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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Avicenna Journal of Phytomedicine
- نوع مقاله: Journal Article
- کلمات کلیدی: oxidative stress,Nigella sativa,IL-10,TNF-α,Behcet’s disease
- چکیده:
- چکیده انگلیسی: Objective: Behcet's disease (BD) is a chronic inflammatory disorder characterized by recurrent oral and genital aphthous ulcers, uveitis and skin lesions. Oxidative stress and inflammation have important role in the pathogenesis of BD. The aim of this study was to assess the effect of Nigella sativa (NS) oil administration on malondialdehyde (MDA), total anti-oxidant capacity (TAC), tumor necrosis factor-α (TNF-α), IL-10 and high sensitivity C-reactive protein (hs- CRP) levels in patients with BD.
Materials and Methods: In this randomized, double-blind and placebo-controlled clinical trial, 96 BD patients were randomly assigned to NS or placebo groups. Study groups received 1000 mg/day NS oil and placebo soft gels for 8 weeks. Serum levels of TNF-α, IL-10, hs-CRP, MDA and TAC were measured before and after treatment.
Results: Eighty-nine individuals completed the study. Significant decreases in the serum levels of MDA and increases in the serum levels of TAC were found in the NS group. However, differences in the changes of MDA and TAC in the NS and placebo groups were not significant. Pre- and post-intervention changes of TNF-α, IL-10 and hs-CRP levels in the NS group were non-significant.
Conclusion: NS 1000 mg per day is probably not effective in reducing the inflammatory and oxidative markers in BD.- انتشار مقاله: 17-02-1398
- نویسندگان: Shahrzad Amizadeh,Nadereh Rashtchizadeh,Alireza Khabbazi,Amir Ghorbanihaghjo,Ali-Asghar Ebrahimi,Amir-Mansour Vatankhahc,Aida Malek Mahdavi,Mohsen Taghizadeh
- مشاهده
- جایگاه : پژوهشی
- مجله: Avicenna Journal of Phytomedicine
- نوع مقاله: Journal Article
- کلمات کلیدی: Nigella sativa,Behcet's disease,Iranian Behcet’s disease dynamic activity measure (IBDDAM),Behcet’s disease current activity form (BDCAF)
- چکیده:
- چکیده انگلیسی: Objective: Nigella sativa (NS) is a herbal medicine with anti-inflammatory and anti-oxidant functions. This study was designed to evaluate the effect of oral administration of NS seeds oil on the treatment of Behcet’s disease (BD).
Materials and methods:In this double-blind randomized controlled study, 130 patients with BD were screened and 71 patients with BD were randomly allocated to the treatment (n=37) and control (n=34) groups. Finally, 32 and 30 patients in the treatment and control groups, respectively, completed the study.The study protocol was registered in the Iranian Registry of Clinical Trials (IRCT) with registration No. IRCT201511086975N5. Treatment and control groups received soft gels containing 1000 mg NS oil or 1000 mg placebo per day for 12 months, respectively. Disease activity using the Iranian Behcet’s disease dynamic activity measure (IBDDAM), total inflammatory activity index (TIAI) and Behcet’s disease current activity form (BDCAF) were evaluated in all patients before initiation of the trial and every 2 months, for 12 months.
Results: Disease activity decreased in the study groups; difference between the two groups was not significant. No serious adverse events were seen in the treatment and control groups.
Conclusion: NS oil at the dose of 1000 mg/day is not effective in controlling BD activity.- انتشار مقاله: 11-06-1396
- نویسندگان: Hadiseh Kavandi,Mehrzad Hajialilo,Alireza Khabbazi
- مشاهده
- جایگاه : پژوهشی
- مجله: Avicenna Journal of Phytomedicine
- نوع مقاله: Journal Article
- کلمات کلیدی: Nigella sativa,Behcet's disease,Iranian Behcet’s disease dynamic activity measure (IBDDAM),Behcet’s disease current activity form (BDCAF)
- چکیده:
- چکیده انگلیسی: Objective: Nigella sativa (NS) is a herbal medicine with anti-inflammatory and anti-oxidant functions. This study was designed to evaluate the effect of oral administration of NS seeds oil on the treatment of Behcet’s disease (BD).
