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- جایگاه : پژوهشی
- مجله: Iranian Journal of Pathology
- نوع مقاله: Journal Article
- کلمات کلیدی: Adenosine deaminase,C reactive protein,Brucelloses
- چکیده:
- چکیده انگلیسی: Background and Objective: Brucellosis is a main transmittable zoonotic disease, which is endemic, and a common health burden in Iran. Adenosine deaminase (ADA) is an essential enzyme which is involved in purine metabolism and its role in immune system is very important. The aim of this study was to determine serum changes of ADA and C-reactive protein (CRP) levels in patients with brucellosis. Patients and Methods: The study was a case-control one on 36 patients and 36 controls. The serum level of ADA and quantitative CRP was measured in both patients and controls. We also measured the Wright, Coomb,s Wright and 2-mecapto ethanol (2ME) in two participants groups. Statistical analysis was performed using SPSS for windows Version 11.5 Results: ADA serum level in patients group showed a significant difference compared to control group (31.64±25.1 vs. 13.97±3.9, P<0.0001). Quantitative CRP level in patients group was higher than control group significantly (25 ±20.7 vs 6.9±4.4 , P,s Wright, and 2ME with serum ADA and CRP levels (P=NS). Conclusion: This finding shows the serum level of ADA and CRP are two important parameters in diagnosis, treatment of brucellosis with the considering of the clinical manifestations and other paraclinic findings. However it is advisable to perform more studies.
- انتشار مقاله: 06-07-1393
- نویسندگان: Alireza Abdollahi,Mehrnaz Rasoulinejad,Seyed Jalil Mousavi,Fatemeh Fattahi,Akram Sarbiaei
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pathology
- نوع مقاله: Journal Article
- کلمات کلیدی: Iran,Nerve Sheath Tumors,Head Neoplasms,Neck Neoplasms
- چکیده:
- چکیده انگلیسی: Background and Objective: Approximately 45% of benign peripheral nerve sheath tumors (PNST) occur in head and neck regions. Malignant peripheral nerve sheath tumors (MPNST) are less common and only 8-15% of these tumors occur in head and neck region. In this study, we aimed at evaluating the demographic characteristics, pathologic findings, locations, main clinical presentations and family history of these tumors in head and neck regions. Patients and Methods: In a cross sectional and retrospective study, we analyzed head and neck peripheral nerve sheath tumors in patients who referred to Amir-Aalam Hospital affiliated to Tehran University of Medical Sciences for 10 years (1996 to 2005). Results: There were 113 cases with a kind of nerve sheath tumor; the female/male ratio was 1.09. The frequency of schwannoma, neurofibroma and MPNST was 66.37%, 30.1% and 3.53%, respectively including 39 cases of acoustic neuroma, 18 cases of cervical nerve trunk involvement, 12 cases of facial nerve involvement, 11 cases of the 10th cranial nerve PNST and only one case of cervical sympathetic nerve involvement. Conclusion: Schwannomas are the most common types of PNSTs seen in head and neck regions, and aucoustic neuroma comprises the majority of them. About 25- 45% of extracranial schwannomas also occur in head and neck regions that usually present a slow growing of the mass lesion and various mass effects. Although neurofibroma and MPNSTs are less common, they must be kept in mind as differential diagnoses of other benign and malignant lesions in this region.
