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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Iranian Journal of Biotechnology
- نوع مقاله: Journal Article
- کلمات کلیدی: Cytarabine,reactive oxygen species,Olea,Sunphenon,Stomach neoplasms
- چکیده:
- چکیده انگلیسی: Background: According to the epidemiological studies, consuming olive products can decrease the incidence of the different types of cancers mostly due to the high anti-oxidant properties of their polyphenolic compounds.
Objectives: To evaluate the anti-oxidant and anti-proliferative potentials of the olive fruits total polyphenols on the gastric adenocarcinoma MKN45 cells in comparison to the normal Hu02 cells.
Materials and Methods: The total phenolic content of the olive fruits and radical scavenging activity were determined by Folin and 2,2-diphenyl-1-picrylhydrazyl (DPPH) tests respectively. MTT assay was performed for the evaluation of the cell viability. Intracellular reactive oxygen species (ROS) level was measured using DCFH-DA. Statistical analysis was performed using SPSS 16 statistical software.
Results: Treatment of the MKN45 cells with the phenolic compounds extracted from olive fruits decreased growth and viability of the cells in a dose- and time-dependent manner. In addition, treatment of the MKN45 cells with a combination of the phenolic compounds extracts and cytarabine further decreased cell compared to monotherapy of the cells with each compound alone. Mechanistically, we showed that the anti-cancer effects of the olive polyphenols in the MKN45 cells are mediated through depletion of ROS. Similarly, polyphenolic extracts were found to decrease ROS level in the normal cells at the concentrations of 500 and 1000 μg.mL-1 and short treatment times (6 h), but the viability of these cells did not significantly change. At high concentrations (2000 μg.mL-1) of the phenolic extracts or at longer times of incubation (12 h), however, both ROS levels and the viability of the cells were significantly decreased in the normal cells.
Conclusions: The olive fruits polyphenolic extract modulates ROS levels and selectively targets cancerous cells at low concentrations. Also, the effects of cytarabine could be potentiated by the olive fruits polyphenols. Thus, for a combined protocol of cancer cell therapy, olive fruit polyphenolic compound could be proposed as a proper candidate.- انتشار مقاله: 13-04-1396
- نویسندگان: Alireza Amiri-nowdijeh,Mohammad Amin Moosavi,Simzar Hosseinzadeh,Masoud Soleimani,Farzaneh Sabooni,Mehdi Hosseini-Mazinani
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Chemistry and Chemical Engineering
- نوع مقاله: Journal Article
- کلمات کلیدی: Medicinal plants,Quercetin,extraction,Nanoporous,Molecularly imprinted polymers,Bioactive
- چکیده:
- چکیده انگلیسی: In this work, the template, monomer, and cross-linker with the ratio of 1:8:40 were used to synthesize Molecularly Imprinted Polymers (MIPs) for extraction of the bioactive chemical compounds from some traditional herbs as a sorbent material. Quercetin, Methacrylic Acid (MAA), Trimethylolpropanetrimethacrylate (TRIM) and Tetrahydrofuran (THF) were used as a template, functional monomer, cross-linker, and porogen, respectively. Polymer particles have been evaluated by Atomic Force Microscopy (AFM), Field Emission Scan Electron Microscopy (FESEM), Transmission Electron Microscopy (TEM) and Brunauer–Emmett–Teller (BET). The produced nanoporous MIPs, with a good specific surface area 167.899 m2/g comparatively to Non-Imprinted Polymers (NIPs), exhibited a good affinity to quercetin with the binding capacity of 392.08 mg/g in acetonitrile-water (1:1v/v). The results showed that the MIPs can be used as a sorbent. Thus, direct extraction of certain pharmacophoric components from herbal plants is considerable by MIPs technology.