Materials and methods:In this double-blind randomized controlled study, 130 patients with BD were screened and 71 patients with BD were randomly allocated to the treatment (n=37) and control (n=34) groups. Finally, 32 and 30 patients in the treatment and control groups, respectively, completed the study.The study protocol was registered in the Iranian Registry of Clinical Trials (IRCT) with registration No. IRCT201511086975N5. Treatment and control groups received soft gels containing 1000 mg NS oil or 1000 mg placebo per day for 12 months, respectively. Disease activity using the Iranian Behcet’s disease dynamic activity measure (IBDDAM), total inflammatory activity index (TIAI) and Behcet’s disease current activity form (BDCAF) were evaluated in all patients before initiation of the trial and every 2 months, for 12 months.
Results: Disease activity decreased in the study groups; difference between the two groups was not significant. No serious adverse events were seen in the treatment and control groups.
Conclusion: NS oil at the dose of 1000 mg/day is not effective in controlling BD activity.- انتشار مقاله: 11-06-1396
- نویسندگان: Hadiseh Kavandi,Mehrzad Hajialilo,Alireza Khabbazi
- مشاهده
- جایگاه : پژوهشی
- مجله: Avicenna Journal of Phytomedicine
- نوع مقاله: Journal Article
- کلمات کلیدی: Medicinal plants,toxicity,Stem cells,Neuronal injury
- چکیده:
- چکیده انگلیسی: Objective: Arsenic, an environmental pollutant, decreases neuronal migration as well as cellular maturation and inhibits the proliferation of neural progenitor cells. Curcumin has been described as an antioxidant and neuroprotective agent with strong therapeutic potential in some neurological disorders. Human adipose-derived stem cells (hADSCs), a source of multipotent stem cells, can self-renew and differentiate into neural cells. The aim of the present study was to investigate the preventive effect of curcumin against arsenic toxic effects on the viability, telomerase activity, and apoptosis of neural stem/progenitor cells (NSPCs) derived from hADSCs.
Materials and Methods: The characteristics of human adipose tissue were identified by immunocytochemistry for surface markers namely, CD105, CD73, and CD90. Using neurosphere assay, hADSCs were differentiated into neuronal cells. To characterize neural cells, expression of nestin, SOX2, MAP2, and GFAP were assessed by immunocytochemistry. Cytotoxicity and viability of NSPCs were evaluated by MTT assay. Reactive oxygen species (ROS) generated by arsenic exposure, were measured and caspase 3/7 activity and caspase-3 processing as well as the telomerase activity were determined.
Results: The isolated hADSCs positively expressed CD105, CD73, and CD90. Nestin, Sox2, GFAP, and MAP2 were expressed in the neurospheres derived from hADSCs. Curcumin/arsenic co-treatment significantly increased telomerase activity of NSPCs compared to arsenic group. Furthermore, curcumin significantly reduced arsenic-induced apoptosis (via inactivation of caspases) as well as arsenic-associated ROS generation.
Conclusion: Our findings revealed that curcumin has the potential to prevent harmful effects of arsenic on neurogenesis.- انتشار مقاله: 05-07-1395
- نویسندگان: Ali Jahanbazi Jahan-Abad,Parastoo Morteza-zadeh,Sajad Sahab Negah,Ali Gorji
- مشاهده
- جایگاه : پژوهشی
- مجله: Avicenna Journal of Phytomedicine
- نوع مقاله: Journal Article
- کلمات کلیدی: oxidative stress,Nigella sativa,Rheumatoid arthritis,IL-10,TNF-α
- چکیده:
- چکیده انگلیسی: Objectives: Nigella sativa is a medicinal plant that has long been used in traditional medicine for treating various conditions. Numerous animal studies provided evidences that the seed may elicit a broad anti-inflammatory/anti-oxidant activity. The aim of the present clinical trial was to evaluate anti-inflammatory and antioxidant properties of Nigella sativa oil in patients with rheumatoid arthritis (RA).
Materials and Methods: Forty-two patients with RA were assigned into two groups in this randomized, double blind, placebo-controlled clinical trial. Subjects in intervention group received two capsules, 500 mg each, of Nigella sativa oil, each day for 8 weeks. The other group consumed two capsules as placebo per day for the same period of time. Serum TNF-α, IL-10, and whole blood levels of oxidative stress parameters were measured at baseline and end of the trial.
