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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Journal of Kerman University of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: diabetes,Ultrasound,lipid profile,intima-media thickness,Carotid artery
- چکیده:
- چکیده انگلیسی: Background & Aims: Diabetes is a very important factor for stroke due to blocked blood vessels. It can involve systemic and cerebrovascular arteries at the same time via microangiopathy and macroangiopathy. This project aimed to compare the intima-media thickness of carotid artery in children with diabetes type and the control group. Methods: In this case-control study, 50 children with the age of 5-18 years were enrolled in two equal groups of patients and controls. After obtaining informed consent and completing the demographic data, carotid artery ultrasound, lipid profile test and checking random blood pressure was conducted for the subjects. Then, the data were statistically analyzed using SPSS software. Results: The mean intima-media thickness of the carotid artery was 0.45 ± 0.09 and 0.38 ± 0.06 in control and patient groups, respectively. There was a statistically significant difference between the two groups (P = 0.004). Conclusion: The intima-media thickness of the carotid artery and serum lipid profiles in children with diabetes was significantly higher than the control group. In addition, in children with diabetes, the systolic blood pressure was significantly correlated with the increased intima-media thickness of the carotid artery
- انتشار مقاله: 22-04-1395
- نویسندگان: Ahmad Enhesari,Akbar Ahmadi,Elham Maleki,Abdolrasool Mohammdi
- مشاهده
- جایگاه : پژوهشی
- مجله: Journal of Information Technology Management
- نوع مقاله: Journal Article
- کلمات کلیدی: Educational Data Mining,Customer churn,customer relation management,withdrawal
- چکیده:
- چکیده انگلیسی: Student withdrawal in higher education is one the important challenges in universities. This paper considers the admission of fee paid students as a business and their withdrawals as customer churn. The aim is to investigate the attrition and predicted risk of attrition to adapt interventionist polices deterrent. This study is a descriptive an applicable technique that uses quantitative and qualitative data. It uses Crisp technology of data mining. The data are derived from educational system of University of Tehran including 21420 fee paid students accepted at 2010 to 2014. The main goal is to analyze the behavior that is at risk of attrition and withdrawal. After data analyze and construction of predictive modeling, the probability table of attrition and regression model will be presented. The final results show that the first and second semester (especially the age range 24-31) of M.Sc students are the most likely risk of withdrawal of happening.
- انتشار مقاله: 26-12-1393
- نویسندگان: Saied Ali Akbar Ahmadi,Davood Karimzadgan,Toraj Khairati Kazerooni
- مشاهده
- جایگاه : پژوهشی
- مجله: Journal of Health Management and Informatics
- نوع مقاله: Journal Article
- کلمات کلیدی:
- چکیده:
- چکیده انگلیسی: Introduction: The main purpose of this study was to assess fulfillment of goals about “Health Transformation Plan (HTP) of Ministry of Health, Treatment and Medical Education” from the perspective of managers, which is as one of the most important management challenges in the Health System Reform Plan. These goals included six packages determined by the Ministry of Health, Treatment and Medical Education, the fulfillment of each of which one was evaluated separately as sub-goals in the current study. Finally, the rank of each package in comparison to other packages was determined and presented, using means rank test (Friedman test).Method: This study was conducted using a questionnaire in which comments of the senior and middle managers of Nemazee hospital were collected as the research data. Due to the fact that about one year has passed since the beginning of implementation of HTP and since there were no documented methods or questionnaires, the researcher designed a self-made questionnaire. The basis of designing the questionnaire was the set of guidelines developed for Health System Reform Plan. These guidelines include goals that a hospital should achieve during implementation of Health System Reform Plan. After sharing these goals with senior and middle managers of Nemazee hospital (as the place of research), they were converted to a questionnaire including 20 questions. The questionnaire included the goals that must be achieved in Nemazee hospital of Shiraz during the implementation of the plan. After designing the questionnaire, a preliminary test was taken to assess the reliability.Results: Cronbach’s alpha coefficient (0.88) showed a high rate of reliability in the above questionnaire. After the final data collection, the questionnaire was tested in a sample of 100 senior and middle managers; the results showed that about six packages were specified by the Ministry of Health, Treatment and Medical Education. The majority of respondents (about 57%) believed that the HTP has greatly achieved its goals, and about 43% of them believed that the success of this plan was average.Conclusion: In ranking among the six main packages which was considered as sub-goals of this plan, the results showed that the studied packages were ranked respectively as follows: Package number 1, Package number 2, Package number 6, Package number 3, Package number 5 and Package number 4.Keywords: Health System Reform Plan, Ministry of Health, Hospital, Managers
- انتشار مقاله: 07-10-1394
- نویسندگان: Ali Akbar Ahmadi,Fatemeh Bahari,Hakimeh Parsaei,Maryam Golami
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Basic Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Thalidomide,IL-6,TNF-α,Cirrhotic cardiomyopathy,SOCS1
- چکیده:
- چکیده انگلیسی: Objective(s): Cirrhotic cardiomyopathy is a complication of uncured cirrhosis which is associated with hyporesponsiveness of the heart to sympathetic stimulation. The enhancement of portal pressure, nitric oxide (NO) level, pro-inflammatory mediators and down-regulation of Suppressor of Cytokine Signaling 1 (SOCS1) are involved in this situations. The present study seeks to examine the beneficial effect of thalidomide on cirrhotic cardiomyopathy.
