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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pathology
- نوع مقاله: Journal Article
- کلمات کلیدی: Cytotoxicity,Rose, Antimicrobial Agents, Antioxidant
- چکیده:
- چکیده انگلیسی: Background and Objectives: There is a profound inclination among people toward consumption of herbs and herbal products. Some of these products are harmful while health-promoting potentials of some others should be discovered. In the present study the antibacterial, antioxidant, acute and subchronic and cancer cell toxicity of methanolic and aqueous extracts of Rosa damascena Mill. was studied. Materials and Methods: Antimicrobial activities were determined by agar disc diffusion method. Total phenol content was estimated. Antioxidative properties of the extracts were determined by bleaching of beta carotene or 2,20-diphenylpicrylhydrazyl (DPPH). The Ferric-Reducing Antioxidant Power (FRAP) was expressed as gallic acid equivalents or known Fe (II) concentration for rose extracts and blood sera respectively. Acute and subchronic toxicity and cytotoxicity of the extracts were tested using animal model or Hela cells. Hematology and clinical chemistry parameters were noted. Results: Staphylococcus aureus was found susceptible. The total phenol contents of the methanolic and aqueous extracts were 132.67±3.51 and 117.33±6.81 μg Gallic acid equivalent/mg sample, respectively. Antioxidative effects were higher than those of the synthetic antioxidants were. A dose dependent levels of FRAP was noted in blood sera of rats gavaged with the extracts. Decrease in cholesterol/HDL and LDL/HDL ratios, fasting glucose, blood urea nitrogen, creatinine and uric acid is suggestive of promising therapeutic potentials of the extract. Inhibitory concentration of 50% (IC50) of 4.5 µg/ml was determined for cytotoxicity of the extract against Hela cell line. Conclusion: The results suggest application of rose extract as a natural antioxidant and health-promoting agent.
- انتشار مقاله: 29-06-1393
- نویسندگان: Seyedeh Maryam Sharafi,Iraj Rasooli,Ali Dehghan Kashani,Parviz Owlia,Mohammad Bagher Rezaee,Shakiba Darvish Alipoor Astaneh
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Otorhinolaryngology
- نوع مقاله: Journal Article
- کلمات کلیدی: Interleukins,Pediatrics,Inflammatory cytokines,Otitis media with effusion
- چکیده:
- چکیده انگلیسی: Introduction:
To evaluate the role of allergic-type and infectious-type cytokines in children with chronic otitis media with effusion (OME)
Materials and Methods:
We investigated serum levels of interleukins (IL)-4, IL-5, and IL-13, along with interferon-gamma (IFN-γ) and tumor necrosis factor-alpha (TNF-α), by enzyme-linked immunosorbent assay (ELISA) in 35 children with OME and 28 healthy controls.
Results:
Children with OME had significantly higher levels of IL-5 in comparison with the control group, ranging from 1 pg/ml in cases to 0.04 pg/ml in controls (P=0.009). However, after adjusting for confounding variables, there was no significant difference in serum levels of IL-13, IL-4, IFN-γ, or TNF-α between the two groups (P=0.287, P=0.627, P=0.793, and P=0.217, respectively)
Conclusions:
The findings of this study suggest that in comparison with the control group, serum IL-5 levels were elevated in OME cases.- انتشار مقاله: 25-11-1394
- نویسندگان: Saba Arshi,Fatemeh Dehghani-Firouzabadi,Babak Ghalehbaghi,Ali Dehghani-Firouzabadi,Farhad Jalali,Mehdi Shekarabi,Reza Sirous,Mohammad Dehghani-Firouzabadi
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Otorhinolaryngology
- نوع مقاله: Journal Article
- کلمات کلیدی: adenoid cystic carcinoma,Salivary Gland Tumour,pleomorphic adenoma,Mucoepidermoid carcinoma,MTA1
- چکیده:
- چکیده انگلیسی: Introduction:
Salivary gland tumors (SGTs) are important parts of human neoplasms. The most common SGT is pleomorphic adenoma and the most common malignant SGTs are mucoepidermoid carcinoma and adenoid cystic carcinoma (ACC). Metastasis-associated genes 1 (MTA1), a member of the nucleosome remodeling and histone deacetylation complex, is one newly discovered gene which recruits histone deacetylation, causing ATP-dependent chromosome remodeling, and regulating transcription. MTA1 had been shown to be overexpressed in malignant tumors with the enhancement of invasion and metastasis.