- انتشار مقاله: 30-09-1394
- نویسندگان: Alireza Amiri,Ali Ramazani,Mohsen Jahanshahi,Ali Akbar Moghadamnia
- مشاهده
- جایگاه : پژوهشی
- مجله: Biquarterly Iranian Journal of Analytical Chemistry
- نوع مقاله: Journal Article
- کلمات کلیدی: HPLC,Ionic Liquid,dispersive liquid-liquid microextraction,Water sample,Spirotetramat
- چکیده: در این مطالعه، یک روش ساده و حساس برای پیش تغلیظ و اندازه گیری اسپروتترامات (سم) با استفاده از تکنیک میکرواستخراج مایع-مایع پخشی جفت شده با کروماتوگرافی مایع با عملکرد بالا توسعه داده شده است. پس از استخراج اسپیروتترامات با مایع یونی 1-بوتیل-3-متیل ایمیدازولیوم هگزافلوئوروفسفات، این سم از محلول جدا شده و به دستگاه کروماتوگرافی جهت اندازه گیری تزریق می شود. در شرایط بهینه، یک گستره خطی در محدوده 05/0 تا 2میکروگرم بر میلی لیتر حاصل شد (9987/0 =R2) و همچنین فاکتور تغلیظ 250 بود. حدتشخیص و انحراف استاندارد نسبی به ترتیب 0.01 و 2.7 میکروگرم بر میلی لیتر بدست آمد. روش پیشنهادی برای پیش تغلیظ و اندازه گیری اسپیروتترامات در نمونه های آبی تزریق شده بطور موفقیت آمیزی بکار گرفته شد که متوسط بازیابی ها بین 94 تا 96 درصد شد.
- چکیده انگلیسی: In this study, a simple and sensitive method was developed for pre-concentration of spirotetramat (SPT) using the ionic liquid-based dispersive liquid-liquid microextraction. After extracting of SPT into 1-butyl-3-methylimidazolium hexafluorophosphate (ionic liquid), the insecticide was injected into HPLC system for determining. Under the optimum conditions, the developed method provided a linearity in the range of 0.05–2.0 µg mL-1 with R2= 0.9987, and also enrichment factor was 250. The detection limit and relative standard deviation of the developed method were 0.01 µg mL-1 and 2.7%, respectively. The proposed method was successfully applied to the pre-concentration and determination of SPT in spiked water samples with mean recoveries 94.0-96.0%.
- انتشار مقاله: 15-10-1398
- نویسندگان: Fatemeh Nourpishe,Ali Asghar Amiri,Ali Sheibani,Masoud Reza Shishehbore
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Mining and Geo-Engineering
- نوع مقاله: Journal Article
- کلمات کلیدی: combined fuzzy data-driven and knowledge-driven method,geoelectrical resistivity method,karstic groundwater potential modeling,sequential exploration approach.1
- چکیده:
- چکیده انگلیسی: In this research, recognition of karstic water-bearing zones using the management of exploration data in Kal-Qorno valley, situated in the Tepal area of Shahrood, has been considered. For this purpose, the sequential exploration method was conducted using geological evidences and applying remote sensing and geoelectrical resistivity methods in two major phases including the regional and local scales. Thus, geological structures and lithological units in regional scale have been investigated for groundwater potential. In this regard, suitable potential maps have been provided in the geographical information system (GIS) environment, using fuzzy data-driven and knowledge-driven methods. To obtain the final karstic water potential model, the prepared maps were combined using fuzzy ‘AND’ operator. In the local scale, geoelectrical surveys were conducted in the recognized high potential zones. Consequently, the results of geological investigations, analysis of lineaments extracted from satellite imagery and geoelectrical resistivity data modeling and interpretation were integrated to decide on the position of high yield extraction wells. As a result, karstic water zones in the study area were identified, and based on that, two suitable drilling locations to access and extract karstic groundwater in the study area have been suggested.
- انتشار مقاله: 07-11-1393
- نویسندگان: Fereydoun Sharifi,Ali Reza Arab-Amiri,Abolghasem Kamkar-Rouhani,Mahyar Yousefi,Behzad Tokhmechi
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Pediatrics
- نوع مقاله: Journal Article
- کلمات کلیدی: children,Pethidine,Paracetamol,Clinical Trial Study
- چکیده:
- چکیده انگلیسی: Background
Paracetamol and Pethidine are two prevailing analgesics prescribed for postoperative orthopedic patients, each having different side effects and impacts on fracture healing. The present study was conducted to compare the impacts of Paracetamol and Pethidine on postoperative pain relief of children with bone fractures.
Materials and Methods: Fifty children with orthopedic bone fracture surgery candidates were selected in a double-blinded clinical trial study. A random number table was utilized to classify children into two groups of Paracetamol or pethidine treatment. First, the pain intensity of each group was checked using the Visual Analog Scale (VAS). Six hours after the surgery, the first group received Pethidine (1mg/kg of body weight), and the second group received Paracetamol (1gr). Moreover, the VAS scales were checked for both groups 6, 12, and 24 hours later. Afterward, the pain intensity of both groups was assessed according to the VAS scale.
