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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Journal of Nutrition,Fasting and Health
- نوع مقاله: Journal Article
- کلمات کلیدی: Esophageal atresia,growth retardation,Feeding behavior
- چکیده:
- چکیده انگلیسی: Introduction: Esophageal atresia (EA) with or without tracheoesophageal fistula (TEF) is defined as a congenital malformation characterized with the interruption or obstruction of esophagus. Affected neonates may present with cyanosis during breast feeding, sialorrhea, coughing and difficulty in respiration. The defect should be corrected by surgery; otherwise, the condition can be life-threatening. Little is known about the long-term nutritional problems of children with EA. Our aim was to assess growth status and nutritional difficulties in children with EA. Methods: This was a retrospective study on 32 children with EA between 2007 and 2016. Nutritional status and feeding problems were assessed by a questionnaire. Results: The most common EA-associated complications were esophageal stricture (84.4%), dysphagia (46.9%), gastroesophageal reflux disease (37.5%), and respiratory infections (25%). Majority of our patients showed normal growth parameters, and 96.9% of them had experienced at least one complication or feeding problem including needing to drink water to swallow food (25%), coughing during feeding (34.4%), vomiting (12.5%), and abdominal pain (34.4%). There were no significant associations between feeding problems and growth parameters. Conclusions: Feeding problems are relatively common in children with EA. There is a need to provide nutritional consults to these patients to prevent or mitigate these problems.
- انتشار مقاله: 24-01-1398
- نویسندگان: Seyed Mohsen Dehghani,Mahsa Hajizadeh,Homa Ilkhanpour,Iraj Shahramian,Ali Bazi,Gholamreza Kalvandi
- مشاهده
- جایگاه : پژوهشی
- مجله: Journal of Dentistry, Shiraz University of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی:
- چکیده:
- چکیده انگلیسی: Statement of the Problem: Genetic polymorphisms can alter immunity response against pathogens, which in turn influence individuals’ susceptibility to certain infections.Purpose: Our aim was to determine the association of Arg753Gln (rs5743708) and Arg677Trp (rs12191786) polymorphisms of toll like receptor-2 gene with the two clinical forms of apical periodontitis: acute apical abscess (AAA) and asymptomatic apical periodontitis (AAP).Materials and Method: There were 50 patients with AAA as case group and 50 with AAP as control group. Genotyping was done using Tetra-ARMS (amplification refractory mutation system) PCR.Results: Heterozygous genotype of Arg677Trp polymorphism was associated with risk of AAA (OR=1.9, 95% CI: 0.7-5.5, p= 0.05). Although statistically insignificant, Arg677Trp polymorphism promoted the risk of AAA in dominant model (OR=2.1, 95% CI: 0.7-5.9, p> 0.05). The frequency of mutant allele (T) of Arg677Trp polymorphism was higher in AAA (14%) than AAP (7%) subjects (OR=1.7, 95% CI: 0.6-4.7). For Arg753Gln polymorphism, wild homozygous (GG) represented the dominant genotype in both cases (96%) and controls (100%). Variant allele (A) of Arg753Gln polymorphism was identified in 2% of AAA, while no individual represented with this allele in AAP subjects. Individuals with Arg753Gln; Arg677Trp (GG; TC) combination showed an elevated risk of AAA (OR=1.6, 95% CI: 0.5- 4.2, p> 0.05).Conclusion: Arg677Trp polymorphism of TLR-2 rendered a higher risk for the development of abscesses in apical periodontitis. It is recommended to explore role of this polymorphism in other populations.
- انتشار مقاله: 25-07-1395
- نویسندگان: Ebrahim Miri-Moghaddam,Narges Farhad Mollashahi,Nava Naghibi,Yasaman Garme,Ali Bazi
- مشاهده
- جایگاه : پژوهشی
- مجله: Journal of Basic and Clinical Pathophysiology
- نوع مقاله: Journal Article
- کلمات کلیدی: Morris Water Maze,Acute stress,Recent memory,Remote memory
- چکیده:
- چکیده انگلیسی: Background and Objective: It is well known that stress and glucocorticoid, modulate memory processing, though the result is completely dependent on the time of stress induction. This study investigated the effect of acute corticosterone administration on memory retrieval of recent and remote memory in a 4 trials/day (low- intensity learning) or 8 trials/ day (high- intensity learning) Morris water maze protocol.