Results: The serum level of IL-10 was increased in the Nigella sativa group (p<0.01). Moreover, treatment with Nigella sativa led to significant reduction of serum MDA and NO compared with baseline (p<0.05). There were no significant differences in the TNF-α, SOD, catalase, and TAS values between or within the groups, before and after the intervention (p>0.05).
Conclusions: This study indicates that Nigella sativa could improve inflammation and reduce oxidative stress in patients with RA. It is suggested that Nigella sativa may be a beneficial adjunct therapy in this population of patients- انتشار مقاله: 31-06-1393
- نویسندگان: Vahid Hadi,Sorayya Kheirouri,Mohammad Alizadeh,Alireza Khabbazi,Hossein Hosseini
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Squamous Cell Carcinoma,Glutathione S-transferase T1,Glutathione S-transferase M1
- چکیده:
- چکیده انگلیسی: Background: The role of genetic polymorphisms in genes of Glutathione-S-transferases (GST) enzymes in susceptibility
to oral cavity cancers is controversial. Oral Squamous Cell Carcinoma (OSCC) is the most common oral cavity neoplasm.
Aimed to evaluate the potential impacts of two well-known null variants residing in the gene encoding GSTM1 and
GSTT1 enzymes of OSCC patients in the southeast of Iran. Methods: In a case-control design, 113 individuals (50
OSCC patients, and 63 healthy subjects) were included. DNA was extracted using paraffin-embedded tissues. GST
genotyping was carried out using multiplex PCR. Results: In 113 participants, 41 (36.3%) and 72 (63.7%) were males
and females respectively. No significant difference was recognized for distribution of GSTM1 (P=0.11) and GSTT1
(P=0.28) null genotypes between OSCC patients (58%, and 24% respectively) and healthy controls (42.9% and 15.9%
respectively). Also, no significant difference was noted regarding the frequency of GSTM1 null genotype in different
histological grades, however, those patients with more aggressive disease (poorly differentiated or grade III) revealed
with a significantly higher ratio (66.7%) of GSTT1 null genotype (P=0.002). The highest odds ratio for OSCC was related
to combined null genotypes for GSTM1 and GSTT1 (OR=2.5, 95% CI: 0.7-9.2), however, this was not statistically
significant finding (P=0.15). Conclusion: Null genotypes polymorphisms were more common in OSCC than healthy
individuals. GSTT1 null genotype may be an important genetic factor in the progression of OSCC.- انتشار مقاله: 27-02-1397
- نویسندگان: Shirin Saravani,Masoud Miri-Moghaddam,Ali Bazi,Ebrahim Miri-Moghaddam
- مشاهده
- جایگاه : پژوهشی
- مجله: Asia Pacific Journal of Medical Toxicology
- نوع مقاله: Journal Article
- کلمات کلیدی: Iran,Snakebite,Sheltopusik,Petilus
- چکیده:
- چکیده انگلیسی: Background: The vast territory of Iran, due to climate diversity, is a host for various animal species. Snakes may be considered a significant threat to health of the rural regions of Iran. Sheltopusik (Pseudopus apodus), the largest member of the family Anguida, is one of the species of lizard that is considered to be a harmless animal species. This lizard is often mistaken for a faunistic community of reptiles in the area and is well-known as Petilus Snake. To the best of our knowledge, no reports of injury from bites or attacks of this species have previously been published.
Case presentation: The present case report is the first report of describing the attack of a sheltopusik to a 40-year-old white female farmer. Due to the lack of primary identification of the damaging animal, it was initially confused with the snakebite, leading to unnecessary administration of anti-venom and tetanus prophylaxis.
Discussion: The main reason for this event was the lack of reporting a similar medical harm in the area and the snake-like appearance of the lizard. Acquaintance with this kind of damage to the human health and tissue contusion by the hit can help rational management of such patients without conventional modalities for snakebite like antivenom.
Conclusion: The physicians practicing in emergency wards and rural clinics in the area, as the first place of referral, should be trained on proper management of this group of patients to achieve the best clinical outcome.- انتشار مقاله: 31-02-1398
- نویسندگان: Aliyeh Bazi,Seyed Khosro Ghasempouri,Adeleh Sahebnasagh,Fatemeh Saghafi
- مشاهده