در هنگام جستجو کلمه در قسمت عنوان میتوانید کلمات مورد جستجو را با کاراکتر (-) جدا کنید.
کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pathology
- نوع مقاله: Journal Article
- کلمات کلیدی: safety,Aryoseven,bleeding disorders
- چکیده:
- چکیده انگلیسی: Background: Recombinant activated factor VII induces hemostasis in patients with coagulopathy disorders. AryoSeven™ as a safe Iranian Recombinant activated factor VII has been available on our market. This study was performed to establish the safety of AryoSeven on patients with coagulopathy disorder. Methods: This single-center, descriptive, cross sectional study was carried out in Thrombus and Homeostasis Research Center ValiAsr Hospital during 2013-2014. Fifty one patients with bleeding disorders who received at least one dose of Aryoseven were enrolled. Patients’ demographic data and adverse effect of drug and reaction related to Aryoseven or previous usage of Recombinant activated FVII were recorded in questionnaires. Finally data were analyzed to compare side effects of Aryoseven and other Recombinant activated FVII brands. Results: Aryoseven was prescribed for 51 Patients. Of all participants with mean age 57.18+21.38 yr, 31 cases were male and 26 subjects had past history of recombinant activated FVII usage. Glanzman was the most frequent disorder followed by congenital FVII deficiency, hemophilia with inhibitors, factor 5 deficiency, acquired hemophilia, hemophilia A with inhibitor, and hemophilia A or B with inhibitor. The majority of bleeding episodes had occurred in joints. Three patients (5.9%) complained about adverse effects of Aryoseven vs. 11.5 % about adverse effects of other brands. However this difference was not significant, statistically. Conclusion: Based on monitor patients closely for any adverse events, we concluded that Aryoseven administration under careful weighing of benefit versus potential harm may comparable with other counterpart drugs. How to cite this article: Toogeh G, Abolghasemi H, Eshghi P, Managhchi M, Shaverdi-niasari M, Karimi K, et al. Evaluation of Aryoseven Safety (recombinant activated factor VII) in patients with bleeding disorders (An observational post-marketing surveillance, study). Iran J Pathol. 2016; 11(3):204-9.
- انتشار مقاله: 23-08-1393
- نویسندگان: Gholamreza Toogeh,Hassan Abolghasemi,Peyman Eshghi,Mohammadreza Managhchi,Mohammadreza Shaverdi-niasari,Katayoon Karimi,Samin Roostaei,Neda Emran,Alireza Abdollahi
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pathology
- نوع مقاله: Journal Article
- کلمات کلیدی: NRBC,WBC differentiation,Sysmex cell count,WBC flags,Blasts
- چکیده:
- چکیده انگلیسی: Background: Automatic Cell Counter devises make the CBC differential very easy and delivering the results in few second. However, the problem with this device is facing a flag requires a time-consuming microscopic review of the specimen which causes unacceptable wait times for patient as well as costs for laboratories. In this study, we calculated the validity of WBC diff flags in Sysmex XT-1800i. In addition, we verified the correlation between manual and automated samples.
Methods: Overall, 1095 flagged samples were selected in the period of 6 weeks (Imam Hospital complex, Tehran Iran, 2014). The results of both automated and manual counting of the samples were carefully studied and compared. Totally, 624 NRBC flags, 450 Blast flags, 155 abnormal WBC Scatter gram flags, 140 Eosinophilia flags and 468 Monocytosis flags were identified. Results: Considering NRBC and blast flags there was a significant difference between our manual counted and automated counted NRBCs and blasts (P<0.05). There was no significant difference between automated and manual counting of flags for WBC Scatter gram. A significant difference between automated and manual counting data in flags, eosinophilia and monocytosis was foun (P<0.05).