Materials and Methods: Sixty four adult male Wistar rats were used in this research study. Corticosterone was injected subcutaneously (3 mg/kg) 30 min before the probe trial test of Morris water maze. Control animals received the vehicle.
Results: Acute corticosterone, thirty minutes before probe test led to impairment of memory retrieval phase in recent (p
Conclusion: Apparently, learning enhancement was just effective for protecting deleterious effects of corticosterone in recent memory and had no effect on remote memory. Thus, acute stress may impair memory retrieval in a time-dependent manner.- انتشار مقاله: 28-03-1396
- نویسندگان: Amir Sina Homayooni,Rafie Belali,Farzane Malekpour,Ali Shahbazi,Farnaz Nikbakht
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Pathology
- نوع مقاله: Journal Article
- کلمات کلیدی: Acute myeloid leukemia, Acute promyelocytic leukemia, Blood cancer, Survival, t(15,17)(q22,q12)
- چکیده:
- چکیده انگلیسی: Background & Objective: Acute promyelocytic leukemia (APL) with t(15;17)(q22;q12) is a relatively common subtype of acute myeloid leukemia (AML). Here, our objective was to ascertain the survival of patients with this leukemia in north-east of Iran.
Methods: Survival rates of 42 APL patients with t(15;17)(q22;q12) were assessed. Clinical information was obtained from archived medical records. Statistical analysis was performed by SPSS 18 software using log-ranked test and Kaplan Maier survival analysis.
Results: Females and males comprised 49% and 51%, respectively. The mean age at diagnosis was 34.3 ± 14.1 years old. During the study period, 17 demises occurred in males, while this number was 7 in females. The mean survival of patients (month) was 23.22 ± 3.57 (95% CI: 16.21 ± 30.2). The five-year survival rate obtained 30%. Regarding demographic and clinical features, the highest rates of 5-year survival were recorded in patients with 20-35 years old (47.6%), males (51%), white blood cell count <10±/l (48%), and platelet count >140 ± /l (100%).
Conclusion: Younger age, lower WBC count and higher platelet count were significantly associated with longer survival in AML patients with t(15;17)(q22; q12).- انتشار مقاله: 07-11-1397
- نویسندگان: Hossein Ayatollahi,Ali Bazi,Mohammad Hadi Sadeghian,Ali Fani,Payam Siyadat,Maryam Sheikhi,Omolbanin Sargazi-aval
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Neonatology
- نوع مقاله: Journal Article
- کلمات کلیدی: Infantile colic,Keywords: Calprotectin,Intestinal inflammation,Leukocyte L1 antigen complex
- چکیده:
- چکیده انگلیسی: Background: There is limited knowledge on the potential applicability of fecal calprotectin (f-CP) as an inflammatory screening parameter in infantile colic (IC). This study aimed to evaluate f-CP in neonates with IC as a useful diagnostic indicator regarding this condition.
Methods: The present study was conducted on 100 cases, including 50 newborns with IC and 50 non-colicky neonates. The diagnosis of IC was fulfilled by the Wessel Criteria. The level of f-CP was determined by a specific enzyme-linked immunosorbent assay kit (Calprotectin ELISA, EuroImmun, Germany). The statistical analysis was performed in SPSS software (version 19).
Results: Out of 100 neonates, 57 cases were male and 43 subjects were female. The age spectrum ranged from 19-90 days (40.4±15.9). Colicky newborns were slightly younger (P=0.06) with higher birth weight compared to the infants without colic (P<0.0001). The level of f-CP was significantly higher in colicky neonates (113.7±98.2 µg/g) than non-colicky cases (71.4±45.5 µg/g) (P=0.007). Overall, 37%, 30%, 26%, and 7% of the newborns showed f-CP levels<50, 50-100, 100-200, and >200 µg/g, respectively. There was a significant difference regarding the distribution of these f-CP categories between neonates with IC and the cases without IC (P=0.02). There were no significant correlations between the f-CP and newborn age, pregnancy age, present or birth weights, and number of pregnancies. Receiver operating characteristic analysis rendered an area under the curve of 0.642 (95% CI: 0.534-0.748) (P=0.01). At the cut-off value of 74 µg/g, f-CP showed sensitivity of 60% and specificity of 59% for the detection of IC.
