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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Journal of Midwifery and Reproductive Health
- نوع مقاله: Journal Article
- کلمات کلیدی: Ovary,Serous Cystadenoma,Ovarian neoplasm
- چکیده:
- چکیده انگلیسی: While ovarian masses are common findings in gynecology, unusually huge masses are quite rare. However, such cases can still be found today. Mismanagement of common complaints in patients can be a leading cause of facing such findings. Herein, we introduce a case of a giant ovarian cyst, which was mismanaged in a young virgin female patient. The patient had received gastrointestinal medications for months before being admitted to our clinic, given the bloating sensation and lack of any gynecologic problems. Ultrasonography disclosed a giant cyst, probably related to the ovary, originating from the pelvis and extending toward the diaphragm. After a successful surgery, the ovarian cyst, measuring 40 centimeters and weighing 8 kilograms, was removed. Pathology report revealed serous cystadenoma. Existence of such cases can be an alarming sign for physicians to manage prevalent complaints more seriously, particularly those non-responsive to treatment.
- انتشار مقاله: 15-09-1393
- نویسندگان: Jila Agah,Reza Jafarzadeh Esfehani,Batool Kamalimanesh,Mojtaba Fattahi Abdizadeh,Amir Reza Jalilian
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pharmaceutical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Cytotoxicity,Radiopharmaceutical,Brine shrimp,bis-Thiosemicar bazones
- چکیده:
- چکیده انگلیسی: In the present study, aqueous solutions of some copper-complexing ligands were screened for their cytotoxicity using brine shrimp lethality test. Among the ligands tested, diacetyl-bis(N4-methylthiosemicarbazones) (ATSM) proved to be the most safe and non-toxic compound (2% lethality at 10 ppm), while pyruvaldehyde Bis(N4-methyl)thiosemicarbazone (PTSM) was shown to possess low toxicity (7% lethality at 10 ppm) and glyoxal-bis-thiosemicarbazone (GTS) proved to be a toxic compound even at 1 ppm (20% lethality). An interesting structure-toxicity relationship was observed for the ligands based on their water solubility leading to more toxicity which can be related to polysaccharide crustae of the shrimps. Considering the 1-10 ppm to be the maximum possible concentration of the ligands in the final pharmaceutical samples, the safety of these ligands are ATSM>PTSM>GTS.
- انتشار مقاله: 13-11-1390
- نویسندگان: Amir Reza Jalilian,Aytak Novinrooz,Sahar Sadraee,Marzieh Heydarieh,Mehdi Akhlaghi
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Medical Physics
- نوع مقاله: Journal Article
- کلمات کلیدی: modeling,Biodistribution,Compartmental Analysis,Samarium- 153,Maltolate
- چکیده:
- چکیده انگلیسی: Introduction
Compartmental analysis allows the mathematical separation of tissues and organs to determine activity concentration in each point of interest. Biodistribution studies on humans are costly and complicated, whereas such assessments can be easily performed on rodents.
In this study, we aimed to develop a pharmacokinetic model of 153Sm-maltolate complex as a novel therapeutic agent and free 153Sm cation in normal rats using compartmental analysis to evaluate the behavior of this complex.
Materials and Methods
We developed a physiologically-based pharmacokinetic model for scaling up the activity concentration in each organ with respect to time. In the mathematical model, physiological parameters including organ volume, blood flow rate, and vascular permeability were used. The compartments (organs) were connected anatomically, which allowed the use of scale-up techniques to predict new complex distribution in each body organ.
Results
The concentration of 153Sm-maltolate complex and free 153Sm cation in various organs was measured at different time intervals. The time-dependent behavior of the biodistribution of these two radiotracers was modeled, using compartmental analysis; the detected behaviors were drawn as a function of time.
Conclusion
The variation in radiopharmaceutical concentration in organs of interest could be described by summing seven to nine exponential terms, which approximated the experimental data with a precision of > 1% in comparison with the original data from animal studies.- انتشار مقاله: 22-04-1394
- نویسندگان: Amir Hakimi,Amir Reza Jalilian,Ali Ghanbarzadeh,Hamed Rezaee Jam
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Medical Physics
- نوع مقاله: Journal Article
- کلمات کلیدی: Dosimetry,Gallium-67,Radiation Dose
- چکیده:
- چکیده انگلیسی: Introduction
Gallium-67 (67Ga) has been used as a radionuclide for imaging a variety of solid tumors since 1969. Since then use of various gallium-based radiotracers has been reported. Recently, 67Ga-labeled acetylacetate bis(thiosemicarbazones) (67Ga-AATS) complex with significant tumor accumulation and fast blood clearance has been employed.
Materials and Methods
In this study, the absorbed dose of 67Ga-AATS in each human organ was evaluated and compared with 67Ga-citrate as the most commonly used form of 67Ga in nuclear medicine. 67Ga was produced via 68Zn(p,2n)67Ga reaction at 30 MeV cyclotron. Moreover, 67Ga-AATS was produced by adding 50 µl of AATS to absolute ethanol (1 mg/ml) in a gallium-containing vial at 80-90 °C. The absorbed dose of each human organ was calculated, using RADAR method, based on biodistribution data in Wistar rats.
Results
According to the results, 67Ga-AATS was produced with radionuclidic and radiochemical purity higher than 99% and 93%, respectively. The highest absorbed dose was reported in the bone surface (0.401 mGy/MBq), whereas the whole-body absorbed dose was 0.092 mGy/MBq.
