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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: loop electrosurgical excision procedure,Mefenamic acid,pain control,Preinvasive cervical cancer
- چکیده:
- چکیده انگلیسی: Objective: To investigate the effectiveness of pre-procedural oral mefenamic acid compared with placebo in women undergoing Loop Electrosurgical Excision Procedure (LEEP) with intracervical lidocaine injection. Study designs: A prospective double-blinded randomized control trial. Materials, Setting, Methods: Women undergoing LEEP for any indications were asked to participate in the study. The participants were randomly allocated into two groups. In group 1 (oral mefenamic acid), the participants were offered oral mefenamic acid (500 mg) for 30 minutes before procedures. In group 2 (placebo), the patients were given oral placebo (identical tablet) for 30 minutes before operation. All participants received immediate 10 mL of 2% lidocaine with 1:100,000 of epinephrine intracervical injection before undergoing the LEEP. All participants were excised in one piece of LEEP. No top-hat excision in this study. The patients graded their pain on a 10-cm visual analog scale (VAS) at different points during the procedure, including speculum insertion, at starting excision, and 30 minutes post excision. Primary outcomes revealed the difference of VAS during all steps of LEEP by generalized estimating equations procedure. Results: Sixty participants (30 in mefenamic group and 30 in placebo group) participated in this study. The study did not find differences of VAS during all steps of LEEP and analgesic drug requirement at 30 minutes after LEEP procedure. All patients reported no immediate complications and no intervention-related adverse events were observed. Conclusion: Using pre-procedural oral mefenamic acid before LEEP procedure was not associated with pain reduction during all steps of excision.
- انتشار مقاله: 02-07-1399
- نویسندگان: Poochit Dabpookhiew,Amornrat Temtanakitpaisan,Chumnan Kietpeerakool,Bandit Chumworathayi,Apiwat Aue-Aungkul,Fa-Ngam Chareonpol,Nampet Jampathong
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: attitude,Knowledge,human papillomavirus,nationwide,social media site
- چکیده:
- چکیده انگلیسی: Objectives: This study was performed first to assess Thai women’s knowledge and attitude toward Human papillomavirus (HPV) infection and vaccination and second to find out factors associated with knowledge in this regard. Methods: The survey announcement was advertised via Facebook from 17 May 2019 to 14 June 2019 to recruit women aged 18-26 years living in Thailand. A score below 5 out of total score of 10 on the survey was considered as a poor level of knowledge. Multivariate analysis was applied to identify factors associated with HPV infection and vaccination knowledge. Results: A total of 1,175 participants were recruited. The participants’ median age was 22 years. Approximately, 46% of the participants had poor level of knowledge regarding HPV infection and vaccination. Factors associated with poor knowledge included low educational level (adjusted OR, 1.35; 95% CI 1.04-1.77), low family income (adjusted OR, 2.14; 95% CI 1.65-2.78), being Christian (adjusted OR, 4.04; 95% CI 1.22-13.40), being engaged in sexual intercourse (adjusted OR, 0.75; 95%CI 0.58-0.97), and being unvaccinated against HPV infection (adjusted OR, 5.74; 95% CI 3.07-10.74). Conclusion: Nearly half of the Thai women who participated in the survey had poor level of knowledge regarding HPV infection and vaccination, indicating a need for more effective health education intervention. Factors associated with knowledge included socioeconomic status and sexual behavior.
- انتشار مقاله: 14-11-1398
- نویسندگان: Naratassapol Likitdee,Chumnan Kietpeerakool,Bandit Chumworathayi,Amornrat Temtanakitpaisan,Apiwat Aue-aungkul,Wilasinee Nhokaew,Nampet Jampathong
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Overall Survival,Risk Factor,Recurrence-free survival,Endometrial cancer,adenomyosis
- چکیده:
- چکیده انگلیسی: Objective: To determine the effects of uterine adenomyosis on endometrial cancerrecurrence rates. Methods: This
retrospective cohort study reviewed all consecutive patients diagnosed with endometrial cancerwho underwent total
hysterectomy-based surgical staging at Srinagarind Hospital between January, 2010 and January, 2016. The patientswere
divided into two groups:a uterine adenomyosisgroup and a non-adenomyosis group. Patient demographics, type of
surgery, histopathology, stage of endometrial cancer, adjuvant treatment, and survival outcomes were compared.
Results: A total 350 patients were enrolled, with 132 (37.71%) in the adenomyosis group and 218 (62.29%) in the nonadenomyosis group. Deep myometrial invasion and lymphovascular space invasion (LVSI) were more commonly found
among patients who had no adenomyosis compared to those with adenomyosis(52.8% vs 39.4%, P=0.02 and 53.2%
vs. 38.6%, P=0.01). There were no significant differences in terms of five-year recurrence-free survival (HR=1.47;
95%CI 0.88-2.44) and five-year overall survival (HR=0.81; 95%CI 0.43-1.53) between the two comparison groups.
Conclusion: Coexisting uterine adenomyosis in endometrial cancer wasassociated withdeep myometrial invasion and
LVSI but did not have significant impact on survival.- انتشار مقاله: 18-07-1397
- نویسندگان: Sarana Boonlak,Apiwat Aue-Aungkul,Chumnan Kietpeerakool,Pilaiwan Kleebkaow,Bandit Chumworathayi,Sanguanchoke Luanratanakorn,Amornrat Temtanakitpaisan
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: cervical cancer,cervical intraepithelial neoplasia,atypical squamous cell,ASC-H,High-grade squamous intraepithelial lesion
- چکیده:
- چکیده انگلیسی: Objectives: To evaluate prevalence of underlying significant pathologies among women with cervical smears
rated as ‘atypical squamous cells cannot exclude high grade squamous intraepithelial lesion (ASC-H)’, as well as
associated risk factors. Methods: Medical records were reviewed of all consecutive women with ASC-H smears who
had undergone colposcopy at Srinagarind Hospital from January 2008 to July 2016. Significant pathology results
included cervical intraepithelial neoplasia (CIN) 2-3, adenocarcinoma in situ (AIS), endometrial hyperplasia, and
cancer of any original site. Result: During the study period, 133 women with ASC-H were reviewed. The mean age
was 45.3 years (range 21-72). The histopathologic results for the 133 women were as follows: no lesions (58; 43.6%),
CIN 1 (34; 25.6%), CIN 2-3 (33; 24.8%), AIS (2; 1.5%), and cervical cancer (6; 4.5%). The overall rate of significant
pathology was 30.8% (95% confidence interval, 22.9%-38.8%). Women younger than 40 years old carried a higher
risk of harboring significant lesions when compared to older women (41.7% versus 27.8%, respectively). There was
no significant impact of parity and menopausal status on the risk of significant pathology results. Conclusion: The
rate of significant histopathologies among women with ASC-H smears in this study was approximately 31% and the
associated risk factor was patient age.- انتشار مقاله: 28-05-1396
- نویسندگان: Sasivimon Ratree,Pilaiwan Kleebkaow,Apiwat Aue-Aungkul,Amornrat Temtanakitpaisan,Bandit Chumworathayi,Sanguanchoke Luanratanakorn
- مشاهده