Materials and Methods: The male rats were grouped as: Sham/saline, Sham/Thalidomide, Bile Duct Ligation (BDL)/saline and BDL/Thalidomide. BDL model of cirrhosis was used. In the treatment groups, thalidomide (200 mg/kg/day) was administrated by intragastrial gavage for 28 consecutive days, the chronotropic response was assessed in isolated atria by isoproterenol stimulation. Serum levels of NO, IL-6 and TNF-α hepatic level were evaluated. The intrasplenic pulp pressure (ISPP) as the portal pressure and histopathologic assessment were assessed. Real time RT-PCR was used for the evaluation of SOCS1 gene expression.
Results: Our results showed that thalidomide administration could significantly increase the atrial chronotropic response in BDL animals. The increased level of portal pressure decreased by thalidomide in BDL animals. Thalidomide could ameliorate the histopathological conditions of BDL rats. Furthermore, the chronic treatment by this drug diminished the elevated levels of NO, TNF-α and IL-6 in BDL animals. On the other hand, hepatic SOCS1 expression was up-regulated by thalidomide treatment in this group.
Conclusion: Thalidomide improves the chronotropic hyporesponsiveness of isolated atria in BDL. This effect is probably mediated by the inhibiting NO, TNF-α and IL-6 production, reducing portal pressure and increasing the expression of SOCS1.- انتشار مقاله: 08-03-1397
- نویسندگان: Ali Hosseini-chegeni,Farahnaz Jazaeri,Aliakbar Yousefi-Ahmadipour,Mansour Heidari,Alireza Abdollahi,Ahmad Reza Dehpour
- مشاهده
- جایگاه : پژوهشی
- مجله: Iranian Journal of Basic Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Thalidomide,IL-6,TNF-α,Cirrhotic cardiomyopathy,SOCS1
- چکیده:
- چکیده انگلیسی: Objective(s): Cirrhotic cardiomyopathy is a complication of uncured cirrhosis which is associated with hyporesponsiveness of the heart to sympathetic stimulation. The enhancement of portal pressure, nitric oxide (NO) level, pro-inflammatory mediators and down-regulation of Suppressor of Cytokine Signaling 1 (SOCS1) are involved in this situations. The present study seeks to examine the beneficial effect of thalidomide on cirrhotic cardiomyopathy.
Materials and Methods: The male rats were grouped as: Sham/saline, Sham/Thalidomide, Bile Duct Ligation (BDL)/saline and BDL/Thalidomide. BDL model of cirrhosis was used. In the treatment groups, thalidomide (200 mg/kg/day) was administrated by intragastrial gavage for 28 consecutive days, the chronotropic response was assessed in isolated atria by isoproterenol stimulation. Serum levels of NO, IL-6 and TNF-α hepatic level were evaluated. The intrasplenic pulp pressure (ISPP) as the portal pressure and histopathologic assessment were assessed. Real time RT-PCR was used for the evaluation of SOCS1 gene expression.
Results: Our results showed that thalidomide administration could significantly increase the atrial chronotropic response in BDL animals. The increased level of portal pressure decreased by thalidomide in BDL animals. Thalidomide could ameliorate the histopathological conditions of BDL rats. Furthermore, the chronic treatment by this drug diminished the elevated levels of NO, TNF-α and IL-6 in BDL animals. On the other hand, hepatic SOCS1 expression was up-regulated by thalidomide treatment in this group.
Conclusion: Thalidomide improves the chronotropic hyporesponsiveness of isolated atria in BDL. This effect is probably mediated by the inhibiting NO, TNF-α and IL-6 production, reducing portal pressure and increasing the expression of SOCS1.- انتشار مقاله: 08-03-1397
- نویسندگان: Ali Hosseini-chegeni,Farahnaz Jazaeri,Aliakbar Yousefi-Ahmadipour,Mansour Heidari,Alireza Abdollahi,Ahmad Reza Dehpour
- مشاهده
- جایگاه : پژوهشی
- مجله: Ethical Reflections
- نوع مقاله: Journal Article
- کلمات کلیدی: Act utilitarianism,Maximum happiness,Moral rules,Rules of thumb
- چکیده: بررسی مهمترین نقدهای وارد بر فایدهگرایی عملمحور
چکیده
تفکیک میان قاعدهمحوری و عملمحوری یکی از دوگانههای مهم در میان طرفداران فایدهگرایی است. ابتدا قدری درخصوص ماهیت این نزاع و اینکه نقطهی دقیق اختلافی چیست سخن میگوییم. سپس به تاریخچهی این نامگذاری نگاهی میاندازیم. درمرحلهی سوم و اصلی، به نقدهایی مینگریم که بهطورخاص به فایدهگرایی عملمحور وارد کردهاند. برخی از این نقدها از سوی مخالفان فایدهگرایی و برخی دیگر از سوی موافقان فایدهگرایی است که تقریر عملمحورانه را ضعیف میدانند. این نقدها را در سه قسمت دستهبندی میکنیم، توضیح میدهیم و صحت و سقمشان را برمیرسیم. ناعملیبودن، زیانباری و داشتن لوازم غیراخلاقی نام سه نقدی است که بر عملمحوری وارد کردهاند. آیا این تقریر از فایدهگرایی میتواند پاسخ مشکلاتی را بدهد که مخالفان وارد کردهاند یا اینکه باید از این گونهی فایدهگرایی گذر کرد و طرحی نو در انداخت؟- چکیده انگلیسی: The distinction between Rule and Act Utilitarianism is one of the most important dichotomies among Utilitarian philosophers. First, we will briefly discuss the nature of this controversy and the precise point of the divergence. Then, we will take a look at the history of this terminology. In the third and main stage, the critiques particularly levelled at Act Utilitarianism will be probed. It will be indicated that part of these criticisms come from the opponents of utilitarianism while others are presented by its advocates who find the Act reading inefficient. We will categorize these reviews into three groups and examine their authenticity. Impracticality, harmfulness, and immoral effects are the titles of those critiques leveled at Act Utilitarianism. Is this version of utilitarianism capable of answering problems which opponents have made or is it necessary to give up of this type of utilitarianism and throw a new plan?
