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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Iranian Journal of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: oxidative stress,Inflammation,signaling pathway,Receptor for advanced glycation end products,Advanced glycation end producs
- چکیده:
- چکیده انگلیسی: Glycation is a protein modification, which results in a change in a protein structure. Glycation is believed to be the etiology of various age-related diseases such as diabetes mellitus and Alz-heimer’s disease (AD). Activation of microglia and resident macrophages in the brain by glycated proteins with subsequent oxidative stress and cytokine release may be an important factor in the progression of AD. It is also suggested that interaction between an advanced glycation end product (AGE) and its receptor (RAGE) results in glial activation as well as cy-tokine release and reactive oxygen species release. The use of antioxidants, receptor mediated compounds and reactive oxygen species scavenging enzyme produce an opportunity to in-tervene with AGE-RAGE signaling pathway, and thereby to slow down the progression of aging-related diseases.
- انتشار مقاله: 07-02-1393
- نویسندگان: Parisa Younessi,Ali Yoonessi
- مشاهده
- جایگاه : پژوهشی
- مجله: Addiction and Health
- نوع مقاله: Journal Article
- کلمات کلیدی: craving,Analgesics, Opioid,Sleep aids, Pharmaceutical,Recurrence,Sleep wake disorders
- چکیده:
- چکیده انگلیسی: Recent studies have revealed a growing number of patients affected by opioid use disorders (OUDs).
Comorbid disorders are suspected to increase the risk of opioid-related adverse effects or treatment failure.
The correlation of opioid use with sleep disturbances has been reported in many different studies and
suggested to be linked to the brain regions involved in reward processing. This narrative review was intended
to discuss the most recent developments in our understanding of the intricate interaction between sleep
disturbance and OUD. In addition, in this study, the effects of sleep problems on the occurrence of
unpleasant consequences in addiction management, such as craving and relapse in OCD patients, were
highlighted. It has been shown that drug use may trigger the induction of sleep disturbances, and those
suffering from difficulties in sleeping are prone to relapse to drug use, including opioids. Moreover,
pharmaceutical sleep aids are likely to interfere with opiate use.
- انتشار مقاله: 16-02-1399
- نویسندگان: Hamid Reza Fathi,Ali Yoonessi,Ali Khatibi,Fariborz Rezaeitalab,Amir Rezaei-Ardani
- مشاهده