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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Journal of Dentistry, Shiraz University of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: adenoid cystic carcinoma,p63,matrix metalloproteinase,Mucoepidermoid carcinoma,Maspin
- چکیده:
- چکیده انگلیسی: Statement of the Problem: The tumor suppressor role of myoepithelial cells and related mechanisms in breast tumors are well understood. However, the role of these cells in salivary glands tumors is debatable.
Purpose: The present study was designed to determine the expression of p63, Maspin and Matrix metalloproteinase 2 (MMP-2) in mucoepidermoid carcinoma (MEC) and adenoid cystic carcinoma (ADCC) of salivary glands due to various cellular differentiation and structure. The association between the expression of these markers and clinicopathologic features and myoepithelial differentiation were also evaluated.
Materials and Method: P63, Maspin and MMP-2 expression were immunohistochemically studied in 67 cases including35 cases of MEC and 32 cases of ADCC. The smooth muscle actin (SMA) staining was also applied to confirm the presence of myoepithelial differentiation. Data was analyzed using Chi-square test, Mann-Whitney U test and t-test.
Results: The expression of p63 (p = 0.009) and Maspin (p = 0.012) significantly differed between the study groups.P63 positive cells in MEC were negative for SMA staining in contrast to ADCC. Furthermore, the expression of P63 (p = 0.045) and Maspin (p = 0.019) significantly and inversely correlated with histologic grade in ADCC. Likewise, positive significant correlation was detected between histologic grade and expression of P63 (p = 0.018) and MMP-2 (p = 0.003) in MEC samples.
Conclusion: Ourfindings showed thatMEC is devoid of myoepithelial cells. The difference in expression of P63 and Maspin in ADCC and MEC highlighted the role and presence of myoepithelial cells in ADCC. Indeed, the high expression of P63 and Maspin in well differentiated ADCCs suggests the tumor suppressor effect of myoepithelial cells. Considering the association between the evaluated markers and histological grade, p63 in both tumors, Maspin in ADCC and MMP-2 in MEC may be efficient predictors of clinical behavior.- انتشار مقاله: 17-09-1397
- نویسندگان: Nasim Taghavi,Farzad Yazdani,Alireza Akbarzadeh Baghban,Soudabeh Sargolzaei,Parisa Kardouni Khozestani
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Neonatology
- نوع مقاله: Journal Article
- کلمات کلیدی: Disease mapping,Bayesian Approach,Congenital hypothyroidism,spatio-temporal model
- چکیده:
- چکیده انگلیسی: Background: Congenital Hypothyroidism (CH) is one of the reasons for mental retardation and defective growth in neonates. It can be treated if it is diagnosed early. The congenital hypothyroidism can be diagnosed using newborn screening in the first days after birth. Disease mapping helps to identify high-risk areas of the disease. This study aimed to evaluate the pattern of CH using the Poisson Spatio-temporal model in disease mapping under the Bayesian paradigm.
Methods: The recorded data of all infants diagnosed with CH between 2011 and 2018 in Guilan, Iran were used in this study. The Poisson Spatio-temporal model under the Bayesian paradigm was run using the Markov Chain Monte Carlo method in Open BUGS software. Moreover, the maps of the towns in Guilan were prepared via Arc GIS software.
Results: Out of 219800 live births in Guilan, Iran, the incidence of CH was 2:1000 in this time period. The pattern of disease mapping for the posterior mean of relative risk for CH was identical in this 7-year period. Furthermore, the pattern of disease mapping with spatial model excluding time dependence was similar to the maps of the Spatio-temporal model.
Conclusion: The incidence rate of CH was approximately constant during this time, and disease mapping revealed no rising trends in this period. This probably can be due to resolving iodine deficiency as one of the main causes of CH incidence by consuming kinds of seafood and iodized salt in Guilan province.- انتشار مقاله: 18-04-1398
- نویسندگان: Bahare Gholami Chaboki,Sadroddin Mehdipour,Alireza Akbarzadeh Baghban
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Immunology
- نوع مقاله: Journal Article
- کلمات کلیدی: Apoptosis,calprotectin,Severe Early Childhood Caries,α-Defensins,Neutrophil
- چکیده:
- چکیده انگلیسی: Background: The infectious nature of severe early-childhood caries (S-ECC) points to the possible participation of immunologic host responses including neutrophils and their antimicrobial products.
Objectives: The aim of this study was to determine the neutrophil apoptosis, α-defensins (HNP1-3) and calprotectin levels in the saliva of preschool children and the association with S-ECC.
