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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Asia Oceania Journal of Nuclear Medicine and Biology
- نوع مقاله: Journal Article
- کلمات کلیدی: 131I-MIBG,Neuroblastoma,Hematopoietic stem cell transplantation,Prospective study protocol
- چکیده:
- چکیده انگلیسی: Objective(s): High-risk neuroblastoma is a childhood cancer with poor
prognosis despite modern multimodality therapy. Internal radiotherapy using
131I-metaiodobenzylguanidine (MIBG) is effective for treating the disease even if it is
resistant to chemotherapy. The aim of this study is to evaluate the safety and efficacy
of 131I-MIBG radiotherapy combined with myeloablative high-dose chemotherapy
and hematopoietic stem cell transplantation.
Methods: Patients with high-risk neuroblastoma will be enrolled in this study. A total
of 8 patients will be registered. Patients will receive 666 MBq/kg of 131I-MIBG and
after safety evaluation will undergo high-dose chemotherapy and hematopoietic stem
cell transplantation. Autologous and allogeneic stem cell sources will be accepted.
After engraftment or 28 days after hematopoietic stem cell transplantation, the safety
and response will be evaluated.
Conclusion: This is the first prospective study of 131I-MIBG with high-dose
chemotherapy and hematopoietic stem cell transplantation in Japan. The results will
be the basis of a future nationwide clinical trial.- انتشار مقاله: 02-12-1396
- نویسندگان: Raita Araki,Ryosei Nishimura,Anri Inaki,Hiroshi Wakabayashi,Yasuhito Imai,Yoshikazu Kuribayashi,Kenichi Yoshimura,Toshinori Murayama,Seigo Kinuya
- مشاهده
- جایگاه : پژوهشی
- مجله: Asia Oceania Journal of Nuclear Medicine and Biology
- نوع مقاله: Journal Article
- کلمات کلیدی: Thyroid cancer,131I,whole body scan,lower extremity, physiological uptake
- چکیده:
- چکیده انگلیسی: Objective(s): We investigated a frequency of lower extremity uptake on the radioactive iodine (RAI) whole body scan (WBS) after RAI treatment in patients with differentiated thyroid cancer, in order to retrospectively examine whether or not the frequency was pathological.
Methods: This retrospective study included 170 patients with thyroid cancer, undergoing RAI treatment. Overall, 99r (58%) and 71 (42%)patients received single and multiple RAI treatments, respectively. Post-therapeutic WBS was acquired after 3 days of RAI administration. For patients with multiple RAI treatments, the WBS of their last RAI treatment was evaluated. Lower extremity uptake on post-therapeutic WBS was classified into 3 categories: bilateral femoral uptake (type A), bilateral femoral and tibia uptake (type
B), and uptake in bilateral upper and lower extremities (type C). Then, the patients with RAI uptake in the lower extremities on WBS were analyzed with clinical parameters.
Results: Overall, 99 patients (58%) had the extremity uptake on their posttherapeutic RAI WBS. As the results indicated, 42 ,53, and 4 patients had type A, type B, and type C uptakes, respectively. Lower extremity uptake was significantly associated with younger age, not only in subjects with multiple RAI treatments but also in all the patients (P<0.05). Accumulation in patients with multiple RAI treatments was more frequent than patients with single RAI treatment (P<0.05). Lower extremity uptake was not associated with counts of the white blood cell count, hemoglobin level, platelet count, estimated glomerular filtration rate, effective half-time of RAI, serum TSH level, and anti-Tg concentration.
Conclusion: About half of the patients had lower extremity uptake on the posttherapeutic RAI WBS, especially younger patients and those with multiple courses of RAI treatment. Bilateral lower extremity’s RAI uptake on the posttherapeutic WBS should be considered as physiological RAI distribution in bone marrow.- انتشار مقاله: 08-05-1393
- نویسندگان: Hiroshi Wakabayashi,Junichi Taki,Anri Inaki,Ayane Toratani,Daiki Kayano,Seigo Kinuya
- مشاهده