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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Breast cancer,ESR1,Saudi Arabia,genetic variant
- چکیده:
- چکیده انگلیسی: Objective: The present study aimed to determine the role of ESR1 gene rs2234693 T/C polymorphism (PvuII) in the susceptibility to breast cancer and to assess the association of this polymorphism within presence or absence of estrogen, progesterone receptors, human epidermal growth factor receptor 2 (HER2) and with premenopausal and postmenopausal age in Saudi women. Methods: The study was a retrospective case-control study. In this study, 137 breast cancer and 98 normal breast paraffin embedded tissues were included. DNA was extracted and ESR1 gene rs2234693 T/C polymorphism was genotyped by PCR-RFLP. Genetic association tests were performed. Results: The results showed no significant difference in distribution of rs2234693 T/C alleles and genotypes frequencies. Odd ratios (95% CI) were 1.15 (0.8-1.66) and 1.06 (0.5-1.98) and p values were 0.51 and 0.87, respectively. The genotypes and alleles frequencies within different hormonal receptors groups and ages of menopause showed no signification association (odd ratios were less or close to 1 and p values > 0.05). Conclusion: ESR1 gene rs2234693 T/C polymorphism was not associated with susceptibility to breast cancer and different menopausal, hormone receptors, and HER2 status in breast cancer patients. Further analysis using larger sample size will be needed to assess the association of different polymorphisms within the gene and risk of breast cancer.
- انتشار مقاله: 20-03-1399
- نویسندگان: Razan Jamaan Al-Amri,Mohammad Kdaimes H Alotibi,Rawya Ibrahim AL-Raddadi,Weam Talal Yehya Shebli,Emad Ibrahim Yagoub Fallatah,Ahmed Safar Alhujaily,Hiba Salaheldin Mohamed
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: cancer,Prognosis,Colorectal,Cyclin D1
- چکیده:
- چکیده انگلیسی: Background and study aim: Cyclin D1 is a key regulatory protein in the cell cycle and is over-expressed in
many tumors, including endometrial, thyroid, urothelial, breast, brain gliomas, and esophageal cancers. The main
aim of the present study is to examine the expression pattern of cyclin D1 and its correlation with the different
clinicopathological features in patients with colorectal camcer (CRC) from the Madinah region of Saudi Arabia.
Patients and methods: The archival tumor blocks were analyzed using immunohistochemistry for Cyclin D1
over-expression in 324 CRC patients diagnosed from January 2006 to December 2017, at the Department of Pathology,
King Fahad Hospital, Madinah, Saudi Arabia. Results: Cyclin D1 over-expression was absent in normal mucosa, while
15% cases of adenoma showed its over-expression. In CRC, Cyclin D1 was expressed at high levels in 24.1% of case.
No significant correlation was observed between Cyclin D1 over-expression and age, gender, tumor size, type and
location. However, Cyclin D1 over-expression exhibited a significant correlation with tumor differentiation (p=0.04),
lymph node involvement (p=0.001), lymphovascular invasion (p=0.001), distant metastasis (p=0.006) and AJCC staging
(p=0.001). The Kaplan-Meir analysis revealed a shorter period of survival with Cyclin D1 over-expression (p=0.000).
The Cox-regression model analysis showed that Cyclin D1 over-expression was an independent prognostic marker
in CRC (p=0.000). Conclusion: Cyclin D1 over-expression increases during normal-adenoma-carcinoma sequence.
The significant association observed between Cyclin D1 over-expression, advanced tumor stage and short survival
period clearly suggest the role of Cyclin D1 in the carcinogenesis and progression of CRC.- انتشار مقاله: 06-03-1398
- نویسندگان: Abdulkader Mohammed Albasri,Mohammed Aboulmatty Elkablawy,Irfan Altaf Ansari,Ahmed Safar Alhujaily
- مشاهده