Materials and Methods:
Fifty-six samples of salivary tumors from the Khalili Hospital archive, including 20 cases of pleomorphic adenoma, 17 cases of mucoepidermoid carcinoma, 19 cases of ACC, and 23 cases of normal salivary gland tissues were chosen for immunohistochemical analysis of MTA1.
Results:
MTA1 expression in the malignant tumors was significantly higher than that in pleomorphic adenoma (P<0.001), and higher in pleomorphic adenoma than the normal salivary glands
(P< 0.001). In total, 69.6% of normal salivary gland tissues showed MTA1, but all cases of salivary gland tumors were positive for MTA1. High nuclear expression of MTA1 was detected in 83.3% (30/36) of the malignant salivary gland tumors and 45% (9/20) of pleomorphic adenoma, while low MTA1 expression was seen in all of the normal salivary gland tissues. No statistically significant correlation was found between MTA1 protein expression and any clinicopathological features (P>0.05).
Conclusion:
Our findings demonstrate that MTA1 was significantly overexpressed in malignant salivary gland neoplasm in comparison to a lower level in benign pleomorphic adenoma, suggesting that MTA1 protein might be involved in carcinogenesis.- انتشار مقاله: 09-12-1393
- نویسندگان: Azadeh Andisheh-Tadbir,Ali Dehghani -Nazhvani,Mohammad Javad Ashraf,Bijan Khademi,Hosein Mirhadi,Shima Torabi-Ardekani
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Community Based Nursing and Midwifery
- نوع مقاله: Journal Article
- کلمات کلیدی: Education,Health literacy,Multiple Sclerosis,Lecture,Peer group
- چکیده:
- چکیده انگلیسی: Background: Patients with multiple sclerosis (MS) require health literacy to manage the symptoms
and problems of the disease, which improves their quality of life. Health literacy is recognized as
a critical indicator of health care outcomes. This study aimed to compare the effect of peer-led and
lecture-based education on health literacy in MS patients.
Methods: This quasi-experimental study was conducted on MS patients in Jahrom from December
2018 to November 2019. 90 patients were selected using convenience sampling and then assigned into
control (n=45) and intervention groups (n=45). While routine education was presented to patients in
the control group, peer education intervention was held for the intervention group. The number of
sessions held for both groups was six sessions (one session per week). For data collection, MS health
literacy questionnaire (MSHLQ) was used before and one month after the intervention in both groups.
Data were analyzed through SPSS version 21 using Chi-square, Fisher’s exact test and t-test. The
significance level was considered p <0.05.
Results: Paired t-test showed that there was a significant difference between the mean of health literacy
in the intervention group before and after the intervention (P=0.001), while this difference was not
observed in the control group (P=0.39). Independent t-test showed a significant difference in the mean
of health literacy between the intervention and control groups after the intervention (P=0.001).
Conclusion: The results showed that peer group experiences were more effective than lecture-based
education in improving health literacy. It can be beneficial to employ as an educative-supportive
approach in MS patients.- انتشار مقاله: 02-01-1399
- نویسندگان: Ali Dehghani,Ali Dehghani,Ali Dehghani,Ali Dehghani
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Community Based Nursing and Midwifery
- نوع مقاله: Journal Article
- کلمات کلیدی: Iran,qualitative research,Multiple Sclerosis,Activities of Daily Living
- چکیده:
- چکیده انگلیسی: Background: Multiple sclerosis (MS) is a chronic nervous system disease with a wide range of
symptoms that affect the self-care ability of patients in daily activities of life; the patients afflicted
with this disease face with many challenges. This study was conducted to explore the activities of daily
living (ADL) challenges of these patients.
