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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pharmaceutical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Antibiotics,compliance,WHO,Key words: Prescribing,Rational prescribing,Drug core indicators
- چکیده:
- چکیده انگلیسی: Abstract
Background: Prescribing pattern is also important factor to identify the problems related to prescribing and best tool to improve the quality of prescription and patient care.
Methods: The aim of current study was to evaluate the quality of prescription and prescribing practices as per WHO drug core indicators in Lahore, Pakistan. A descriptive and cross- sectional study was carried out to access the prescribing pattern in Lahore, Pakistan. A sample of 300 prescriptions were collected from well –known Pharmacies and hospitals located in Lahore, Pakistan. A Structured data collection form was designed. The standard world health organization (WHO) drugs core prescribing indicators were used to determine the prescribing pattern of physicians. Data was analyzed using IBM SPSS V21.0.
Results: The name of patients was mentioned 93% of total prescriptions. While age and sex mentioned on prescriptions were 67% and 53% respectively.
Only 22% prescriptions were containing patient weight description.32% of total prescriptions were mentioned prescriber address. 16% of total prescriptions were containing patient address. While 60% of total prescriptions were mentioned specliazation of prescribers. The total numbers of drugs prescribed on all encounter was 1122. The average number of drugs prescribed per encounter was 3.74(optimal value 1.6-1.8). The total number of drugs prescribed under generic name was 0% (optimal value 100%). Antibiotics were 42.5% of total drug prescribed (optimal value 20-26.8). Injections were 19.25% of prescriptions (optimal value less 10%). Prescription writing is a tough task.
Conclusion: The result of current study show a poor compliance rate of legal requirement required for prescription writing. Most of prescribers were deviated from standard guidelines. There is dare need to improve the knowledge about prescription writing and prescribing practices. Continuous education is required to ensure the rational prescribing at Lahore, Pakistan in future.- انتشار مقاله: 24-11-1396
- نویسندگان: Mohammad Asim Farooq,Izzatullah Khan,Dolat Haleem Khan,Anam Ahsan,Atif Hussain,Irum Mansoor,Rashida Parveen
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Breast cancer,Pakistan,Cyclooxygenase-2,Indoleamine 2,3-dioxygenase
- چکیده:
- چکیده انگلیسی: Background: Tumors use several immunosuppressive mechanisms to evade immune destruction. Cyclooxygenase-2 (COX-2) expression may be a driver of immunosuppression in breast cancer, but the mechanisms involved remain elusive. COX-2 expression induces the expression of indoleamine 2,3 dioxygenase (IDO) in tumor cells. IDO is an immunosuppressive enzyme which is involved in tumor immune escape mechanisms in breast cancer. Our aim was to evaluate the association between COX-2 and IDO expression to find evidence of immunosuppression in Pakistani breast cancer patients. Methods: Immunohistochemical analysis was performed to evaluate the expression of COX-2, IDO, estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) on formalin-fixed paraffin-embedded breast cancer tissues of 100 patients. Univariable and multivariable logistic regression model was used to identify the independent risk factors of COX-2. Results: A total of 100 patients were included with a mean age and standard deviation of 48.28 ± 11.83. A significant association was observed among COX-2, IDO, ER, PR and tumor grade. In multivariable analysis, three variables were identified as significant independent risk factors for high COX-2: IDO expression high; [adjusted odds ratio (AOR) 6.51; 95% confidence interval (CI) (2.00-21.20), p=0.001], ER; [AOR 5.62; 95% CI (1.80-17.84), p=0.002] and age [AOR 1.04; 95% CI (1.00-1.10), p=0.05] respectively. Conclusion: Our data showed that high IDO expression is associated with high COX-2 expression in Pakistani breast cancer patients. The co-expression of both enzymes may suggest their role in disease pathogenesis. Hence the concurrent targeting of COX-2 and IDO may be a promising therapy for breast cancer.
- انتشار مقاله: 27-06-1398
- نویسندگان: Kashif Asghar,Asif Loya,Iftikhar Ali Rana,Muhammad Abu Bakar,Asim Farooq,Muhammad Tahseen,Muhammad Ishaq,Muhammad Usman Rashid
- مشاهده