Conclusion: The results of this study revealed that the f-CP might be useful in the diagnosis of the IC.- انتشار مقاله: 10-09-1397
- نویسندگان: Iraj Shahramian,Ali Bazi,Alireza Sargazi,Omolbanin Sargazi Aval,Alireza Dechal,Mostafa Bazzi,Masoud Jahantigh
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: systemic lupus erythematosus,Tissue Plasminogen Activator,Antiphospholipid syndrome,Venous Thrombosis
- چکیده:
- چکیده انگلیسی: A 20-year-old woman was admitted to a Gynecology Hospital in her 6th month of pregnancy for high blood pressure and tonic-clonic seizure. Primary diagnosis was eclampsia, and for that reason she underwent cesarean section. She also had headache on frontal and parietal areas without nausea or vomiting. There was not a focal neurological sign. Rheumatology consultation was requested. Systemic lupus erythematosus and secondary antiphospholipid (APS) was confirmed. The patient had headache that continued several days after cesarean section, therefore, brain magnetic resonance imaging (MRI) and magnetic resonance venography (MRV) were performed, and cerebral vein thrombosis was documented. Distal segment of right lateral sinus and sigmoid sinus were not appeared in brain MRV. Abnormal hypersignal intensity of right lateral sinus/coronal T2 was detected. Thrombolytic therapy with 20 mg tissue plasminogen activator on right sigmoid and transverse sinus was performed by an interventional neurologist. After this procedure, the patient#s headache healed and she was discharged in a good condition.
- انتشار مقاله: 09-09-1392
- نویسندگان: Hamid Noshad,Mehrzad Hajialilo,Reza Mohammadian,Ali Reza Khabbazi,Mohammad Hossein Daghighi,Parviz Saleh
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Basic Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Proliferation,Tissue engineering,Motor neuron-like cells,Nanoscaffolds,Stem cell therapy,Three-dimension culture
- چکیده:
- چکیده انگلیسی: Objective(s): Cell therapy has provided clinical applications to the treatment of motor neuron diseases. The current obstacle in stem cell therapy is to direct differentiation of stem cells into neurons in the neurodegenerative disorders. Biomaterial scaffolds can improve cell differentiation and are widely used in translational medicine and tissue engineering. The aim of this study was to compare the efficiency of two-dimensional with a three-dimensional culture system in their ability to generate functional motor neuron-like cells from adipose-derived stem cells.
Materials and Methods: We compared motor neuron-like cells derived from rat adipose tissue in differentiation, adhesion, proliferation, and functional properties on two-dimensional with three-dimensional culture systems. Neural differentiation was analyzed by immunocytochemistry for immature (Islet1) and mature (HB9, ChAT, and synaptophysin) motor neuron markers.
Results: Our results indicated that the three-dimensional environment exhibited an increase in the number of Islet1. In contrast, two-dimensional culture system resulted in more homeobox gene (HB9), Choline Acetyltransferase (ChAT), and synaptophysin positive cells. The results of this investigation showed that proliferation and adhesion of motor neuron-like cells significantly increased in three-dimensional compared with two-dimensional environments.
Conclusion: The findings of this study suggested that three-dimension may create a proliferative niche for motor neuron-like cells. Overall, this study strengthens the idea that three-dimensional culture may mimic neural stem cell environment for neural tissue regeneration.- انتشار مقاله: 02-02-1398
- نویسندگان: Marzieh Darvishi,Hatef Ghasemi Hamidabadi,Sajad Sahab Negah,Ardeshir Moayeri,Taki Tiraihi,Javad Mirnajafi-Zadeh,Ali Jahanbazi Jahan-Abad,Amir Shojaei
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Basic Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Proliferation,Tissue engineering,Motor neuron-like cells,Nanoscaffolds,Stem cell therapy,Three-dimension culture
- چکیده:
- چکیده انگلیسی: Objective(s): Cell therapy has provided clinical applications to the treatment of motor neuron diseases. The current obstacle in stem cell therapy is to direct differentiation of stem cells into neurons in the neurodegenerative disorders. Biomaterial scaffolds can improve cell differentiation and are widely used in translational medicine and tissue engineering. The aim of this study was to compare the efficiency of two-dimensional with a three-dimensional culture system in their ability to generate functional motor neuron-like cells from adipose-derived stem cells.
