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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Nanomedicine Journal
- نوع مقاله: Journal Article
- کلمات کلیدی: Photodynamic therapy,Drug carriers,Capping Agent,SrCO3 NPs
- چکیده:
- چکیده انگلیسی: Objective (s): SrCO3 nanoparticles could be used as new biomedical sources in magnetic resonance imaging as a promising noninvasive imaging modality for the preoperative staging of breast cancer and monitoring of tumor response to therapy. The present study aimed to synthesize SrCO3 nanostructures using microwave irradiation in the presence of honey as a green capping agent and reductant.
Materials and Methods: The optical properties of SrCO3 nanostructures were investigated using ultraviolet-visible (UV-Vis) spectroscopy. Sr(NO3)2.6H2O and NaOH were applied as the starting reagents. Fructose (32.56-38.2%) and glucose (28.54-31.3%), which were the main carbohydrates found in honey, were not only involved in stabilization, but they also acted as the reducing agents in the production of SrCO3 nanostructures. The produced nanostructures were characterized using X-ray diffraction analysis, Fourier transform infrared spectroscopy, scanning electron microscopy, and transmission electron microscopy.
Results: Method of synthesis and chemical reagents were observed to affect the structural parameters, crystallite size, product size, morphology, and antioxidant activity.
Conclusion: According to the results, honey could be used as a green capping agent and reductant for the synthesis of SrCO3 nanostructures as a novel structure to co-deliver therapeutic agents using photo-thermal agents. Moreover, honey has significant potential for diagnostic and therapeutic purposes in the future.- انتشار مقاله: 06-12-1397
- نویسندگان: Maryam Rezaeizadeh,Mehdi Ranjbar,Abbas Pardakhty
- مشاهده
- جایگاه : پژوهشی
- مجله: Nanomedicine Journal
- نوع مقاله: Journal Article
- کلمات کلیدی: CdO/GrO,Hexagonal nanostructures,In vivo targeting,Optical investigation
- چکیده:
- چکیده انگلیسی: Objective(s): Nanomaterials are playing major roles in imaging by delivering large imaging payloads, yielding improved sensitivity. Nanoparticles have enabled significant advances in pre-clinical cancer research as drug delivery vectors. Inorganic nanoparticles such as CdO/GrO nanoparticles have novel optical properties that can be used to optimize the signal-to-background ratio. This paper reports on a novel processing route for preparation of CdO/GrO nanolayer and investigation of its optical properties for application in in vivo targeting and imaging.
Materials and Methods: Nanostructures were synthesized by reacting cadmium acetate and graphene powder. The effects ofdifferent parameters such as power and time of irradiation were also studied. Finally, the efficiency of CdO/GrO nanostructures as an optical composite was investigated using photoluminescence spectrum irradiation. CdO/GrO nanostructures were characterized by means of X-ray diffraction (XRD), atomic force microscopy (AFM), scanning electron microscopy (SEM), Fourier transform infrared (FT-IR) and photoluminescence (PL) spectroscopy.
Results: According to SEM images, it was found that sublimation temperature had significant effect on morphology and layers. The spectrum shows an emission peak at 523 nm, indicating that CdO/GrO nanolayer can be used for in vivo imaging.
Conclusion: The estimated optical band gap energy is an accepted value for application in in vivo imaging using a QD–CdO/GrO nanolayer.- انتشار مقاله: 04-04-1396
- نویسندگان: Abbas Pardakhty,Mohammad Mehdi Foroughi,Mehdi Ranjbar
- مشاهده
- جایگاه : پژوهشی
- مجله: Nanomedicine Journal
- نوع مقاله: Journal Article
- کلمات کلیدی: Ultrasound Irradiation,Surface Area,Drug carriers,Ni-MOF
- چکیده:
- چکیده انگلیسی: Objective(s): According to the unique properties of magnetic nanoparticles, Nickel Metal-Organic Frameworks (MOF) was synthesized successfully by ultrasound irradiation. Metal-organic frameworks (MOFs) are organic–inorganic hybrid extended networks that are constructed via covalent linkages between metal ions/metal clusters and organic ligands called a linker.