Methods: In this conventional content analysis study, fourteen MS patients who were selected
purposively from Iran MS Society in Jahrom (Iran) participated in 2018. Data were gathered using
semi-structured and in-depth interviews. A total of 14 interviews were conducted. These data were
analyzed using MAXQDA 10 Software and the Graneheim and Lundman method.
Results: Analysis of data led to extraction of the main theme “fear of ambiguous future of diseases”
as the most important daily living challenge in MS patients. This challenges were categorized in four
main categories: 1) confrontation to physical, emotional, psychological and behavioral changes, 2) fear
of becoming crippled, 3) tolerance of financial burden of the disease, and 4) confrontation to culturalsocial wrong beliefs.
Conclusion: The results of this study showed that people with MS face a number of ADL challenges.
Fear of an ambiguous future leads to problems in ADL of patients. Therefore, considering the ADL
challenges, health care personnel especially nurses, family members and social organizations can
improve ADL and compromise patients with the disease as much as possible by providing conditions
for application of the self-care activities and their implementation by patients.
- انتشار مقاله: 10-09-1397
- نویسندگان: Ali Dehghani,Mahsa Khoramkish,Sara Shahsavari Isfahani
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Community Based Nursing and Midwifery
- نوع مقاله: Journal Article
- کلمات کلیدی: Iran,qualitative research,coping,Multiple Sclerosis
- چکیده:
- چکیده انگلیسی: Background: Due to many physical and mental disorders that occur in multiple sclerosis patients, identifying the factors affecting coping based on the experiences of patients using qualitative study is essential to improve their quality of life. This study was conducted to explore the antecedents of coping with the disease in patients with multiple sclerosis.Methods: This is a qualitative study conducted on 11 patients with multiple sclerosis in 2015 in Tehran, Iran. These patients were selected based on purposive sampling. Data were collected using semi-structured and in-depth interviews and coded. These data were analyzed using the conventional content analysis. The rigor of qualitative data using the criteria proposed by Guba and Lincoln were assessed. Results: Five main categories were revealed: (1) social support, (2) lenience, (3) reliance on faith, (4) knowledge of multiple sclerosis and modeling, and (5) economic and environmental situation. Each category had several distinct sub-categories.Conclusions: The results of this study showed that coping with multiple sclerosis is a complex, multidimensional and contextual concept that is affected by various factors in relation to the context of Iran. The findings of the study can provide the healthcare professionals with deeper recognition and understanding of these antecedents to improve successful coping in Iranian patients suffering from multiple sclerosis.
- انتشار مقاله: 12-11-1394
- نویسندگان: Ali Dehghani,Nahid Dehghan Nayeri,Abbas Ebadi
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Pediatrics
- نوع مقاله: Journal Article
- کلمات کلیدی: smoking,Adolescent,Environmental,Socioeconomic,Student Risk Factor
- چکیده:
- چکیده انگلیسی: Background: Several environmental and psychosocial risk factors are known for adolescent smoking as the single cause of preventable diseases and premature death. This cross-sectional study aimed to determine the prevalence of cigarette smoking, socio-demographic factors associated with cigarette smoking (age, education level, parents’ job, and family’s socioeconomic statues), and the role of family and friends in cigarette smoking by high school students.
Materials and Methods: In this cross-sectional study which was conducted in Shiraz, Iran, 900 high school boy students (grades 9-11) were selected through multistage random cluster sampling. They responded a researcher designed anonymous questionnaire about smoking experiences of themselves- and their friends and family members. Chi-square and Mann-Whitney U test and Binary logistic regression analysis were used to analysis of the data, using the SPSS version 17.0.
