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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Journal of Simulation and Analysis of Novel Technologies in Mechanical Engineering
- نوع مقاله: Journal Article
- کلمات کلیدی: Functionally Graded Material,Temperature-Dependent Properties,: Infinite thick – walled cylinder,nonlinear heat transfer,classical perturbation method
- چکیده:
- چکیده انگلیسی: In this work, thermo – elastic analysis for functionally graded thick – walled cylinder with temperature - dependent material properties at steady condition is carried out. The length of cylinder is infinite and loading is consist of internal hydrostatic pressure and temperature gradient. All of physical and mechanical properties expect the Poisson's ratio are considered as multiplied an exponential function of temperature and power function of radius. With these assumptions, the nonlinear differential equations for temperature distribution at cylindrical coordinate is obtained. Temperature distribution is achieved by solving this equation using classical perturbation method. With considering strain – displacement, stress – strain and equilibrium relations and temperature distribution that producted pervious, the constitutive differential equation for cylinder is obtained. By employing mechanical boundary condition the radial displacement is yield. With having radial displacement, stresses distribution along the thickness are achieved. The results of this work show that by increasing the order of temperature perturbation series the convergence at curves is occurred and also dimensionless radial stress decrease and other stresses with dimensionless radial displacement increase.
- انتشار مقاله: 27-12-1396
- نویسندگان: Alireza Nadafoskoue,Hadi Mohammadi Hooyeh
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pathology
- نوع مقاله: Journal Article
- کلمات کلیدی: BRAF mutation,Congenital nevi,Dysplastic nevi
- چکیده:
- چکیده انگلیسی: Background & Objective: Predicting the transformation of dysplastic or congenital nevi into malignant lesions results in a significant increase in the survival of patients. Some specific gene mutations have been reported to be very helpful in this regard. Therefore, this study aimed to evaluate the prevalence of BRAF V600E mutation in dysplastic and congenital nevi.
Methods: This cross-sectional study was conducted on patients with congenital (n=30) or dysplastic (n=30) nevi. For genomic analysis, the BRAF gene mutation (V600E) was evaluated using the real-time polymerase chain reaction.
Results: The prevalence of BRAF gene (V600E) mutation was found as 1 case (3.3%) in congenital and 8 cases (26.7%) in dysplastic nevi indicating the higher prevalence of this mutation in patients with dysplastic nevi (p =0.026). Moreover, in the dysplastic nevi group, the presence of BRAF gene mutation (V600E) showed a significant relationship with the severity of dysplasia as the mutation rate was 25% in mild cases, in comparison with 54.5% in moderate dysplasia cases (p =0.009).
Conclusion: According to the results, 3.3% of the patients with congenital nevi and 26.7% of the subjects with dysplastic nevi were positive for BRAF V600E mutation. Furthermore, the severity of dysplasia could have a positive relationship with the presence of the mutation.- انتشار مقاله: 24-04-1399
- نویسندگان: Maryam Nasimi,Alireza Ghanadan,Kambiz Kamyab,Vahidesadat Azhari,Tahereh Yousefi
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pathology
- نوع مقاله: Journal Article
- کلمات کلیدی: immunohistochemistry,Metaplastic Synovial Cyst,Synovial Cyst
- چکیده:
- چکیده انگلیسی: Cutaneous metaplastic synovial cyst (CMSC), presents as a solitary, tender subcutaneous nodule that usually occurs at the site of previous surgery or trauma. Histologically, the lesion is characterized by a cystic structure with villous-like projections that lined by metaplastic synovial tissue. The main cause remains unclear, but trauma is presumed to be a precipitating factor, as most reported cases have a history of antecedent cutaneous injury. Here we present a case of CMSC in a 51 yr old man, presented with a painless deep-seated dermal nodule in the medial aspect of left ankle without history of any trauma or surgery in this site. Immuno-histochemistry study reveals positive reaction for CD68 in the cystic wall and negative reactions for S-100. CMSC is a unique lesion and worthy to attention, and should be included in the differential diagnosis of deep dermal cutaneous cysts.