- انتشار مقاله: 23-02-1398
- نویسندگان: Hamzeh Hojjat Hatampouri,Ali Akbar Ahmadi Aframgani
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Apoptosis,miRNAs,Glioblastoma,miR-4731
- چکیده:
- چکیده انگلیسی: GBM (Glioblastoma multiforme) is the most prevalent and lethal primary brain tumor. Gene therapy is one of the promising approaches and involves the delivery of genetic therapeutic molecules for specific antitumour response/activity. miRNAs can regulate the cell biology functions including replication, cell growth, and apoptosis by regulating gene expression. In this study, we found that down-regulation of miR-4731 expression occurred in GBM cells. We further determined that miR-4731 behaved as a tumor suppressor by inhibiting GBM cell proliferation. We further investigated the molecular mechanisms of miR-4731 and EGFR, ERK-1,2 and AKT-1,2 in GBM cell lines U87 and U251. The in vitro ectopic expression of miR-4731 affected cell proliferation, migration, and invasion of U87 and U251 cells. Luciferase reporter assays validated that miR-4731 targeted the 3′-untranslated region (3′-UTR) of EGFR. In conclusions, we identified that miR-4731 plays a tumor suppressor role in GBM cell proliferation and migration by targeting EGFR expression, and miR-4731 may act as a novel biomarker for early diagnosis or therapeutic target of GBM.
- انتشار مقاله: 05-10-1398
- نویسندگان: Amir Alahverdi,Ehsan Arefian,Masoud Soleimani,Jafar Ai,Aaliakbar Yousefi-Ahmadipour,Abouzar Babaei,Md Shahidul Islam,Somayeh Ebrahimi-Barough
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: sorafenib,Hepatocellular carcinoma,human placenta Mesenchymal stem cell,animal model
- چکیده:
- چکیده انگلیسی: Background: Hepatocellular carcinoma (HCC) is the fifth most diagnosed cancer and the third leading cause
of cancer-related death. sorafenib is used as a standard therapy to treat HCC. mesenchymal stromal cells (MSCs)
have also been used to suppress HCC. Here we investigate the development of a xenograft model of liver cancer to
study the homing of hpMSC-GFP cells, tumor kinetics and molecular characterizations of HCC. Methods: To create
xenograft models of HCC, HepG2 cell lines were inoculated into the flanks of 9 nude mice bilaterally. Animals were
then divided into three groups: the first group received hpMSC-GFP systemically, the second received intra-tumoral
hpMSC-GFP and the third received PBS. The first two groups were sacrificed after 72 hours of MSCs injection but
the third group was followed up for forty days. One tumor from each animal was then transferred to formalin buffer
for H&E staining and immunohistochemistry analysis (KI67 and CD34), and the other tumor was used for ex-vivo
imaging. Blood samples were taken from all subjects before sacrificing them. Results: Histopathological fidelity of
heterotopic HePG2 xenograft models to human HCC tumors was demonstrated. Biochemical evaluation suggested
the health of the animal’s liver and kidneys. Ex-vivo imaging illustrated homing of more hpMSC-GFP cells in tumor
tissues derived from the group receiving intra-tumoral hpMSC-GFP. Conclusion: A standard method was used to
inoculate tumor cells and the intervention was shown to be safe to liver and kidneys. Local injection of MSCs can be
used as cell therapy to fight neoplasms.- انتشار مقاله: 19-09-1396
- نویسندگان: Saieh Hajighasemlou,Saeedreza Pakzad,Jafar Ai,Samad Muhammadnejad,Milad Mirmoghtadaei,Faezeh Hosseinzadeh,Safoora Gharibzadeh,Amir Kamali,Akbar Ahmadi,Javad Verdi
- مشاهده