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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pathology
- نوع مقاله: Journal Article
- کلمات کلیدی: Histopathology,Laboratory,Hemolytic Uremic Syndrome
- چکیده:
- چکیده انگلیسی: Background and objective: Hemolytic uremic syndrome (HUS) is the most prevalent cause of children renal insufficiency which in many cases (90%) occurs following diarrhea. Hemolytic microangiopathic anemia, thrombocytopenia, and renal insufficiency are main symptoms of hemolytic uremic syndrome. This study aims to consider the relationship between pathologic data of nephro-biopsy and laboratory data of children suffering from the disease. Material and Methods: This study has been carried out in retrospective, cross-sectional and descriptive procedures. For this purpose, 28 patients with an average age of 6 years suffering from uremic hemolytic syndrome referred to Ali Asghar Hospital over the last 10 years. Light microscopic data of glomeruli, arterioles, arteries, interstitial tissue, medullary vessels and tubules were evaluated. Laboratory data including hematology, biochemistry, and urinary tests were extracted from patients’ files. Data were analyzed using SPSS software. Results: The most prevalent damages in glomeruli were decreased capillary lumen and thickening of its wall and in arterioles were mild decrease of lumen and in artery thickening of intima and mild infiltration of inflammatory cells and mild edema in interstitial and hyperemia in vaso recta and the most prevalent pathology in tubules was the existence of cast. Significant relationship was found out between time of recovery of hematological disorders and medullary vessels congestion and reduplication of arterial inner elastic lamina and also improvement of biochemistry changes with glomerulus necrosis and leucocytes assembly in vaso recta. Arteriolar rate with creatinine serum level at discharge time was related and tubular rate with platelet count at discharging time was also related. Conclusion: Biopsy is an important tool for prognosis and det ermination of disease intensity. There was valuable statistical relationship between some laboratory data at the time of referral and pathological data which even could influence intensity or prognosis of disease.
- انتشار مقاله: 06-07-1393
- نویسندگان: Mitra Mehrazama,Nakysa Hooman,Alireza Abdollahi,Hasan Otukesh
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pathology
- نوع مقاله: Journal Article
- کلمات کلیدی: Iran,urinary tract infection,Antibiogram
- چکیده:
- چکیده انگلیسی: Background and Objectives: Urinary tract infections (UTI) are one of the most common infectious diseases with different microbial agent and antimicrobial resistant pattern in hospitalized patients and outpatients. In order to assess the adequacy of therapy, knowledge of prevalence and resistance pattern of the bacteria is necessary. The main aim of this study was to evaluate the prevalence and the antimicrobial resistance pattern of main bacterial responsible for UTI in order to establish an appropriate empirical therapy. Methods: All urine samples were referred to Imam Hospital Laboratory, Tehran, Iran during 2011-2012, urine culture isolated and bacteria were identified and the profile of antibiotic susceptibility was characterized. Result: From 1851 urine cultures, UTI was more frequent in woman (68%) E. coli was as usual the most common pathogen implicated in UTI. Most susceptibility was to imipenem (98.9%). nitroforantoin (96%) and amikacin (94.1%) and increased resistance to penicillin (66.6%), nalidixic acid (62.1%) ampicilin (60.1%) and cotrimoxazole 54.3%. Discussion: The most common isolated pathogen was E. coli. According to antibiogram susceptibility, the recommended antimicrobial drugs are nitroforantoin and imipenem. nalidixic acid and cotrimoxazole are not recommended because drug resistance is high.
- انتشار مقاله: 16-08-1392
- نویسندگان: Zohreh Nozarian,Alireza Abdollahi
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Castleman’s disease,Giant lymph node Hyperplasia lymph node,Retroperitoneal space
- چکیده:
- چکیده انگلیسی: Castleman’s disease, giant lymph node hyperplasia, is a kind of benign lymphoproliferative disease with gentle behavior. Its etiology and prevalence are unclear. This rare disease is usually found in mediastinal area asymptomatically and incidentally. It is also rare to see this tumor in the retroperitoneum. In this study, we have introduced a 34-year-old woman who referred just with occasional abdominal pain caused by compressive symptoms. Laboratory findings only reported microcytic anemia (MCH: 18.5, MCV: 63, Hemoglobin 10.2 g/dl). Chest and abdominal X-ray imaging showed no remarkable point. In abdominal ultrasonography, a solid and firm tumor with 12.2×5.3×6.6 cm was reported in patient’s retroperitoneum. Patient’s surgery was done and the tumor (covered by a fibrous thick capsule, with no bizarre appearance and bleeding) was completely removed. Pathologic examination indicated a Castleman’s tumor, type of unicentric and hyaline-vascular. This item had been one of the rare reported items of Castleman’s disease in the retroperitoneal space.