- انتشار مقاله: 06-07-1393
- نویسندگان: Alireza Abdollahi,Hedieh Moradi Tabriz,Ebrahim Razmpa
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pathology
- نوع مقاله: Journal Article
- کلمات کلیدی: Carcinoma,Chronic Granulomatous Disease,Prostatitis
- چکیده:
- چکیده انگلیسی: Background and Objective: Non-specific granulomatous prostatitis is an uncommon diffuse inflammatory condition of the prostate. It is important because it may be mistaken for prostatic carcinoma. The aim of the study was to determine the prevalence of non-specific granulomatous prostatitis (NSGP) and comparing the results of transrectal ultrasonography, serum prostate specific antigen (PSA) and free prostate specific antigen levels, digital rectal exam (DRE) in NSGP with the prostate carcinoma and benign prostate hyperplasia. Materials and Methods: During a cross-sectional study, the prostate needle biopsy cases with the granulomatosts prostatitis diagnosis that had been referred to one of the largest pathology centers (1 year: 2006) were found and their clinical files were revised from the point of DRE, transrectal ultrasonography (TRUS), FPSA, and PSA. Some clinical and pathology findings such as age, microscopic findings, sonography information and experimental findings that had been necessary for the study were gathered and analyzed using SPSS software. Results: Out of 783 needle biopsies of prostate, 8 (1.02%) cases were non-specific granulomatous prostatitis. The age range of patients was 55-76 years (with a mean of 66.1 years). Mean of PSA level was 19.45 ng/ml and fPSA level was 0.7 ng/ml. In 2 patients, TRUS showed focal hypoechoic areas and in other 2 of these DRE revealed asymmetry and mild nodularity. Conclusion: There is no pattern of clinical, biochemical or ultrasound findings that allows a specific diagnosis of granulomatous prostatitis to be made or differentiate it from prostatic carcinoma and the biopsy is still necessary for the certain disease diagnosis.
- انتشار مقاله: 07-07-1393
- نویسندگان: Alireza Abdollahi,Alireza Abdollahi,Alireza Abdollahi
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pathology
- نوع مقاله: Journal Article
- کلمات کلیدی: Celiac disease,Antibodies,gliadin,Transglutaminases
- چکیده:
- چکیده انگلیسی: Background and Objective: Celiac disease is an autoimmune disorder, characterized by inflammation, villous atrophy, and crypt hyperplasia of the small bowel mucosa. In this study we considered and compared sensitivity and specificity of serological tests in patients with celiac disease. Materials and Methods: In this cross-sectional study we prospectively recruited children with suspected celiac disease. An intestinal biopsy specimen was obtained from all patients. Celiac disease diagnosed on the basis of histologic findings of Marsh classification. A serum sample was taken at the time of biopsy for serologic tests. Findings were analyzed using SPSS program, t-test, and chi-square tests. Results: Out of a total of 134 children in this study, seventy (52.21%) patients were boy and sixty four (47.8%) patients were girl. Celiac disease was diagnosed in 14 (10.4%) of the patients. In serologic tests, 11 patients (78.6%) were positive for antigliadin-Ab, 4 (28.6%) for anti tissue-transglutaminase Ab, and 9 (64.3%) for antiendomysial antibody. Sensitivity of antigliadin-Ab was 78.6% and its specificity was 95.9%. Sensitivity of anti tissue-transglutaminase Ab was 28% and its specificity was 95%. Sensitivity of antiendomysial Ab was 64% and its specificity was 96%. Conclusion: Positive serologic tests are supportive of the diagnosis in those with characteristic histopathologic changes on small intestinal biopsy. The best tests for this purpose are the IgA antiendomysial antibody or IgA anti tissue-transglutaminase, both of which are highly sensitive and specific.
- انتشار مقاله: 07-07-1393
- نویسندگان: Alireza Abdollahi,Mitra Mehrazma,Elham Talachian
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pathology
- نوع مقاله: Journal Article
- کلمات کلیدی: Hepatitis C,Hemophilia,Human Immunodificiency Virus
- چکیده:
- چکیده انگلیسی: Background and Objective: Although transfusion therapy has lead to great improvement in longevity for hemophiliacs, but there have been tragic setbacks especially from transmission of human immunodeficiency virus (HIV) and hepatitis C virus (HCV) .HIV was reported to increase the rate of HCV-related liver failure by 4.2 times. In this study, we aimed to determine the seroprevalence of HIV and HCV, the association of HCV with abnormal liver tests, impact of HIV on HCV-related abnormalities and the distribution of HCV genotypes in Iranian hemophiliacs. Patients and Methods: In a cross-sectional study, we determined virological, clinical and epidemiological characteristics for HIV and HCV infection of 236 hemophiliacs attending our center. Data were analyzed using Chi-square test. Results: Ten (4.7%) out of 211 patients tested were HIV seropositive and 145 (83.3%) were HCV seropositive. All tested positive HIV patients also had HCV. HCV seroprevalence was significantly higher in patients with hemophilia A and B as compared to other congenital coagulopathies and it was directly related to coagulation severity. HCV seroprevalence was lower in hemophiliacs with positive HBsAg (p = 0.03) but it did not differ by HBcAb or HBsAb results. HCV genotype 1a (48.5%) was predominant type and genotype 3a (33.3%) was also common. Frequency of abnormal aspartate aminotransferase and alanine aminotransferase liver enzymes was significantly higher in the HCV positive group (p = 0.006). Conclusion: This study provides evidence that hepatitis c virus infection is a major problem for Iranian hemophiliacs and it has higher prevalence in hemophiliacs with higher age, more severe coagulopathies, abnormal alanine aminotransferase level, and human immunodeficiency virus co-infection.
