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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Reviews in Clinical Medicine
- نوع مقاله: Journal Article
- کلمات کلیدی: diabetes,Curcumin,Cardiovascular diseases
- چکیده:
- چکیده انگلیسی: Curcumin (diferuloylmethane) is a yellow, active substance of an herbal origin, which is mainly derived from turmeric of the ginger family. Extensive research has been focused on the therapeutic effects of this substance on diabetes, cancer, and cardiovascular diseases, and the hepatoprotective properties have attracted the attention of researchers. In addition, curcumin significantly improves oxidative stress, mitochondrial dysfunction, and inflammation. It could also modulate various cell signals in cytokines, chemokines, growth factors, and enzymes. Curcumin attenuates the blood glucose by increasing insulin levels. According to findings, consuming one gram of curcumin per day for one month could decrease total cholesterol, low-density lipoprotein cholesterol, triglyceride, and high-density lipoprotein cholesterol. Moreover, it contributes to the control of some of the main parameters associated with the metabolic syndrome, which is an important risk factor for cardiovascular diseases. Hepatic cholesterol metabolism is also regulated by curcumin, which has a similar function to lovastatin in the long run. Curcumin has been reported to prevent the enlargement of solid tumours. Several have confirmed the therapeutic role of curcumin in the management of the metabolic syndromes and cardiovascular diseases. The present study aimed to review the therapeutic effects of curcumin.
- انتشار مقاله: 01-09-1397
- نویسندگان: Asal Yadollahi,Mostafa Dastani,Bita Zargaran,Amir Hossein Ghasemi,Hamid Reza Rahimi
- مشاهده
- جایگاه : پژوهشی
- مجله: Reviews in Clinical Medicine
- نوع مقاله: Journal Article
- کلمات کلیدی: diabetes,Curcumin,Cardiovascular diseases
- چکیده:
- چکیده انگلیسی: Curcumin (diferuloylmethane) is a yellow, active substance of an herbal origin, which is mainly derived from turmeric of the ginger family. Extensive research has been focused on the therapeutic effects of this substance on diabetes, cancer, and cardiovascular diseases, and the hepatoprotective properties have attracted the attention of researchers. In addition, curcumin significantly improves oxidative stress, mitochondrial dysfunction, and inflammation. It could also modulate various cell signals in cytokines, chemokines, growth factors, and enzymes. Curcumin attenuates the blood glucose by increasing insulin levels. According to findings, consuming one gram of curcumin per day for one month could decrease total cholesterol, low-density lipoprotein cholesterol, triglyceride, and high-density lipoprotein cholesterol. Moreover, it contributes to the control of some of the main parameters associated with the metabolic syndrome, which is an important risk factor for cardiovascular diseases. Hepatic cholesterol metabolism is also regulated by curcumin, which has a similar function to lovastatin in the long run. Curcumin has been reported to prevent the enlargement of solid tumours. Several have confirmed the therapeutic role of curcumin in the management of the metabolic syndromes and cardiovascular diseases. The present study aimed to review the therapeutic effects of curcumin.
- انتشار مقاله: 01-09-1397
- نویسندگان: Asal Yadollahi,Mostafa Dastani,Bita Zargaran,Amir Hossein Ghasemi,Hamid Reza Rahimi
- مشاهده
- جایگاه : پژوهشی
- مجله: Nursing and Midwifery Studies
- نوع مقاله: Journal Article
- کلمات کلیدی: Health,Knowledge,Diarrhea,mothers
- چکیده:
- چکیده انگلیسی: Background Diarrhea has been considered as a major cause of mortality in children aged less than five years old. Most of these deaths are due to dehydration and mis management or delayed management of the disease. Most of the diarrhea episodes are treated in the home by mothers. Therefore the mothers’ knowledge in management of diarrhea is likely related to its mortality and morbidity. Objectives This study designed to evaluate the knowledge of the mothers with children under five years old about diarrhea and its management and to identify the relation of the knowledge content with some demographic characteristics. Materials and Methods In this cross-sectional study, 430 mothers who had at least one child aged below five years old were selected by cluster sampling. The mothers were asked to complete the 22 items questionnaire designed to evaluate their knowledge of diarrhea. Some demographic characteristics such as age, number of children, education of the mother and her spouse and the source of knowledge also were recorded. Subsequently, the data analyzed using descriptive statistics and chi-square test. Results Most of the mothers were 25-30 years old (43.8%). Slightly more than half (55.6%) had just one child. The health center, educational programs and the personal reading were the main sources of the knowledge about the treatment (43.7%). Twenty eight point eight percent of the mothers had a good knowledge in diarrhea diagnosis and its treatment, while the 46.5% had medium and 24.7% suffered low knowledge. The knowledge of the mothers had significant relationship with the age of the mother, education of the father, number of children, occupation of the mother, and the source of the knowledge. Conclusions The mothers studied in this research had inadequate knowledge about diagnosis and treatment of diarrhea. The educational programs must be an essential part of the health centers programs.
