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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Report of Health Care- (لغو رتبه)
- نوع مقاله: Journal Article
- کلمات کلیدی: Rat,Alzheimer,Hematological parameters,Centella asiatica
- چکیده:
- چکیده انگلیسی: Introduction: Alzheimer’s disease (AD) is a progressive and irreversible neuropsychiatric disorder of the brain with a deadly outcome and unknown etiology in which the concentration and function of some brain transmitters, particularly acetylcholine, reduce in AD in the cerebral cortex, e.g., the hippocampus. This study aimed to evaluate the effects of aquatic extract of Centella asiatica (CeA) leaf on hematological parameters in NBM (Nucleus Basalis of Mynert)- lesioned rats induced by Ibotenic acid (IA). Methods: Thirty-two male Wistar rats (20- 24 months old; weighing 330±30 g) were selected and randomly divided into four equal groups (n=12) including 1. Control group (which were intact rats), 2. L group (NBM- lesioned rats), 3. CeA group and 4. L+CeA group. NBM was bilaterally lesioned. Seven days after stereotaxic surgery, the total number of white blood cells (WBCs), the total number of red blood cells (RBCs), hemoglobin level (Hb), and hematocrit level (Hct) were assessed. For statistical analysis of data Mann Whitney U- test (p≤0.05) was used. Results: IA treatment induced a significant decrease of WBCs, followed by significant decrease in RBCs, Hb and Hct compared with control group (p≤0.05). Also, the lesion of the NBM after oral administration of Centella asiatica extract had no effect on the above blood parameters and even all of the parameters in two groups of CeA and CeA+L compared with the control group showed a non-significant increase (p≥0.05). Conclusion: It appears that some blood parameters decrease in rat model of Alzheimer's disease. Also, this research shows the important role of the cholinergic neurons of central nervous system in the regulation of erythropoiesis, also Centella asiatica extract can stimulate hematopoiesis.
- انتشار مقاله: 26-04-1395
- نویسندگان: Abdolhassan Doulah,Maryam Rafieirad
- مشاهده
- جایگاه : پژوهشی
- مجله: Report of Health Care- (لغو رتبه)
- نوع مقاله: Journal Article
- کلمات کلیدی: Cell phone,Ear,Staphylococci,Erm Genes
- چکیده:
- چکیده انگلیسی: Introduction: Resistance to macrolide can be created by erm genes in Staphylococcus. The aim of the current study was to determine whether or not cell phone use can result in the antibiotic resistance of 16S rDNA, Coa, ermA, ermB and ermC genes in Staphylococci isolated from cell phone users’ and non- users’ ears. Methods: A total of 150 isolates of Staphylococci were tested by the disk diffusion method. The isolates were examined by PCR for 16S rDNA, Coa, ermA, ermB and ermC genes. Results: According to PCR results, in two statistical societies, 65.33% cell phone users with positive Coa had only one erm, 33.33% cell phone non-users with negative Coa had only one erm and %1.34 had genes, whereas 24
% cell phone non-users with positive Coa had one erm, %44 cell phone non-users with negative Coa had one erm and 32% had a minority of genes. Results showed that 16S rDNA, Coa, ermA, ermB, and ermC genes in the cell phone users group were more prevalent than the other group in Staphylococci isolated from ears. Conclusion: It is revealed that the presence of 16S rDNA, Coa, and erms genes had a significant relation to erythromycin and methicillin. Detection of ermA, ermB and ermC plays crucial roles in the molecular mechanisms, epidemiology of the efflux pump and methylase erythromycin ribosome. Since antibiotic resistant Staphylococci isolates may mutate and prompt constitutive resistances it is suggested that inducible resistance test should be implemented on erythromycin resistant sensitive isolates to prevent treatment failures.- انتشار مقاله: 16-11-1396
- نویسندگان: Tayabe Avazzadeh,Abbas Ali Rezaeian,Shafie Ghorbani Tazhandarreh,Roohollah Zarei Koosha,Davood Ghorbani Tazhandarreh,Abdolhassan Doulah
- مشاهده
- جایگاه : پژوهشی
- مجله: Journal of the Iranian Chemical Research
- نوع مقاله: Journal Article
- کلمات کلیدی: Cyclocondensation,1-(5-bromo-2-chloro-6-methylpyrimidin-4-yl)-1-methylhydrazine,pyrimidothiadiazine,Dimethylthio carbamoylchloride
- چکیده:
- چکیده انگلیسی: Treatment of 1-(5-bromo-2-chloro-6-methylpyrimidin-4-yl)-1-methylhydrazine with
dimethylthiocarbamoylchloride gave 7-chloro-N,N, 1,5-tetramethyl-1H-pyrimido[4,5-
e][1,3,4]thiadiazin-3-amine in basic acetonitrile. The latter compounds were reacted with
secondary amines in boiling ethanol to afford the related 7-amino derivatives.- انتشار مقاله: 14-11-1389
- نویسندگان: Abdolhassan Doulah,Masoud Mirzaei,Mohsen Nikpour,Yaghoub Farbood
- مشاهده
- جایگاه : پژوهشی
- مجله: Journal of Midwifery and Reproductive Health
- نوع مقاله: Journal Article
- کلمات کلیدی: Screening,Breast cancer,Performance,Knowledge
- چکیده:
- چکیده انگلیسی: Background & aim: Breast cancer is recognized as the most common type of cancer among Iranian women. Cancer screening and early diagnosis are among the most effective strategies to reduce the associated mortality and healthcare costs. Accordingly, the aim of this study was to investigate the level of knowledge and practice of breast cancer screening among women referred to hospitals affiliated to Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Methods: This cross-sectional, descriptive, analytical study was conducted on 70 women, referred to hospitals affiliated to Ahvaz University of Medical Sciences. The subjects were randomly selected via cluster sampling. For data collection, a questionnaire consisting of three parts, i.e., demographic, knowledge, and practice information, was used. For statistical analysis, Chi-square test was performed, using SPSS version 16.
