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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Archives of Bone and Joint Surgery
- نوع مقاله: Journal Article
- کلمات کلیدی: Methylene blue,Fibrosis,Anterior Cruciate Ligament,Arthrofibrosis,Stifle
- چکیده:
- چکیده انگلیسی: Background: One of the major challenges in orthopedic surgery is the prevention of arthrofibrosis, which can be
successfully alleviated in its early stages. Many studies suggest the administration of methylene blue (MB) as an
accessible and effective agent for the prevention of post-operation adhesions. The purpose of this study was to evaluate
the efficacy of MB in the prevention of arthrofibrosis.
Methods: This study was conducted on 18 New Zealand white female mature rabbits. The anterior cruciate ligament
of the left stifle joint of each animal was cut during aseptic surgery. In the next step, the rabbits were divided into three
groups based on their treatments. The rabbits in the first, second, and third groups were subjected to the injection of
normal saline, 1% MB solution, and 2% MB solution into their synovial space, respectively. The postoperative stifle
range of motion was measured every week. After 4 weeks, the animals were euthanized and all joints were dissected
for histopathology.
Results: The histopathological evaluation of tissues indicated the presence of fibrotic connective tissue as a sign of
fibrosis in all groups. The fibrosis rate, inflammatory rate, tissue disarrangement, fibroblastic cellularity, and granulation
tissue formation were at their highest levels in the 1% MB group. The integrity of articular cartilage in the 2% MB group
was lower than the other groups. The level of bone degeneration was similar in both MB groups; however, it was more
than the control saline group. The range of motion was reduced during the first week, then increased in the second and
third weeks, and finally decreased in the fourth week.
Conclusion: The MB was not an effective method regarding the prevention or treatment of arthofibrosis and the
subsequent osteoarthritis. In contrast with previous studies, fibrosis was lower in the high dose MB group, compared
to the low dose MB group. The alterations in the range of motion were related to the reduced movement caused by the
pain and stiffness of the operated joints. The current study can be considered as the first report addressing the adverse
effect of MB on synovial components.- انتشار مقاله: 21-05-1396
- نویسندگان: Hamid Namazi,Mohammad J. Emami,Fatemeh Dehghani Nazhvani,Ali Dehghani Nazhvani,Zeinab Kargarshouroki
- مشاهده
- جایگاه : پژوهشی
- مجله: Archives of Bone and Joint Surgery
- نوع مقاله: Journal Article
- کلمات کلیدی: Methylene blue,Fibrosis,Anterior Cruciate Ligament,Arthrofibrosis,Stifle
- چکیده:
- چکیده انگلیسی: Background: One of the major challenges in orthopedic surgery is the prevention of arthrofibrosis, which can be
successfully alleviated in its early stages. Many studies suggest the administration of methylene blue (MB) as an
accessible and effective agent for the prevention of post-operation adhesions. The purpose of this study was to evaluate
the efficacy of MB in the prevention of arthrofibrosis.
Methods: This study was conducted on 18 New Zealand white female mature rabbits. The anterior cruciate ligament
of the left stifle joint of each animal was cut during aseptic surgery. In the next step, the rabbits were divided into three
groups based on their treatments. The rabbits in the first, second, and third groups were subjected to the injection of
normal saline, 1% MB solution, and 2% MB solution into their synovial space, respectively. The postoperative stifle
range of motion was measured every week. After 4 weeks, the animals were euthanized and all joints were dissected
for histopathology.
Results: The histopathological evaluation of tissues indicated the presence of fibrotic connective tissue as a sign of
fibrosis in all groups. The fibrosis rate, inflammatory rate, tissue disarrangement, fibroblastic cellularity, and granulation
tissue formation were at their highest levels in the 1% MB group. The integrity of articular cartilage in the 2% MB group
was lower than the other groups. The level of bone degeneration was similar in both MB groups; however, it was more
than the control saline group. The range of motion was reduced during the first week, then increased in the second and
third weeks, and finally decreased in the fourth week.
Conclusion: The MB was not an effective method regarding the prevention or treatment of arthofibrosis and the
subsequent osteoarthritis. In contrast with previous studies, fibrosis was lower in the high dose MB group, compared
to the low dose MB group. The alterations in the range of motion were related to the reduced movement caused by the
pain and stiffness of the operated joints. The current study can be considered as the first report addressing the adverse
effect of MB on synovial components.- انتشار مقاله: 21-05-1396
- نویسندگان: Hamid Namazi,Mohammad J. Emami,Fatemeh Dehghani Nazhvani,Ali Dehghani Nazhvani,Zeinab Kargarshouroki
- مشاهده
- جایگاه : پژوهشی
- مجله: Journal of Dentistry, Shiraz University of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: oral squamous cell carcinoma,salivary glands,Mucoepidermoid carcinoma,Mel-CAM
- چکیده:
- چکیده انگلیسی: atement of the Problem: Mel-CAM (CD146, MUC18) is a 113-kD heterophilic cell-cell adhesion glycoprotein found in normal and tumoral tissues.
