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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Control and Optimization in Applied Mathematics
- نوع مقاله: Journal Article
- کلمات کلیدی: optimization,Operational matrix,spectral method,Fractional optimal control,Noise function
- چکیده: این مقاله، روشی عددی برپایه روش طیفی ریتز را برای حل دستهای از مسائل کنترل بهینه کسری در دامنه محدود دارای نویز بکار میبرد. پایههای چندجملهای برنشتاین به همراه ماتریس عملیاتی مشتق برای تخمین توابع نامعین حالت و کنترل مورد استفاده قرار می گیرند. با جایگذاری توابع تخمینی کنترل و حالت در تابع هدف، یک مساله بهینهسازی نامقید ایجاد میشود. برای حل و شبیهسازی آن از نرمافزار lr{Matlab} و جعبه ابزارهای آن استفاده خواهد شد. در مسائل مورد بحث، تابع هدف شامل توابع کنترل و توابع حالت میباشد. روش پیشنهادی با توجه به سازگاری آن در مدیریت شرایط اولیه و مرزی و نویز، قابل اعتماد و اطمینان است. برای نشان دادن کارآیی و کاربردی بودن روش، چند مثال کاربردی در انتهای مقاله آورده شده است.
- چکیده انگلیسی: This paper presents a numerical solution of a class of fractional optimal control problems (FOCPs) in a bounded domain having a noise function by the spectral Ritz method. The Bernstein polynomials with the fractional operational matrix are applied to approximate the unknown functions. By substituting these estimated functions into the cost functional, an unconstrained nonlinear optimization problem is achieved. In order to solve this optimization problem, the Matlab software and its optimization toolbox are used. In the considered FOCP, the performance index is expressed as a function of both state and control functions. The method is robust enough because of its computational consistency in the presence of the noise function. Moreover, the proposed scheme has a good pliability satisfying the given initial and boundary conditions. At last, some test problems are investigated to confirm the efficiency and applicability of the new method.
- انتشار مقاله: 25-03-1398
- نویسندگان: Ali Nemati,Ali Alizadeh,Fahime Soltanian
- مشاهده
- جایگاه : پژوهشی
- مجله: Avicenna Journal of Phytomedicine
- نوع مقاله: Journal Article
- کلمات کلیدی: IL-6,Conjugated linoleic acid,COPD,Sirtuin 1,BODE index
- چکیده:
- چکیده انگلیسی: Objective: Chronic obstructive pulmonary disease (COPD) is characterized by systemic inflammation and accelerated inflammaging of the lungs. Some studies showed that conjugated linoleic acid (CLA) has anti-inflammatory effects. The aim of the present study was to evaluate the effect of CLA supplementationon serum levels of interleukin (IL)-6 and sirtuin1 (SIRT1) in patients with COPD.
Materials and Methods: 82 patients with stable COPD were enrolled in a double blind clinical trial. Subjects were randomly assigned to two groups: placebo (n=42) and 3.2 g CLA daily supplementation (n=40). Forced expiratory volume in one second (FEV1%), BODE index, and serum levels of IL-6, and SIRT1 were measured at the baseline and six weeks after the intervention. In addition, the study parameters in the two groups were compared based on the Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria.
Results: After supplementation with CLA, serum levels of IL-6 and BODE index significantly decreased (p Conclusion: Supplementation with CLA can modify the inflammatory markers and improve the health status of COPD patients. The results suggest that CLA supplementation in COPD patients can be useful in the management of the disease.- انتشار مقاله: 30-05-1398
- نویسندگان: Mohammad Reza Aslani,Somaieh Matin,Ali Nemati,Mehran Mesgari Abbasi,Saeid Ghorbani,Hassan Ghobadi
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Esophageal Cancer,Haptoglobingenotype,Cancer risk factors
- چکیده:
- چکیده انگلیسی: Introduction: Esophageal cancer is one of the most lethal gastrointestinal cancers that has a complex and diverse etiology, with several genetic and nutritional factors involved in its etiology. The purpose of this study was to investigate the type of haptoglobin genotype and its relationship with some nutritional and biochemical risk factors affecting the prevalence of esophageal cancer in patients with early stage esophageal cancer. Materials and methods: In this study, 44 patients (20 males and 24 females) with early stage esophageal cancer and 44 healthy subjects, classified as control group, (19 males and 25 females) were selected. Haptoglobin (HP) genotype was determined employing PCR technique. Nutritional data were analyzed using standard food frequency questionnaire (FFQ) method. Serum levels of malondialdehyde (MDA), nitrate and nitrite were measured employing the colorimetric method. Serum levels of p53 protein were measured using the enzyme-linked immunosorbent assay (ELISA) technique. Results: The results of our study showed for the first time that HP1-1 genotype was the most prevalent genotype in esophageal cancer patients in Golestan province, Iran. HP2-2 genotype was the most frequent in the control group. Serum levels of MDA were significantly higher in the patients’ group compared to the control group (P˂0.001). Weight and body mass index (BMI) were significantly lower in the patients’ group than the control group (P<0.01). Food frequency analysis revealed that the consumption of fruits and vegetables in the patients’ group was lower than that of the control group (P<0.05). Conclusion: The results of our study showed for the first time that HP1-1 genotype is the dominant genotype in patients with esophageal cancer in Golestan province. As well, modification of nutritional pattern and consumption of high level of antioxidant compounds can be effective in reducing the prevalence of esophageal cancer in this region.
- انتشار مقاله: 06-07-1397
- نویسندگان: Sara Hosseinzadeh,Reza Alipanah-Moghadam,Fazel Isapanah Amlashi,Ali Nemati
- مشاهده