- انتشار مقاله: 12-02-1393
- نویسندگان: Afsaneh Rajabiani,Alireza Abdollahi,Zahra Farahani
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Basic Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Thalidomide,IL-6,TNF-α,Cirrhotic cardiomyopathy,SOCS1
- چکیده:
- چکیده انگلیسی: Objective(s): Cirrhotic cardiomyopathy is a complication of uncured cirrhosis which is associated with hyporesponsiveness of the heart to sympathetic stimulation. The enhancement of portal pressure, nitric oxide (NO) level, pro-inflammatory mediators and down-regulation of Suppressor of Cytokine Signaling 1 (SOCS1) are involved in this situations. The present study seeks to examine the beneficial effect of thalidomide on cirrhotic cardiomyopathy.
Materials and Methods: The male rats were grouped as: Sham/saline, Sham/Thalidomide, Bile Duct Ligation (BDL)/saline and BDL/Thalidomide. BDL model of cirrhosis was used. In the treatment groups, thalidomide (200 mg/kg/day) was administrated by intragastrial gavage for 28 consecutive days, the chronotropic response was assessed in isolated atria by isoproterenol stimulation. Serum levels of NO, IL-6 and TNF-α hepatic level were evaluated. The intrasplenic pulp pressure (ISPP) as the portal pressure and histopathologic assessment were assessed. Real time RT-PCR was used for the evaluation of SOCS1 gene expression.
Results: Our results showed that thalidomide administration could significantly increase the atrial chronotropic response in BDL animals. The increased level of portal pressure decreased by thalidomide in BDL animals. Thalidomide could ameliorate the histopathological conditions of BDL rats. Furthermore, the chronic treatment by this drug diminished the elevated levels of NO, TNF-α and IL-6 in BDL animals. On the other hand, hepatic SOCS1 expression was up-regulated by thalidomide treatment in this group.
Conclusion: Thalidomide improves the chronotropic hyporesponsiveness of isolated atria in BDL. This effect is probably mediated by the inhibiting NO, TNF-α and IL-6 production, reducing portal pressure and increasing the expression of SOCS1.- انتشار مقاله: 08-03-1397
- نویسندگان: Ali Hosseini-chegeni,Farahnaz Jazaeri,Aliakbar Yousefi-Ahmadipour,Mansour Heidari,Alireza Abdollahi,Ahmad Reza Dehpour
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Basic Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Thalidomide,IL-6,TNF-α,Cirrhotic cardiomyopathy,SOCS1
- چکیده:
- چکیده انگلیسی: Objective(s): Cirrhotic cardiomyopathy is a complication of uncured cirrhosis which is associated with hyporesponsiveness of the heart to sympathetic stimulation. The enhancement of portal pressure, nitric oxide (NO) level, pro-inflammatory mediators and down-regulation of Suppressor of Cytokine Signaling 1 (SOCS1) are involved in this situations. The present study seeks to examine the beneficial effect of thalidomide on cirrhotic cardiomyopathy.
Materials and Methods: The male rats were grouped as: Sham/saline, Sham/Thalidomide, Bile Duct Ligation (BDL)/saline and BDL/Thalidomide. BDL model of cirrhosis was used. In the treatment groups, thalidomide (200 mg/kg/day) was administrated by intragastrial gavage for 28 consecutive days, the chronotropic response was assessed in isolated atria by isoproterenol stimulation. Serum levels of NO, IL-6 and TNF-α hepatic level were evaluated. The intrasplenic pulp pressure (ISPP) as the portal pressure and histopathologic assessment were assessed. Real time RT-PCR was used for the evaluation of SOCS1 gene expression.
Results: Our results showed that thalidomide administration could significantly increase the atrial chronotropic response in BDL animals. The increased level of portal pressure decreased by thalidomide in BDL animals. Thalidomide could ameliorate the histopathological conditions of BDL rats. Furthermore, the chronic treatment by this drug diminished the elevated levels of NO, TNF-α and IL-6 in BDL animals. On the other hand, hepatic SOCS1 expression was up-regulated by thalidomide treatment in this group.
