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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pathology
- نوع مقاله: Journal Article
- کلمات کلیدی: HIV,Cytomegalovirus,Serology,Toxoplasmosis
- چکیده:
- چکیده انگلیسی: Background and Objective: Opportunistic infections are the leading cause of death among patients subjected to the human immunodeficiency virus (HIV) infection and acquired immune deficiency syndrome (AIDS). The aim of this study was to compare the seroprevalence of Cytomegalovirus (CMV) and toxoplasmosis infection in newly diagnosed HIV infected patients with healthy controls and it’s correlation with CD4+ cell counts (CD4+). Materials and Methods: A case controlled study was carried out to investigate CMV and toxoplasmosis serology among newly diagnosed HIV infected patients referred to University affiliated hospital in Tehran and compared them to healthy subjects as control. A total of 100 HIV positive patients and 100 healthy controls were recruited. Clinical characteristics and CD4+ cell counts were evaluated. The statistical package SPSS 17 for windows was used for analysis. Results: Patients with HIV infection had a significantly higher positive serology for CMV than healthy controls (100% vs. 93% P<0.05). There was no significant difference between HIV positive and HIV negative patients in terms of toxoplasmosis serology. There was no significant difference between males and females with respect to CMV or toxoplasmosis serology. Conclusion: CMV and toxoplasmosis infection are highly prevalent among HIV infected patients and also healthy controls, with a higher seropositive rate of CMV in HIV cases.
- انتشار مقاله: 01-04-1391
- نویسندگان: Alireza Abdollahi,Saeed Shoar,Sara Sheikhbahaei,Siroos Jafari
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pathology
- نوع مقاله: Journal Article
- کلمات کلیدی: White blood cell count,Gamma Glutamyltransferase,C- Reactive Protein
- چکیده:
- چکیده انگلیسی: Background & Objective: There are many common infections and inflammations among people over the world. This demands an affordable and reliable test with high sensitivity/specificity to predict or confirm the diagnosis of such cases in routinely clinical practice. In the present study, we aimed to find any potential correlation between serum levels of GGT and CRP- Q and/or hs- CRP and WBC count as the well- known markers of inflammation in human body. Materials and Methods: Through a cross- sectional study, serum levels of CRP-Q, hs- CRP, and GGT, in addition to WBC count were measured in 1,500 healthy people, referred to Blood Transfusion Organization from across the country. Data were analyzed after the patients were checked by physical examination for ruling out the presence of any inflammation or other illness. Serum levels of GGT, CRP- Q, hs- CRP, and WBC count were analyzed by SPSS for windows version 16. Results: Analysis showed a positive linear correlation between CRP- Q and hs- CRP with GGT also confirmed by non- parametric tests. Conclusion: Serum GGT may be an inflammatory index and a useful marker in approaching to inflammatory diseases.
- انتشار مقاله: 22-06-1390
- نویسندگان: Alireza Abdollahi,Saeed Shoar
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pathology
- نوع مقاله: Journal Article
- کلمات کلیدی: Bacteria,Hospital,Air
- چکیده:
- چکیده انگلیسی: Background and Aims:Nosocomial infections cause considerable morbidity and mortality and pose high financial burden on healthcare systems. Although surface contact, surgical incisions, wounds and catheters are responsible for a high percentage of nosocomial infections, bacterial and fungal air contaminations in hospitals have an important role in development of hospital infections. The purpose of this study was to determine the microbial profile of air contamination in some hospital wards. Furthermore, we compared the results with cultures obtained from hospitalized patients. Materials and Methods:We performed a cross-sectional analysis at Imam Hospital, Tehran, Iran. Active (Quick Take 30 pump) and passive air samplings were performed in different wards of the hospital. Air samples were cultured to detect fungi and microorganisms. The results were compared with cultures obtained from hospitalized patients at the same time. Air microbial profiles of various wards were also compared. Results: The microbial profile of air samples showed that Micrococcus was the most common bacteria. Cladosporium was the most frequent fungi found while Aspergillus niger and Alternaria were the least frequent ones. Conclusion:In some wards, the results of blood cultures were similar to microbial profile of air samples. Thus, utilizing air purification systems and air sterilization is recommended. Our findings emphasized the role of regular monitoring of the biological risk for both patient and health care workers. The results would be useful in planning for employing appropriate strategies to reduce air burden in this hospital and other hospitals with similar conditions.
