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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Reviews in Clinical Medicine
- نوع مقاله: Journal Article
- کلمات کلیدی: Prognosis,Traumatic brain injury,Brain metabolite,Diffuse axonal injury
- چکیده:
- چکیده انگلیسی: Introduction: Magnetic resonance spectroscopy (MRS) is an imaging technique that provides spectroscopic information about changes in biological markers. Studies suggest that MRS can be helpful in determining the prognosis of patients with diffuse axonal injury (DAI).
Methods: The PubMed and Scopus databases were systematically searched in June 2015 using following search strategy: (“Magnetic resonance spectroscopy” OR MRS OR “MR spectroscopy”) AND [(“Diffuse axonal injury” OR DAI] AND Prognosis) to find relevant articles in which the prognostic value of MRS had been investigated in patients with traumatic DAI. All relevant information was extracted from the identified articles and used to synthesize the data for the purpose of this study.
Result: In total, 19 articles were found in PubMed and 151 in Scopus. Of these, eight documents were selected for further data extraction following the application of the inclusion/exclusion criteria. The total number of patients who participated in the research studies described in the selected documents was 197. All of the selected documents showed that MRS can be used to quantitatively assess metabolite changes in patients with DAI.
Discussion: The results of the studies indicate that MRS imaging as a sensitive method can quantitatively determine even small variations in metabolites. Any changes in the metabolite level of the brain after traumatic injury may be a useful predictor of a patient’s outcome; therefore, if the sensitivity of MRS is proven, this method can have prognostic value when employed with patients with DAI.
Conclusion: Based on the results of this systematic review, MRS is a sensitive tool that is helpful in determining the prognosis of patients with DAI.- انتشار مقاله: 02-11-1393
- نویسندگان: Ali Shamsa,Ali Shamsa,Ali Shamsa
- مشاهده
- جایگاه : پژوهشی
- مجله: Journal of Teaching Language Skills
- نوع مقاله: Journal Article
- کلمات کلیدی: structural equation modeling,narrative intelligence,verbal intelligence,Speaking,IELTS,Construct validity
- چکیده:
- چکیده انگلیسی: The aim of this study was to investigate the role of linguistic and intelligence factors in the Iranian IELTS candidates’ speaking performance. Linguistic factors include depth and breadth of vocabulary knowledge as well as grammar knowledge. Narrative and verbal intelligences represent the non-linguistic factors. The participants included 329 learners who took 5 validated tests and also participated in a simulated IELTS interview session. Model 1 (excluding the intelligence factors) represents the conventional view, whereas Model 2 (including all factors) is proposed for the first time in this study. The Structure Equation Modeling (SEM) was used to analyze the data. Using the SEM, both proposed models were examined to see which one fits the data more. The results of the comparisons made between the parameter estimates and fit indices of the two models demonstrate that Model 2 outfits Model 1, implying that in contrast to the conventional view, intelligence factors do play a significant and undeniable role in developing the speaking construct. Finally, the applications of the findings to promote the construct validity of IELTS are discussed.
- انتشار مقاله: 09-07-1391
- نویسندگان: Reza Pishghadam,Mohammad Ali Shams
- مشاهده
- جایگاه : پژوهشی
- مجله: Journal of Nanostructures
- نوع مقاله: Journal Article
- کلمات کلیدی: AGS cell line,Radiationtherapy,Radiosensitization,Tungsten Oxide Nanoparticles,PBMC Cells
- چکیده:
- چکیده انگلیسی: Radiotherapy which consists of external beam radiotherapy (EBRT) and internal radioisotope therapy (RIT), has a wide usage for treating cancer as clinical trials.This study provides some conditions to prove that tungsten oxide nanoparticles (WO3) is a radiosensitizer.The peripheral blood mononuclear cells (PBMCs) were used to calculate inhibitory concentration (IC).The AGS cell line exposed the concentration of 89.6 µg/mL (IC20) nanoparticle WO3 that was optimal and its radiosensitization was examined in megavoltage photons radiation of 6 MV x-rays. The sensitivity enhancement ratio (SER) and dose enhancement factor (DEF) was determined 1.24 and 1.68 respectively. We described the mechanisms of creating nanoparticles WO3 toxicity and genotoxicity in different concentrations on AGS cell line. The mean size of WO3 NPs by transmission electron microscopy wasmeasured 31.89 3.82 nm.Tungsten oxide Nanoparticles cause to reduce cell viability, remove membrane and damage to DNA. There was a meaningful increasing in damages to DNA and proliferation cell potency and also significantly reducing cell viability in concentrations more than 100 µg/mL.
- انتشار مقاله: 29-08-1397
- نویسندگان: Amin Hassanvand,Mohammad Hossein Zare,Ali Shams,Abolfazlal Nickfarjam,Masood Shabani,Hossein Rahavi
- مشاهده
- جایگاه : پژوهشی
- مجله: Journal of Kerman University of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Anthropology,Head circumference,Brain volume,Intelligence quotient
- چکیده:
- چکیده انگلیسی: Background: Anthropometry is a branch of anatomy. One of the important parts of anthropometry is cephalometry, which is characterized by anatomical dimensions of the head area. The aim of this study was to investigate the relationship between brain volume, weight, and IQ in children.