Materials and Methods: The nanoparticles were synthesized by Ultrasound Method Under a synthesis conditions, All chemicals were used as received without further purification. Scanning electron microscopy (SEM) images were obtained on LEO- 1455VP equipped with an energy dispersive X-ray spectroscopy at university of Kashan in Iran. Transition electron microscopy (TEM) images were obtained on EM208 Philips transmission electron microscope with an accelerating voltage of 200 kV.
Results: Results showed that Ni-MOF synthesized by this method, had smaller particle size distribution and It was found that the different kinds of ligand leads to preparation products with different morphologies and textural properties. Moreover, ultrasound irradiation method has significant effect on microstructures of as-synthesized MOFs and can improve their textural properties compared to method without using hydrothermal route.The XRD patterns of the samples obtained from ultrasound irradiation was well matched with that of as-prepared Ni-MOF by solvothermal method.
Conclusion: This rapid method of ultrasonic radiation as compared to the classical solvothermal synthesis, showed promising results in terms of size distribution, surface area, pore diameter and pore volume.- انتشار مقاله: 31-06-1395
- نویسندگان: Abbas Pardakhty,Mehdi Ranjbar
- مشاهده
- جایگاه : پژوهشی
- مجله: Nanomedicine Journal
- نوع مقاله: Journal Article
- کلمات کلیدی: Photodynamic therapy,Drug carriers,Capping Agent,SrCO3 NPs
- چکیده:
- چکیده انگلیسی: Objective (s): SrCO3 nanoparticles could be used as new biomedical sources in magnetic resonance imaging as a promising noninvasive imaging modality for the preoperative staging of breast cancer and monitoring of tumor response to therapy. The present study aimed to synthesize SrCO3 nanostructures using microwave irradiation in the presence of honey as a green capping agent and reductant.
Materials and Methods: The optical properties of SrCO3 nanostructures were investigated using ultraviolet-visible (UV-Vis) spectroscopy. Sr(NO3)2.6H2O and NaOH were applied as the starting reagents. Fructose (32.56-38.2%) and glucose (28.54-31.3%), which were the main carbohydrates found in honey, were not only involved in stabilization, but they also acted as the reducing agents in the production of SrCO3 nanostructures. The produced nanostructures were characterized using X-ray diffraction analysis, Fourier transform infrared spectroscopy, scanning electron microscopy, and transmission electron microscopy.
Results: Method of synthesis and chemical reagents were observed to affect the structural parameters, crystallite size, product size, morphology, and antioxidant activity.
Conclusion: According to the results, honey could be used as a green capping agent and reductant for the synthesis of SrCO3 nanostructures as a novel structure to co-deliver therapeutic agents using photo-thermal agents. Moreover, honey has significant potential for diagnostic and therapeutic purposes in the future.- انتشار مقاله: 06-12-1397
- نویسندگان: Maryam Rezaeizadeh,Mehdi Ranjbar,Abbas Pardakhty
- مشاهده
- جایگاه : پژوهشی
- مجله: Nanomedicine Journal
- نوع مقاله: Journal Article
- کلمات کلیدی: CdO/GrO,Hexagonal nanostructures,In vivo targeting,Optical investigation
- چکیده:
- چکیده انگلیسی: Objective(s): Nanomaterials are playing major roles in imaging by delivering large imaging payloads, yielding improved sensitivity. Nanoparticles have enabled significant advances in pre-clinical cancer research as drug delivery vectors. Inorganic nanoparticles such as CdO/GrO nanoparticles have novel optical properties that can be used to optimize the signal-to-background ratio. This paper reports on a novel processing route for preparation of CdO/GrO nanolayer and investigation of its optical properties for application in in vivo targeting and imaging.
Materials and Methods: Nanostructures were synthesized by reacting cadmium acetate and graphene powder. The effects ofdifferent parameters such as power and time of irradiation were also studied. Finally, the efficiency of CdO/GrO nanostructures as an optical composite was investigated using photoluminescence spectrum irradiation. CdO/GrO nanostructures were characterized by means of X-ray diffraction (XRD), atomic force microscopy (AFM), scanning electron microscopy (SEM), Fourier transform infrared (FT-IR) and photoluminescence (PL) spectroscopy.