Methods: Oral examinations were performed on 87 children aged 3-5 years and non stimulated whole saliva samples were collected. Thirty of these subjects were considered S-ECC children, 30 with moderate caries (MC) and 27 were caries free (CF). To detect apoptosis, cell staining was done with Annexin-V-Fluos and propidium iodide, and they were analyzed by fluorescent microscopy. The concentration of α-defensins and calprotectin were assessed using ELISA.
Results: There were no statistical differences between groups considering the HNP1-3 or calprotectin salivary levels (p=0.06 and p=0.23, respectively). The HNP1-3 and calprotectin levels were negatively correlated and the correlation was significant in MC group (p=0.03). Lower levels of apoptotic neutrophils were obtained from CF subjects as compared with S-ECC children (p=0.03).
Conclusions: Our findings establish that apoptotic mechanisms could be implicated in the immunity responses associated with S-ECC. We cannot yet- انتشار مقاله: 15-05-1395
- نویسندگان: Lida Toomarian,Mandana Sattari,Nazanin Hashemi,Nikoo Tadayon,Alireza Akbarzadeh Baghban
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Basic Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: NMR,Thyroid cancer,Serum,Metabolomics,Multinodular goiter
- چکیده:
- چکیده انگلیسی: Objective(s): As the most prevalent endocrine system malignancy, papillary thyroid carcinoma had a very fast rising incidence in recent years for unknown reasons besides the fact that the current methods in thyroid cancer diagnosis still hold some limitations. Therefore, the aim of this study was to improve the potential molecular markers for diagnosis of benign and malignant thyroid nodules to prevent unnecessary surgeries for benign tumors.
Materials and Methods: In this study, 1H-NMR metabolomics platform was used to seek the discriminating serum metabolites in malignant papillary thyroid carcinoma (PTC) compared to benign multinodular goiter (MNG) and healthy subjects and also to better understand the disease mechanisms using bioinformatics analysis. Multivariate statistical analysis showed that PTC and MNG samples could be successfully discriminated in PCA and OPLS-DA score plots.
Results: Significant metabolites that differentiated malignant and benign thyroid lesions included citrate, acetylcarnitine, glutamine, homoserine, glutathione, kynurenine, nicotinic acid, hippurate, tyrosine, tryptophan, β-alanine, and xanthine. The significant metabolites in the PTC group compared to healthy subjects also included scyllo- and myo-inositol, tryptophan, propionate, lactate, homocysteine, 3-methyl glutaric acid, asparagine, aspartate, choline, and acetamide. The metabolite sets enrichment analysis demonstrated that aspartate metabolism and urea cycle were the most important pathways in papillary thyroid cancer progression.
Conclusion: The study results demonstrated that serum metabolic fingerprinting could serve as a viable method for differentiating various thyroid lesions and for proposing novel potential markers for thyroid cancers. Obviously, further studies are needed for the validation of the results.- انتشار مقاله: 15-12-1396
- نویسندگان: Reyhaneh Farrokhi Yekta,Mostafa Rezaei Tavirani,Afsaneh Arefi Oskuie,Mohamad Reza Mohajeri Tehrani,Ahmad Reza Soroush,Alireza Akbarzadeh Baghban
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Basic Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: NMR,Thyroid cancer,Serum,Metabolomics,Multinodular goiter
- چکیده:
- چکیده انگلیسی: Objective(s): As the most prevalent endocrine system malignancy, papillary thyroid carcinoma had a very fast rising incidence in recent years for unknown reasons besides the fact that the current methods in thyroid cancer diagnosis still hold some limitations. Therefore, the aim of this study was to improve the potential molecular markers for diagnosis of benign and malignant thyroid nodules to prevent unnecessary surgeries for benign tumors.
Materials and Methods: In this study, 1H-NMR metabolomics platform was used to seek the discriminating serum metabolites in malignant papillary thyroid carcinoma (PTC) compared to benign multinodular goiter (MNG) and healthy subjects and also to better understand the disease mechanisms using bioinformatics analysis. Multivariate statistical analysis showed that PTC and MNG samples could be successfully discriminated in PCA and OPLS-DA score plots.
Results: Significant metabolites that differentiated malignant and benign thyroid lesions included citrate, acetylcarnitine, glutamine, homoserine, glutathione, kynurenine, nicotinic acid, hippurate, tyrosine, tryptophan, β-alanine, and xanthine. The significant metabolites in the PTC group compared to healthy subjects also included scyllo- and myo-inositol, tryptophan, propionate, lactate, homocysteine, 3-methyl glutaric acid, asparagine, aspartate, choline, and acetamide. The metabolite sets enrichment analysis demonstrated that aspartate metabolism and urea cycle were the most important pathways in papillary thyroid cancer progression.