Conclusion: We propose the NRBC flags to be ignored and report negative except for the neonatal ward, and the Blasts flags to be ignored and report negative in all the cases. The WBC Scatter gram should be report positive. For eosinophilia and monocytosis flags, we propose, the Sysmex results should be considered correct and the manual checking would not be necessary.- انتشار مقاله: 30-03-1394
- نویسندگان: Parya Bameni Moghaddam,Fatemeh Mahjoub,Amirhossein Emami,Alireza Abdollahi
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pathology
- نوع مقاله: Journal Article
- کلمات کلیدی: Diagnosis,children,Infants,HIV infection
- چکیده:
- چکیده انگلیسی: It is estimated that the number of HIV infected children globally has increased from 1.6 million in 2001 to 3.3 million in 2012. The number of children below 15 years of age living with HIV has increased worldwide. Published data from recent studies confirmed dramatic survival benefit for infants started anti-retroviral therapy (ART) as early as possible after diagnosis of HI. Early confirmation of HIV diagnosis is required in order to identify infants who need immediate ART. WHO has designed recommendations to improve programs for both early diagnoses of HIV infection and considering ART whenever indicated? It is strongly recommended that HIV virologocal assays for diagnosis of HIV have sensitivity of at least 95% and ideally greater than 98% and specificity of 98% or more under standardized and validated conditions. Timing of virological testing is also important. Infants infected at or around delivery may take short time to have detectable virus. Therefore, sensitivity of virological tests is lower at birth. In utero HIV infection, HIV DNA or RNA can be detected within 48 h of birth and in infants with peripartum acquisition it needs one to two weeks. Finally it is emphasized that all laboratories performing HIV tests should follow available services provided by WHO or CDC for quality assurance programs. Both clinicians and staffs providing laboratory services need regular communications, well-defined SOPs and nationally validated algorithms for optimal use of laboratory tests. Every country should use assays that have been validated by national reference laboratory.
- انتشار مقاله: 03-11-1393
- نویسندگان: Alireza Abdollahi,Hana Saffar
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pathology
- نوع مقاله: Journal Article
- کلمات کلیدی: HIV,AIDS,Cryptosporidiosis,Clinical characteristic
- چکیده:
- چکیده انگلیسی: Background: Cryptosporidiumis known as an opportunist disease-causing agent in man in recent decades. It causes diarrhea and intestinal disorders in the immune deficit and immune competent individuals. This study was aimed to investigate the clinical characteristics of HIV/AIDS patients withcryptosporidiosisinfection.
Methods: This cross-sectional descriptive study was performed on 53 HIV/AIDS patients referred to the Behavior Disease Consultation Center of Imam Khomeini Hospital in Tehran, Iran in 2013. First, the patients were studied clinically and the context data were recorded in a questionnaire for parasitological examination and referred to the laboratory for eosinophil count, and CD4 count per ml of blood.
Results: Cryptosporidiosiswas observed in 4 (7.6%) of the total 53 HIV/AIDS patients. The highest prevalence of infection was observed in the age range of 30-39 yr.Itwas observed in different sexes as 5.7% of male and 1.9% of female, but statistically was insignificant (P=0.163).75% of patients had no intestinal symptom, 11.4% with acute diarrhea and 3.8% with chronic diarrhea. Cryptosporidiosis cases were observed in 5.7% of patients without intestinal symptom. Conclusion: Practitioners in the clinicalexamination for the detectionof the opportunistic intestinal protozoan infection should use clinical and paraclinical characteristics of the HIV/AIDS patients for the diagnostic of Cryptosporidium and other opportunistic parasitic diseases.- انتشار مقاله: 10-08-1393
- نویسندگان: Rashid Gholami,Shirzad Gholami,Hamid Emadi-Kouchak,Alireza Abdollahi,Mona Shahriari
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pathology
- نوع مقاله: Journal Article
- کلمات کلیدی: Thyroid cancer,Papillary Thyroid Carcinoma,Thyroid microcarcinoma
- چکیده:
- چکیده انگلیسی: Background: Thyroid carcinoma is the most common malignancy of the endocrine system. Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer, accounting for 70–90% of well-differentiated thyroid malignancies. Thyroid papillary microcarcinoma is a subtype of papillary carcinoma that included tumors with less than 10mm diameter. As a result of diagnostic methods improvement, prevalence of this tumor is increasing. In this study we reviewed different characteristics of tumor. Methods: We searched various factors about this tumor in different databases (PubMed, Ovid, Google scholar, Iran medex and SID databases,July 2012 till August 2013), after that the articles were classified. Data of each article were extracted and sorted in tables.Data of each factor in different articles were summarized. Results:Etiology, clinical presentation, prognosis, histopathology, follow-up, diagnosis and also age, gender, tumor size and treatment were factors about this tumor described in details here. Conclusion: Awareness and better understanding of the characteristics of this tumor and manage it as an individual and valuable tumor can take an effective step in promoting public health practice.