Results: According to SEM images, it was found that sublimation temperature had significant effect on morphology and layers. The spectrum shows an emission peak at 523 nm, indicating that CdO/GrO nanolayer can be used for in vivo imaging.
Conclusion: The estimated optical band gap energy is an accepted value for application in in vivo imaging using a QD–CdO/GrO nanolayer.- انتشار مقاله: 04-04-1396
- نویسندگان: Abbas Pardakhty,Mohammad Mehdi Foroughi,Mehdi Ranjbar
- مشاهده
- جایگاه : پژوهشی
- مجله: Nanomedicine Journal
- نوع مقاله: Journal Article
- کلمات کلیدی: Ultrasound Irradiation,Surface Area,Drug carriers,Ni-MOF
- چکیده:
- چکیده انگلیسی: Objective(s): According to the unique properties of magnetic nanoparticles, Nickel Metal-Organic Frameworks (MOF) was synthesized successfully by ultrasound irradiation. Metal-organic frameworks (MOFs) are organic–inorganic hybrid extended networks that are constructed via covalent linkages between metal ions/metal clusters and organic ligands called a linker.
Materials and Methods: The nanoparticles were synthesized by Ultrasound Method Under a synthesis conditions, All chemicals were used as received without further purification. Scanning electron microscopy (SEM) images were obtained on LEO- 1455VP equipped with an energy dispersive X-ray spectroscopy at university of Kashan in Iran. Transition electron microscopy (TEM) images were obtained on EM208 Philips transmission electron microscope with an accelerating voltage of 200 kV.
Results: Results showed that Ni-MOF synthesized by this method, had smaller particle size distribution and It was found that the different kinds of ligand leads to preparation products with different morphologies and textural properties. Moreover, ultrasound irradiation method has significant effect on microstructures of as-synthesized MOFs and can improve their textural properties compared to method without using hydrothermal route.The XRD patterns of the samples obtained from ultrasound irradiation was well matched with that of as-prepared Ni-MOF by solvothermal method.
Conclusion: This rapid method of ultrasonic radiation as compared to the classical solvothermal synthesis, showed promising results in terms of size distribution, surface area, pore diameter and pore volume.- انتشار مقاله: 31-06-1395
- نویسندگان: Abbas Pardakhty,Mehdi Ranjbar
- مشاهده
- جایگاه : پژوهشی
- مجله: Nanomedicine Journal
- نوع مقاله: Journal Article
- کلمات کلیدی: release profile,omega-3 fatty acids,Nano-vesicles,Physical Stability,Size Analysis
- چکیده:
- چکیده انگلیسی: Objective(s): Omega-3 fatty acids play a key role in maintaining human health. The present study aimed to reduce the fishy smell and taste of omega-3 fatty acids through the encapsulation of lipid vesicles.
Materials and Methods: Different non-ionic surfactants from the sorbitan ester family and egg lecithin with cholesterol were utilized to form micro-niosomal and liposomal formulations in order to encapsulate omega-3. The size of the selected microparticulate suspension was reduced using the liposome extruder. In addition, the vesicular physical stability, encapsulation efficiency (EE), release profile, and organoleptic properties were evaluated.
Results: All the amphiphiles formed omega-3 vesicles with masked omega-3 taste and smell. Span/Tween (ST) 60 niosomes had the highest EE (98.60%), while the physical stability of the liquid state forming the mixture (ST 20/cholesterol) was significantly lower compared to the other formulations. Moreover, the two-step release profile of omega-3 was achieved following entrapment in lipid bilayers.
Conclusion: According to the results, lipid vesicular systems on the micro or nano-scale could be used to encapsulate and protect omega-3 for the production of functional foods with appropriate organoleptic properties.- انتشار مقاله: 17-07-1398
- نویسندگان: Sahar Shariat,Vahid Hakimzadeh,Abbas Pardakhty
- مشاهده
- جایگاه : پژوهشی
- مجله: Journal of Kerman University of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Boswellia serrata,dementia,Traditional Iranian Medicine (TIM),Mild Cognitive Impairment (MCI)
- چکیده:
- چکیده انگلیسی: Background: Mild cognitive impairment (MCI) is the stage between the expected cognitive decline of normal aging and the more serious decline of dementia. In the present study, the effect of Boswellia serrata (BS) on improvement of memory impairment in patients with MCI was investigated.
