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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Reviews in Clinical Medicine
- نوع مقاله: Journal Article
- کلمات کلیدی: treatment,lichen planopilaris,Frontal fibrosing alopecia
- چکیده:
- چکیده انگلیسی: Introduction: Lichen planopilaris (LPP) and frontal fibrosing alopecia (FFA) are skin diseases that affect the quality of life. Although a systematic review on LPP and FFA treatment was published in 2013, further updates are needed. The aim of this study is to review systematically the studies published after the last systematic review.
Methods: We searched Scopus, PubMed, Embase, and ISI Web of Science. All the studies published during March 2012-June 2017 were included in this review. Two reviewers separately selected the studies and extracted the data. The results of studies were categorized as unimproved, stabilized, and improved based on the articles reports.
Result: Among the 38 studies, 20, 17, and one studies assessed LPP, FFA, and both treatments, respectively. The papers were case reports, case series, cohorts, and randomized controlled trials. Antimalarial agents and pioglitazone resulted in enhancement in 73 and 71% of the LPP patients, respectively. Improvement and stabilization were observed in almost one third of the topical steroid users and 6/12 of Tacrolimus/Pimecrolimus users in LPP. Improvement and stabilization in FFA was found in 68% of the individuals using antimalarial agents, 83% of intralesional steroid users, all cases of finasteride users, and 95% of the people utilizing dutasteride.
Conclusion: Contrary to the previous systematic review, we found antimalarial agents more effective than steroids in LPP. Finasteride/dutasteride may have favorable impacts on FFA. Intralesional steroids showed to be more effective than antimalarial agents in FFA. Still further studies are needed in order to define a treatment protocol. Low quality and heterogeneity of the articles were among the limitations for making a conclusion.- انتشار مقاله: 16-11-1396
- نویسندگان: Behnoush Bakhshoudeh,Maryam Salehi,Ramin Sadeghi,Alireza Omranzadeh,Toktam Sahranavard,Soheil Arekhi,Ali Jafarzadeh Esfehani,Naghmeh Zabolinejad
- مشاهده
- جایگاه : پژوهشی
- مجله: Reviews in Clinical Medicine
- نوع مقاله: Journal Article
- کلمات کلیدی: Adverse Reactions,International Classification of Diseases,Drug-related Side-effects
- چکیده:
- چکیده انگلیسی: Introduction: An adverse event (AE) is defined as an intended condition caused by medical errors or during hospitalization. Evidence in this regard is scarce and outdated. The present study aimed to evaluate the prevalence of medical and surgical AEs in three tertiary hospitals in the northeast of Iran.
Methods: This cross-sectional study was conducted on all the admitted patients to three trauma-specialized hospitals affiliated to Mashhad University of Medical Sciences due to AEs (n=1,121) in 2014. Identification of the AEs was accomplished using the International Classification of Diseases 10.
Results: The prevalence of AEs was estimated at 1.2%. The mean age of the patients exposed to AEs was 36.5±19.5 years, and 74% of these cases (n=830) were male. The mean length of hospital stay in these patients was 9.8±12.7 days. The majority of the reported AEs (n=1,020; 91%) were caused by surgical and other medical procedures, such as the abnormal reaction of patients, later complication, and not mentioning the misadventure upon the procedure. The mortality rate among the patients was determined to be 2.4%.
Conclusion: Although the rate of postoperative complications was relatively low, more strict academic protocols must be exploited in order to prevent AEs, especially in critical periods, such as summer.- انتشار مقاله: 05-12-1397
- نویسندگان: Masoumeh Sarbaz,Khalil Kimiafar,Majid Khadem-Rezaiyan,Mohammad Javad Ghasri,Mohammad Reza Farhang Far,Yones Bondar Sahebi,Alireza Omranzadeh
- مشاهده
- جایگاه : پژوهشی
- مجله: Reviews in Clinical Medicine
- نوع مقاله: Journal Article
- کلمات کلیدی: treatment,lichen planopilaris,Frontal fibrosing alopecia
- چکیده:
- چکیده انگلیسی: Introduction: Lichen planopilaris (LPP) and frontal fibrosing alopecia (FFA) are skin diseases that affect the quality of life. Although a systematic review on LPP and FFA treatment was published in 2013, further updates are needed. The aim of this study is to review systematically the studies published after the last systematic review.
Methods: We searched Scopus, PubMed, Embase, and ISI Web of Science. All the studies published during March 2012-June 2017 were included in this review. Two reviewers separately selected the studies and extracted the data. The results of studies were categorized as unimproved, stabilized, and improved based on the articles reports.
Result: Among the 38 studies, 20, 17, and one studies assessed LPP, FFA, and both treatments, respectively. The papers were case reports, case series, cohorts, and randomized controlled trials. Antimalarial agents and pioglitazone resulted in enhancement in 73 and 71% of the LPP patients, respectively. Improvement and stabilization were observed in almost one third of the topical steroid users and 6/12 of Tacrolimus/Pimecrolimus users in LPP. Improvement and stabilization in FFA was found in 68% of the individuals using antimalarial agents, 83% of intralesional steroid users, all cases of finasteride users, and 95% of the people utilizing dutasteride.
Conclusion: Contrary to the previous systematic review, we found antimalarial agents more effective than steroids in LPP. Finasteride/dutasteride may have favorable impacts on FFA. Intralesional steroids showed to be more effective than antimalarial agents in FFA. Still further studies are needed in order to define a treatment protocol. Low quality and heterogeneity of the articles were among the limitations for making a conclusion.- انتشار مقاله: 16-11-1396
- نویسندگان: Behnoush Bakhshoudeh,Maryam Salehi,Ramin Sadeghi,Alireza Omranzadeh,Toktam Sahranavard,Soheil Arekhi,Ali Jafarzadeh Esfehani,Naghmeh Zabolinejad
- مشاهده
- جایگاه : پژوهشی
- مجله: Reviews in Clinical Medicine
- نوع مقاله: Journal Article
- کلمات کلیدی: Adverse Reactions,International Classification of Diseases,Drug-related Side-effects
- چکیده:
- چکیده انگلیسی: Introduction: An adverse event (AE) is defined as an intended condition caused by medical errors or during hospitalization. Evidence in this regard is scarce and outdated. The present study aimed to evaluate the prevalence of medical and surgical AEs in three tertiary hospitals in the northeast of Iran.
Methods: This cross-sectional study was conducted on all the admitted patients to three trauma-specialized hospitals affiliated to Mashhad University of Medical Sciences due to AEs (n=1,121) in 2014. Identification of the AEs was accomplished using the International Classification of Diseases 10.
Results: The prevalence of AEs was estimated at 1.2%. The mean age of the patients exposed to AEs was 36.5±19.5 years, and 74% of these cases (n=830) were male. The mean length of hospital stay in these patients was 9.8±12.7 days. The majority of the reported AEs (n=1,020; 91%) were caused by surgical and other medical procedures, such as the abnormal reaction of patients, later complication, and not mentioning the misadventure upon the procedure. The mortality rate among the patients was determined to be 2.4%.
Conclusion: Although the rate of postoperative complications was relatively low, more strict academic protocols must be exploited in order to prevent AEs, especially in critical periods, such as summer.- انتشار مقاله: 05-12-1397
- نویسندگان: Masoumeh Sarbaz,Khalil Kimiafar,Majid Khadem-Rezaiyan,Mohammad Javad Ghasri,Mohammad Reza Farhang Far,Yones Bondar Sahebi,Alireza Omranzadeh
- مشاهده