
- چکیده:
- چکیده انگلیسی: Objective(s):Spinal cord injury (SCI) is one of the most serious clinical diseases and its treatment has been a subject of interest to researchers. There are two important therapeutic strategies in the treatment of SCI: replacing lost tissue cells through cells implantation and scar elimination. Therefore, in this study we used human adipose-derived stem cells (hADSCs) implantation and injection of Chondroitinase ABC.
Aim of present study was to answer to this question: which one is more efficient for Improvement of locomotor recovery after SCI in rat? Transplantation of hADSCs or injection of ChABC.
Materials and Methods: The spinal cord of rats was injured by contusion using a weight-drop at the level of T8-9, the hADSCs and Chondroitinase ABC were infused in to the spinal cord tissue after injury. BBB test was performed and recorded for each animal weekly for 8 weeks. After the 8th weeks, Serial cross-sections were stained with cresyl violet and examined under a light microscope and area of cavity in the spinal cord was measured.
Results: At 8th weeks after injection, hADSCs and ChABC significantly promote locomotor function (P<0.01) and spinal cords of hADSCs and ChABC group had cavities much smaller than those of the control group (P<0.001).
Conclusion: Results of the present study shows dealing with inappropriate neuro-inhibitory environment and glial scar by ChABC have equal role compare to cell therapy (with hADSCs) for improving motor function after SCI and this result in adoption of proper therapeutic strategies for SCI intervention is important.- انتشار مقاله: 02-07-1393
- نویسندگان: Arash Sarveazad,Mehrdad Bakhtiari,Asrin Babahajian,Atusa Janzade,Ali Fallah,Fatemeh Moradi,Mansoureh Soleimani,Mohammadreza Younesi,Farjam Goudarzi,Mohammad Taghi Joghataei
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Pediatrics
- نوع مقاله: Journal Article
- کلمات کلیدی: Fecal incontinence,Constipation,Pediatrics,Antegrade Colonic Enema
- چکیده:
- چکیده انگلیسی:
Background
Some controversy exists about the role of cecostomy in the management of fecal disorders. The present meta-analysis aims provide a comprehensive evaluation on the role of cecostomy on management of fecal incontinence and constipation in children.
Materials and Methods
An extensive search was performed on the Medline, Embase, Scopus, and Web of Science until July 2017. Two independent researchers screened the title and abstracts of the studies and then relevant studies were included. Finally, pooled effect size was presented as standardized mean difference (SMD) or pooled prevalence with 95% confidence interval (95% CI).
Results
14 articles were entered (740 children). The success rate of cecostomy in management of fecal disorders was 90.6% (success rate=90.6%; 95% CI: 86.4 to 94.2). The most common side effects of this technique include granulation tissue formation (29.6%), cecostomy tube leakage (8.5%), tube dislodgement (7.0%), and tube site infection (2.3%).
Conclusion
The results of the present meta-analysis show that the cecostomy is safe and an effective technique in the management of fecal disorder in children. However, the findings presented on the eligible articles have have shown a low level of evidence and it is suggested that clinical trials should be conducted in this field.
- انتشار مقاله: 18-11-1397
- نویسندگان: Asrin Babahajian,Jebreil Shamseddin,Arash Sarveazad,Mahmoud Yousefifard
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Iran,Breast cancer,Survival,Metastasis,clinical stage
- چکیده:
- چکیده انگلیسی: Introduction: Currently breast (BC) cancer is a serious medical problem in all countries of the world. Survival
depends on many factors. The present study focused on 5-year survival and its related factors in patients with BC in
Iran. Material and methods. The present analytical retrospective study was performed (from March 2010 until March
2015) on patients with BC followed for at least 6 months. The main variables assessed were tumor size, grade of lymph
node involvement, metastasis, stage, history, human epidermal growth factor receptor expression, and tumor origin.
Analysis of survival was accomplished using the Kaplan- Meier method. Results: Some 351 (80.2%) of the total of
438 individuals had unilateral and 87(19.8%) had bilateral cancer, 28 (35.6%) of the latter being synchronous and
56(64.4%) metachronous. Mean duration of follow-up was 47.44±28.19 months, during which 61 (17.3%) patients
with unilateral and 18 with bilateral cancer eventually died. The 5-year survival rate in patients with unilateral BC was
significantly higher than those with bilateral BC (Log-rank Test chi2= 3.11, p=0.032). In addition, with metachronous
cases, the survival rate was 64.2% in comparison with 51.6% for synchronous BCs. Survival rate was significantly
(p value =0.038) higher with metachronous than with synchronous cancers (Log-rank Test chi2=3.54, p=0.038). The
highest survival rate was reported for BCs originating from lobule tissue and the lowest rate examples of interstitial
tissue origin (Log-rank Test chi2=11.54, p=0.0001). Patients with earl stage lesions (M1) survived longer than with
other stages (Log-rank Test chi2= 9.55, p=0.001). Conclusion: In this study, most women with BC had a positive
family history and were married. The 5-year survival rate was lower with advanced stages of cancer. According to our
findings, survival rates might improve if patients undergo screening and diagnosis is made at an early stage of the disease.- انتشار مقاله: 22-12-1396
- نویسندگان: Arash Sarveazad,Asrin Babahajian,Jebreil Shamsadin,Mansour Bahardoust
- مشاهده