Methods: In this single-center randomized double-blind placebo-controlled clinical trial study, 118 patients with mild cognitive impairment (MCI) were included and randomly divided into two groups (case and control). Control group (n=59) received BS 300 mg/kg body weight twice a day and control group (n=59) received placebo for a period of three and six months. Montreal Cognitive Assessment (MoCA) test for detecting cognitive impairment was done at baseline, three and six months after the intervention.
Results: A significant difference was reported in the MoCA mean score between the groups after three months (24.64 vs. 22.83) and six months of the intervention (25.22 vs. 22.7). Memory item had the greatest impact on the average final score (P≤0.0001).
Conclusion: BS has a significant effect on the improvement of memory impairment in patients with MCI. Further studies are required with higher doses of BS and longer duration of treatment to assess the effects of BS on memory of patients with MCI.- انتشار مقاله: 13-09-1398
- نویسندگان: Soheila Rezakhani,Behnaz Sedighi,Abbas Pardakhty,Kaveh Shafiee
- مشاهده
- جایگاه : پژوهشی
- مجله: Journal of Kerman University of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: Apoptosis,Breast cancer,Cytotoxicity,Cell cycle,Propolis
- چکیده:
- چکیده انگلیسی: Background: Cancer is one of the major health problems worldwide and natural resources are being explored to develop anticancer drugs with fewer side effects. Iranian propolis contains components including flavonoids and polyphenols and has various medicinal properties. The aim of this study was to investigate the effect of Ethanolic Extract of Sirch Propolis (EESP) on three breast cancer cell lines. Methods: The MDA-MB-231, SKBR-3 and MCF-7 cells were treated for 24 and 48 h at the presence of 1% and 10% fetal bovine serum (FBS) concentration. MTT, BrdU and flow cytometry assays were used for measuring cytotoxicity, cell proliferation and apoptosis. Results: The highest cytotoxicity was seen on MDA-MB-231 cell at the presence of 1% and 10% FBS respectively following 48 h treatment. BrdU assay showed that treatment with 200 μg/ mL of EESP at the presence of 1% FBS for 48 h, reduced proliferation of MDA-MB-231 cell to 75% and that of MCF-7 and SKBR-3 cells to 70% and 60% respectively. Cell cycle analysis by flow cytometry showed that EESP at 200 μg/mL for 48h, induced G0/G1 phase arrest in MCF-7 and SKBR-3 cells and G2/M, S phase arrest in MDA-MB-231 cell. The cytotoxic effects of EESP were primarily found to be due to the induction of early stage apoptosis on SKBR-3 cell and early and late stage apoptosis on MCF-7 and MDA-MB-231 cells. Conclusion:The results demonstrated that EESP is a natural anticancer mixture capable of reducing breast cancer cells proliferation and inducing cell cycle arrest and apoptosis in them.
- انتشار مقاله: 14-09-1398
- نویسندگان: Vagiheh Soltaninejad,Nasrin Kazemipour,Mohammad Mehdi Yaghoobi,Abbas Pardakhty
- مشاهده
- جایگاه : پژوهشی
- مجله: Addiction and Health
- نوع مقاله: Journal Article
- کلمات کلیدی: Opium,Controlled release,New drug delivery systems
- چکیده:
- چکیده انگلیسی: Novel drug delivery systems for controlled-release of opioid agonists as a long time painkillers or opioid antagonists for opium, heroin, and alcohol addiction are under development or in clinical use today. In this article, the field of “new drug delivery systems” is momentarily reviewed from the viewpoint of the marketed opioid agonists/antagonists dosage forms today.
- انتشار مقاله: 25-02-1395
- نویسندگان: Hoda Soltani,Abbas Pardakhty
- مشاهده