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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Inorganic Chemistry Research
- نوع مقاله: Journal Article
- کلمات کلیدی: DNA,CT-DNA,UV-Vis absorption spectroscopy,Fluorescence spectroscopy,BSA theoretical studies
- چکیده:
- چکیده انگلیسی: In this research, the interaction of [CuL(DMF)], [NiL(DMF)] and [VOL(DMF)] (where L = ((E)-4-((2-amino-5-nitrophenylimino)methyl)benzene-1,3-diol)) complexes derived from tridentate Schiff base ligand with bovine serum albumin (BSA) and DNA was investigated via electronic absorption and fluorescence spectroscopy. The Ultraviolet-Visible (UV-Vis) spectra exhibited an isosbestic point for the complexes through titration with DNA. The experimental results showed the presence of intercalation interaction between the complexes and calf-thymus DNA (CT-DNA). The interaction of BSA protein and complexes was significant. The recorded florescence spectra of complexes interacting with DNA and BSA revealed the static quenching manner. The free binding energies of complexes and their interaction modes with DNA and BSA were determined by the molecular docking. MTT-dye reduction technique was applied to define cytotoxicity of [NiL(DMF)], [CuL(DMF)] and [VOL(DMF)] complexes against breast cancer 4T1 and colon carcinoma C26 cell lines. The [VOL(DMF)] complex had cytotoxic activity against 4T1 and C26 cell lines.
- انتشار مقاله: 09-03-1398
- نویسندگان: Morteza Dostani,Ali Hossein Kianfar,Hossein Farrokhpour,Fatemeh Abyar,Amir Abbas Momtazi-Borojeni,Elham Abdollahi
- مشاهده
- جایگاه : پژوهشی
- مجله: Inorganic Chemistry Research
- نوع مقاله: Journal Article
- کلمات کلیدی: Schiff base,Phosphane,Cobalt(III) complexes,X-Ray crystal structure
- چکیده:
- چکیده انگلیسی: The new [Co(Salen)(PBu3)2]ClO4, [Co(Salen)(PBu3)2]BF4, [Co(Salpn)(PBu3)2]ClO4 and [Co(Salen)(PMe2Ph)2]ClO4 ( where salen = bis(salisylaldehyde)ethylenediimine)) complexes were synthesiszed and chracterized by IR, UV-Vis, 1H NMR spectroscopy and elemental analysis. The IR and 1H NMR spectra cofirmed that the synthesised complexes contain Schiff base ligand, phosphane and conter ion and the elemental analysis is in good agreement with those calculated for the proposed formula. The coordination geometry of [Co(Salen)(PMe2Ph)2]ClO4 and [Co(Salen)(PBu3)2]ClO4 complexes were determined by X-ray crystallography. It has been found that all the complexes are hexa coordinate in the solid state. Cobalt atom exhibits a distorted octahedral geometry and the salen ligand has the N2O2 coordinated environment in the equatorial plane.
Cobalt complexes with ligands derived from salicylaldehyde have been well studied.[1] They are regarded as models for the Cobalamine (B12) coenzymes [2-4] classified as an oxygen carrier [5] and used as a catalyst for the preparative oxygenation of phenols [6] indols [7] and amines.[8]. The catalytic activity of Co(III) with salen complexes has been investigated. It was shown the catalytically active species contains cobalt in the Co(III) oxidation state [9-15].- انتشار مقاله: 30-01-1394
- نویسندگان: Ali Hossein Kianfar,Hamid Reza Khavasi
- مشاهده
- جایگاه : پژوهشی
- مجله: Inorganic Chemistry Research
- نوع مقاله: Journal Article
- کلمات کلیدی: Vanadyl complexes,Tridentate schiff base ligands,Schiff base Complexes,Thermogravimetry,Electrochemistry,Ab initio calculations
- چکیده:
- چکیده انگلیسی: The VO(IV) complexes of tridentate ONO Schiff base ligands derived from 2- aminobenzoicacid and salicylaldehyde derivatives were synthesized and characterized by IR, UV–Vis and elemental analysis. Electrochemical properties of the vanadyl complexes were investigated by cyclic voltammetry. A good linear correlation was observed between the oxidation potentials and the electron-withdrawing character of the substituents on the Schiff bases, showed the following trend: MeO < H < Br < NO2. The thermogravimetry (TG) and differential thermoanalysis (DTA) of the synthesized complexes were carried out in the range of 20–700 °C. All of the complexes decomposed in three steps. The thermal decomposition pathways were closely related to the nature of the Schiff base ligands and preceded via first-order kinetics. The structures of compounds were determined by ab initio calculations. The optimized molecular geometry was calculated at the B3LYP/6-31G(d) level. The results suggested that, in the complexes, V(IV) ion was in square-pyramid or TBP (trigonal bipyramidal) NO4 coordination geometry. Also the bond lengths and angles were studied and compared.