Results: Independent t-test results revealed a significant difference between the pain intensity of paracetamol (44.24 ± 6.44), and Pethidine (52.68 ± 10.47) groups 6 hours after the surgery (p=0.03). Moreover, there was also a significant statistical difference between the pain intensity of two groups 12 and 24 hours after the surgery.
Conclusion
Given the effectiveness of Paracetamol and Pethidine on postoperative pain, both medications can be used for children with bone fractures.- انتشار مقاله: 04-06-1399
- نویسندگان: Ali Rokni,Majid Sezavar,Abdolmajid Eslahtalab,Mohammad Mobin Mirimoghaddam,Sara Behzadfar,Mohammad Mahdi Jalalpour,Ali Pour Amiri
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Pediatrics
- نوع مقاله: Journal Article
- کلمات کلیدی: children,Iran,Macrophage activation syndrome,Kawasaki disease
- چکیده:
- چکیده انگلیسی: Introduction
Macrophage activation syndrome (MAS) is a rare and life-threatening complication of Kawasaki Disease (KD) that is usually diagnosed at the same time or after KD. We report a case of MAS as the initial manifestation of KD.
Case Report
A previously healthy 3-year old girl was admitted to the pediatric infectious diseases ward of Bahrami Children’s Hospital, Tehran, Iran. She had a 3-day history of fever and lymphadenopathy which persisted despite antibiotic therapy. Patient's general condition gradually worsened and she developed loss of consciousness. After being diagnosed with MAS based on laboratory findings, she developed mucocutaneous manifestations of KD. She responded to methylprednisolone pulse therapy, intravenous immunoglobulin and dipyridamole. The follow-up at 2 weeks and 2 months showed no abnormal findings.
Conclusion
MAS may manifest even before the diagnosis of KD is made. Early recognition of MAS associated with KD and prompt treatment with corticosteroids can improve the outcome.- انتشار مقاله: 25-04-1398
- نویسندگان: Ali Ahmadzadeh Amiri,Payman Sadeghi,Mahdieh Mousavi Torshizi
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Mining and Geo-Engineering
- نوع مقاله: Journal Article
- کلمات کلیدی: fast Hankel transforms,forward modelling,frequency domain data,HCP coils system,HEM method,sensitivity matrix
- چکیده:
- چکیده انگلیسی: The helicopter-borne electromagnetic (HEM) frequency-domain exploration method is an airborne electromagnetic (AEM) technique that is widely used for vast and rough areas for resistivity imaging. The vast amount of digitized data flowing from the HEM method requires an efficient and accurate inversion algorithm. Generally, the inverse modelling of HEM data in the first step requires a precise and efficient technique provided by a forward modelling algorithm. The exact calculation of the sensitivity matrix or Jacobian is also of the utmost importance. As such, the main objective of this study is to design an efficient algorithm for the forward modelling of HEM frequency-domain data for the configuration of horizontal coplanar (HCP) coils using fast Hankel transforms (FHTs). An attempt is also made to use an analytical approach to derive the required equations for the Jacobian matrix. To achieve these goals, an elaborated algorithm for the simultaneous calculation of the forward computation and sensitivity matrix is provided. Finally, using two synthetic models, the accuracy of the calculations of the proposed algorithm is verified. A comparison indicates that the obtained results of forward modelling are highly consistent with those reported in Simon et al. (2009) for a four-layer model. Furthermore, the comparison of the results for the sensitivity matrix for a two-layer model with those obtained from software is being used by the BGR Centre in Germany, showing that the proposed algorithm enjoys a high degree of accuracy in calculating this matrix.
