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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Trends in Pharmaceutical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی:
- چکیده:
- چکیده انگلیسی: Some N-substituted piperidine structures were synthesized and evaluated for cytotoxic activity against four different cell lines using the standard MTT assay method and Doxorubicin was used as the reference drug. The result of cytotoxic activity as a measurement of IC50 values revealed that three of the synthesized compounds were active against breast cancer cell line. Compound 6a bearing hydroxyl at para position of piperidine ring was the most active compound within this series. The N-subtituted piperidine with propene substructure could be considered as a lead structure for further studies of structure activity relationship to develop more potent compounds in future.
- انتشار مقاله: 17-12-1392
- نویسندگان: Farzaneh Fesahat,Mehdi Khoshneviszadeh,Alireza Foroumadi,Alireza Vahidi,Maryam Fereidounpour,Amirhossein Sakhteman
- مشاهده
- جایگاه : پژوهشی
- مجله: Research Journal of Pharmacognosy
- نوع مقاله: Journal Article
- کلمات کلیدی: Mice,Inflammation,Hydroalcoholic extract,Apium Graveolens,nociception
- چکیده:
- چکیده انگلیسی: Background and objectives: Pain is an unpleasant feeling which affects the quality of life and relieving from pain is an important goal in many treatment protocols. Apium graveolens L. (celery) has been considered as sedative, analgesic, carminative, antispasmodic and diuretic in Iranian traditional medicine. The aim of present study was to evaluate the anti-nociceptive and anti-inflammatory effect of celery root in mice. Method: Repeated maceration was employed as extraction method. Hot plate and acetic acid writhing test were conducted to assess analgesic effect of celery root. The extract was also evaluated for anti-inflammatory probable effect by formalin induced ear edema and xylene induced paw edema tests. Results: Total flavonoid content determined by aluminum chloride colorimetric method was 0.0625 mg quercetin/g extract. No significant difference was observed between the positive control group which received morphine and test group in hot plate test and the most effective dose of celery root extract was 200 mg/kg, while the frequency of writhings was significantly different in all test groups in comparison with control group (p value< 0.05), the extract (100, 200 and 400 mg/kg) significantly suppressed inflammation in formalin induced edema assay, 60 and 120 min after injection. The results of xylene test also demonstrated notable antiedematogenic effect in applying 200 and 400 mg/kg of extract. Conclusion: Celery root has analgesic and anti-inflammatory effects which might be related to the flavonoids and resins present in the species.
- انتشار مقاله: 17-11-1397
- نویسندگان: Ali Mohammad Ranjbar*,Alireza Vahidi,Mohammad Ebrahim Rezvani,Vahid Ramezani,Minoo Boroumand,Yadollah Jahani
- مشاهده
- جایگاه : پژوهشی
- مجله: Algebraic Structures and Their Applications
- نوع مقاله: Journal Article
- کلمات کلیدی: local cohomology modules,Cousin complexes,Serre subcategories
- چکیده:
- چکیده انگلیسی: Let $R$ be a commutative Noetherian ring with non-zero identity, $mathfrak{a}$ an ideal of $R$, $X$ an arbitrary $R$--module, $mathcal{F}$ a filtration of $operatorname{Spec}(R)$ which admits $X$, and $s, s', t, t'$ non-negative integers such that $s+ t= s'+ t'$. In this paper, we study the membership of $R$--modules $operatorname{H}^{s}_mathfrak{a}(operatorname{H}^{t- 1}(operatorname{C}_R(mathcal{F}, X)))$ and $operatorname{H}^{s'- 1}(operatorname{H}^{t'}_mathfrak{a}(operatorname{C}_R(mathcal{F}, X)))$ in Serre subcategories of the category of $R$--modules and find some sufficient conditions which ensure the existence of an isomorphism between them, where $operatorname{C}_R(mathcal{F},X)$ is the Cousin complex for $X$ with respect to $mathcal{F}$. As applications, we give some new facts and represent some older facts about the local cohomology modules and the Cousin complexes.
- انتشار مقاله: 16-12-1397
- نویسندگان: Alireza Vahidi,Faisal Hassani,Maryam Senshenas
- مشاهده
- جایگاه : پژوهشی
- مجله: Algebraic Structures and Their Applications
- نوع مقاله: Journal Article
- کلمات کلیدی: Filter regular sequences,local cohomology modules,Nagel-Schenzel formula
- چکیده:
- چکیده انگلیسی: Let $R$ be a commutative Noetherian ring with non-zero identity, $mathfrak{a}$ an ideal of $R$, $M$ a finitely generated $R$--module, and $a_1, ldots, a_n$ an $mathfrak{a}$--filter regular $M$--sequence. The formula
begin{align*}
operatorname{H}^i_mathfrak{a}(M)cong
left{begin{array}{lll}
operatorname{H}^i_{(a_1, ldots, a_n)}(M) & text{for all} mathrm{i< n},\
operatorname{H}^{i- n}_mathfrak{a}(operatorname{H}^n_{(a_1, ldots, a_n)}(M)) & text{for all} mathrm{igeq n},
end{array}right.
end{align*}
is known as Nagel-Schenzel formula and is a useful result to express the local cohomology modules in terms of filter regular sequences. In this paper, we provide an elementary proof to this formula.- انتشار مقاله: 03-07-1396
- نویسندگان: Alireza Vahidi,Alireza Vahidi,Alireza Vahidi
- مشاهده