- انتشار مقاله: 11-10-1348
- نویسندگان: Amir Abdollah Ghasemi,Ahmad Talebian,Negin Masoudi Alavi,Gholam Abbas Mousavi
- مشاهده
- جایگاه : پژوهشی
- مجله: Journal of Optimization in Industrial Engineering
- نوع مقاله: Journal Article
- کلمات کلیدی: Multi-criteria decision making (MCDM),Technique for order of preference by similarity to ideal solution (TOPSIS),Interval type 2 fuzzy sets (IT2FSs),alpha cuts
- چکیده:
- چکیده انگلیسی: The technique for order of preference by similarity to ideal solution (TOPSIS) is a method based on the ideal solutions in which the most desirable alternative should have the shortest distance from positive ideal solution and the longest distance from negative ideal solution. Depending on type of evaluations or method of ranking, different approaches have been proposing to calculate distances in the TOPSIS method. In a recent paper, Dymova et al. (2015) extended the TOPSIS approach using interval type 2 fuzzy sets (IT2FSs) in which distances were calculated using alpha cuts. When investigating their paper, we found out that the extended method has some drawbacks such that it leads to the incorrect calculations and results when solving an IT2FSs-based multi-criteria decision making (MCDM) problem. In this note, the corrected version of extended TOPSIS method is being presented to eliminate its limitations. In order to show effectiveness and possibility of the proposed approach, it is also implemented in two illustrative examples and one case study. The results have showed that the optimal alternative obtained by the corrected TOPSIS approach has the similar rank to the others, whereas it is different from the results of existing TOPSIS approach.
- انتشار مقاله: 30-02-1398
- نویسندگان: Amir Mohamadghasemi,Amir Mohamadghasemi,Amir Mohamadghasemi
- مشاهده
- جایگاه : پژوهشی
- مجله: Journal of Kerman University of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Efficacy,safety,Rosa damascene,Acarbose
- چکیده:
- چکیده انگلیسی: Background: Diabetes is a global health problem that its prevalence is increasing rapidly. Rosa damascena extract has shown to have an intensive non-competitive inhibitory effect on α-glucosidase in an animal study. The aim of this study was to assess the safety and efficacy of Rosa damascena (RD) Mill in diabetic patients and healthy subjects. Methods: In a triple-blind, placebo and Acarbose-controlled randomized trial in Kerman in the south-east of Iran, we randomly allocated diabetic patients (n=32) and healthy volunteers (n=28) to 100mg Acarbose, 200 mg RD-methanolic extract, 400mg RD-methanolic extract and placebo groups. Over 15 days, the participants were followed up to monitor the changes in blood biochemical parameters and apparent symptoms. Analyses were carried out by intention to treat. Results:RD extract decreased postprandial blood glucose levels comparable to the effects of Acarbose, demonstrating its α-glucosidase inhibitory activity. Besides, fasting plasma glucose levels significantly decreased in patients treated with 400 mg/day RD-methanolic extract compared to the 200 mg RD-methanolic extract (127.6±26.8vs. 165.5±27.1, p=0.041), suggesting that Rosa damascena Mill is effective in a dose dependent manner. No major or minor hypoglycemic event was observed. NO adverse event was observed in the RD treatment groups in comparison with Acarbose or placebo groups. Serum levels of biochemical parameters did not fluctuate significantly in RD treatment groups compared to Acarbose and placebo controls. Conclusion:Rosa damascena not only decreases blood glucose levels, but also is safe to be used for the purpose of controlling blood glucose levels in drug naïve patients with type II diabetes.