- انتشار مقاله: 14-11-1393
- نویسندگان: Shiva Dideban,Alireza Abdollahi,Alipasha Meysamie,Shokouh Sedghi,Mona Shahriari
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pathology
- نوع مقاله: Journal Article
- کلمات کلیدی: Plasmapheresis,Exchange the Plasma
- چکیده:
- چکیده انگلیسی: Plasmapheresis, which is defined as the removal of plasma, can be either "adjusted plasma" or “exchange of plasma”. The former is defined as selective withdrawal of certain (un)-pathological plasma components in different ways such as perfusion and then returning the remained donor plasma to him, the latter is non-selective removal of all components of plasma to provide blood products for injection into patients or to be used as the input of blood transfusion refinery or to remove the pathogen contained plasma before compensating for the volume losses with an equal volume of plasma or more commonly, replacing plasma with a substitute fluid (colloid or crystalloid) such as albumin. Plasmapheresis was divided generally into two groups: 1- Plasma products by donor plasmapheresis 2- Therapeutic plasmapheresis Therapeutic plasma exchange or TPE are often attributed to plasma that exit from the body of patient then compensated by any kind of replacement fluid volumes to support neurmolemic situation of patients. Plasmapheresis is currently used as a therapeutic modality in a wide array of conditions. Generally, plasmapheresis is used when a substance in the plasma, such as immunoglobulin, is acutely toxic and can be efficiently removed. Myriad conditions fall under this category, including neurologic, hematologic, metabolic, dermatologic, rheumatologic, and renal diseases, as well as intoxications, that can be treated with plasmapheresis.
- انتشار مقاله: 04-05-1392
- نویسندگان: Alireza Abdollahi,Alireza Abdollahi,Alireza Abdollahi
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pathology
- نوع مقاله: Journal Article
- کلمات کلیدی: Pleural Effusion,bacterial infection,Bacterial Sensitivity Test
- چکیده:
- چکیده انگلیسی: Background and Objectives:Infection of pleural fluid is a common disease and because of antibiotic administration, the microbiology of this fluid has changed. The aim of this study was to determine the common bacteria and suitable antibiotics for treatment in pleural effusion (PE). Materials and Methods: In this cross sectional study, 1210 samples with exudative features were cultured for possible growth of microbial pathogens and then examined for antibiotics sensitivity. Samples’ characteristics were then analyzed according to the age and sex difference. Results: Among 1210 exudative pleural effusions, 38.2% were obtained from females and 61.8% from males. Of 142 pleural fluid samples, 11.7% had a positive culture. Aerobic gram negative organism was the most common type among the other samples with a prevalence of 52% followed by aerobic gram positive (25.3%), non- aerobic gram negative (15.7%), non- aerobic gram positive (6.2%) and fungi (0.8%). E. coli, Staphylococcus Aureus and Acinetobacter baumannii were the most common types of organism among adult population. Conclusion:Aerobic gram positive bacteria had the highest prevalence among the pathogens, and cephalosporins, aminopenicillins and β-lactams were the most effective antibiotics for their treatment.