- انتشار مقاله: 27-06-1394
- نویسندگان: Mina Majdi,Hana Saffar,Alireza Ghanadan
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pathology
- نوع مقاله: Journal Article
- کلمات کلیدی: Diagnosis,eczema,Psoriasis
- چکیده:
- چکیده انگلیسی: Background & Objectives: Accurate differentiation of eczema and psoriasis can be difficult, especially in areas of palm and sole. This study was designed to evaluate histopathological features and identify statistically significant parameters in distinguishing palmoplantar psoriasis from eczema of these regions in patients referring to Razi Skin Hospital, Tehran, Iran. Methods: In a cross-sectional study, the patients referring to Razi Skin Hospital were subjected. Biopsies of 36 patients with palmoplantar psoriasis and 16 patients with eczema of these regions were collected from archive of pathology. All of the biopsies were examined blind to the clinical diagnosis by four dermatopathologists separately and data collection forms were completed. Then obtained data were analyzed by SPSS software. Results: The females were more affected than males. There was no difference on involving palm and sole between psoriasis and eczema. Hypogranulosis (P<0.0001), Monro’s microabscess (P<0.0001), tortuous blood vessels in papillary dermis (P<0.0001), suprapapillary plate thinning (P=0.020), confluent parakeratosis (P=0.044) and spongiform pustule (P=0.047) were found to be statistically significant contributors to the clinicopathological concordance in cases of psoriasis. Plasma mounds (P=0.022) were significantly associated with diagnosis of eczema. Conclusion: Psoriasis was more common than eczema in the palms. Histopathologic finding like hypogranulosis, Monro’s microabscess, tortuous blood vessels in papillary dermis, suprapapillary plate thinning, confluent parakeratosis and spongiform pustule had significant relationship with psoriasis and might be useful for its diagnosis.
- انتشار مقاله: 30-04-1392
- نویسندگان: Kambiz Kamyab-Hesari,Zahra Safaei-Naraghi,Alireza Ghanadan,Azita Nikoo,Mojtaba Sabaghi
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Otorhinolaryngology
- نوع مقاله: Journal Article
- کلمات کلیدی: Iran,Lymphoma,Hodgkin disease,Non-Hodgkin's Lymphoma
- چکیده:
- چکیده انگلیسی: Introduction:
This study is aimed to assess the prevalence and characteristics of head and neck lymphoma in a defined group of an Iranian population.
Materials and Methods:
In this retrospective study, 126,450 biopsy reports from two referral Pathology Departments, (Tehran, the capital of Iran) were evaluated. In cases with head and neck lymphoma, other variables such as age, sex, specific location of lesions, and histopathological findings were recorded. Descriptive statistics were used to measure the prevalence and characteristics of head and neck lymphoma by means of SPSS soft ware, version 18.
Results:
In total, 513 (0.4%) cases had head and neck lymphoma (46.9% male, 27.1% female) with a mean age of 46±6.2. Of the total lesions, 200 (0.15%) were Hodgkin lymphoma and 313 (0.25%) were non-Hodgkin lymphoma. Nodular sclerosis was the most common (62.5%) histopathological subtype among Hodgkin lymphoma. In non-Hodgkin lymphoma, diffuse large B-cell lymphoma (62.3%) had the highest frequency. In Hodgkin disease, classic Hodgkin lymphocytic rich, mixed cellularity, and lymphocyte depletion were only seen in the neck compartment. Bone involvement was only found in Hodgkin nodular lymphocytic predominant variation. In non-Hodgkin lymphoma, the tongue, palate, and vestibular mucosa were affected only by diffuse large B-cell lymphoma. Jaw bones were only involved with diffuse large B-cell lymphoma compared to other bony structures. T-cell lymphoma and mucosal associated lymphoid tissue lymphoma were also found.
Conclusion:
Diffuse large B-cell lymphoma is the most common subtype of non-Hodgkin lymphoma especially in the tongue, palate, vestibular mucosa, and jaw bones.- انتشار مقاله: 27-10-1395
- نویسندگان: Nafiseh Shamloo,Alireza Ghannadan,Mahsa Jafari,Samane Ahmadi,Hamed Mortazavi,Maryam Baharvand
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Sulfur mustard,mycosis fungoides,Lymphoma, T-Cell, Cutaneous,Environmental exposure
- چکیده:
- چکیده انگلیسی: Mycosis fungoides (MF) is the most common form of cutaneous T-cell lymphoma. Persistent antigenic stimulation has been claimed to play a role in the development of this malignancy. We aimed to show the role of sulfur mustard in the pathogenesis of MF. A 45-year-old man with MF is introduced herein. He was a victim of chemical exposure in 1987 during the Iran–Iraq war. He developed skin lesions 3 years after exposure to sulfur mustard gas at the age of 21. Seven years after his exposure to sulfur mustard gas, a biopsy from the posterior distal part of his calf, which was injured and had bulla, revealed MF. Later, he developed more lesions on his extremities, trunk, and abdomen. On his previous admission, his left eyebrow was involved. A punch biopsy specimen was obtained from his eyebrow lesion, which rendered diffuse infiltration of atypical lymphocyte cells with some convoluted nuclei and scant cytoplasm admixed with lymphocytes, histiocytes, and mast cells compatible with the nodular stage of MF. At his last admission, a biopsy was obtained from the plaque lesions on his left thigh, and a TCR-γ gene rearrangement of the paraffin block of the plaque lesions revealed positive monoclonality. All the findings supported the MF diagnosis. We concluded that sulfur mustard could be a risk factor for MF development.