Conclusion: The study results demonstrated that serum metabolic fingerprinting could serve as a viable method for differentiating various thyroid lesions and for proposing novel potential markers for thyroid cancers. Obviously, further studies are needed for the validation of the results.- انتشار مقاله: 15-12-1396
- نویسندگان: Reyhaneh Farrokhi Yekta,Mostafa Rezaei Tavirani,Afsaneh Arefi Oskuie,Mohamad Reza Mohajeri Tehrani,Ahmad Reza Soroush,Alireza Akbarzadeh Baghban
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Pediatrics
- نوع مقاله: Journal Article
- کلمات کلیدی: Breastfeeding,Infancy,Domestic violence,Reproductive period
- چکیده:
- چکیده انگلیسی:
Background
Due to the prevalence of domestic violence and its effect on women's health, especially during breastfeeding, this study was conducted to investigate the factors associated with physical domestic violence during breastfeeding in Iranian women.
Materials and Methods
This descriptive cross-sectional study was performed through multi-stage sampling on 549 women who had infants up to 6 months of age during breastfeeding, and referred to health centers affiliated to Shahid Beheshti University of Medical Sciences in Tehran, Iran. For data collection demographic, obstetrics, breastfeeding status and WHO physical domestic violence questionnaires were used. Data analysis was performed with SPSS software version 19.0.
Results
The results showed that the rate of physical violence was 35.7%, and 5.8% of women experienced physical violence more than 5 times during breastfeeding. In logistic regression, husband’s occupation (p <0.014), women’s education (p <0.007), household income (p <0.003), independent income of women (p <0.002), infant gender (p <0.002), husband’s support in breastfeeding (p <0.035), exclusive breastfeeding (p <0.001) were associated with physical domestic violence during breastfeeding.
Conclusion
Some socioeconomic characteristics such as education, occupation of women and their husband, age of husband, duration of the marriage, infant gender, household income, and the independent income of women were related to physical violence during breastfeeding. It is necessary to identify women exposed to violence to prevent its complications, especially during breastfeeding.
- انتشار مقاله: 16-05-1399
- نویسندگان: Zahra Bazazbanisi,Sedigheh Amir Ali Akbari,Mohammad Ali Emamhadi,Alireza Akbarzadeh Baghban
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: depression,Stress,Childhood cancer,Play therapy,Filial therapy
- چکیده:
- چکیده انگلیسی: Background: Childhood cancer is an overwhelming life event that can completely change the lives of the sufferers and their parents. Todays, advances of medical science have shifted the fetal nature of childhood cancer to chronic one exposing children and their family to behavioral and psychosocial problems. The aim of this study was to investigate the effect of filial therapy on children’s depressive symptoms and their mother’s stress, anxiety, and depression. Materials and Methods: In this randomized controlled trial, 32 mothers with their children who suffered from cancer were recruited (16 in each group). During a 10-week training sessions, filial therapy group underwent child-parent relation therapy (CPRT). Training sessions were held once a week. Control group received no training and only individual counseling sessions were held for them we needed. Both groups were assessed before and after the intervention using depression, anxiety, and stress questionnaire-21 (DASS-21), children depression inventory (CDI), and Wong-Baker faces pain rating scale (WBFPRS). Sample randomization and data analysis were conducted by using SPSS (version 20) and running independent t-test and chi-square test. P value< 0.05 was set as the significant level. Results: Mothers in the filial therapy group experienced significant decrease in their level of depression, anxiety, and stress in the posttest (p < 0.001). In contrast to filial therapy group, mothers in the control group did not show an improvement in their level of depression, anxiety, and stress. Moreover, the results of the current investigative showed that depression of children in the filial therapy group significantly reduced at post-test (p < 0.001). On the other hand, the mean of children’s depression in the control group remained steady. Conclusion: The findings of the present study revealed that using filial therapy could reduce the depression of children with cancer and their parent’s depression, anxiety, and stress. Accordingly, we suggest filial therapy programs as a routine for addressing psychosocial problems of children with cancer and their families.
- انتشار مقاله: 30-11-1397
- نویسندگان: Elaheh Ebrahimi,Hooshang Mirzaie,Mehrdad Saeidi Borujeni,Ghazal Zahed,Alireza Akbarzadeh Baghban,Navid Mirzakhani
- مشاهده