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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Asian Pacific Journal of Cancer Prevention
- نوع مقاله: Journal Article
- کلمات کلیدی: Expression,Gastric cancer,Polymorphism,IL-6,ASIC1
- چکیده:
- چکیده انگلیسی: Abstract: Gastric cancer is one of the most common upper gastrointestinal malignancies. Some Iranian provinces,
such as in the northern and northwestern areas, are at a high risk, whereas the central and western provinces are at
a medium and the southern regions at low risk. This study was carried out to estimate the impact of the expression
patterns of ASIC1 and IL-6 genes and the IL-6rs-174 and ASIC1rs 75624685 polymorphisms in the pathogenesis of
gastric cancer. Materials and methods: Tetra-ARMS PCR was employed to analyze the polymorphism status of the
ASIC1 and IL-6 genes with 85 paraffin-embedded tissue blocks from cases and 117 normal blood samples as controls.
We also investigated mRNA expression levels of these genes in 12 cases and controls using real-time PCR. Results:
Our results showed a significant association between expression of ASIC1 and elevated risk of gastric cancer (p<0.001).- انتشار مقاله: 09-11-1396
- نویسندگان: Abdulkuddous Heydari-Mehrabadi,Dor Mohammad Kordi-Tamandani,Tayebeh Baranzehi,Simin Hemati
- مشاهده