- انتشار مقاله: 15-06-1390
- نویسندگان: Alireza Abdollahi,Sanam Mahmoudzadeh
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pathology
- نوع مقاله: Journal Article
- کلمات کلیدی: Atorvastatin calcium,Lipoprotein A,Acute Coronary Syndromes
- چکیده:
- چکیده انگلیسی: Background and Objectives: Lipoprotein-a potentially represents a useful tool for risk stratification in cardiovascular accidents. The aim of this study was to evaluate the atorvastatin effect on serum lipid profile & lipoprotein A. Material & Methods: In 2009, 405 patients with acute coronary syndrome randomly were divided into 2 groups, taking 20 & 40 mg atorvastatin daily for 3 months. Lipid profile & lipoprotein-A serum levels were checked at the beginning of the study and also one and three months later. Results: There was no statistical difference between the two groups in all measurements except in patients with unstable angina. The difference lay in the change of LP-a level after one month (P=0.045) and in apo-A level in all patients in the second and the third measurements compared with the first one (P=0.001 & P=0.002). Discussion: It appears that the two doses (20mg and 40mg) of atorvastatin have a reduction effect on lipoprotein-A and serum lipid levels, but no difference is seen in the level of reduction. The 40 mg atorvastatin leaves more effects on reduction of apo-A than on the 20 mg after one and three months.
- انتشار مقاله: 20-03-1390
- نویسندگان: Amirfarhang Zand Parsa,Sara Ashoori,Alireza Abdollahi
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pathology
- نوع مقاله: Journal Article
- کلمات کلیدی: Creatinine,Troponin-T,Troponin-I,Left Ventricular Dysfunction,Chronic Renal Failure
- چکیده:
- چکیده انگلیسی: Background and Objectives: The aim of this study was to survey the relationship between the level of creatinine,cardiac troponins serum and the function of the left ventricle in patients with kidney insufficiency,without acute coronary syndrome. Materialsand Methods:The sample was150 patients with nondialysis chronic kidney disease without acute coronary syndrome, hospitalized at Imam Khomeini Center through 2008-2009. All the patients had serum creatinine (cr) 1.5mgor greater and no symptoms of acute coronary syndrome in the first month. Serum Cr and troponin T and I were measured in blood samples and patients left ventricular function (LVEF) were estimated by echocardiography. Then based on the objectives, the findings were analyzed with SPSS soft ware. Results:Serum troponin T levels were significantly higher in patients with greater Cr levels but there was no significant relationship between troponin I and Cr levels. Patients with greater degrees of LV dysfunction had significantly upper levels of troponin T(P=0.0001). In this category, patients with diabetes, old age, cigarette smokers, greater levels of Cr, advanced stages of chronic kidney disease and greater degrees of LV dysfunction showedsignificantly higher levels of troponin T(P=0.0001). Conclusion:To identify chronic kidney disease patients at increased risk for cardiovascular events, serum troponin T can be used. In high-riskpatients, the evaluation for cardiovascular diseases could be done earlier in the course of chronic kidney disease.
- انتشار مقاله: 28-06-1393
- نویسندگان: Amir Farhang Zand-Parsa,Mahsa Sedaghati-Hagh,Mitra Mahdavi-Mazdeh,Alireza Abdollahi
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pathology
- نوع مقاله: Journal Article
- کلمات کلیدی: Newborn,Sepsis,Group B Streptococcal
- چکیده:
- چکیده انگلیسی: Newborns’ bacterial infections due to group B Streptococcus (GBS) happen in two forms including early-onset disease or late-onset disease. In this paper, we report a case of early-onset GBS infection in a male infant. A 22-year-old primigravid woman delivers a term normal looking male infant. Nasal flaring, grunting, and poor feeding presented soon after birth. An empiric treatment with intravenous ampicillin and amikacin initiated. On the second day, he was transferred to Newborn Intensive Care Unit (NICU). The intravenous antibiotics were changed to tazocin and vancomycin in NICU. The blood culture (BC) was positive for GBS. After 48 hours, respiratory distress symptoms disappeared, BC was negative, and ABG and CBC became normal. Finally, the infant was discharged after 15 days.GBS is a normal flora of women's gastrointestinal and genitourinary tracts. Infants with early-onset GBS sepsis need very close observation including repeated vital signs evaluation.