- انتشار مقاله: 07-07-1393
- نویسندگان: Alireza Abdollahi,Reza Shahsiah,Mohssen Nassiri Toosi,Manije Lak,Katayoun Karimi,Mohammadreza Managhchi,Katayoun Samimi-rad
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pathology
- نوع مقاله: Journal Article
- کلمات کلیدی: Carcinoma,Breast,Tissue array,Biologic markers
- چکیده:
- چکیده انگلیسی: Background and Objective: In this study, we explored expression rate, some biomarkers affecting the prognosis of the breast carcinoma, and the relationship between these markers and clinicopathologic features of the disease as well as the relationship between each of these markers through a tissue array technique. Materials and Methods: This study was an observational and cross-sectional study. From 100 breast samples which had been diagnosed as invasive ductal carcinoma, blocks were prepared through a tissue array method and were stained by monoclonal antibodies of the markers. All data were analyzed using SPSS program. Results: The appearance rate of EGF-R marker had a direct relationship with the degree of malignancy (p=0.026), metallothionein marker with the mean number of mitosis (p=0.044), sialyl-Tn marker with the macroscopic size of tumor (p=0.036), the appearance of cyclin B1 marker with the appearance of metallothionein marker (p=0.012), and the appearance rate of EGF-R marker had a reverse relationship with Nm23 (p=0.020). Conclusion: Through investigating the relationship between some biomarkers such as EGF-R and metallothionein and the clinicopathogenic features of tumor or the relationship between each marker and the other parameters, we can assess the state of invasion and metastasis process or the degree of its malignancy or determine its prognosis.
- انتشار مقاله: 07-07-1393
- نویسندگان: Alireza Abdollahi,Issa Jahanzad,Peyman Mansuri Mehrabani
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pathology
- نوع مقاله: Journal Article
- کلمات کلیدی: Glumerulonephritis,Electron microscope,Kidney biopsy
- چکیده:
- چکیده انگلیسی: Background and Objective: Glumerular diseases are among the most prevalent causes of renal chronic insufficiencies. This study aimed to analyze the prevalence of various kinds of glumerulonephritis based on the findings of electron microscope. Materials and Methods: This study had a descriptive retrospective and cross sectional strategy. Slides of patients (124 cases) who had undergone kidney biopsy during a one-year period due to renal diseases were reviewed and compared. The required data were collected and analyzed using SPSS software. Results: It was found out that 52.4% of the patients were female and 47.6% were male. The average age of the female patients was 28.26 and of the male ones was 29.8 years old. The most prevalent type of glumerulonephritis was membranous and the most prevalent stage was stage II. The prevalent fluorescence pattern of the IgG deposits in the basal membrane of glomerulus. Conclusion: Regarding the variety in the prevalence of different kinds of glumerulonephritis fond within different ages and sex, all cases should be taken into consideration while dealing with the patients. It should also be noticed that immunofluorscence is a complementary diagnosis method and does not have much use without electron and light microscope. In those cases where several contradictory diagnoses have been suggested in light microscope or a particular change has not been observed or the sample has not been sufficient to be analyzed, electron microscope has a final and significant role.