Results: The mean age of the participants was 16.11 (1.16) years and 19.7% of the students were ever smokers. Students’ higher educational grade (P=0.001), fathers’ lower education level (P=0.03), live with one parent or people other than parents (P=0.024), father’s, siblings’, and friends’ smoking, and family members’ cigarette smoking at home (P<0.001), were significantly related to the students’ smoking experience. Indeed, having smoker siblings was the strongest predictor of smoking among the students.
Conclusion: Cigarette smoking is a public health concern in all families from different socio-economic status. Special attention to orphans and children of divorce, setting rules about cigarette smoking in families, monitoring and being aware of offspring’s and their friends’ behavior can be recommended.- انتشار مقاله: 14-10-1395
- نویسندگان: Masoud Karimi,Mohammad Hossein Kaveh,Mohammad Ali Morowatisharifabad,Ali Dehghani,Ghasem Dastjerdi
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Social Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: attitude,E-tourism,Subjective norms,tehranian travelers,the theory of Reasoned Action
- چکیده:
- چکیده انگلیسی:
- انتشار مقاله: 11-07-1392
- نویسندگان: Alireza Dehghan,Yalda Erfanifard
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Industrial Electronics Control and Optimization
- نوع مقاله: Journal Article
- کلمات کلیدی: optimization,Orientation,orientation search algorithm,Heuristic algorithms,orientation game
- چکیده:
- چکیده انگلیسی: Random based inventive algorithms are being widely used for optimization. An important category of these algorithms comes from the idea of physical processes or the behavior of beings. A new method for achieving quasi-optimal solutions related to optimization problems in various sciences is proposed in this paper. The proposed algorithm for optimizing the orientation game is a series of optimization algorithms that are formed with the idea of an old game and search operators are an arrangement of players. These players are displaced in a certain space, under the influence of the game referee's orders. The best position is achieved by the laws are there in this game .In this paper, the real version of the algorithm is presented. The results of optimization of a set of standard functions confirm the optimal efficiency of the proposed method, as well as the superiority of the proposed algorithm over the genetic algorithm and the particle swarm optimization algorithm.
- انتشار مقاله: 16-05-1397
- نویسندگان: Mohammad Dehghani,Zeinab Montazeri,Om Parkash Malik,Ali Ehsanifar,Ali Dehghani
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Advanced Biological and Biomedical Research
- نوع مقاله: Journal Article
- کلمات کلیدی: Entrepreneurial spirit,Wood and paper industry,Educational and academic factors
- چکیده:
- چکیده انگلیسی:
The purpose of this paper is to explore the influential factors on entrepreneurial spirit of wood and paper industries students in two universities, namely Agriculture and natural resources faculty of Tehran University and Shahid Rajaiee teacher training University. A sample of 100 students were selected from a target population of 572 students using the Cochran formula. The respondents were asked to provide their answers to a standardized questionnaire. Results indicated that from the students’ perspective such factors as motivation, providence and achievement propensity had the greatest impact on entrepreneurial spirit of the respondents whilst factors like internal control, exception ability and having systematic attitude had the least influence. Moreover concerning the effect of educational and academic factors on entrepreneurial spirit, the most effective items were respectively favorable access to computer and internet and learned and efficient instructors whereas the least effective items considered were degree orientation, students’ apprenticeships in executive environments and education at the university. The findings showed a significant positive relation at the significance level of 0.05 between the level of education and age with the creation of entrepreneurial spirit amongst students. Furthermore a significant positive relation was observed between educational and academic factors, propensity to achievement, risk taking and ambiguity toleration, control source and family with entrepreneurial spirit at the significance level of 0.01. Also the results of multiple regression analysis showed that 79.7%of entrepreneurial spirit (the dependent variable) variance was explained by such independent variables as educational and academic factors, achievement propensity, being innovative, risk taking and ambiguity toleration, control source and family.- انتشار مقاله: 02-08-1397
- نویسندگان: Feizollah Monavari Fard,Seyed Alireza Dehghan,Amine Lotfian,Laleh Salehi
- مشاهده