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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Iranian Journal of Medical Physics
- نوع مقاله: Journal Article
- کلمات کلیدی: Radiotherapy,Gynecology,Treatment Planning,Photon energy
- چکیده:
- چکیده انگلیسی: Introduction: To compare the dosimetric outcomes of 6 and 10 MV flattening filter free beam (FFFB) energies in gynaecological malignancies RapidArc (RA) planning.
Material and Methods: The RA plans were generated for a cohort of 20 patients using 6 and 10 MV FFFBs. The plans aimed to deliver a dose of 50.4Gy in 28 fractions to planning target volume (PTV); moreover, planning objectives were kept as low as reasonably achievable for organs at risk (OARs). Dosimetric analysis was performed in terms of PTV coverage, conformity index (CI), homogeneity index (HI), dose to OAR’s, integral dose to normal tissue (NTID), and total number of monitor units (MU’s).
Results: According to the results, volumes of PTV receiving prescription dose and CI values were 95.03±0.10% and 95.02±0.18%, as well as 1.018±0.028 and 1.024±0.027, respectively. Moreover, HI values were estimated at 1.063±0.008 and 1.068±0.010. Additionally, the corresponding values of mean NTID and MUs were 280.3±42.5 and 267.9±39.1 (liter-Gy), as well as 610.3±30.3 and 630.6±39.7 for FFFB using 6 and 10 MV, respectively. The 6 and 10 MV FFFBs were statistically similar in terms of mean dose to bladder, rectum and both femoral heads, while comparison yielded significant difference (p <0.05) in terms of HI, CI, MUs and NTID.
Conclusion: The FFFB of 6MV was found superior, compared to 10MV, for RA planning in case of gynaecological malignancies. Moreover, it offers better HI and CI values, as well as fewer numbers of MUs (3.33%). In addition, it delivers more NTID (4.42%) for similar target coverage and OAR’s sparing.- انتشار مقاله: 19-06-1398
- نویسندگان: Lalit Kumar,Vimal Kishore,Manindra Bhushan,Girigesh Yadav,Abhinav Dewan,Pawan Kumar,Gourav Kumar,Rahul Chowdhary
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Malignancy,Ovarian masses,human epididymis secretory protein E4,CA-125
- چکیده:
- چکیده انگلیسی: Background: Early diagnosis of ovarian cancer is essential for long term disease control and mortality reduction.
This has been achieved using tumor markers like cancer antigen 125 (CA-125) which is elevated in malignant as well
as non-malignant conditions. This dilemma led to efforts towards development of newer markers like serum human
epididymis secretory protein E4 (HE4). Present study aimed to evaluate role of HE4 in diagnosing ovarian cancers
and comparing it with CA-125. Methods: Serum samples from 67 patients with ovarian cancer, 42 with benign
ovarian masses and 26 healthy controls were collected preoperatively and tested for serum HE4 levels and CA-125
levels. Diagnostic performance of both tumor markers (HE4/CA-125) to diagnose malignancy in ovarian masses was
calculated and compared to each other. Results: Mean CA-125 and HE4 levels were significantly higher in patients
with ovarian cancer than in those with benign disease (p<0.001) or healthy controls (p< 0.001). Serum HE4 levels
significantly increased in epithelial ovarian cancers when compared to non-epithelial ovarian cancers (p<0.01). Using
benign control as comparison, receiver operating characteristic curve (ROC) was generated to predict a cut-off value
for diagnosing malignancy for serum HE4 and CA-125. Compared to CA-125, HE4 had a similar sensitivity (83.6%
vs. 85.10%) and higher specificity (100% vs. 90.48%); combination of serum HE4 and CA-125 improved the sensitivity
to detect ovarian cancer to 92.54%. Sensitivity of HE4 to detect early stage ovarian cancer was superior to CA-125
(92.61% vs. 63.41%). Conclusion: Serum HE4, a novel tumor marker, discriminated epithelial ovarian cancer from
benign ovarian masses. HE4 levels were related to the stage and histological types with the lowest levels in mucinous
epithelial ovarian cancer and non-epithelial malignancy. Measuring serum HE4 levels alongwith CA-125 may provide
higher accuracy for detecting epithelial ovarian cancer particularly in the early stages.- انتشار مقاله: 24-05-1397
- نویسندگان: Rupali Dewan,Abhinav Dewan,Meera Jindal,Mausumi Bhardawaj
- مشاهده
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Intensity modulated Radiotherapy,Flatten beam,Flattening filter free photon beam,Secondary cancer risk
- چکیده:
- چکیده انگلیسی: Purpose: Intensity modulated radiotherapy (IMRT) plan quality, beam on time and integral dose were compared using
6MV FB (Flattened Beam) and FFFB (Flattening filter free beam) for carcinoma of cervix. Materials and Methods:
Ten patients with stage II–IIIB cervix cancer (Ca.Cx) were retrospectively identified from the department database.
Target volume (TV) and organ at risk (OAR) were delineated as per Radiation Therapy Oncology Group (RTOG) cancer
guidelines. Dose prescribed to planning target volume (PTV) was 50.4Gy in 28 fractions. Two plans (6MV FB IMRT
and 6MV FFFB IMRT) were generated to achieve 95% of prescription dose to PTV and sparing OAR as per normal
tissue guidelines. Numbers of beams and their orientations were the same for all plans. The homogeneity index (HI),
conformity index (CI), treatment monitor unit (MU), beam on time (BOT) and non-tumor integral dose (NTID) were
chosen for comparison. Results: FFFB generated plans were clinically acceptable. There was a statistically significant
difference among the FB IMRT and FFFB IMRT plans with respect to CI, HI, D50%, D2% in PTV coverage, bladder
V50Gy, MU, mean NTID and non-tumor low dose volume. Conclusions: 6MV flattened and flattening filter free photon
beams produce comparable plans by IMRT . FFF beams allow time efficient treatment delivery and may help reduce
the risk of secondary malignances in carcinoma cervix cases.- انتشار مقاله: 28-12-1395
- نویسندگان: Suresh Tamilarasu,Madeswaran Saminathan,SK Sharma,Anjali Pahuja,Abhinav Dewan
- مشاهده