- انتشار مقاله: 28-09-1395
- نویسندگان: Hossein Mortazavi,Leila Izadi Firouzabadi,Alireza Ghanadan,Hassan Seirafi,Seyed Naser Emadi,Safoura Shakoei
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Dermatology
- نوع مقاله: Journal Article
- کلمات کلیدی: treatment,Terbinafine,Fluconazole,confluent and reticulate papillomatosis
- چکیده:
- چکیده انگلیسی: Confluent and Reticulate Papillomatosis (CRP) is a rare disease withpoorly recognized etiology. Various agents such as antibacterial,topical/systemic antifungal and topical/oral retinoids have beenused as treatment. Here, we report a 15-year-old female withCRP in whom yeasts of Malassezia were found in the PAS stainof the skin lesions. Topical terbinafine hydrochloride 1% sprayand oral fluconazole disappeared the lesions, supporting thehypothesis that CRP maybe a reactive dermatosis to Malassezia..
- انتشار مقاله: 11-10-1348
- نویسندگان: Pedram Noormohammadpour,Somayeh Khezri,Zahra Safaee Naraghi,Alireza Ghanadan,Farzaneh Khezri
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Dermatology
- نوع مقاله: Journal Article
- کلمات کلیدی:
- چکیده:
- چکیده انگلیسی: Morphea is an autoimmune connective tissue disease of the dermis and subcutaneous fat characterized by sclerosis due to excessive collagen deposition. Morphea is classified into different subtypes based on clinical and histological characteristics of cutaneous lesions. An extremely rare subtype of morphea is termed unilateral generalized morphea (UGM). UGM is characterized by indurated plaques on dermatomes of the trunk or back with a sharp midline demarcation line. Ipsilateral limbs may also be affected. There is still debate on whether this type of morphea should be considered as a distinct type or a presentation of linear morphea. Here we report the case of an 8-year-old boy with this type of morphea.
- انتشار مقاله: 01-10-1398
- نویسندگان: Maryam Nasimi,Arghavan Azizpour,Robabeh Abedini,Alireza Ghanadan
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Dermatology
- نوع مقاله: Journal Article
- کلمات کلیدی:
- چکیده:
- چکیده انگلیسی: Background: Basal cell carcinomas (BCC) are the most prevalent among non-melanoma skin cancers (NMSC), which correspond to the most common skin cancers. BCC histopathological subtyping is a problem in therapeutic management. Therefore, we have decided to perform a histopathologic study for better classification of BCCs based on interobserver diagnostic judgment. Methods: We conducted this cross-sectional study on 100 randomly selected pathologically confirmed BCC cases of various subtypes at Razi Hospital, Tehran, Iran during 2013 and 2014. A total of four dermatopathologists independently reviewed each pathology slide to evaluate the interobserver concordance rate. Results: The overall Fleiss’ kappa statistic (kappa) for the BCC subtypes was 0.18 (P<0.001), which indicated slight agreement. We observed moderate agreement on superficial and nodular BCC (kappa: 0.0-0.4); fair agreement on infiltrative and keratotic BCC (kappa: 0.2-0.4); and slight agreement on pigmented, micronodular, and metatypical BCC (kappa: 0.0-0.2). There was moderate agreement diagnosis for the low and high risk growth pattern categories. Conclusion: Overall, we found that the dermatopathologists had inconsistent nomenclature for the BCC subtypes, however they had better agreement for the diagnosis of superficial, nodular, and infiltrative subtypes and the high risk growth pattern.
- انتشار مقاله: 01-10-1398
- نویسندگان: Reza Yaghoobi,Nader Pazyar,Hooman Kalantar,Azita Nikoo,Zahra Naraghi,Kambiz Kamyab,Alireza Ganadan,Zohre Khodashenas,Azadeh Goodarzi,Fatemeh Mohaghegh
- مشاهده
- جایگاه : پژوهشی
- مجله: Energy Equipment and Systems
- نوع مقاله: Journal Article
- کلمات کلیدی: Heating Needed Energy,Number of People Per Area,Supportive Space
- چکیده:
- چکیده انگلیسی: Decreasing heating needed energy of building located in mountainous areas without any urban infrastructure of energy supply and services is one of the most important things to get thermal comfort. Accordingly, using building conditions based on different types of applicability and passive design strategies should be considered. Therefore, the objective of this study was to achieve the proper heating needed energy for proposing functional model as a mountainous shelter located in Iran. Two influence factors namely, number of people per area and different supportive space were considered. The analysis has been performed by Honeybee and Ladybug add-ons in Rhino/Grasshopper software. Material characteristic, zone load, location and climate data as sub-parameter were calculated using ASHRAE Standard 90.1-2010. The results indicated that regarding to time-use period of the shelter that is mostly in warm months, the highest performance of the space, based on minimum heating needed energy was attributed to the maximum size of supportive space by 608 m2 when the number of people was 0.26 per area. The reduction of heating needed energy was 17% in cold month and 23% in warm month.
- انتشار مقاله: 17-12-1395
- نویسندگان: Azin Keshtkarbanaeemoghadam,Mohammad Hadi Kaboli,Ali Dehghanbanadaki
- مشاهده