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کاربرد نوع شرط:
- جایگاه : پژوهشی
- مجله: Journal of Kerman University of Medical Sciences
- نوع مقاله: Journal Article
- کلمات کلیدی: spermatogenesis,Infertility,Cyclophosphamide,Garlic,Orchid
- چکیده:
- چکیده انگلیسی: Background:One of the most common side effects of cyclophosphamide (CP) is oligo-spermatozoa, azoospermia and elimination of spermatogenic cycles. This study was done to find the efficacy of simultaneous consumption of garlic (Allium sativum L.) and orchid (Orchismaculata L.) hydroalcoholic extracts on spermatogenesis and sex hormones in rats treated with CP. Methods:Forty-two male rats were divided into the six groups: control, sham, CP
(5 mg/kg), garlic (10 mg/kg) + CP, orchid (40 mg/kg) + CP, garlic+ orchid + CP. All of the agents were administered through oral gavage for 28 days. Results: The number of sperms increased in garlic+ CP and orchid+ CP groups. The percentage of sperm forward motility increased in groups receiving garlic, orchid, and garlic +orchid compared with the group that received only CP. Antioxidant total capacity and testosterone level showed significant increases in garlic+ orchid, garlic and orchid groups respectively compared with the group that received only CP (P<0.05). Also, the tissue and serum malondialdehyde levels reduced in the group received garlic +orchid compared with the group that received only CP. Conclusion:Garlic and orchid could increase the number and the motility of sperms, index of sertoli cell, antioxidant capacity and serum testosterone level.- انتشار مقاله: 07-04-1398
- نویسندگان: Firouze Sadeghzadeh,Azizieh Sadeghzadeh,Saeed Changizi-Ashtiyani,Abass Alimoradian,Mehry Mashayekhei,Ali Zarei,Farideh Jalali-Mashayekhi
- مشاهده
- جایگاه : پژوهشی
- مجله: Asia Pacific Journal of Medical Toxicology
- نوع مقاله: Journal Article
- کلمات کلیدی: drugs,Poisoning,Epidemiology,Traditional Drugs,Synthetic Drugs
- چکیده:
- چکیده انگلیسی: Background: Drug abuse is a global problem in most countries and poisoning caused by them has involved the emergency department (ED). This paper aims to investigate the changes in the epidemiological pattern of poisoned cases due to drugs in Hamadan province of Iran.
Methods: In this five year cross - sectional study, we assessed the epidemiologic pattern of poisoned cases due to drugs hospitalized in Farshchian - Sina Hospital of Hamadan, west Iran from March 2015 to March 2019.
Results: During this period, 7199 poisoned patients referred to hospital and 1773 of them hospitalized due to any kind of drugs.81% were male and 19% were female (p <0.001). The mean age in male cases was 40.85 ± 16.85 and in female cases was 42.37 ± 18.36. 86.4% of the cases lived in urban areas and 13.6% of them lived in rural areas. The most common drugs were opium (33%), methadone (22.7%) and methamphetamine (20.9%). In 35.1% male cases and in 45.8% female cases the most common drugs were opium and methamphetamine, respectively (p <0.001). In 79.2% of cases, overdose and in 20.5% of them, suicide attempt was the most common causes of use. Most cases were alive and only 1.7% were deceased.
Conclusions: Although, poisoning by traditional drugs was still the most common cause of poisoning at the time of the study in this province, poisoning by synthetic drugs are on the rise.
- انتشار مقاله: 09-05-1399
- نویسندگان: Saeed Afzali,Abass Moradi,Hasti Alinaghizadeh
- مشاهده
- جایگاه : پژوهشی
- مجله: Asia Pacific Journal of Medical Toxicology
- نوع مقاله: Journal Article
- کلمات کلیدی: drugs,Poisoning,Epidemiology,Traditional Drugs,Synthetic Drugs
- چکیده:
- چکیده انگلیسی: Background: Drug abuse is a global problem in most countries and poisoning caused by them has involved the emergency department (ED). This paper aims to investigate the changes in the epidemiological pattern of poisoned cases due to drugs in Hamadan province of Iran.
Methods: In this five year cross - sectional study, we assessed the epidemiologic pattern of poisoned cases due to drugs hospitalized in Farshchian - Sina Hospital of Hamadan, west Iran from March 2015 to March 2019.
Results: During this period, 7199 poisoned patients referred to hospital and 1773 of them hospitalized due to any kind of drugs.81% were male and 19% were female (p <0.001). The mean age in male cases was 40.85 ± 16.85 and in female cases was 42.37 ± 18.36. 86.4% of the cases lived in urban areas and 13.6% of them lived in rural areas. The most common drugs were opium (33%), methadone (22.7%) and methamphetamine (20.9%). In 35.1% male cases and in 45.8% female cases the most common drugs were opium and methamphetamine, respectively (p <0.001). In 79.2% of cases, overdose and in 20.5% of them, suicide attempt was the most common causes of use. Most cases were alive and only 1.7% were deceased.
Conclusions: Although, poisoning by traditional drugs was still the most common cause of poisoning at the time of the study in this province, poisoning by synthetic drugs are on the rise.
- انتشار مقاله: 09-05-1399
- نویسندگان: Saeed Afzali,Abass Moradi,Hasti Alinaghizadeh
- مشاهده