Conclusion: Thalidomide improves the chronotropic hyporesponsiveness of isolated atria in BDL. This effect is probably mediated by the inhibiting NO, TNF-α and IL-6 production, reducing portal pressure and increasing the expression of SOCS1.- انتشار مقاله: 08-03-1397
- نویسندگان: Ali Hosseini-chegeni,Farahnaz Jazaeri,Aliakbar Yousefi-Ahmadipour,Mansour Heidari,Alireza Abdollahi,Ahmad Reza Dehpour
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Basic Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Testis,Apoptosis,Ischemia-reperfusion,Testicular torsion,Rapamycin
- چکیده:
- چکیده انگلیسی: Objective(s):Rapamycin is an immunosuppressant compound with a broad spectrum of pharmaco-logical activities. In recent years, it has been used successfully to decrease ischemia-reperfusion injury in several organ systems. The purpose of the present study was to examine the effect of rapamycin on testicular ischemia-reperfusion injury.
Materials and Methods: Seventy-two adult male Wistar rats were divided into six groups: control (group1), sham-operated (Group2), T/D + DMSO as vehicle group (group3), and groups 4–6; respectively received 0.5, 1, and 1.5 mgkg-1 of rapamycin , IP 30 min before detorsion. Ischemia was achieved by twisting the right testis 720o clockwise for 1 hr. The right testis of 6 animals from each group were excised 4 hr after detorsion for the measurement of lipid peroxidation, caspase-3, and antioxidant enzyme activities. Histopathological changes and germ cell apoptosis were determined by measuring mean of seminiferous tubules diameters (MSTD) and TUNEL test in right testis of 6 animals per group, 24 hr after detorsion.
Results: Testicular T/D caused increases in the apoptosis, malondialdehyde (MDA), and caspase-3 levels and decreases in the superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) activities in ipsilateral testis (P<0.001). The rats treated with rapamycin had significant decreases in the MDA and caspase-3 levels and significant increases in the SOD, CAT and GPx activities in ipsilateral testis compared with the T/D group (P<0.001); germ cell apoptosis was decreased, and MSTD was improved.
Conclusion: Rapamycin administration during testicular torsion decreased ischemia/reperfusion (I/R) cellular damage.- انتشار مقاله: 14-05-1396
- نویسندگان: Morteza Ghasemnejad-berenji,Mahmoud Ghazi-Khansari,Iraj Yazdani,Seyed Soheil Saeedi Saravi,Maliheh Nobakht,Alireza Abdollahi,Javad Mohajer Ansari,Hojjat Ghasemnejad-berenji,Sarvin Pashapour,Ahmad Reza Dehpour
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Basic Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Pain,diabetes,Neuropathy,Intrathecal,WIN 55,212-2
- چکیده:
- چکیده انگلیسی: Objective(s):Diabetic neuropathy (DN) is a common complication of diabetes that leads to allodynia, impaired nerve conduction, and progressive sensory loss. The aim of this study was to observe the effect of a high-affinity cannabinoid receptors agonist, WIN 55,212-2, on thermal hyperalgesia, nerve conduction velocity and sciatic nerve histopathology in diabetic rats. Materials and Methods: Diabetes was induced in rats using a single dose of streptozotocin (45 mg/kg IP). Results: Intrathecal (IT) administration of WIN55, 212-2 (1, 10, 100 µg/10 µl, IT), produced antinociceptive effects in the hot plate test and also improved nerve conduction velocity (100 µg/10 µl, IT) and sciatic nerve histology. Conclusion: These data show that cannabinoids have potent antinociceptive effects through direct actions in the spinal dorsal horn of nociceptive pathway. This suggests that intrathecally administered cannabinoids may offer hopeful strategies for the treatment of diabetic neuropathic pain.
- انتشار مقاله: 05-02-1395
- نویسندگان: Samane Jahanabadi,Mohamad Reza Hadian,Javad Shamsaee,Seyed Mohammad Tavangar,Alireza Abdollahi,Ahmadreza Dehpour,Shahram Ejtemaei Mehr
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Group Theory
- نوع مقاله: Journal Article
- کلمات کلیدی: Noninner automorphism,finite p-groups,the center
- چکیده:
- چکیده انگلیسی: A longstanding conjecture asserts that every finite nonabelian $p$-group admits a noninner automorphism of order $p$. Let $G$ be a finite nonabelian $p$-group. It is known that if $G$ is regular or of nilpotency class $2$ or the commutator subgroup of $G$ is cyclic, or $G/Z(G)$ is powerful, then $G$ has a noninner automorphism of order $p$ leaving either the center $Z(G)$ or the Frattini subgroup $Phi(G)$ of $G$ elementwise fixed. In this note, we prove that the latter noninner automorphism can be chosen so that it leaves $Z(G)$ elementwise fixed.
