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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Journal of Kerman University of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Iran,mapping,Leishmaniasis,Geographic Information System (GIS),Geographical pathology
- چکیده:
- چکیده انگلیسی: Background & Aims: Despite improvements in public health in Iran, cutaneous leishmaniasis has become a growing health issue. About 90% of cutaneous leishmaniasis cases occur in 8 countries including Iran. Kala-azar or visceral leishmaniasis, as an important parasitic disease, is endemic in some areas of Iran. Mapping the distribution of parasitic diseases and determining their relations to geographic factors are increasing in importance for experts. This study was carried out to provide distribution maps of the geographical pathology of leishmaniasis in Iran with no emphasis on medical entomology or parasitology. Methods: A systematic literature review was performed and the data and/or metadata were used for evaluation of findings. Data of leishmaniasis were obtained from the Iran Center for Diseases Control, in the Ministry of Health in 2002 and 2009. Incidence or prevalence of the diseases and also scientific names of vectors and reservoirs with collection details were arranged as a shapefile in ArcGIS software and were mapped. Results: Distribution maps of the diseases, host reservoirs, and vectors are provided as a systematic review. Conclusion: It seems that zoonotic cutaneous leishmaniasis is mostly observed in desert and semi-desert habitats far from Alborz and Zagros mountainous areas. Visceral leishmaniasis in dogs may be related to precipitation, temperature, and elevation in Ardebil Province, Iran. There are some gaps in distribution maps which represent future study opportunities for scholars as this lack of data does not signify the lack of prevalence of the disease but the lack of studies in these areas
- انتشار مقاله: 29-04-1395
- نویسندگان: Abdolreza Salahi-Moghaddam,Alireza Khoshdel,Aahmad-Ali Hanafi-Bojd,Mohammad-Mahdi Sedaghat
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Apoptosis,Gastric cancer,Cornus mass L. extract,L929 cells,AGS cell line
- چکیده:
- چکیده انگلیسی: Aim and objectives: Natural products and derivatives of medicinal vegetation can play an important role to the
cure tumor. The Present study was focused to determine the effect of Cornus mass L. extract on the induction of
apoptosis in AGS gastric carcinoma cell line in compared to L929 cells. Methods: In this experimental study, AGS
and L929 cells were cultured and treated with different concentrations (0–10 mg/ml) of Cornus mass L. extract for 48
and 72 hours. Cell proliferation was assessed by MTT assay. The optical density of the colored solution was quantified
at 570 nm wavelengths by an ELISA Reader. Making use of the apoptosis detection kit of Annexin V-FITC, PI and
double staining with Annexin V-FITC were carried out for flow cytometry investigations. Data were analyzed by
ANOVA. Variations with a P-value less than 0.05 were considered significant. Results: shows a noticeable deviation
among various concentrations of extract when cells were treated for 48, 72 h declined cell viability in AGS cell line in
comparison L929 cell lines in a dose and time-dependent manner (P < 0.05). This extract also displayed approximately
several-fold increased anti-cancer potency in AGS compared to L929 cells. The IC50 value in AGS cells (evaluated
after 48,72h) of the extract against AGS cells was 5/44, 2/44 mg/ml (p≤0.05). The analysis results of flow cytometry
indicated that apoptosis was induced by the extract in AGS cells treated, compared with L929 cells. Conclusion: Each
of our results implicates the reality that Cornus mass L. extract acts as a novel, potent inhibitor of cancer proliferation
in in vitro. This may result in developing a promising therapeutic agent for the treatment of indole-sensitive cancers.- انتشار مقاله: 17-02-1397
- نویسندگان: Farzaneh Sadat Hosseini,Mojgan Noroozi Karimabad,Mohammad Reza Hajizadeh,Alireza Khoshdel,Soudeh Khanamani Falahati-Pour,Mohammad Reza Mirzaei,Seyed Mehdi Mirmohamadi,Mehdi Mahmoodi
- مشاهده