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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Trends in Pharmaceutical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: 1,Organic synthesis,In silico studies,Tyrosinase Inhibitor,3-Indandione
- چکیده:
- چکیده انگلیسی: Melanogenesis is a process of melanin synthesize, which is a primary response for the pigmentation of human skin. Tyrosinase is a key enzyme, which catalyzes a rate-limiting step of the melanin formation, natural products have shown potent inhibitors, but some of these possess toxicity. Numerous synthetic inhibitors have been developed in recent years may lead to the potent anti-tyrosinase agents. Therefore its inhibition may be an efficient way for the development of depigmenting agents. A novel series of 2-arylidine-1H-indene-1,3(2H)-dione analogs were designed, synthesized and screened for their in vitro tyrosinase inhibitory activity. 3d derivative bearing nitrothiophene revealed excellent anti-tyrosinase activity with an IC50 value of 3.55 μM comparable to kojic acid as a positive control. 3d as the most potent inhibitor and 3f as the least active derivative were subjected to in silico evaluations considering the 3D conformations, ΔGb of bindings and interactions within the active site of tyrosinase.
- انتشار مقاله: 30-06-1399
- نویسندگان: Aida Iraji,Ali Nemati,Hona Hosseinpoor,Najmeh Edraki,Mahsima Khoshneviszadeh,Mahshid Attarroshan,Hossein Sadeghpour,Mehdi Khoshneviszadeh
- مشاهده
- جایگاه : پژوهشی
- مجله: Journal of Health Sciences and Surveillance System
- نوع مقاله: Journal Article
- کلمات کلیدی: BTEX,VOCs,Energy,Biogas plant,Tedlar bags
- چکیده:
- چکیده انگلیسی: AbstractBackground: Biogas is obtained by anaerobic decomposition of organic wastes buried materials used to produce electricity, heat and biofuels. Biogas is at the second place for power generation after hydropower and in 2000 about 6% of the world power generation was allocated to biogas. Biogas is composed of 40–45 vol% CO2, 55–65 vol% CH4, and about 1% non-methaneVOCs, and non-methane volatile organic compounds. Emission rates are used to evaluate the compliance with landfill gas emission regulations by the United States Environmental Protection Agency (USEPA). BTEX comounds affect the air quality and may be harmful to human health. Benzene, toluene, ethylbenzene and xylene isomers that are generally called BTEX compounds are the most abundant VOCs in biogas.Methods: Sampling of VOCs in biogas vents was operated passively or with Tedlar bags. 20 samples were collected from 40 wells of old and new biogas sites of Shiraz’ landfill. Immediately after sampling, the samples were transferred to the laboratory. Analysis of the samples was performed with GC-MS.Results: The results showed that in the collection of the old and new biogas sites, the highest concentration of VOCs was observed in toluene (0.85ppm) followed by benzene (0.81ppm), ethylbenzene (0.13ppm) and xylene (0.08ppm).Conclusion: The results of the study showed that in all samples, most available compounds in biogas vents were aromatic hydrocarbon compounds.These compounds’ constituents originate from household hazardous waste materials deposited in the landfill or from biological/chemical decomposition processes within the landfill.
- انتشار مقاله: 19-01-1394
- نویسندگان: Fahime Khademi,Mohammad Reza Samaei,Kourosh Azizi,Abbas Shahsavani,Hassan Hashemi,Aida Iraji,Abdolkhalegh Miri
- مشاهده
- جایگاه : پژوهشی
- مجله: Journal of Dentistry, Shiraz University of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Rats,Periodontitis,Hypericum perforatum,Calendula officinalis
- چکیده:
- چکیده انگلیسی: Statement of the Problem: Periodontitis is one of the most common bacterial infections of the oral cavity. It is important to find adjunctive methods to chemical treatment of periodontitis with less complications and proven therapeutic properties.
Purpose: The aim of this study was to compare the effects of Calendula officinalis and Hypericum perforatum on antioxidant, antiinflammatory and histopathologic indices of induced periodontitis in male rats.
Materials and Method: In this experimental animal study forty adult male Sprague-Dawley rats were randomly divided into 4 groups (n=10) and then experimental periodontitis was induced by 3-0 nylon non-absorbable ligature. Each group was treated for 10 days as follows: 1) H. perforatum hydroalcoholic extract, 1000 mg/kg/daily, orally; 2) C. officinalis hydroalcoholic extract, 1000 mg/kg/daily, orally; 3) a mix of the two plants, 1000 mg/kg/daily, orally; 4) normal saline solution. At the end of study, blood sample were obtained via cardiocentesis and the rats were euthanized and their maxillae were removed. The samples were analyzed for histopathological scores, total antioxidant capacity and IL-1β were measured.
Results: Mixed hydroalchoholic extract of H. perforatum and C. officinalis decreased IL-1β (4.3020±0.63), and increased the antioxidant parameter in comparison to the control group (3.1192±0.43) (p < 0.001). There were significant histopathological differences between the treatment groups and the control group.
Conclusion: Mixed hydroalchoholic extract of H. perforatum and C. officinalis might be considered as an adjunctive treatment for periodontitis.- انتشار مقاله: 23-07-1398
- نویسندگان: Nader Tanideh,Vajihe Ghafari,Reyhaneh Ebrahimi,Raha Habibagahi,Omid Koohi-Hosseinabadi,Aida Iraji
- مشاهده
- جایگاه : پژوهشی
- مجله: Current Medical Mycology
- نوع مقاله: Journal Article
- کلمات کلیدی: Antifungal activity,Biofilm,Candidiasis,Candida,aromatic water,Trachyspermum ammi
- چکیده:
- چکیده انگلیسی: Background and Purpose: Aromatic waters (AWs) are therapeutic distillates, which harbor both essential oil and water-soluble components of a plant. Due to the dispersion of the light amount of essence through the AWs, they have their specific pleasant smell, taste, and medicinal properties. In Iranian traditional medicine, Trachyspermum ammi AW is used to treat gastrointestinal disorders. The present study was conducted to determine the chemical composition of the essential oil extracted from T. ammi AW and its antifungal activities against Candida species.
Materials and Methods: The composition of the essential oil extracted from T. ammi AW was analyzed by gas chromatography-mass spectrometry. In addition, the evaluation of the antifungal activity of AW against Candida species was performed using broth microdilution methods as recommended by the Clinical Laboratory Standard Institute. Moreover, the biofilm formation inhibition, antioxidant properties, and experimental activity of AW were determined in an animal model.
Results: According to the results, thymol (78.08%) was the major compound of EO, followed by carvacrol (8.20%) and carvotanacetone (6.50%). Furthermore, T. ammi AW exhibited antifungal activities against the examined fungi and inhibited the biofilm formation of C. albicans at a concentration of up to 0.25 V/V. Histopathological analyses revealed that Candida colonization declined in the mice following the administration of T. ammi AW in a therapeutic trial.
Conclusion: It seems that the presence of phenolic monoterpenes in AW has resulted in antifungal effects. Pleasant odor and antioxidant properties are extra bonuses to the antimicrobial effects of this plant. Based on the findings, AW might have the potential to be used in the management of alimentary candidiasis or oral hygienic products.
- انتشار مقاله: 17-09-1398
- نویسندگان: Ali Arabi Monfared,Seyyed Amin Ayatolahi Mousavi,Kamiar Zomorodian,Davood Mehrabani,Aida Iraji,Mahmood Reza Moein
- مشاهده