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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Nanomedicine Journal
- نوع مقاله: Journal Article
- کلمات کلیدی: Nanoparticles,Cytotoxicity,biocompatibility,Aluminium Nitride
- چکیده:
- چکیده انگلیسی: Objective(s): Aluminium nitride (AlN) could be used in implantable biomedical sensor devices, for which cytotoxicity analysis is of utmost importance.
Materials and Methods: AlN nanoparticles were synthesized using a simple and effective solvothermal method. The X-ray diffraction results revealed the cubic phase of AlN, and the field emission scanning electron microscopy analysis demonstrated the structural morphology of the synthesized materials. In addition, the cytotoxicity of the AlN nanoparticles was assessed against healthy (HEK-293, HUVEC, and MCF10A) and cancerous cell line (HeLa). The intensity of the reactive oxygen species was also measured to determine the induced oxidative stress in the treated cells.
Results: The cytotoxicity analysis indicated that the AlN nanoparticles were nontoxic against the cancerous and normal cell lines. No significant changes were observed between the low doses of the AlN nanoparticles in the treated and control cells. However, morphological changes were detected by a phase contrast microscope, while insignificant changes were observed similar to the control cells.
Conclusion: The findings of this study could lay the groundwork for the development of AlN nanoparticles for further biomedical applications.- انتشار مقاله: 22-02-1399
- نویسندگان: Manjot Kaur,Kulwinder Singh,Paviter Singh,Amanpreet Kaur,Ramovatar Meena,Gajendra Pratap Singh,Hamed Barabadi,Muthupandian Saravanan,Akshay Kumar
- مشاهده
- جایگاه : پژوهشی
- مجله: Asia Oceania Journal of Nuclear Medicine and Biology
- نوع مقاله: Journal Article
- کلمات کلیدی: FDG PET/CT,Primary extranodal lymphoma,NHL
- چکیده:
- چکیده انگلیسی: Non-Hodgkin lymphoma (NHL) is a group of malignant lymphoproliferative disorders arising predominantly in the lymph nodes with various clinical and histological characteristics. At least 25% of NHL originates from tissues other than lymph nodes and sometimes even from sites that do not contain lymphoid tissue. These are referred to as primary extranodal lymphomas (pENLs). pENL is a universal diagnostic challenge to the clinicians and pathologists due to their varied clinical presentations, morphological mimicry, and molecular alterations. The GIT is the most common site of pENL followed by nasopharynx/oropharynx, testis, uterus/ovary, thyroid, and central nervous system. Long bones (tibia), maxillary sinus, skin, and paraspinal soft tissues are the other rare anatomic sites of pENL. We reported a case of a 60-year-old female presented with pain and mass in the pelvis region. 18F-Fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) and fused PET/CT was done, which revealed extensive extranodal involvement of the lung, bilateral kidneys, uterus, ovaries, bones, and muscles with no involvement of lymph nodes or lymphomatous organs. Extensive extranodal involvement with sparing of lymphomatous organ has not been reported earlier.
- انتشار مقاله: 23-02-1399
- نویسندگان: Vijay Singh,Akshay Kumar,Prakash Singh,Manish Ora,Sanjay Gambhir
- مشاهده