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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Oropharyngeal cancer,Radiotherapy/Chemotherapy,MDADI,Deglution
- چکیده:
- چکیده انگلیسی: Introduction: Organ preservation protocol (based on chemo-radiotherapy) for oropharyngeal tumors include
dysphagia as a possible sequel leading to function impairment and changes in patient’s quality of life. Objectives:
The aim of this study is to assess dysphagia severity after treatment in advanced oropharyngeal cancer patients treated
with concurrent chemo-radiation. Methods: This prospective cross-sectional study included 64 participants who
had been disease free for at least six months after primary treatment. Dysphagia severity was assessed by fibre-optic
endoscopic evaluation of swallowing (FEES) and the Dysphagia Outcome and Severity Scale (DOSS); the occurrence
of penetration/aspiration during swallowing was also investigated. All participants also completed the M. D. Anderson
Dysphagia Inventory (MDADI). The correlation of FEES results with clinical-demographic variables and MDADI
scores was assessed. Descriptive analysis was performed, and qualitative variables were compared using either the
chi-square or Fisher’s exact test. Results: FEES revealed silent aspiration in 18.8% of the patients. Approximately 6.3%
of the patients exhibited severe dysphagia (scores 1-2 in DOSS). Dysphagia severity was significantly associated with
the MDADI physical domain scores. The participants with scores 5-7 in DOSS (no or mild dysphagia) exhibited less
limitations in the MDADI physical domain (p=0.015). Conclusions: Silent aspiration was detected in one of every five
patients treated with concurrent chemo-radiotherapy; almost half of the patients exhibit at least moderate dysphagia.
Assessment of the participant’s quality of life via the MDADI revealed an association between the physical domain
scores and dysphagia severity.- انتشار مقاله: 21-01-1397
- نویسندگان: Giselle Mateus Da Silva,Juliana Portas,Rossana Verónica Mendoza López,Daniela Ferreira Côrrea,Lidia Maria Rebolho Batista Arantes,André Lopes Carvalho
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Quality of Life,head and neck cancer,induction chemotherapy,Swallow
- چکیده:
- چکیده انگلیسی: Objective: To evaluate the effect of induction chemotherapy on swallowing and swallowing-related quality of life
of patients with oropharyngeal, laryngeal and hypopharyngeal cancer. Study design: Prospective study of 33 patients
with locally advanced tumors who were eligible for treatment with neoadjuvant chemotherapy followed by radiotherapy
and concurrent chemotherapy. A multidimensional assessment of swallowing was performed using the following
tools: (1) Clinical analysis, numerical scale for general pain and painful swallowing, American Speech and Hearing
Association (ASHA) Functional Communication Measures (FCM) swallowing assessment scales, (2) assessment
of Swallowing-Related Quality of Life (The MD Anderson Dysphagia Inventory - MDADI), and (3) swallowing
videofluoroscopy. Results: There was a reduction in general pain scale (p=0.021), and quality of life (emotional,
functional and physical) improved from average limitation (score of 61-80) to minimal limitation (81-100) after
induction chemotherapy. According to the swallowing videofluoroscopy results, 26 (78.7%) of the patients had some
degree of dysphagia pre-treatment, which decreased to 21 (63.6%) after induction. Conclusion: Our results suggest
that induction chemotherapy improves numerous aspects of swallowing and has a positive impact on the quality of
life of pre-chemoradiotherapy patients.- انتشار مقاله: 22-01-1397
- نویسندگان: Juliana Portas,Daniela Corrêa,Débora Queija,Lidia Maria Rebolho Batista Arantes,Luciano De Souza Viana,André Lopes Carvalho
- مشاهده