Methods: This descriptive-analytical study was performed on 300 students. Conventional measuring instruments were used for anthropometric measurements. Body weight and skull dimensions were measured. Then, using the appropriate formulas, the volume and weight of the brain and the brain index were measured.
Results: The Pearson correlation coefficient confirmed a weak correlation between the amounts of IQ and anthropometric dimension in female samples. The mean head circumference of males was 2 cm above the mean head circumference of females. Compared to the central index and the dispersion, anthropometric dimensions were significant between boys and girls. According to the analysis of neural network, the anthropometric dimensions of head height, brain weight, head width, and brain index in boys and anthropometric dimensions around the head volume of head width and head height in girls were the most important in relation to IQ.
Conclusion: The results of this study showed that there was a significant statistical difference between the central index and the distribution of anthropometric dimensions in boys and girls. Moreover, there was not a significant relationship between IQ and anthropometric dimensions of the body. In girls, there was a weak correlation between IQ and head width, head height, brain volume, and brain weight.- انتشار مقاله: 21-05-1398
- نویسندگان: Fatemeh Pouya,Mahdieh Zamani,Seyed Hassan Eftekhar-Vaghefi,Yunes Jahani,Farzaneh Raaii,Ali Shamsara
- مشاهده
- جایگاه : پژوهشی
- مجله: Journal of Kerman University of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Stroke,Ascorbic acid,Neuroprotection
- چکیده:
- چکیده انگلیسی: Background & Aims: Stroke is the third leading cause of death. Oxidative stress has a principal role in the complications of stroke. Due to this fact and the antioxidant effects of ascorbic acid, this study was designed to evaluate the effect of ascorbic acid on reduction of stroke complications in a permanent model of middle cerebral artery (MCA) occlusion in male rats. Methods: In this experimental study, the rats were divided into 3 groups of control, ascorbic acid, and surgicalsham. Stroke wasinduced by cauterization of MCA. The animals' brain wassliced and stained using tetrazolium chloride (TTC) 48 hours after stroke induction. Then, infarction volume was determined using image processing software. In addition, behavioral tests, such as neurologic deficits, were evaluated 24 and 48 hours afterstroke induction. Data were statistically analyzed using One-way ANOVA test. Results: The infarct volume significantly reduced in the ascorbic acid treated group in comparison with control group (P < 0.010). Moreover, blood-brain barrier (BBB) breakdown, brain edema volume (P < 0.001), and the level of matrix metallopeptidase-9 (MMP-9) (P < 0.050) significantly reduced following treatment by ascorbic acid. Neurologic deficits, which were assessed using the Bederson Grading System, showed relative improvement in the ascorbic acid treated group (P < 0.050). Conclusion:Thisstudy showed that ascorbic acid, due to its neuroprotective effects, can significantly reduce the complications ofstroke.
- انتشار مقاله: 23-04-1395
- نویسندگان: Fatemeh Amin,Amin Taghavi-Rafsanjani,Ali Shamsizadeh,Amir Moosaei,Shayan Rezayi,Ali Hasani,Sodabeh Naderi,Sedigheh Esmaeili,Mohammad Allahtavakoli
- مشاهده
- جایگاه : پژوهشی
- مجله: Journal of Information Technology Management
- نوع مقاله: Journal Article
- کلمات کلیدی: Iran,Science & Technology Parks,distribution information and knowledge,production of information and knowledge
- چکیده:
- چکیده انگلیسی: This study was conducted in order to identity Qualitative factors affecting the production and distribution of information and knowledge in science and technology parks of Iran. The research was Applied Research in which, qualitative method was carried out. The population of the study was included of 10 managers of Knowledge-based Companies. The data was collected from the population using semi-structured and in-depth interviews. For data analysis, content analysis was used. Results of the qualitative factors affecting the production and distribution of information and knowledge in science and technology parks of Iran, led to extraction of 39 components which were classified in four categories: I) Foreign and domestic policy, II) Financial and economic support, III) Infrastructure barriers and IV) Cultural barriers. Results howed that overcoming the political, financial and economic, infrastructural and cultural barriers has undeniable impact on production and distribution of information and knowledge.