Purpose: The aim of this study is assessing the expression of Mel-CAM in common oral carcinomas like salivary gland mucoepidermoid carcinoma (MEC) and oral squamous cell carcinoma (OSCC) to differentiate the OSCC from high-grade MEC.
Materials and Method: This study was performed on 19 specimens of MEC and 17 specimens of OSCC, which were retrieved from the archive of Department of Pathology of Taleghani Hospital, Tehran, Iran. Immunohistochemical staining was performed by using antibody against CD146. The data was analyzed by using SPSS software through Mann-Whitney, Spearman's correlation coefficient, and Kruskal-Wallis tests.
Results: Mel-CAM was expressed in all MEC samples and 10 OSCC cases. The two groups were significantly different regarding the CD146 expression (p = 0.035). Furthermore, the CD146 expression was found to be significantly correlated with the invasion mode (p = 0.002), tumor size (p = 0.012), and histologic grade (p = 0.024) in OSCC group. No significant correlation existed between the expression, intensity and location with the histologic grade of MEC (p > 0.05). Nor was any significant correlation detected between the CD146 expression and lymph node metastasis in neither group.
Conclusion: Regarding the significant correlation between the CD146 expression and the prognostic factors in OSCC, this marker may predict the prognosis in OSCC patients, but not the MEC lesions. It cannot be used for differentiating high-grade MEC and OSCC.- انتشار مقاله: 26-09-1397
- نویسندگان: Nafise Shamloo,Nasim Taghavi,Samira Behrad,Ali Dehghani Nazhvani
- مشاهده
- جایگاه : پژوهشی
- مجله: Journal of Dentistry, Shiraz University of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی:
- چکیده:
- چکیده انگلیسی: Statement of the Problem: After introducing digital radiography, practitioners started reading radiographs from computer monitors; however, many still prefer hard-copy radiographs.Purpose: This study aimed to assess the possible superiority of either type of radiograph recording media (computer monitor, film, or paper) in diagnosis and perception of the depth of the cariogenic lesions.Materials and Method: Twenty digital bitewing radiographs, obtained from 200 posterior extracted teeth, were displayed on an LG monitor and printed on paper and film using Kodak printers. Two observers independently measured lesions depth on the images. Serial sections of teeth were obtained and the sections were evaluated by a stereomicroscope to determine the actual depth of cariogenic lesions. The efficacy of the each medium was assessed by determining its specificity and sensitivity in comparison with those of histological images. Weighted kappa coefficients and the ROC analysis were used for the statistical analysis.Results: Strong intra- and inter-observer agreements (0.818 to 0.958, 0.77 to 0.85) were found for all detection methods. The highest Az value was obtained with the monitor-displayed images (Az: 0.879); however, differences between detection methods were not statistically significant (p> 0.05).Conclusion: Monitor-displayed bitewing radiographs, paper, and film prints used in our study performed similarly in the detection of proximal caries.Key Words Dental caries; Film; Paper; Bitewing radiography;
- انتشار مقاله: 03-12-1395
- نویسندگان: Sadaf Adibi,Anita Amrollahi,Ali Dehghani Nazhvani,Najmeh Movahedian
- مشاهده
- جایگاه : پژوهشی
- مجله: Journal of Dentistry, Shiraz University of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی:
- چکیده:
- چکیده انگلیسی: Statement of the Problem: Odontogenic keratocyst (OKC) is a developmental odontogenic cyst with specific histopathological features, high recurrence rate, and aggressive clinical behavior. Angiogenesis might be considered as an important factor for the growth, expansion, and distribution of this lesion.Purpose: The aim of the present study was to determine the mean vascular densities (MVD) of OKCs and dentigerous cysts to evaluate their relationship with the biologic behavior of these lesions.Materials and Method: In this cross-sectional analytical study, angiogenesis was assessed in OKC and dentigerous cyst by measuring the MVD. Immunohistochemistry was carried out using CD34 and CD105. The results were analyzed with independent samples t-test. The data were analyzed, setting p value at 0.05.Results: The MVDs with the use of CD34 and CD105 markers were significantly higher in OKC compared to dentigerous cyst (p< 0.05). In addition, MVDs obtained by CD105 in dentigerous cysts and OKC were significantly less than those based on CD34 (p< 0.05).Conclusion: Based on the results of the present study, it can be suggested that angiogenesis might be one of the possible mechanisms involved in higher aggressive biologic behavior and greater recurrence rate of OKC compared to dentigerous cysts.Keywords ● CD105 ● CD34 ● Dentigerous cyst ● Immunohistochemistry ● Odontogenic keratocyst
- انتشار مقاله: 23-11-1394
- نویسندگان: Shokoofeh Jamshidi,Massoumeh Zargaran,Ghodratollah Roshanaei,Fatemeh Hadadi,Ali Dehghani Nazhvani
- مشاهده
- جایگاه : پژوهشی
- مجله: Journal of Dentistry, Shiraz University of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی:
- چکیده:
