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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Trends in Pharmaceutical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی:
- چکیده:
- چکیده انگلیسی: Heavy metals are environmental pollutants which pose toxicity toward biological systems. Most organs are susceptible to heavy metals-induced toxicity. Hence, finding protective agents against heavy metals-induced toxicity is valuable. The post-nuclear supernatant (PNS) has been accepted as an in vitro model for assessing xenobiotic-induced toxicity toward biological systems. Monitoring the toxic effects of a large number of xenobiotics in a short time is one of the superiorities of PNS system. The goal of the present study was to validate the PNS as an in vitro model for investigating the effect of heavy metals (Cd, Co, Cu, Fe, As, Hg, Cr, and Pb)-induced toxicity and evaluating the potential protective effects of glycine and betaine. Markers of oxidative stress including ROS formation, lipid peroxidation and glutathione content in addition of succinate dehydrogenase activity (MTT test) were monitored in the presence of heavy metals alone or in combination with glycine (1 mM) and betaine (100 µM). Our results suggest that PNS preparations can be used as an appropriate model for future investigation of xenobiotics-induced toxicity and estimation of the protective properties of different agents. Indeed, further evaluations in other experimental models could reveal the protective properties of betaine and glycine against heavy metals-induced organ injury.
- انتشار مقاله: 12-03-1397
- نویسندگان: Reza Heidari,Hamidreza Mohammadi,Asrin Ahmadi,Vahid Ghanbarinejad,Faraz Kasra,Amir Khosravi
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Materials Forming
- نوع مقاله: Journal Article
- کلمات کلیدی: Phase-change,non-Fourier heat conduction,meshless radial point interpolation method
- چکیده:
- چکیده انگلیسی: Casting is considered as a major manufacturing process. Thermal analysis of a solidifying medium is of great importance for appropriate design of casting processes. The conventional governing equation of a solidifying medium is based on the Fourier heat conduction law, which does not account for the phase-lag between the heat flux and the temperature gradient. In this paper, the concept of phase-lag during the phenomenon of solidification is investigated. This concept is considered by utilization of the hyperbolic heat conduction equation, known generally as the Maxwell–Cattaneo relation. In this way, the effect of finite heat wave speed on the thermal behavior of a solidifying medium is studied. In this context, some numerical example problems are analyzed with the meshless radial point interpolation method. The effect of the relaxation time on the thermal behavior of the solidifying medium is investigated. Moreover, the results of Fourier and non-Fourier heat conduction equations are compared. It is observed that based on the specific solidification process and the amount of relaxation time, the results of the Fourier and non-Fourier conduction laws can be quite different. The most prominent effect of the relaxation time is to alter the initiation of the solidification at each point.
- انتشار مقاله: 16-03-1395
- نویسندگان: Amir Khosravifard,M. R. Hematiyan
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Political Science
- نوع مقاله: Journal Article
- کلمات کلیدی: Iran,Palestine,Arab countries,Keywords: Israel,New Israeli regional strategy
- چکیده:
- چکیده انگلیسی: Abstract:
This study intends to review Israel's efforts to increase political and economic relations with Arab countries. It is clear that most Arab countries did not have any ties with Israel since the 1980s, and only two Egyptian states had established political relations with Israel since the 1973 war. But over the past few years, and especially after the start of the third millennium, a new trend has been formed by the Israeli authorities, which is still ongoing. This exit-isolation process is aimed at establishing friendships with Arab countries such as Saudi Arabia, the United Arab Emirates, Kuwait and other Arab league members. However, the occurrence of the Islamic Revolution and the initiation of a new ideology in the Middle East brought the new Israeli regional strategy closer to speed, and Iran gradually became the main enemy of the two sides’ in the third millen-nium. It seems that the Arab countries have forgotten their aspirations towards the Pal-estinian people and help Israel achieve its goals.- انتشار مقاله: 03-01-1399
- نویسندگان: Samira Zarghami Khosravi,Mehdi Zakerian Amiri,Kayhan Barzegar,Ali Asghar Kazemi Zand
- مشاهده