Materials and Methods: We compared motor neuron-like cells derived from rat adipose tissue in differentiation, adhesion, proliferation, and functional properties on two-dimensional with three-dimensional culture systems. Neural differentiation was analyzed by immunocytochemistry for immature (Islet1) and mature (HB9, ChAT, and synaptophysin) motor neuron markers.
Results: Our results indicated that the three-dimensional environment exhibited an increase in the number of Islet1. In contrast, two-dimensional culture system resulted in more homeobox gene (HB9), Choline Acetyltransferase (ChAT), and synaptophysin positive cells. The results of this investigation showed that proliferation and adhesion of motor neuron-like cells significantly increased in three-dimensional compared with two-dimensional environments.
Conclusion: The findings of this study suggested that three-dimension may create a proliferative niche for motor neuron-like cells. Overall, this study strengthens the idea that three-dimensional culture may mimic neural stem cell environment for neural tissue regeneration.- انتشار مقاله: 02-02-1398
- نویسندگان: Marzieh Darvishi,Hatef Ghasemi Hamidabadi,Sajad Sahab Negah,Ardeshir Moayeri,Taki Tiraihi,Javad Mirnajafi-Zadeh,Ali Jahanbazi Jahan-Abad,Amir Shojaei
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Chemistry and Chemical Engineering
- نوع مقاله: Journal Article
- کلمات کلیدی: Underbalanced drilling,Pressure profile,transient flow,CFD technique
- چکیده:
- چکیده انگلیسی: Nowadays, UnderBalanced Drilling (UBD) technology is widely applicable in the petroleum industry due to its advantages to an overbalanced drilling operation. UBD success depends on maintaining the drilling fluid circulating pressure below the reservoir pore pressure during operations. One of the main prerequisites of a successful UBD operation is the correct estimation of the pressure profile. In this investigation, the pressure profile was obtained with consideration of the influx to the wellbore. A spreadsheet was developed to obtain the pressure profile using an analytical solution for aerated mud in UBD operation. Moreover, a numerical simulation was employed to simulate the three-phase flow in annulus through the UBD operation and the transient Eulerian model flow via the turbulence k-ε model. The effects of solid particle size and rotation of the inner pipe were considered on the pressure drop. It was observed that pressure drop was significantly increased with increasing solid particle size while it remained almost constant with increasing of the inner pipe rotation. The analytical and numerical results
were compared with published experimental results and showed a good agreement.- انتشار مقاله: 17-03-1395
- نویسندگان: Meysam Dabiri Atashbeyk,Khalil Shahbazi,Moslem Fattahi
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of New Chemistry
- نوع مقاله: Journal Article
- کلمات کلیدی: Nano-silica,Rheology,Fluid Migration,Well Cementing,preventing strategies
- چکیده:
- چکیده انگلیسی: There are various vital reasons for cementing operation, in which fluid migration through cement slurry, as one of the most dangerous and complicated challenges faces drilling industry has been occurred. This phenomenon has become a global problem with its disastrous effects this review paper focused on the gas migration types, factors affecting on each of them and some theoretical and experimental solution. Immediate, short term and long term are the three types of gas migration based on the lifecycle of the well. There are different strategies to prevent gas migration, each type of migration have special strategies. Technical solution development, application of different cement additives in cement slurry and prediction technique for cement quality are number of strategies are developed. Hydrostatic pressure less than pore pressure and the existence of a path to gas migration are two major factors that must be stopped simultaneously to prevent migration. Understanding the mechanisms of cement hydration in early times is necessary to investigate these factors. Cement hydration can lead to swelling and shrinkage at the same time. At the beginning of cementation chemical shrinkage occurs, followed by swelling and autogenously shrinkage, and their intensity depends on the type and amount of the cement additives, the degree of hydration, the water-cement ratio and the fineness of cement. The most important factors that make the annulus pressure less than the pore pressure are: cement placement, Cement hydration in liquid state, and Cement hydration in solid-liquid state.
- انتشار مقاله: 17-11-1398
- نویسندگان: Mahmoud Bayanak,Soroush Zarinabadi,Khalil Shahbazi,Alireza Azimi
- مشاهده