- انتشار مقاله: 11-07-1395
- نویسندگان: Ali Haji Shamsaei,Fatemeh Nooshinfard,Fahimeh Babalhavaeji
- مشاهده
- جایگاه : پژوهشی
- مجله: Journal of Information Technology Management
- نوع مقاله: Journal Article
- کلمات کلیدی: Integration,Conceptual Model,Complex Systems,expanded organizational informatics domain,inter-organizational information systems
- چکیده:
- چکیده انگلیسی: The goal of this article is to proposing a conceptual model explaining the Information Systems Integration. In this paper, passing the concept of Intra-Organizational Information Systems Integration, we emphasis on the concept of Inter-Organizational Integration.The problem is what the Information Systems Integration is, and which problems the organizations face.The method using in this research is a four step method proposed according to the system thinking and related theories in this domain. Due to the fact that, emphasizing on the Inter-Organizational Information Systems, at the first step we draw an expanded conceptual model of the Organizational Informatics Doman between the two organizations. After that, this model expands within the network of organizations. This model has a lot of applications. For example, using this model, we can provide a list of the important and required managerial and technical issues for the successful implementation of integration projects, which these expensive projects and programs will fail without this notification. Moreover, aggregating cognitive propositions extracting from this model, we are able to achieve an initial theory regarding Information Systems Integration.
- انتشار مقاله: 15-12-1393
- نویسندگان: Hassanali Nemati Shamsabad,Ali Moeini
- مشاهده
- جایگاه : پژوهشی
- مجله: Journal of Chemical Health Risks
- نوع مقاله: Journal Article
- کلمات کلیدی: Nano-TiO2,Antibacterial agents,Naphthooxazinones,Eco-friendly catalyst
- چکیده:
- چکیده انگلیسی: Oxazines naturally occurs and synthetically exhibit wide-ranging biological activity. In this study, a highly practical and efficient of 1,2-dihydro-1-phenylnaphtho[1,2-e][1,3]oxazine-3-one derivatives was developed via a multi-component reaction of 2-naphthol, aldehydes and urea in the presence of nano-titanium oxide as solid, recyclable catalyst at one-pot and solvent-free conditions. These synthetic compounds 2a-e were evaluated as potential antibacterial agents. The structures of products were confirmed by spectral analysis FT-IR and 1H NMR. The antibacterial activity of the compounds was screened against Staphylococcus aureus and Escherichia coli. These results showed that these compounds exhibited significant to moderate activities against both Gram (+) and Gram (-) organisms.
- انتشار مقاله: 27-06-1395
- نویسندگان: Khalil Pourshamsian,Khalil Pourshamsian,Khalil Pourshamsian
- مشاهده
- جایگاه : پژوهشی
- مجله: Journal of Advanced Medical Sciences and Applied Technologies
- نوع مقاله: Journal Article
- کلمات کلیدی: Chemokine,Global cerebral ischemia,Postconditioning
- چکیده:
- چکیده انگلیسی: Objectives: Cerebral ischemic preconditioning lessens stroke-induced injuries, but it is clinically feasible only when the occurrence of stroke is predictable. Reperfusion plays a critical role against cerebral injury after stroke; we tested the hypothesis that interrupting ischemia during early reperfusion, i.e. Postconditioning (POCO) affects CXC chemokine expression and further reduce inflammation in rat model of ischemia/reperfusion. Materials & Methods: Adult male Wistar rats (250-300 g) were used in this experiment. Using 4-vessel occlusion method, global cerebral ischemia was induced and POCO was performed by applying 3 cycles of 15-s/15-s reperfusion/reocclusion after a 45-s reperfusion (POCO-45-15/15). Western blotting analysis was used to investigate CXCL1, CXCL10 and CXCL12 expression 24 h, 48 h and one week after ischemic postconditioning (iPOCO).Results: Based on the results, iPOCO attenuates the expression of inflammatory chemokines CXCL1 and CXCL10 in hippocampus area of postconditioned rats, while the CXCL12 was not affected by iPOCO.Conclusion: Current findings may support chemokines role in iPOCO via reduction of inflammation. Also there could be a link between postconditioning, stress and inflammation through chemokines.
- انتشار مقاله: 31-04-1397
- نویسندگان: Mahshid Tahamtan,Ali Shamsizadeh,Mohammad Allahtavakoli,Mohammad Nami,Neda Mohammadi,Gholamhossein Hassanshahi
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pathology
- نوع مقاله: Journal Article
- کلمات کلیدی: Iran,Kidney,Primitive Neuroectodermal Tumor
- چکیده:
- چکیده انگلیسی: Primitive neuroectodermal tumor (PENETs) is an uncommon malignancy of bone and soft tissue witch rarely occurs in the kidney. In more than 90% of the cases, the tumor cells relieves a balanced translocation (11; 22) (q24; q12). Immunohistochemical staining may be required for diagnosis of PENET. The cells of tumor express CD99, vimentin, NSE, FL1 but do not express Ck, LCA, myogenin, and WT1. We present a 36-year –old female with left –side tender abdominal swelling, and history of trauma to abdominal. CT imaging confirmed a huge solid mass of kidney, also extending into renal pelvis. Histological section of the lesion showed a malignant proliferation of small round cells in rosette-like pattern with foci of necrosis area. Tumor cells expressed high level of CD 99 antigen. The diagnosis of the lesion was primitive neuroectodermal tumors (PNET). Following-up after 6 months showed no recurrence.
- انتشار مقاله: 28-01-1391
- نویسندگان: Amir Hossein Jafarian,Abbas Ali Omidi,Ali Shamsa,Saeedeh Khajeh Ahmadi
- مشاهده