- چکیده انگلیسی: Statement of the Problem: Fixed retainers were developed to maintain incisor alignments after orthodontic treatments. Although the effects of fixed retainers on periodontal health are clinically studied, no studies have still evaluated the histological changes in the periodontium after the placement of thefixed retainers.Purpose: The aim of this study was to evaluate the effects of customised retainers on periodontium histologically.Materials and Method: Forty pairs of maxillary and mandibular central incisors of twenty rabbits were randomly divided into four equal groups: The first group was considered as the control and in the second group, Fiber Reinforced Composite (FRC), in the third group, 0.014 inch stainless steel (SS) wire and in the fourth group, 0.175 inch multistrand stainless steel (MSS) wire were bonded on the labial surfaces of the incisors. After sixty days; animals' periodontium were evaluated histologically.Results: The number of bone resorption lacuna in the control group was significantly less than FRC and 0.014 SS groups. The periodontal vessel count and their diameter in the control group was significantly lower than the other groups. The pulp vessel count and their diameter in controls were significantly more than the 0.014 SS and the 0.175 MSS groups.Conclusion: Findings of this study suggest that FRC fixed retainer might cause detrimental effects on the periodontal ligaments and supporting bone and the 0.014- inch and 0.175- inch fixed retainers can cause hyalinization and possibly the necrosis of the pulp.Key Words: Fixed orthodontic retainers; Periodontium; Histology; Rabbits
- انتشار مقاله: 17-04-1393
- نویسندگان: Morteza Oshagh,Somayeh Heidary,Ali Dehghani Nazhvani,Fatemeh Koohpeima,Omid Koohi Hosseinabadi
- مشاهده
- جایگاه : پژوهشی
- مجله: Journal of Dentistry, Shiraz University of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی:
- چکیده:
- چکیده انگلیسی: Statement of the Problem: Alveolar bone necrosis induced by Herpes zoster infection is considered as a rare manifestation of osteomyelitis and few case reports are presented in the literature.Purpose: The aim of this study was to evaluate mandibular osteomyelitis caused by herpes zoster in the immunocompromised patients with histopathologically documented osteomyelitis in the mandible and herpes zoster infection.Materials and Method: 30 patients were recruited in this cross-sectional study. 19 patients were completely edentulous, 4 patients were partially edentulous and 7 with complete dentition. In all cases, specimens were analyzed using a conventional polymerase chain reaction (PCR) test for varicella zoster virus. Results: 16 patients underwent dialysis, 9 patients received chemotherapy treatments and 5 patients had transplantation (four kidneys and one liver). Histopathological assessment demonstrated a nonspecific bone necrosis exhibiting an eosinophilic, homogeneous non-vital bone tissue with peripheral resorption surrounded by reactive connective tissue. PCR test was positive in 21 cases.Conclusion: This study demonstrated that the frequency of osteomyelitis induced by herpes zoster could be more than the records provided by previous studies. Histopathological findings might be nonspecific in such patients. PCR test was not positive for all HZ induced osteomyelitis patients.Key Words: Zona; Osteomyelitis; Mandible; Herpes zoster
- انتشار مقاله: 17-04-1393
- نویسندگان: Reza Tabrizi,Ali Dehghani Nazhvani,Amir Vahedi,Mehdi Gholami,Raziyeh Zare,Raha Etemadi Parsa
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: ginger,Curcumin,oral squamous cell carcinoma,Saffron,Cinnamon
- چکیده:
- چکیده انگلیسی: Backgrounds: Oral squamous cell carcinoma (OSCC) is among the most frequent oral cancers in individuals under 40. Documents have endorsed that a diet enriched with fruit and vegetables can banish the risk of developing major cancers. This study aimed to evaluate the effects of different concentrations of four medicinal herbs including saffron, ginger, cinnamon and curcumin on OSCC cell line. Methods: Having obtained the aqueous extract of the four herbs, they were administered on OSCC cell lines per se and in dual, triple, and quadruple combinations. Their effects were measured in different concentrations and in 24 and 48 hours by using MTT assay. Results: The minimum and maximum effective concentrations were respectively 108 and 217 mg/ml for curcumin with IC30 of 77mg/ml, 108 and 270 mg/ml for ginger with IC30 of 58 mg/ml, 2 and 10 mg/ml for saffron with IC30 of 1.9 mg/ml, and 5 and 40 mg/ml for cinnamon with IC30 of 3.3 mg/ml. The best effect of the combinations was seen for cinnamon-saffron after both 24 and 48 hours and the four herbs combination after 48 hours. Conclusion: Although all the four herbs were effective on OSCC cell line, the strongest extract was saffron, followed by cinnamon. Combination of cinnamon-saffron and combination of the four herbs showed maximum effects. These findings suggest that traditional medicinal herbs may potentially contribute to oral cancer treatment; providing new windows for the development of new therapeutic strategies for OSCC.
- انتشار مقاله: 30-06-1398
- نویسندگان: Ali Dehghani Nazhvani,Najmeh Sarafraz,Fatemeh Askari,Fahimeh Heidari,Mahboobeh Razmkhah
- مشاهده