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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pharmaceutical Research
- نوع مقاله: Journal Article
- کلمات کلیدی: cancer,Nanoparticles,ICD-85,HeLa Cell Line,MTT assay,Caspase-8
- چکیده:
- چکیده انگلیسی: The biological application of nanoparticles (NPs) is a rapidly developing area of nanotechnology that raises new possibilities in the treatment of human cancers. The cytotoxicity was evaluated by MTT and LDH assays. The apoptotic effect of free ICD-85 and ICD-85 NPs on HeLa cells was assessed using caspase-8 colorimetric assay. The MTT assay showed that ICD-85 NPs could enhance the in-vitro cytotoxicity against HeLa cellscompared to the free ICD-85. The IC50 value at 72 h was reduced from 25 ± 2.9 μg/mL for free ICD-85 to 15.5 ± 2.4 μg/mL for ICD-85 NPs. However, LDH assay demonstrated that ICD-85 has dose-dependent cytotoxicity on HeLa cells while ICD-85 NPs exhibited weaker cytotoxicity on same cells. The results also indicate that ICD-85-induced apoptosis on HeLa cells is associated with the activation of caspase-8. Moreover, caspase-8 assay analysis demonstrated that the ICD-85 NPs induced a higher apoptotic rate in HeLa cells compared to free ICD-85. Our results demonstrated that the encapsulation of ICD-85 enhances its anti-proliferative effects. Taken together, these results suggest that the delivery of ICD-85 in nanoparticles may be a promising approach for the treatment of the cancer.
- انتشار مقاله: 10-10-1390
- نویسندگان: Saeed Moradhaseli,Abbas Mirakabadi,Ali Sarzaeem,Morteza Kamalzadeh,Reza Haji Hosseini
- مشاهده
- جایگاه : پژوهشی
- مجله: International Economics Studies
- نوع مقاله: Journal Article
- کلمات کلیدی: Oil Price Shock,Oil Exporting Countries,Business Cycle,Markov switching model
- چکیده:
- چکیده انگلیسی: In this paper, we empirically investigate the relationship between oil price changes and output in a group of oil exporting countries. The dynamics of business cycles in Libya, Saudi Arabia, Nigeria, Kuwait, Venezuela and Qatar are modeled by alternative regime switching models. We show that the extension of uni-variate Markov Switching model in order to include oil revenue improves dating business cycles in these economies. For all countries, the optimal specification suggested by the data is to consider three cycles or regimes, namely, high growth, mild growth, and recession. These three regimes can be associated to high positive oil shock, mild positive oil shock and negative oil price shock. An interesting finding of the paper is that there is a variety of relationships between oil price shocks and business cycles. Thus, in order to see the effects of an oil price shock one should take into consideration the economic regime when the oil price shock hits the economy. Therefore, it is not possible to talk about a general relationship between oil price shocks and macroeconomic variables for all the main oil exporting countries.
JEL Classification: E31, E32, E52, Q41- انتشار مقاله: 07-06-1392
- نویسندگان: Emanuele Bacchiocchi,Ali Sarzaeem
- مشاهده