Conclusion
The absorbed dose of each human organ was comparable with the absorbed dose received by each organ after 67Ga-citrate injection. Considering this interesting finding and the significant tumor uptake, it seems that 67Ga-AATS can be used as an appropriate SPECT tracer.- انتشار مقاله: 07-07-1393
- نویسندگان: Hassan Yousefnia,Samaneh Zolghadri,Amir Reza Jalilian
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Chemistry and Chemical Engineering
- نوع مقاله: Journal Article
- کلمات کلیدی: Antibacterial activity,Triazole,thiazole
- چکیده:
- چکیده انگلیسی: Starting from readily available 2-substituted-4-methylthiazole-5-carboxylic acid hydrazide (1), The title compounds were prepared. The reaction of compound 1 (R=CH3) with formic acid yielded 1-(formyl)-2-(2,4-dimethylthiazole-5-carboxyl) hydrazine (2). Refluxing the latter with phosphorous pentasulfide in xylene afforded compound 3, the reaction of compound 2 with phosphorous pentoxide afforded compound 4. Reaction of compound 1 with substituted isothiocyanates followed by cyclization of the intermediate 5 in basic medium gave 4-alkyl-5-(2-substituted-4-methyl-5-thiazolyl)-,4-dihydro-3H-1,2,4-triazole-3-thione (6). Alkylation of compound 6 followed by subsequent oxidation of intermediate 7 gave compound 8. The reaction of acid chloride 11 with hydrazide 12 afforded compound 13 which was cyclized by P2S5 to compounds 14 or 15 respectively. Compounds 3 and 14 showed significant activities against E. Coli and Bacillus Subtilis.
- انتشار مقاله: 23-07-1375
- نویسندگان: Abbas Shafiee,Amir Reza Jalilian,Mojtaba Tabatabaiee Yazdi
- مشاهده
- جایگاه : پژوهشی
- مجله: Asia Oceania Journal of Nuclear Medicine and Biology
- نوع مقاله: Journal Article
- کلمات کلیدی: Ga-68,Octreotide,Internal Dosimetry,Somatostatin
- چکیده:
- چکیده انگلیسی:
Objective(s): Gallium-68 DOTA-DPhe1-Tyr3-Octreotide (68Ga-DOTATOC) has been applied by several European centers for the treatment of a variety of human malignancies. Nevertheless, definitive dosimetric data are yet unavailable. According to the Society of Nuclear Medicine and Molecular Imaging, researchers are investigating the safety and efficacy of this radiotracer to meet Food and Drug Administration requirements. The aim of this study was to introduce the optimized procedure for 68Ga-DOTATOC preparation, using a novel germanium-68 (68Ge)/68Ga generator in Iran and evaluate the absorbed doses in numerous organs with high accuracy.
Methods: The optimized conditions for preparing the radiolabeled complex were determined via several experiments by changing the ligand concentration, pH, temperature and incubation time. Radiochemical purity of the complex was assessed, using high-performance liquid chromatography and instant thin-layer chromatography. The absorbed dose of human organs was evaluated, based on biodistribution studies on Syrian rats via Radiation Absorbed Dose Assessment Resource Method.
Results: 68Ga-DOTATOC was prepared with radiochemical purity of >98% and specific activity of 39.6 MBq/nmol. The complex demonstrated great stability at room temperature and in human serum at 37°C at least two hours after preparation. Significant uptake was observed in somatostatin receptor-positive tissues such as pancreatic and adrenal tissues (12.83 %ID/g and 0.91 %ID/g, respectively). Dose estimations in human organs showed that the pancreas, kidneys and adrenal glands received the maximum absorbed doses (0.105, 0.074 and 0.010 mGy/MBq, respectively). Also, the effective absorbed dose was estimated at 0.026 mSv/MBq for 68Ga-DOTATOC.
Conclusion: The obtained results showed that 68Ga-DOTATOC can be considered as an effective agent for clinical PET imaging in Iran.- انتشار مقاله: 15-02-1394
- نویسندگان: Mojdeh Naderi,Samaneh Zolghadri,Hassan Yousefnia,Ali Ramazani,Amir Reza Jalilian
- مشاهده
- جایگاه : پژوهشی
- مجله: Asia Oceania Journal of Nuclear Medicine and Biology
- نوع مقاله: Journal Article
- کلمات کلیدی: Bone pain palliation,Lu-177,TTHMP,Dosimetry
- چکیده:
- چکیده انگلیسی: Objective(s): Recently, bone-avid radiopharmaceuticals have been shown to have potential benefits for the treatment of widespread bone metastases. Although 177Lutriethylene tetramine hexa methylene phosphonic acid (abbreviated as 177Lu- TTHMP), as an agent for bone pain palliation, has been evaluated in previous studies, there are large discrepancies between the obtained results. In this study, production, quality control, biodistribution, and dose evaluation of 177Lu-TTHMP have been investigated and compared with the previously reported data.
Methods: TTHMP was synthesized and characterized, using spectroscopic methods. Radiochemical purity of the 177Lu-TTHMP complex was determined using instant thin-layer chromatography (ITLC) and high performance liquid chromatography (HPLC) methods. The complex was injected to wild-type rats and biodistribution was studied for 7 days. Preliminary dose evaluation was investigated based on
biodistribution data in rats.
Results: 177Lu was prepared with 2.6-3 GBq/mg specific activity and radionuclide purity of 99.98%. 177Lu-TTHMP was successfully prepared with high radiochemical purity (>99%). The complex showed rapid bone uptake, while accumulation in other organs was insignificant. Dosimetric results showed that all tissues received almost insignificant absorbed doses in comparison with bone tissues.
Conclusion: Based on the obtained results, this radiopharmaceutical can be a good candidate for bone pain palliation therapy in skeletal metastases.- انتشار مقاله: 23-01-1393
- نویسندگان: Samaneh Zolghadri,Hassan Yousefnia,Amir Reza Jalilian,Mohammad Ghannadi-maragheh
- مشاهده