- انتشار مقاله: 28-06-1393
- نویسندگان: Alireza Abdollahi,Hedieh Moradi-Tabriz,Baharak Mehdipour Aghabagher
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pathology
- نوع مقاله: Journal Article
- کلمات کلیدی:
- چکیده:
- چکیده انگلیسی:
- انتشار مقاله: 29-06-1393
- نویسندگان: Alireza Abdollahi,Alireza Abdollahi,Alireza Abdollahi
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pathology
- نوع مقاله: Journal Article
- کلمات کلیدی:
- چکیده:
- چکیده انگلیسی: Background and Objectives: A. baumannii is a cause of various infections with significant morbidity and mortality in the world. The aim of this study was to determine infection rate and antimicrobial susceptibility of A. baumannii in an Iranian tertiary care Hospital. Materials and Methods: This study was performed on 166 positive blood cultures for A. baumannii, received from different wards of Imam Hospitals complex in Tehran, during two years. Disk diffusion method was used to survey several antibiotics resistance. Data were analyzed by spss software, chi square test. Results: A. baumannii was resistant to imipenem (26.9%), gentamicine (32.2%), carbenicillin (36.4%), cephotaxime(41.7%), ampicillin (66.7%), amikacine (69.4%), ciprofloxacin (74.3%), cotrimoxazol (86.3%),piperacillin (91%), Ceftriaxone (92.5%), cefixime (99.2%), amoxiclave (100%), cefepime(100%), ceftazidime (100%). ICUs (50.6%) and Pediatrics Wards (2.4%) were the most and the least frequent wards in which A. baumannii were isolated. Conclusions: Due to antibiotic resistance pattern change among A. baumannii and its consequences, it is recommended to control infection associated risk factors as well as further researches aiming identification of different of patterns in resistance and sensitivity to antibiotic.
- انتشار مقاله: 29-06-1393
- نویسندگان: Hedieh Moradi-Tabriz,Alireza Abdollahi,Baharak Mehdipour,Saeideh Mahfoozi
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pathology
- نوع مقاله: Journal Article
- کلمات کلیدی: HIV,Salmonella typhimurium,Pneumonias
- چکیده:
- چکیده انگلیسی: HIV-related Immunosuppression significantly increases the risk of acquiring opportunistic infections. This report describes a 69-year-old man, referred to hospital with decreased consciousness and productive cough. This man was a known case of human immunodeficiency virus positive. The sputum of this patient was positive for Salmonella typhimurium. Pulmonary auscultation signaled brief and scattered crackles especially in the lung bases. Lung graphy showed bronchopulmonary infiltration. Diagnosed with pneumonia due to Salmonella, the patient underwent treatment but he succumbed after 48 hours in septic shock. This case report demonstrates the importance of including general medical causes of immunosuppression and their treatment in the differential diagnosis and aetio-pathogenesis of HIV-infected patients with unusual clinical presentations.
- انتشار مقاله: 29-06-1393
- نویسندگان: Alireza Abdollahi,Hedieh Moradi-Tabriz,Mehrnaz Rasoulinejad
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pathology
- نوع مقاله: Journal Article
- کلمات کلیدی: Iran,Lipoma,Sigmoid colon
- چکیده:
- چکیده انگلیسی: Lipomas of the gasterointestinal Tract are relatively uncommon in clinical practice. Most cases are asymptomatic with small tumor size and do not need any special treatment but the large ones are known to cause symptoms such as abdominal pain, obstruction, intussusceptions, and bleeding. The majority (90%) of these lesions are submucosal with predominantly right sided with a slight preponderance in females. Recurrence or malignant transformation has not documented in these lesions. We present a case of giant submucosal lipoma in a 33 years old male in sigmoid colon presenting with abdominal pain and rectal bleeding from Imam Hospitals’ complex, Tehran-Iran. In patients with gastrointestinal symptoms and large mass in sigmoid and with non-specific findings in colonoscopy, this disease has to be taken into consideration.
- انتشار مقاله: 06-07-1393
- نویسندگان: Alireza Abdollahi,Hayedeh Haeri,Alireza Alaie Alamooti
- مشاهده