- انتشار مقاله: 14-10-1391
- نویسندگان: Alireza Abdollahi,Saeed Shoar,Hiva Saffar,Hana Saffar,Azita Yazdi
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pathology
- نوع مقاله: Journal Article
- کلمات کلیدی: Quality Control,Real-Time Polymerase Chain Reaction,Hepatitis B,Virus Load
- چکیده:
- چکیده انگلیسی: Background and Objectives: HBV DNA monitoring is important in management of chronic viral hepatitis B infection. HBV DNA measurements are carried out over period of months to years. So the analytical system must be stable and reproducible. The aim of this study was to determine the performance characteristics and to plan a statistical quality control system of a laboratory-developed real-time quantitative PCR assay for HBV DNA quantification. Methods: Values of systematic and random error at two clinical decision points;4.2 Log IU/mL (20000 IU/mL) and 3.2 Log IU/mL (2000 IU/mL) were determined. Candidate quality control procedures were selected and performance of the method by application of normalized operational process specification (OPSpecs) charts was determined. Results: The performance of the assay at level of 4.2 Log IU/mL and 3.2 Log IU/mL were excellent and good respectively. Moreover, a13.5S rule with two measurements offered 90% probability of error detection at level of 4.2 Log IU/mL, while no rule offered 90% probability of error detection at level of 3.2 Log IU/mL. Conclusion: Minimizing the formation of primer-dimer and nonspecific products and concentrating the target DNA during the purification process are proposed for accurate quantitative PCR particularly when CT values are high.
- انتشار مقاله: 24-03-1392
- نویسندگان: Fatemeh Nili,Reza Shahsiah,Farid Azmoudeh Ardalan,Mohsen Nassiri Toosi,Alireza Abdollahi
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pathology
- نوع مقاله: Journal Article
- کلمات کلیدی: Minor salivary gland,Malignant Mixed Tumor
- چکیده:
- چکیده انگلیسی: Salivary gland tumors accounts for less than 1% of all tumors. Minor salivary gland tumors (MSGTs) are uncommon and make up about 10% of all salivary gland neoplasms. The clinical and histopathological distribution of these tumors vary geographically. A case of a 38 yr old man with a minor salivary gland mass at chin region isreported here. The tumor invaded into the anterior surface of the mandible bone and the surrounding soft tissues. The tumor was resected completely with a safe surgical margin of soft tissue and adjacent bone. Histologically, the tumor is characterized by a biphasic pattern, composed of admixture of epithelial and stromal components, associated with cytological atypia and prominent mitoses. The stromal elements are myxoid, chondroid, and osteoid. The chondroid component is more abundant and shows more atypical changes. Overall, the findings were interpreted as malignant pleomorphic adenoma of minor salivary glands of buccal mucosa.
- انتشار مقاله: 16-11-1390
- نویسندگان: Afsaneh Rajabiani1,Fatemeh Kamrani Kanafi,Naser Kamalian,Saeed Shoar,Alireza Abdollahi,Sara Sheikhbahaei
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pathology
- نوع مقاله: Journal Article
- کلمات کلیدی:
- چکیده:
- چکیده انگلیسی: Background and Objectives: The most prevalent malignancy among women is known to be breast cancer (BC). Several factors contribute to determining tumor prognosis and treatment strategies. In this study, the frequency and relevance of these factors are discussed. Materials and Methods: This cross-sectional study was carried out on 214 patients with BC, who referred to the Cancer Institute of Imam Hospital complex, Tehran, Iran in 2010 and 2011. The data about biomarkers (ER, PR, P53, HER-2) status and clinic pathologic features were extracted from patients files. Results: Invasive ductal carcinoma (90.7%) was the most common pathology of BC. The frequency of estrogen receptor (ER), progesterone receptor (PR), P53 and HER2 was estimated as 63.6%, 58.9%, 37.4% and 21.9% respectively. None of these markers had significant relationship with age, tumor size, tumor pathology, vascular invasion, calcification, nipple invasion, benign component, skin invasion and mitosis. Between low grade histology of tumor and ER, PR significant positive relationship was found (P=0.001). Lymph node involvement was positively associated with P53 expression. A positive relationship found between ER and PR (P=0.001). Both P53 and HER-2 inversely correlate with ER, PR (P=0.001). HER2 and P53 had no significant relationship. Conclusion: We found a significantly higher PR(+), ER(+) expression in low grade tumors. Although P53 and HER2 expressions were not found to be correlated with tumor grade, P53 expression was associated with poorer prognosis due to higher lymph node involvement and perineural invasion.
- انتشار مقاله: 02-02-1391
- نویسندگان: Alireza Abdollahi,Sara Sheikhbahaei,Somaye Safinejad,Issa Jahanzad
- مشاهده