- انتشار مقاله: 19-10-1397
- نویسندگان: Mojgan Sanjari,Ahmad Gholamhoseinian Najar,Gholamreza Asadikaram,Mahboubeh Mashayekhi,Amirfarhad Ghaseminejad Tafreshi
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Medical Physics
- نوع مقاله: Journal Article
- کلمات کلیدی: modeling,Radiation Therapy,Complications,Acute Esophagitis,Concurrent Chemotherapy
- چکیده:
- چکیده انگلیسی: Introduction: The current study aimed to compare the performance of radiobiological models in predicting acute esophagitis (AE) complications after three-dimensional conformal radiation therapy (3D-CRT).
Material and Methods: Out of a total of 100 patients, 50 patients with concurrent chemotherapy and 50 patients without such therapy were treated with different total doses and a daily dose range of 1.8-2.4 Gy on the basis of 5 days a week for 3 months. Predictions of AE were based on Lyman–Kutcher–Burman (LKB) and equivalent uniform dose (EUD)-based radiobiological models. Consequently, 3 months of follow-upwere performed to monitor the complication incidence among the studied patients. Receiver operating characteristic (ROC) and univariable logistic regression analyses were carried out to determine the effect of mean dose, volume percentage, and weight loss percentage on the probability of AE grade ³ 2.
Results: The EUD-basedmodel showed a better concordance with the clinical data for all patients (area under the curve [AUC]=0.919) and the concurrent chemoradiotherapy (CCRT) group (AUC=0.986). For the radiation therapy group, the LKB model had a better performance than the EUD-based model (AUC=0.921). Grade ³ 2 esophagitis occurred 37.94±4.0 and 68.39±7.1 days after the initiation of radiation therapy in the chemoradiation and radiation therapy groups, respectively.
Conclusion: The EUD-basedmodel showed a higher agreement with the follow-up data. The incidence time of grade ³ 2 AE in the CCRT was approximately two times shorter than that in the non-CCRT group.- انتشار مقاله: 30-02-1398
- نویسندگان: Mostafa Alizade-harakiyan,Amir Ghasemi Jangjoo,Behnam Nasiri,Tohid Jafari-Koshki,Murat Okutan,Asghar Mesbahi
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Basic Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: ELISA,vaccine,Brucella melitensis,Fusion protein,Immune reactivity
- چکیده:
- چکیده انگلیسی: Objective(s): Brucella spp. are facultative intracellular pathogens which can stay alive and multiply in professional and nonprofessional phagocytes. Immunity against Brucella melitensis involves antigen-specific CD4+ and CD8+ T-cells activation and humoral immune responses. Due to negative aspects of live attenuated vaccines, much attention has been focused on finding Brucella-protective antigens to introduce them as potential subunit vaccine candidates.
Materials and Methods: A chimeric gene encoding trigger factor (TF), Omp3148-74 and BP2687-111 fragments (TOB) from B. melitensis was successfully cloned, expressed in Escherichia coliBL21-DE3 and purified by Ni-NTA agarose column. Antibodies to recombinant TOB (rTOB) have been investigated in Brucella-infected human sera and a pool serum prepared from B. melitensis-vaccinated rabbits.
Results: Our results showed that the immunized rabbit pool serum strongly reacted with rTOB. In addition, antibodies against rTOB were detectable in 76.5% of sera obtained from infected patients.