Results: The results showed that the majority of the patients were married and within the age range of 35-39 years. Most participants (42.9%) had poor knowledge of breast self-examination. Based on the findings, knowledge and practice of breast cancer screening were not significantly associated with age or educational level. Nevertheless, a significant relationship was found between the knowledge level and marital status of the subjects.
Conclusion: Based on the findings, women's knowledge and practice of breast cancer screening were quite poor. Therefore, it is suggested to promote the current level of knowledge in order to prevent delayed diagnosis.- انتشار مقاله: 28-06-1395
- نویسندگان: Afsaneh Alivand,Abdolhassan Doulah,Saeed Ziagham
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Heterocyclic Chemistry
- نوع مقاله: Journal Article
- کلمات کلیدی: 1-(5-bromo-2-chloro-6-methylpyrimidin-4-yl)-1-methylhydrazine,dimethylthiocarbamoylchloride,pyrimidothiadiazine,15- lipoxygenase
- چکیده:
- چکیده انگلیسی: Treatment of 1-(5-bromo-2-chloro-6-methylpyrimidin-4-yl)-1-methylhydrazine with dimethylthiocarbamoylchloride gave 7-chloro-N,N,1,5-tetramethyl-1H-pyrimido[4,5-e][1,3,4]thiadiazin-3-amine in basic acetonitrile. The latter compounds were reacted with secondary amines in boiling ethanol to afford the related 7-amino derivatives.
- انتشار مقاله: 05-03-1395
- نویسندگان: Abdolhassan Doulah,Hamid Sadeghian
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Heterocyclic Chemistry
- نوع مقاله: Journal Article
- کلمات کلیدی: Protein,Hydrogen bonding,Proline,Molybdenum,Polyoxometallates,Hybrid,Keggin,Peptide
- چکیده:
- چکیده انگلیسی: Crystallographic data analyses indicate that three types of prolinium cations, along with two types of hydrogen bonding, produce and stabilize the helical structure of triprolinium 12-phosphomolybdate. There are similarities between this organic-inorganic compound and peptides/proteins. The stronger “conventional” hydrogen bonds and the less common C-H…O attractions play critical roles in generating and stabilizing the DNA-like network.
- انتشار مقاله: 05-03-1395
- نویسندگان: Abdolhassan Doulah,Hossein Eshtiagh-Hosseini,Masoud Mirzaei,Ali Fazlara
- مشاهده
- جایگاه : پژوهشی
- مجله: International Journal of Heterocyclic Chemistry
- نوع مقاله: Journal Article
- کلمات کلیدی: 1-(5-bromo-2-chloro-6-methylpyrimidin-4-yl)-1-methylhydrazine,dimethylthiocarbamoylchloride,pyrimidothiadiazine,15- lipoxygenase
- چکیده:
- چکیده انگلیسی: Treatment of 1-(5-bromo-2-chloro-6-methylpyrimidin-4-yl)-1-methylhydrazine with dimethylthiocarbamoylchloride gave 7-chloro-N,N,1,5-tetramethyl-1H-pyrimido[4,5-e][1,3,4]thiadiazin-3-amine in basic acetonitrile. The latter compounds were reacted with secondary amines in boiling ethanol to afford the related 7-amino derivatives.
- انتشار مقاله: 25-03-1393
- نویسندگان: Abdolhassan Doulah,Abdolhassan Doulah,Abdolhassan Doulah
- مشاهده