- انتشار مقاله: 07-12-1391
- نویسندگان: Alireza Abdollahi,S. Mohsen Ghoraishi
- مشاهده
- جایگاه : پژوهشی
- مجله: Avicenna Journal of Phytomedicine
- نوع مقاله: Journal Article
- کلمات کلیدی: hypertension,Cholesterol,Cinnamon,HDL,LDL
- چکیده:
- چکیده انگلیسی: Objective: Cinnamon effect on blood pressure remains controversial. The present pilot study assessed cinnamon effect on blood pressure, and metabolic profile of stage 1 hypertension patients (S1HTN).
Materials and Methods: This double-blind placebo-controlled randomized trial was conducted between June and October 2019, in Mashhad, Iran. Study inclusion criteria comprised S1HTN diagnosis, based on 24-hour ambulatory blood pressure monitoring (ABPM). Subjects were randomly assigned to two groups: cinnamon group (capsule, 1500 mg/day, 90 days) and placebo group. On days 0 and 90, ABPM derived systolic and diastolic blood pressure (SBP and DBP, respectively), blood lipid profile, and fasting blood sugar (FBS) were recorded.
Results: The two groups did not differ significantly regarding vascular risk factors, educational status, lipid profile and blood pressure at baseline, except for lower HDL-c in cinnamon group (p=0.03). On day 90, there was no significant difference between two study groups for lipid profile and blood pressure. A statistically significant decrease in mean 24-hr SBP and mean day SBP was observed in the cinnamon group, while mean night SBP and mean night DBP were decreased significantly in the placebo group after 90 days. A statistically significant decrease in mean change of day value of SBP was found in the cinnamon group, compared to the placebo. On day 90, FBS remained practically unchanged but a significant increase in HDL-c (5.8 unit; p=0.01) and a significant decrease in LDL-c levels (17.7 unit; p=0.009) were observed in the cinnamon group compared to placebo group.
Conclusion: Cinnamon caused a statistically significant decrease in mean ambulatory SBP but in a clinically moderate way, and lipid profile was significantly improved. Therefore, cinnamon might be considered a complementary treatment in subjects with S1HTN.- انتشار مقاله: 19-01-1399
- نویسندگان: Fatemeh Shirzad,Negar Morovatdar,Ramin Rezaee,Konstantinos Tsarouhas,Alireza Abdollahi Moghaddam
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Squamous Cell Carcinoma,Gene expression,Nanog,SOX2,Oct4
- چکیده:
- چکیده انگلیسی: Objective: Oral squamous cell carcinoma (OSCC) accounts for over 90% of oral neoplasms. Finding molecular
markers for predicting prognosis is a high priority. The core transcription factors, OCT4, SOX2, and NANOG that
regulate embryonic stem cell pluripotency have been implicated in progression of various malignancies. The predictive
value of these markers and their role in the development of OSCC is still controversial. In this study, we therefore
evaluated their expression in OSCCs and adjacent non-tumor tissue. Methods: A total of 60 frozen tumor and adjacent
non-tumor tissue samples from 30 patients with OSCC were examined using quantitative reverse transcription polymerase
chain reaction (qRT-PCR). Clinical and pathological data of patients including tumor stage, lymph node metastasis
and tumor grade were also recorded. Results: Expression of SOX2 was significantly higher in adjacent non-tumor as
compared to tumor tissue (P=0.04). No statistically significant differences were found for expression of OCT4 (P=0.50)
and NANOG (P=0.68). Also, there was no significant association between expression of OCT4, SOX2, and NANOG
and clinical or pathological data (P>0.05), although slightly higher values were noted in patients without lymph node
metastasis. Conclusion: Based on the present data, decreased expression of SOX2 is correlated with carcinogenesis
in the oral cavity and development of OSCC.- انتشار مقاله: 06-10-1396
- نویسندگان: Fereshteh Baghai Naini,Pouyan Aminishakib,Alireza Abdollahi,Mahshid Hodjat,Hadiseh Mohammadpour,Neda Kardouni Khoozestani
- مشاهده