- انتشار مقاله: 12-03-1393
- نویسندگان: Ali Hossein Kianfar,Hajar Mohamadi Malek Abadi,Roghayeh Hashemi Fath,Mahmoud Roushani
- مشاهده
- جایگاه : پژوهشی
- مجله: Inorganic Chemistry Research
- نوع مقاله: Journal Article
- کلمات کلیدی: DNA,CT-DNA,UV-Vis absorption spectroscopy,Fluorescence spectroscopy,BSA theoretical studies
- چکیده:
- چکیده انگلیسی: In this research, the interaction of [CuL(DMF)], [NiL(DMF)] and [VOL(DMF)] (where L = ((E)-4-((2-amino-5-nitrophenylimino)methyl)benzene-1,3-diol)) complexes derived from tridentate Schiff base ligand with bovine serum albumin (BSA) and DNA was investigated via electronic absorption and fluorescence spectroscopy. The Ultraviolet-Visible (UV-Vis) spectra exhibited an isosbestic point for the complexes through titration with DNA. The experimental results showed the presence of intercalation interaction between the complexes and calf-thymus DNA (CT-DNA). The interaction of BSA protein and complexes was significant. The recorded florescence spectra of complexes interacting with DNA and BSA revealed the static quenching manner. The free binding energies of complexes and their interaction modes with DNA and BSA were determined by the molecular docking. MTT-dye reduction technique was applied to define cytotoxicity of [NiL(DMF)], [CuL(DMF)] and [VOL(DMF)] complexes against breast cancer 4T1 and colon carcinoma C26 cell lines. The [VOL(DMF)] complex had cytotoxic activity against 4T1 and C26 cell lines.
- انتشار مقاله: 09-03-1398
- نویسندگان: Morteza Dostani,Ali Hossein Kianfar,Hossein Farrokhpour,Fatemeh Abyar,Amir Abbas Momtazi-Borojeni,Elham Abdollahi
- مشاهده
- جایگاه : پژوهشی
- مجله: Inorganic Chemistry Research
- نوع مقاله: Journal Article
- کلمات کلیدی: Schiff base,Phosphane,Cobalt(III) complexes,X-Ray crystal structure
- چکیده:
- چکیده انگلیسی: The new [Co(Salen)(PBu3)2]ClO4, [Co(Salen)(PBu3)2]BF4, [Co(Salpn)(PBu3)2]ClO4 and [Co(Salen)(PMe2Ph)2]ClO4 ( where salen = bis(salisylaldehyde)ethylenediimine)) complexes were synthesiszed and chracterized by IR, UV-Vis, 1H NMR spectroscopy and elemental analysis. The IR and 1H NMR spectra cofirmed that the synthesised complexes contain Schiff base ligand, phosphane and conter ion and the elemental analysis is in good agreement with those calculated for the proposed formula. The coordination geometry of [Co(Salen)(PMe2Ph)2]ClO4 and [Co(Salen)(PBu3)2]ClO4 complexes were determined by X-ray crystallography. It has been found that all the complexes are hexa coordinate in the solid state. Cobalt atom exhibits a distorted octahedral geometry and the salen ligand has the N2O2 coordinated environment in the equatorial plane.
Cobalt complexes with ligands derived from salicylaldehyde have been well studied.[1] They are regarded as models for the Cobalamine (B12) coenzymes [2-4] classified as an oxygen carrier [5] and used as a catalyst for the preparative oxygenation of phenols [6] indols [7] and amines.[8]. The catalytic activity of Co(III) with salen complexes has been investigated. It was shown the catalytically active species contains cobalt in the Co(III) oxidation state [9-15].- انتشار مقاله: 30-01-1394
- نویسندگان: Ali Hossein Kianfar,Hamid Reza Khavasi
- مشاهده
- جایگاه : پژوهشی
- مجله: Inorganic Chemistry Research
- نوع مقاله: Journal Article
- کلمات کلیدی: Vanadyl complexes,Tridentate schiff base ligands,Schiff base Complexes,Thermogravimetry,Electrochemistry,Ab initio calculations
- چکیده:
- چکیده انگلیسی: The VO(IV) complexes of tridentate ONO Schiff base ligands derived from 2- aminobenzoicacid and salicylaldehyde derivatives were synthesized and characterized by IR, UV–Vis and elemental analysis. Electrochemical properties of the vanadyl complexes were investigated by cyclic voltammetry. A good linear correlation was observed between the oxidation potentials and the electron-withdrawing character of the substituents on the Schiff bases, showed the following trend: MeO < H < Br < NO2. The thermogravimetry (TG) and differential thermoanalysis (DTA) of the synthesized complexes were carried out in the range of 20–700 °C. All of the complexes decomposed in three steps. The thermal decomposition pathways were closely related to the nature of the Schiff base ligands and preceded via first-order kinetics. The structures of compounds were determined by ab initio calculations. The optimized molecular geometry was calculated at the B3LYP/6-31G(d) level. The results suggested that, in the complexes, V(IV) ion was in square-pyramid or TBP (trigonal bipyramidal) NO4 coordination geometry. Also the bond lengths and angles were studied and compared.
- انتشار مقاله: 12-03-1393
- نویسندگان: Ali Hossein Kianfar,Hajar Mohamadi Malek Abadi,Roghayeh Hashemi Fath,Mahmoud Roushani
- مشاهده