- انتشار مقاله: 30-11-1392
- نویسندگان: Abolfazl Asadian,Ali Moradzadeh,Alireza Arab-Amiri,Ali Nejati Kalateh,Davood Rajabi
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Mining and Geo-Engineering
- نوع مقاله: Journal Article
- کلمات کلیدی: classification,SVM,Hyperspectral,cross-validation,hughes phenomenon,Hydrothermal alteration
- چکیده:
- چکیده انگلیسی: To prospect mineral deposits at regional scale, recognition and classification of hydrothermal alteration zones using remote sensing data is a popular strategy. Due to the large number of spectral bands, classification of the hyperspectral data may be negatively affected by the Hughes phenomenon. A practical way to handle the Hughes problem is preparing a lot of training samples until the size of the training set is adequate and comparable with the number of the spectral bands. In order to gather adequate ground truth instances as training samples, a time-consuming and costly ground survey operation is needed. In this situation that preparing enough field samples is not an easy task, using an appropriate classifier which can properly work with a limited training dataset is highly desirable. Among the supervised classification methods, the Support Vector Machine is known as a promising classifier that can produce acceptable results even with limited training data. Here, this capability is evaluated when the SVM is used to classify the alteration zones of Darrehzar district. For this purpose, only 12 sampled instances from the study area are utilized to classify Hyperion hyperspectral data with 165 useable spectral bands. Results demonstrate that if parameters of the SVM, namely C and σ, are accurately adjusted, the SVM can be successfully used to identify alteration zones when field data samples are not available enough.
- انتشار مقاله: 13-11-1393
- نویسندگان: Amir Salimi,Mansour Ziaii,Mahdieh Hosseinjani Zadeh,Ali Amiri,Sadegh Karimpouli
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Finance and Managerial Accounting
- نوع مقاله: Journal Article
- کلمات کلیدی: DEA two-step,value creativity,profitability,fuzzy multi-phase
- چکیده:
- چکیده انگلیسی: The aim of this study is to provide a new two-stage DEA model with fuzzy multi-objective programming approach for evaluating the performance of companies listed in the Tehran Stock Exchange. In this study, a two-stage DEA model, different from the traditional model, we introduce for performance analysis. In this regard, the stable operation of companies, into two sub-process, have divided, which includes the profitability (first phase) and the value creativity (the second phase), which can be used to identify the status of the company's operations and potential for future growth. Therefore, the profitability, including two entrances (the ratio of total debt, the ratio of total equity) and two outputs (ROA, ROE) and the value creativity (the second stage) includes two outputs (the ratio of book value to market value of B / M, the cost income ratio E / P) consider, that is, the outputs of the first stage are inputs for the second stage. The decision matrix proposed in this study, can clearly define the benchmark that can be emulated by inefficient companies and help managers to develop appropriate strategies needed to enhance their overall efficiency. The results show that due to general inefficiency, ineffectiveness was in one of the two sub-processes. The results show that the multi-phase two-stage DEA model is able to identify the causes of inefficiencies and provides a scale to compare performance.
- انتشار مقاله: 29-05-1397
- نویسندگان: Mohammad Reza Ravanshad,Ali Amiri,Hojjat Salari
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Hospital Research
- نوع مقاله: Journal Article
- کلمات کلیدی: Statistical analysis,Emergency department, Resilience engineering, Patient trust, Z-Number data envelopment analysis (ZDEA)
- چکیده:
- چکیده انگلیسی: Background and Objectives: Emergency departments often encounter several risk and health issues which significantly impact on overall healthcare performance. Resilience engineering (RE) enables emergency departments to confront sudden changes and handling health risk issues. Patient trust (PT) is also one of the most effective factors which improve quality of care along with patient satisfaction.
Methods: This study integrates resilience engineering and trust to enhance the overall performance of emergency departments (EDs). A unique algorithm is introduced to demonstrate the superiority of the proposed integrated approach. It is composed of Z-number data envelopment analysis (DEA), fuzzy DEA, and statistical analysis. The required data are collected using standard questionnaires from a real-life emergency department. The obtained results are verified and validated by FDEA.
Findings: The results indicate that considering RE and trust increases ED efficiency significantly. Also, flexibility, fault-tolerance, reporting culture, and specialty level are the most effective factors. Moreover, trust and resiliency have similar statistical impacts on overall system efficiency.
Conclusions: One of the concerns of medical service providers nowadays is to build an efficient ED capable of providing services to a large number of patients. Therefore, to evaluate the performance of the ED, both concepts of PT and RE which are applicable to enhance the preventive safety and promote the performance, are simultaneously considered for the first time in this study.- انتشار مقاله: 31-01-1396
- نویسندگان: Maryam Tohidifard,Reza Yazdanparast,Ali Bozorgi-Amiri,Ali Azadeh
- مشاهده