- انتشار مقاله: 07-07-1393
- نویسندگان: Alireza Abdollahi,Issa Jahanzad,Siamak Fakhrian
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pathology
- نوع مقاله: Journal Article
- کلمات کلیدی: Helicobacter pylori,Gastric cancer,Peptic ulcer
- چکیده:
- چکیده انگلیسی: Background and Objective: Long period risk of gastric carcinoma in people affected with chronic Helicobacter pylori gastritis is 5 times more than normal people. Perhaps histological changes due to helicobacter pylori infection could be used for screening people at risk of gastric carcinoma and peptic ulcer. Materials and Methods: This study has been carried out as a cross-sectional process and we compared histological changes observed in Helicobacter pylori chronic gastritis in 30 patients with peptic ulcer and 30 patients without the ulcer and then classified them according to Sydney scoring system, and after collecting data, we analyzed them by SPSS software. Results: Sixty percent of patients with ulcer were male and forty percent were female. In addition, 56.7% of patients without ulcer were male and 43/3% were female without a statistically significant difference (p = 0.793). Mean age in ulcer group was 56.4 years and in non-ulcer group was 48.9 years that there was no significant statistical difference (p = 0.057). Chronic gastritis frequency increases within people in their sixth decade and after that. There was no significant difference for degree of infection with Helicobacter pylori (p = 0.346), metaplasia (p =0.885), chronicity (p = 0.796) and degree of activity (p = 0.249), atrophy (p = 0.781) in patients with or without ulcer. Conclusion: There was no significant difference in any of the variables of the study including degree of infection with Helicobacter pylori, chronicity, disease activity and intestinal metaplasia between both groups with and without peptic ulcer.
- انتشار مقاله: 07-07-1393
- نویسندگان: Alireza Abdollahi,Farid Azmoudeh Ardalan,Hossein Foroutan,Firouzeh Moradkarami
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pathology
- نوع مقاله: Journal Article
- کلمات کلیدی: Serratia marcescens,Endocarditis,Mediastinitis
- چکیده:
- چکیده انگلیسی: Serratia marcescens (S.M) is a species of gram–negative bacteria in the family enterobacteriaceae. A human pathogen, S. marcescens is involved in nosocomial infections, particularly in urinary tract and wound infections. This report describes a 63 years-old man that referred to hospital with dyspnea FC IV and he underwent cardiac valves replacement surgery with a diagnosis of severe mitral stenosis (M.S), severe tricuspid regurgitation (T.R), and moderate aortic insufficiency (A.I). Five days after operation, he presented with 40 °C fever, respiratory distress, elevation of liver enzymes, and decreased consciousness. Sepsis work up showed positive blood culture for Serratia marcescens. Despite therapy, he died due to Serratia marcescens endocarditis and mediastinitis. Positive blood culture for Serratia marcescens is very rare but it should be considered in post operation patients after cardiac valve replacement presenting with fever. Besides, prevention of endocarditis due to Serratia marcescens should be observed.
- انتشار مقاله: 07-07-1393
- نویسندگان: Alireza Abdollahi,Shaghayegh Nasirpour,Narges Shahmohammad3,Ali Zolfaghari
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pathology
- نوع مقاله: Journal Article
- کلمات کلیدی: Computed Tomography,Fluoroscopy,needle biopsy
- چکیده:
- چکیده انگلیسی: Background and Objective: Computerized tomography and fluoroscopic computerized tomography are amongst the methods used for guiding needle biopsy processes; however, fluoroscopic computerized tomography demonstrates the images during the process of biopsy. This study aims to compare and contrast the success of biopsy under guide of computerized tomography and fluoroscopic computerized tomography, independently and based on the location of the mass. Background and Objective: Computerized tomography and fluoroscopic computerized tomography are amongst the methods used for guiding needle biopsy processes; however, fluoroscopic computerized tomography demonstrates the images during the process of biopsy. This study aims to compare and contrast the success of biopsy under guide of computerized tomography and fluoroscopic computerized tomography, independently and based on the location of the mass. Results: In this study, among 206 subjects, 122 were examined under guide of fluoroscopic tomography and 84 under guide of conventional computerized tomography. In all anatomical locations of the mass except for mediastinum, negative cases of biopsy in conventional computerized tomography were more than fluoroscopic computerized tomography the total rate of success in fluoroscopic computerized tomography group was 86.1% and in conventional computerized tomography it was 76.2%. Conclusion: The results of this study showed that the fluoroscopic computerized tomography in biopsy is more successful than conventional computerized tomography in pelvis, abdomens, bone and liver and this might be the result of the feasibility of watching the biopsy needle during the procedure.
- انتشار مقاله: 06-07-1393
- نویسندگان: Alireza Abdollahi,Mitra Mehrazma,Hossein Ghanaati
- مشاهده