Conclusion: These findings suggest that rTOB may provide a potential immunogenic candidate which could be considered in future vaccine studies.- انتشار مقاله: 13-02-1394
- نویسندگان: Jafar Amani,Amir Ghasemi,Reza Ranjbar,Mahdi Shabani,Mahdi Zandemami,Reza Golmohammadi
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Chemistry and Chemical Engineering
- نوع مقاله: Journal Article
- کلمات کلیدی: Adsorption,activated carbon,biosorbent,algae,Sargassum sp
- چکیده:
- چکیده انگلیسی: In this research, the batch removal of toxic hexavalent chromium ions from wastewater and aqueous solution using dried (BD) Sargassum sp. (brown marine algae) and Activated Carbon (AC) prepared from it was examined. Biomass, pH and the initial concentration of Cr(VI), adsorption models and kinetic studies were investigated. The experiment was performed in a batch system and theeffect of solution pH, initial concentration and contact time on biosorption by both biomasses were investigated and compared. When we used AC and BD as biosorbents, optima conditionswere established at pH=2.0, Cr6+ concentration at 3.69 mg/g BD and 6.877 mg/g ACand equilibrium time of 120 min. The adsorption was in therange of 83.55% and 91.98%, respectively. The experimental adsorption data were fitted to the Langmuir adsorption model.The chromium (VI) uptake by the biosorbents was best described by a pseudo second-order rate model.
- انتشار مقاله: 12-07-1389
- نویسندگان: Akbar Esmaeili,,Samira Ghasemi,Fariba Zamani
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Advanced Design and Manufacturing Technology
- نوع مقاله: Journal Article
- کلمات کلیدی: Surface roughness,Ultrasonic Vibrations,Incremental Forming,Formability,Rotating Tool
- چکیده:
- چکیده انگلیسی: Incremental forming is one of the forming methods that is considered because of no need to specific die, especially for rapid prototyping. In this study, the incremental forming process is carried out by using a rotating tool and assisted ultrasonic vibration. Purpose of this research is to investigate the effect of rotation speed and ultrasonic vibrations in the incremental forming process. According to the obtained results, mean and maximum values of forming force reduced by using a rotating tool and applying ultrasonic vibrations. The results of surface roughness tests demonstrated that by increasing rotational speed, the surface roughness improved 44% and applying ultrasonic vibrations with tool rotation can reduce surface roughness about 74%. Applying ultrasonic vibrations lead to increase micro-hardness up to 84%, but, by increasing rotational speed, surface hardness slightly reduces. Results of straight groove test determined ultrasonic vibrations with the rotating tool can increase stretching limit up to 41.79% due to the affect on the sheet plasticity behavior.
- انتشار مقاله: 24-03-1397
- نویسندگان: Saeed Amini,Farshad Nazari,Mohammad Baraheni,Amir Hossein Ghasemi
- مشاهده
- جایگاه : پژوهشی
- مجله: Immunology and Genetics Journal
- نوع مقاله: Journal Article
- کلمات کلیدی: TREC,KREC,newborns screening
- چکیده:
- چکیده انگلیسی: Primary immunodeficiencies contain a group of several different diseases. Giving the fact that their clinical outcome ranges from mild to potentially life-threatening,
detection of patients with these diseases in the neonatal period is the main goal of efforts is currently being made. It has been reported that T-cell receptor excision circles (TRECs) and kappa-deleting recombination excision circles (KRECs) are circular DNA segments produced in T and B cells during their maturation in the thymus and bone marrow, respectively. Fortunately, excision circles can be reliably quantified using real-time quantitative PCR techniques. The TREC and KREC assays, introduced in the newborn screening program (NBS), allow early disease identification and may lead to discovery of new genetic defects including Severe combined immunodeficiencies (SCID), primary agammaglobulinaemias (such as X-linked agammaglobulinaemia) and inherited haemophagocytic syndromes (such as familial haemophagocytic lymphohistiocytosis). In this regard, the cost-effectiveness, survival of children and successful in improving quality of life children involved in newborn screenings for severe combined immunodeficiencyand has been demonstrated.
Here we discuss about TREC and KREC assay, their applications and also assessment of the cost effective of establishment of a program for newborn screening based on TRECs and KRECs quantification in Iran.- انتشار مقاله: 27-07-1398
- نویسندگان: Amir Ghasemi,Amir Ghasemi,Amir Ghasemi
- مشاهده