در هنگام جستجو کلمه در قسمت عنوان میتوانید کلمات مورد جستجو را با کاراکتر (-) جدا کنید.
کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Apoptosis,Cancer therapy,immunoconjugate,scFv,EndoG
- چکیده:
- چکیده انگلیسی:
Aim: Immunotoxins are proteins that consist of an antibody fragment linked to a toxin, used as agents for targeted therapy of cancers. Although the most potent immunotoxins are made from bacterial and plant toxins, obstacles which contribute to poor responses are immunogenicity in patients and rapid development of neutralizing antibodies. In the present study we proposed a new therapeutic immunotoxin for targeted cancer therapy of ROR1 expressing cancers: an anti ROR1 single chain fragment variable antibody (scFv)-endonuclease G (anti ROR1 scFv-EndoG). Methods: The three-dimensional structure of anti ROR1 scFv-EndoG protein was modeled and structure validation tools were employed to confirm the accuracy and reliability of the developed model. In addition, stability and integrity of the model were assessed by molecular dynamic (MD) simulation. Results: All results suggested the protein model to be acceptable and of good quality. Conclusions: Anti-ROR1 scFv-EndoG would be expected to bind to the ROR1 extracellular domain by its scFv portion and selectively deliver non-immunogenic human endonuclease G enzyme as an end-stage apoptosis molecule into ROR1-expressing cancer cells and lead rapidly to apoptosis. We believe that anti ROR1 and other anti-tumor antigen scFv-EndoG forms may be helpful for cancer therapy.- انتشار مقاله: 14-04-1396
- نویسندگان: Peyman Bemani,Mozafar Mohammadi,Ali Hakakian
- مشاهده
- جایگاه : پژوهشی
- مجله: Advance Researches in Civil Engineering
- نوع مقاله: Journal Article
- کلمات کلیدی: Piano keys sound,Artificial acceleration,Response Spectrum,Frequency content,Correlation coefficient
- چکیده:
- چکیده انگلیسی: Today, one of the most important issues in designing of structures is their reliability and functional design. In order to obtain reliability, different parameters of the earthquake history are considered as probabilistic and that their effects on the reliability of the structures. In fact, it is necessary to consider all possible scenarios in the earthquake event in the probability of failure of the structure, which is recorded using natural ground motions. In response to this engineering requirements, the use of simulated artificial earthquake records is one alternative. Therefore the most important point in using artificial records is to use a model that can more effectively capture the effective parameters in earthquake production. In this case, by obtaining uncertainties regarding the efficient parameters in that model, it is possible to produce an accidental earthquake production. In this study, the use of piano keys was applied as an artificial record. To achieve this goal, 6 pieces of a piano-sounded that has an initial landing, up and then secondary landing are selected. To compare the results, the 6 ground motion records of near field with pulse effect and 6 ground motion records of far field for soil type II was extracted from the PEER site . In order to compare the records, the response spectrum and their correlation were used. The results showed that the correlation between the selected artificial records for the far field of faults is more than near field.
- انتشار مقاله: 14-01-1399
- نویسندگان: Ali Kia,Reza Kia,Amin Bai
- مشاهده